Search

Background: The Koebner phenomenon is defined as ‘the development of psoriasis at sites of traumatized skin’. The ‘all-or-none principle’ means that, if psoriasis occurs in one area of injury, all injured areas develop psoriasis or vice versa. The aim is to demonstrate the concordance of patients with the all-or-none principle when a standard method of trauma is employed. Methods: Sixty-two patients with psoriasis were enrolled in the study. Demographic data and disease characteristics were recorded. The medial aspects of both forearms, devoid of lesions, were pricked using two sets of five 30-gauge needles at an angle of 30°, with 2-cm intervals. On days 14 and 28, the patients’ forearms were checked for the presence of a typical psoriatic plaque of white scales on an erythematous papule. Results: On day 28, 45 patients (72.5%) had a negative Koebner response in all prick sites whereas 1 patient (1.6%) had psoriatic papules in 10 out of 10 prick sites. The rest of the patients (n = 16, 25.8%) had between 1 and 9 papules in number. Conclusion: Using standard methods of trauma, it is possible to induce psoriasis lesions as a Koebner response but this response is not always in concordance with the all-or-none principle previously described.

Background Surgical techniques have recently been introduced for patients with vitiligo. Randomized controlled trials have not been performed. Aim To compare the efficacy and side-effects of two surgical methods (suction blister vs. thin split-thickness graft technique) for the treatment of vitiligo. Methods Three suction blisters, approximately 0.8 cm in diameter, made with a special tool attached to a vacuum extractor, which were converted to erosions by removal of the roofs of the bullae, and one round erosion of approximately the same diameter, made using a silver knife, were created. One roof of a blister and two cutaneous thin split-thickness grafts taken from the gluteal region were transferred onto recipient vitiliginous areas; one was left alone. The results were evaluated by one non-blind and two blind observers bimonthly during the 3-month follow-up period. Results Repigmentation rates were 25-65% in the suction blister technique and 90% in the thin split-thickness graft technique (P < 0.001). Conclusions The thin split-thickness graft technique is superior to the suction blister technique in treating vitiligo.

Background Intraepidermal IgA pustulosis is a rare vesiculopustular condition characterized by intercellular IgA deposits, neutrophilic infiltration and mild acantholysis. This condition is usually reported in middle-aged or elderly people. We present the clinical, histological and immunofluorescence data of a child with this condition. Observation Our case is an 11-year-old girl who presented a pruritic vesiculopustular eruption involving the trunk, upper extremities, face and oral mucosa. Histopathologic examination revealed an intraepidermal pustule formation composed of neutrophils and some eosinophils and acantholytic cells in the spinal layer. Direct immunofluorescent test showed the deposition of IgA in the intercellular spaces throughout the whole of the epidermis. No circulating IgA anti-intercellular antibodies were detected by indirect immunofluorescence. She was treated with prednisolone 30 mg/daily. After discontinuation of corticosteroid treatment, we did not observe any skin lesions during a follow-up period of 2 years. Conclusion We consider this eruption intraepidermal IgA pustulosis (histologically intraepidermal neutrophilic type) based on clinical and histopathological findings. Intraepidermal IgA pustulosis should be considered in the differential diagnosis of vesiculopustular eruption in childhood.

We report a 17-year-old male patient with erythromelanosis follicularis faciei et colli (EFFC), oral leucokeratosis and diabetes mellitus without islet cell antibody. His sister also had minimal findings of EFFC and minimal follicular papules on her shoulders and extensor surfaces of the arms. The father had only fine follicular papules, but no erythromelanosis. Skin and mucous membrane lesions of the proband were investigated histopathologically. Interestingly, in peripheral lymphocyte cultures of the family members, chromosomal breakage was not observed spontaneously, but it was seen with nitrogen mustard, although this disease may be of autosomal recessive inheritance. Thus, we suggest that EFFC may be a polyaetiological disorder (i.e. familial and environmental) and might be considered one of the chromosomal instability syndromes.

Scleredema adultorum is a rare skin disorder reported to occur usually following streptococcal infections. It has characteristic clinical and histopathologic findings; however, associated hyperkeratosis is not known. We report a 6-year-old girl with scleredema adultorum and hyperkeratosis. The patient's disease had a benign course. To our knowledge, this patient is the first reported with scleredema adultorum associated with hyperkeratosis.

Objective To report three cases of mycosis fungoides with milia formation in the regressing lesions. Patients and setting Dermatology clinic of a university hospital (referral center). Three patients with mycosis fungoides with body surface involvement of 10% in one case (stage IIb) and exceeding 30% in two cases (stages IIb and III). All patients were treated with photochemotherapy and topical nitrogen mustard ointment in a concentration of 0.01%. After approximately 3 months multiple milia erupted on regressing plaques. Results The presence of milia was evident and was confirmed by histopathology. Regression of mycosis fungoides was noted in these plaques both clinically and in comparison with the pretreatment histologic appearance. Two of the patients showed a histological picture of follicular mucinosis. Conclusions We do not know the significance of milia in mycosis fungoides (MF). However, we suggest that follicular rupture or a degenerative process might result in milia formation.

Atrophia maculosa varioliformis cutis (AVMC) was first described by Heidingsfeld in 1918, as a rarely reported form of idiopathic macular atrophy on the cheek (1). It is characterized, clinically, by shallow, sharply demarcated depressions in various shapes. Extrahepatic biliary atresia (2) and pachydermodactyly (3) have been the only conditions associated with AMVC reported in the past 80 years. Although keratosis pilaris is a common skin disorder, it is related to other idiopathic atrophic conditions considered in the differential diagnosis of AMVC, namely keratosis pilaris atrophicans (4). However, the two associations may be coincidental. We observed a patient with keratosis pilaris, and her brother and an unrelated young man, whose findings led to a diagnosis of AMVC.

Aim/Objective. To prove the effectiveness of cryotherapy in the treatment of leishmaniasis cutis in a large group of patients. Subjects Two hundred and sixty-six lesions of 227 patients with leishmaniasis cutis. Methods Cryotherapy with a double freeze-thaw cycle by a CS-76 apparatus and liquid nitrogen. Results All lesions responded well with cosmetically acceptable scars. The recurrance rate was only 4%. Conclusion Cryotherapy is an effective method of treatment of leishmaniasis cutis. © 1995. The screeningo f the patientsi n this studyw as supportedb y the grant of the InvestigationF und of Qkurova University.

Follicular atrophoderma has been associated with a variety of findings. In our patient's family the disease was present in the mother and all of her living children. Scrotal tongue was also found in all but one child. We think that follicular atrophoderma is probably inherited as an autosomal dominant trait.

To the Editor.— We found that 91 (61%) of 141 cases in a study that were clinically diagnosed as onychomycosis yielded fungi by potassium hydroxide mount or culture, or both. Material from 18 (20%) of these cases failed to yield fungi in culture, although they were shown to contain such organisms in the potassium hydroxide mounts. Trichophyton rubrum was isolated from 16 of the remaining 73 patients; T mentagrophytes from 15; Microsporum canis from six; M gypseum from one; M audouinii from one; Candida albicans from 30; C tropicalis from two; C krusei from one; and C pelliculosa from one. Epidermophyton floccosum was not isolated from any patient. Nail infections from Microsporum sp are exceedingly rare. 1 In our eight patients, only the nails were infected. Five of six patients with M canis onychomycosis and one patient with M audouinii onychomycosis were adults with toenail involvement. These infections involved two