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2. Evaluation of levels, specificity and pathophysiology of anti-C1q autoantibodies in pregnancy

Author

Agostinis, C., primary, Zito, G., additional, Toffoli, M., additional, Balduit, A., additional, Mangogna, A., additional, Belmonte, B., additional, Romano, F., additional, Stampalija, T., additional, Salviato, T., additional, Defendi, F., additional, Di Simone, N., additional, Kishore, U., additional, Giuseppe, R., additional, and Bulla, R., additional

Published
2023
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3. Effective revascularization of non-healing wounds by the human Stromal Vascular Fraction relies on direct cell integration and paracrine signals

Author

Vuerich, R, primary, Groppa, E, additional, Vodret, S, additional, Ring, N, additional, Stocco, C, additional, Bossi, F, additional, Agostinis, C, additional, Colliva, A, additional, Simoncello, F, additional, Benvenuti, F, additional, Agnelli, A, additional, Dore, F, additional, Bulla, R, additional, Papa, G, additional, and Zacchigna, S, additional

Published
2022
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4. Immunomodulation mediated by a herbal syrup containing a standardized Echinacea root extract: a pilot study in healthy human subjects on cytokine gene expression

Author

Dapas, B., Dall'Acqua, S., Bulla, R., Agostinis, C., Perissutti, B., Invernizzi, S., Grassi, G., and Voinovich, D.

Subjects
Materia medica, Vegetable -- Health aspects, Pharmacology, Experimental, Pharmacognosy -- Research, Plant extracts -- Health aspects, Echinacea -- Health aspects, Biological sciences, Health, Science and technology
Abstract

ABSTRACT In this study, the immunomodulatory effect of a triply standardized Echinacea angustifolia root extract (Polinacea®) was evaluated in 10 healthy subjects. Ten ml of syrup containing one hundred mg [...]

Published
2014
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5. Acute and Subacute Outcome Predictors in Moderate and Severe Traumatic Brain Injury: A Retrospective Monocentric Study

Author

Gritti, P, Zangari, R, Carobbio, A, Zucchi, A, Lorini, F, Ferri, F, Agostinis, C, Lanterna, L, Brembilla, C, Foresti, C, Barbui, T, Biroli, F, Gritti P, Zangari R, Carobbio A, Zucchi A, Lorini F, Ferri F, Agostinis C, Lanterna LA, Brembilla C, Foresti C, Barbui T, Biroli F., Gritti, P, Zangari, R, Carobbio, A, Zucchi, A, Lorini, F, Ferri, F, Agostinis, C, Lanterna, L, Brembilla, C, Foresti, C, Barbui, T, Biroli, F, Gritti P, Zangari R, Carobbio A, Zucchi A, Lorini F, Ferri F, Agostinis C, Lanterna LA, Brembilla C, Foresti C, Barbui T, and Biroli F.

Abstract

Background: Prognostic factors affecting outcome of traumatic brain injury (TBI), despite their importance, are still under discussion. The purpose of this study was to describe risk factors of in-hospital mortality and outcome at 1 year in a homogeneously treated population of patients with moderate/severe TBI. Methods: A total of 193 consecutive patients with moderate or severe TBI (Glasgow Coma Scale [GCS] score 13–3, including patients with initial GCS score of 13 at high risk for subsequent neurologic deterioration), admitted to the intensive care unit, were retrospectively analyzed. In-hospital mortality and unfavorable outcome at 1 year, based on a Glasgow Outcome Scale–Extended score ≤4, were considered as primary and secondary outcomes. Results: At 1 year, unfavorable outcome occurred in 47.2%, including an in-hospital mortality of 19.7%. Increasing age, GCS motor score <3, coagulation disorders, and intracranial hypertension were acute risk factors of in-hospital mortality. In the 155 remaining survivors, Oxford Handicap Scale (OHS), posttraumatic cerebral infarction, cerebrospinal fluid disturbances, and length of intensive care unit stay were associated with unfavorable outcome at 1 year, in univariate analysis. A cutoff OHS score ≥3 discriminated the probability of an unfavorable outcome (area under the curve, 0.87; P < 0.001; specificity, 74%; sensitivity, 84%). Combining the effect of acute and subacute variables in a multivariate analysis, increasing age and OHS score were independent predictors of outcome. Conclusions: The results of this retrospective study confirmed age as the main acute risk factor and identified OHS as new potential subacute predictor of unfavorable outcome in moderate and severe TBI.

