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Background: Increasing the use of traditional therapy is an obvious reality in some country. The bark of Khaya senegalensis is suspected to treat diabetes. That is what this type of work is started. Aims & Objective: The aim of this work is to test the effect of total Khaya senegalensis barks extracts on the hepatic liberation of glucose in vitro. Materials and Methods: The dried extracts obtained from barks powder had been prepared at concentrations of 0, 2, 5, 10 and 20 μg/L and applied on fragments of mice Wistar isolated liver, kept in Mack -Ewen solution. After incubation at 37°C in oven, glucose level in the solution had been measured by spectrophometer, using GOD-PAP® regent, for each extracts concentration at the times T=0, 10, 20, 30, 40, 50 and 60 minutes. Results: Glucose level in the solution had varied in time function from one extracts concentration to another. Khaya senegalensis barks total extracts had reduced hepatic liberation of glucose. This effect had been comparable to the effect of insulin 2,5IU solution used like reference substance in this experimentation. The total extracts of Khaya senegalensis barks could actuate on enzymes implicated in the metabolism of intra hepatocytary glucose. Conclusion: This investigation had been coupled to phytochimic analyses that showed the presence of saponoïdes, anthracitic derivers and steroids in Khaya senegalensis barks. [ABSTRACT FROM AUTHOR]

Rift Valley fever (RVF) is a zoonotic disease, which caused several epidemics in humans in many countries of Africa. Using an inhibition enzyme-linked immunosorbent assay (ELISA), real-time reverse transcription PCR, and nested one-step reverse transcription PCR, we conducted a cross-sectional study in populations of sheep and goats from the Mongo County in 2014 to determine the circulation of the Rift Valley fever virus (RVFV) in small ruminants from this area. From a total of 201 small ruminants (95 sheep and 106 goats), the overall IgG seroprevalence against the RVFV was 6.47% (13/201). No RVFV RNA was detected in the animal plasmas. Logistic regression analysis showed that age, species, sex, and locality were not the significant risk factors. The findings of this study highlight the risk of RVF for domestic ruminants bred in this region and for the human rural population living in contact with these animals and they emphasize the need to develop adequate control measures to limit this threat.