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9 results on '"Agosto-Perez, Francisco J."'

4. POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes

Author

Zhou, Haixia, primary, Brekman, Angelika, additional, Zuo, Wu-Lin, additional, Ou, Xuemei, additional, Shaykhiev, Renat, additional, Agosto-Perez, Francisco J., additional, Wang, Rui, additional, Walters, Matthew S., additional, Salit, Jacqueline, additional, Strulovici-Barel, Yael, additional, Staudt, Michelle R., additional, Kaner, Robert J., additional, Mezey, Jason G., additional, Crystal, Ronald G., additional, and Wang, Guoqing, additional

Published
2016
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7. An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules

Author

Qin, Huaxia, primary, Chan, Michael WY, additional, Liyanarachchi, Sandya, additional, Balch, Curtis, additional, Potter, Dustin, additional, Souriraj, Irene J, additional, Cheng, Alfred SL, additional, Agosto-Perez, Francisco J, additional, Nikonova, Elena V, additional, Yan, Pearlly S, additional, Lin, Huey-Jen, additional, Nephew, Kenneth P, additional, Saltz, Joel H, additional, Showe, Louise C, additional, Huang, Tim HM, additional, and Davuluri, Ramana V, additional

Published
2009
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8. A MicroRNA Signature of Hypoxia

Author

Kulshreshtha, Ritu, primary, Ferracin, Manuela, additional, Wojcik, Sylwia E., additional, Garzon, Ramiro, additional, Alder, Hansjuerg, additional, Agosto-Perez, Francisco J., additional, Davuluri, Ramana, additional, Liu, Chang-Gong, additional, Croce, Carlo M., additional, Negrini, Massimo, additional, Calin, George A., additional, and Ivan, Mircea, additional

Published
2007
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9. POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes.

Author

Haixia Zhou, Brekman, Angelika, Wu-Lin Zuo, Xuemei Ou, Shaykhiev, Renat, Agosto-Perez, Francisco J., Rui Wang, Walters, Matthew S., Salit, Jacqueline, Strulovici-Barel, Yael, Staudt, Michelle R., Kaner, Robert J., Mezey, Jason G., Crystal, Ronald G., and Guoqing Wang

Subjects
*TRANSCRIPTION factors, *AIRWAY (Anatomy), *PROGENITOR cells, *CELL differentiation, *GENE expression
Abstract

In the process of seeking novel lung host defense regulators by analyzing genome-wide RNA sequence data from normal human airway epithelium, we detected expression of POU domain class 2-associating factor 1 (POU2AF1), a known transcription cofactor previously thought to be expressed only in lymphocytes. Lymphocyte contamination of human airway epithelial samples obtained by bronchoscopy and brushing was excluded by immunohistochemistry staining, the observation of upregulation of POU2AF1 in purified airway basal stem/progenitor cells undergoing differentiation, and analysis of differentiating single basal cell clones. Lentivirus-mediated upregulation of POU2AF1 in airway basal cells induced upregulation of host defense genes, including MX1, IFIT3, IFITM, and known POU2AF1 downstream genes HLA-DRA, ID2, ID3, IL6, and BCL6. Interestingly, expression of these genes paralleled changes of POU2AF1 expression during airway epithelium differentiation in vitro, suggesting POU2AF1 helps to maintain a host defense tone even in pathogen-free condition. Cigarette smoke, a known risk factor for airway infection, suppressed POU2AF1 expression both in vivo in humans and in vitro in human airway epithelial cultures, accompanied by deregulation of POU2AF1 downstream genes. Finally, enhancing POU2AF1 expression in human airway epithelium attenuated the suppression of host defense genes by smoking. Together, these findings suggest a novel function of POU2AF1 as a potential regulator of host defense genes in the human airway epithelium. [ABSTRACT FROM AUTHOR]

Published
2016
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