Published
2019

6. Native Aortic Arch Interruption in Adulthood: Surgical Management

Author

Federici, D, Bichi, S, Montesi, G, Matiashvili, D, Agostinis, C, Morzenti, C, Sironi, S, Galletti, L, Federici D., Bichi S., Montesi G., Matiashvili D., Agostinis C., Morzenti C., Sironi S., Galletti L., Federici, D, Bichi, S, Montesi, G, Matiashvili, D, Agostinis, C, Morzenti, C, Sironi, S, Galletti, L, Federici D., Bichi S., Montesi G., Matiashvili D., Agostinis C., Morzenti C., Sironi S., and Galletti L.

Abstract

Aortic coarctations in adults are mainly represented by recurrent critical narrowing at the site of previous surgical correction, or less frequently by native forms of complex obstructive malformations of the distal arch and isthmus. We present our experience with an unusual form of native adult aortic coarctation presenting as a complete interruption of the aortic arch.

Published
2019

9. Study of the prognostic significance of the protein C1q in carcinomas

Author

Mangogna, A, Agostinis, C, Bonazza, D, Belmonte, B, Zacchi, P, Zito, G, Romano, A, Zanconati, F, Ricci, G, Bulla, R, Mangogna, A, Agostinis, C, Bonazza, D, Belmonte, B, Zacchi, P, Zito, G, Romano, A, Zanconati, F, Ricci, G, and Bulla, R

Subjects
carcinomas, Complement, C1q
Published
2019

10. THE CLINICOPATHOLOGICAL AND PROGNOSTIC SIGNIFICANCES OF C1Q EXPRESSION IN GLIOMAS: A BIOINFORMATICS ANALYSIS

Author

Belmonte, B., Mangogna, A., Zacchi, P., Morello, G., Agostinis, C., Balduit, A., Iacopino, D. G., Martorana, A., Rodolico, V., Bonazza, D., Zanconati, F., Bulla, R., Belmonte, B., Mangogna, A., Zacchi, P., Morello, G., Agostinis, C., Balduit, A., Iacopino, D. G., Martorana, A., Rodolico, V., Bonazza, D., Zanconati, F., and Bulla, R.

Subjects
C1Q, GLIOMAS, BIOINFORMATICS ANALYSIS, GLIOMAS, C1Q
Abstract

Introduction. The complement system represents an important component of the inflammatory response and acts as a functional bridge between the innate and adaptive immune response. The contribution of the complement component C1q in the pathophysiology of brain cancers has been recently considered in light of its well-known involvement in carcinogenesis. Brain malignancies arise from cells of the CNS and are classified according to the tissue of phylogenetic origin. Gliomas represent the most common and aggressive form of brain tumours in adults. They derive from glial cells that help to support the functions of the other main brain cells type, the neurons (1). These are a heterogeneous group of diseases with multiple subtypes (1, 2). Glioblastoma multiforme (GBM) is the most common and fatal form of a primary brain tumour, accounting for approximately 60% of all glioma cases (3), whereas grade-II and -III gliomas are the second most common type of glioma in adults (~30%) (3). C1q molecule, together with other complement components, can be locally produced within the CNS by microglia and astrocytes, rendering it an attractive player in primary brain tumour development (4). The role of C1q in gliomas microenvironment is still poorly characterized and it is still quite puzzling whether it exerts a beneficial or a harmful activity for cancer progression. In the present study we performed a bioinformatics analysis aimed at investigating if C1q can serve as a potential prognostic marker for gliomas. Methods. The expression levels of C1qA, C1qB and C1qC genes in gliomas were analysed using Oncomine analysis. Available genomics data from The Cancer Genome Atlas project was used for Kaplan–Meier survival analysis to generate survival probability plots, using UALCAN analysis. Results. From the analysis performed on several data- sets using Oncomine, we showed a significantly higher mRNA expression levels for C1qA, C1qB and C1qC chains were detected in gliomas (different histotypes and grades) as compared to normal brain tissue (Fig. 1). We observed a positive correlation between the mRNA expression of C1qA, C1qB and C1qC mRNA poly- peptide chains and the unfavorable prognosis only in gliomas grade-II and -III, where the survival probability is indeed reduced (P

Published
2019

13. Complement Component 3 expressed by the endometrial ectopic tissue is involved in the endometriotic lesion formation through mast cell activation

Author

Agostinis, C., primary, Zorzet, S., additional, Balduit, A., additional, Zito, G., additional, Mangogna, A., additional, Macor, Paolo, additional, Romano, F., additional, Toffoli, M., additional, Belmonte, B., additional, Martorana, A., additional, Borelli, V., additional, Ricci, G., additional, Kishore, U., additional, and Bulla, R., additional

Published
2020
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21. What is hiding behind bubbles of air? an unusual streptococcus pyogenes meningitis [Cosa si nasconde dietro le bolle d’aria? Un’inusuale meningite da Streptococcus pyogenes]

Author

Gritti, P, Lanterna, A, Sarnecki, T, Brembilla, C, Agostinis, C, Rizzi, M, Lorini, F, Gritti P, Lanterna AL, Sarnecki T, Brembilla C, Agostinis C, Rizzi M, Lorini F, Gritti, P, Lanterna, A, Sarnecki, T, Brembilla, C, Agostinis, C, Rizzi, M, Lorini, F, Gritti P, Lanterna AL, Sarnecki T, Brembilla C, Agostinis C, Rizzi M, and Lorini F

Abstract

Streptococcus pyogenes is a rare but aggressive cause of meningitis, which often evolves in a poor outcome with fatal consequences. Although lumbar puncture and CT scan of the brain are the gold standard of diagnosis of cerebral infections, they can have some limitations. We report and describe the clinical history and neuroimaging of a 36-year-old woman admitted to the emergency department of our hospital three days after the onset of earache and otorrhoea. When the patient developed an emergent refractory status epilepticus, the CT scan of the brain showed an unusual pneumocephalus. However, the MRI study of the brain revealed a pachymeningitis with partial thrombosis of the right transverse sinus and subdural empyema due to a S. pyogenes otitis media. Prompt diagnosis and the specific findings of the MRI allowed rapid correct treatment and thus led to a good outcome for the patient.

Published
2014

22. Neonatal haemochromatosis with reversible pituitary involvement

Author

Indolfi, G, Berczes, R, Pelliccioli, I, Bosisio, M, Agostinis, C, Resti, M, Zambelli, M, Lucianetti, A, Colledan, M, D'Antiga, L, Indolfi G, Berczes R, Pelliccioli I, Bosisio M, Agostinis C, Resti M, Zambelli M, Lucianetti A, Colledan M, D'Antiga L, Indolfi, G, Berczes, R, Pelliccioli, I, Bosisio, M, Agostinis, C, Resti, M, Zambelli, M, Lucianetti, A, Colledan, M, D'Antiga, L, Indolfi G, Berczes R, Pelliccioli I, Bosisio M, Agostinis C, Resti M, Zambelli M, Lucianetti A, Colledan M, and D'Antiga L

Abstract

Neonatal haemochromatosis is a rare alloimmune gestational disease with a high mortality. The hallmark of neonatal haemochromatosis is severe neonatal liver failure associated with extrahepatic siderosis. Thus far, no pituitary dysfunction has been reported to result from the tissue damage associated with extrahepatic siderosis. The present report describes a neonate with neonatal haemochromatosis and secondary hypothyroidism associated with pituitary iron deposition. Both the conditions were successfully treated by ABO-incompatible liver transplantation. Pituitary gland dysfunction is another possible extrahepatic manifestation of neonatal haemochromatosis, and it is reversible after liver transplantation.

Published
2014

23. The use of inhaled nitric oxide and prone position in an ARDS patient with severe traumatic brain injury during spine stabilization

Author

Gritti, P, Lanterna, L, Re, M, Martchenko, S, Olivotto, P, Brembilla, C, Agostinis, C, Paganoni, G, Lorini, F, Gritti P, Lanterna LA, Re M, Martchenko S, Olivotto P, Brembilla C, Agostinis C, Paganoni G, Lorini F, Gritti, P, Lanterna, L, Re, M, Martchenko, S, Olivotto, P, Brembilla, C, Agostinis, C, Paganoni, G, Lorini, F, Gritti P, Lanterna LA, Re M, Martchenko S, Olivotto P, Brembilla C, Agostinis C, Paganoni G, and Lorini F

Abstract

The use of inhaled nitric oxide in patients with traumatic brain injury, intracranial hypertension, and acute respiratory distress syndrome (ARDS) has been reported in an intensive care unit setting only in a few case reports. The use of the prone position for patients with traumatic brain injury and lung impairment has been reported only in selected cases. Here we report our experience with the use of both inhaled nitric oxide and the prone position together in the operating room in a patient with head injury and ARDS who underwent column stabilization.

Published
2013

36. C1q is involved in human trophoblast invasion

Author

Bulla, R., primary, Agostinis, C., additional, Bossi, F., additional, Rizzi, L., additional, Tripodo, C., additional, Radillo, O., additional, De Seta, F., additional, Ghebrehiwet, B., additional, and Tedesco, F., additional

Published
2007
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37. C1q Is Involved in Human Trophoblast Invasion

Author

Agostinis, C, primary, Rizzi, L, additional, Bossi, F, additional, Debeus, A, additional, Tripodo, C, additional, Radillo, O, additional, De Seta, F, additional, Bulla, R, additional, and Tedesco, F, additional

Published
2007
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38. The Combination of N-Acetyl Cysteine, Alpha-Lipoic Acid, and Bromelain Shows High Anti-Inflammatory Properties in Novel In Vivo and In Vitro Models of Endometriosis.

Author

Agostinis, C., Zorzet, S., De Leo, R., Zauli, G., De Seta, F., and Bulla, R.

Subjects
*CYSTEINE, *ANTI-inflammatory agents, *BROMELIN, *ACETYL compounds, *ENDOMETRIOSIS, *ENDOTHELIAL cells
Abstract

To evaluate the efficacy of an association of N-acetyl cystein, alpha-lipoic acid, and bromelain (NAC/LA/Br) in the treatment of endometriosis we set up a new in vivo murine model. We explored the anti-inflammatory and proapoptotic effect of this combination on human endometriotic endothelial cells (EECs) and on endothelial cells isolated from normal uterus (UtMECs). We implanted fragments of human endometriotic cysts intraperitoneally into SCID mice to evaluate the efficacy of NAC/LA/Br treatment. UtMECs and EECs, untreated or treated with NAC/LA/Br, were activated with the proinflammatory stimulus TNF-α and their response in terms of VCAM1 expression was evaluated. The proapoptotic effect of higher doses of NAC/LA/Br on UtMECs and EECs was measured with a fluorogenic substrate for activated caspases 3 and 7. The preincubation of EECs with NAC/LA/Br prior to cell stimulation with TNF-α prevents the upregulation of the expression of the inflammatory “marker” VCAM1. Furthermore NAC/LA/Br were able to induce EEC, but not UtMEC, apoptosis. Finally, the novel mouse model allowed us to demonstrate that mice treated with NAC/LA/Br presented a lower number of cysts, smaller in size, compared to untreated mice. Our findings suggest that these dietary supplements may have potential therapeutic uses in the treatment of chronic inflammatory diseases like endometriosis. [ABSTRACT FROM AUTHOR]

Published
2015
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40. Dementia after first stroke.

Author

Censori B, Manara O, Agostinis C, Camerlingo M, Casto L, Galavotti B, Partziguian T, Servali MC, Cesana B, Belloni G, Mamoli A, Censori, B, Manara, O, Agostinis, C, Camerlingo, M, Casto, L, Galavotti, B, Partziguian, T, Servalli, M C, and Cesana, B

Published
1996
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47. Alterazioni morfologiche dei nervi e vie ottiche nei pazienti con Neurofibromatosi tipo 1: Sono vere neoplasie?

Author

Barbò, R., Facchinetti, A., Fera, L., Fiorentini, P., Ruggeri, M., Agostinis, C., Albertini, F., Manara, O., Pecoraro, M.G., Piazzalunga, B., and Bonaldi, G.

Abstract

La diagnosi e la terapia delle lesioni delle vie ottiche, in pazienti affetti da Neurofibromatosi tipo 1, rappresentano argomenti problematici che non godono ancora di linee guida uniformemente accettate. In particolare il decorso benigno della maggior parte di queste alterazioni e soprattutto la loro non evolutività nel tempo, sembrerebbero giustificare una cauta sorveglianza clinico strumentale.Anche la nostra osservazione permetterebbe di considerare benigno, simil amartomatoso displastico, il decorso delle lesioni che coinvolgono i nervi ottici od il chiasma: in tutti i nostri casi infatti, alla stabilità del quadro radiologico si sono associate assenza di rilevanti modificazioni cliniche o strumentali.Un comportamento aggressivo ha caratterizzato invece le lesioni più posteriori, a sede ipotalamo-chiasmatica: in questi casi riteniamo indispensabili controlli radiologici ravvicinati nel tempo per stabilire il timing di un'eventuale terapia citoriduttiva.

Published
1999
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48. L'osservazione di un emangioma del cavo di Meckel

Author

Marina, R., Grimaldi, M., Agostinis, C., and Moschini, L.

Abstract

Si descrivono gli aspetti clinici e neuroradiologici di un caso di emangioma capillare del cavo di Meckel.Questi tumori sono di raro riscontro nella sede intracranica extracerebrale; in particolare questa è la seconda osservazione di emangioma della regione trigeminale riportata in letteratura.

Published
1995
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49. Neuroradiologia dei paragangliomi

Author

Moschini, L. and Agostinis, C.

Abstract

I paragangliomi rappresentano un sistema multicentrico con funzione chemo e barocettrice costituito da numerose strutture sostanzialmente ubiquitarie situate in stretta relazione anatomica con vasi e nervi.La patologia dei paragangliomi è essenzialmente tumorale. Nella maggior parte dei casi si tratta di tumori benigni non secernenti che si manifestano per l'effetto massa e per la compressione di organi adiacenti. Risultano più frequenti nel sesso femminile e nella 3ae 4adecade di vita. Per quanto riguarda il distretto cranio-cervicale, si riconoscono quattro sedi principali: in ordine di frequenza, carotidea, giugulare, timpanica e vagale. Questi tumori si presentano sia sporadicamente, sia nel 10% dei casi in forme famigliari con meccanismo di trasmissione autosomico dominante.Il protocollo diagnostico si basa sulla RM, sulla TC e sull'angiografia digitale, che con il ricorso all'embolizzazione preoperatoria può rappresentare anche l'inizio del programma terapeutico.

Published
1996
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50. What is hiding behind bubbles of air? an unusual streptococcus pyogenes meningitis,Cosa si nasconde dietro le bolle d’aria? Un’inusuale meningite da Streptococcus pyogenes

Author

Paolo Gritti, Lanterna, A. L., Sarnecki, T., Brembilla, C., Agostinis, C., Rizzi, M., Lorini, F. L., Gritti, P, Lanterna, A, Sarnecki, T, Brembilla, C, Agostinis, C, Rizzi, M, and Lorini, F

Subjects
Meningiti, Cerebral empyema, Sinus thrombosi, Pneumocephalu, Streptococcus pyogene
Abstract

Streptococcus pyogenes is a rare but aggressive cause of meningitis, which often evolves in a poor outcome with fatal consequences. Although lumbar puncture and CT scan of the brain are the gold standard of diagnosis of cerebral infections, they can have some limitations. We report and describe the clinical history and neuroimaging of a 36-year-old woman admitted to the emergency department of our hospital three days after the onset of earache and otorrhoea. When the patient developed an emergent refractory status epilepticus, the CT scan of the brain showed an unusual pneumocephalus. However, the MRI study of the brain revealed a pachymeningitis with partial thrombosis of the right transverse sinus and subdural empyema due to a S. pyogenes otitis media. Prompt diagnosis and the specific findings of the MRI allowed rapid correct treatment and thus led to a good outcome for the patient.

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