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300 results on '"Aglago, Elom K"'

1. Hepatic steatosis, metabolic dysfunction and risk of mortality: findings from a multinational prospective cohort study

Author: Mayén, Ana-Lucia, Sabra, Mirna, Aglago, Elom K., Perlemuter, Gabriel, Voican, Cosmin, Ramos, Ines, Debras, Charlotte, Blanco, Jessica, Viallon, Vivian, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Langmann, Fie, Dahm, Christina C., Rothwell, Joseph, Laouali, Nasser, Marques, Chloé, Schulze, Matthias B., Katzke, Verena, Kaaks, Rudolf, Palli, Domenico, Macciotta, Alessandra, Panico, Salvatore, Tumino, Rosario, Agnoli, Claudia, Farràs, Marta, Molina-Montes, Esther, Amiano, Pilar, Chirlaque, María-Dolores, Castilla, Jesús, Werner, Mårten, Bodén, Stina, Heath, Alicia K., Tsilidis, Kostas, Aune, Dagfinn, Weiderpass, Elisabete, Freisling, Heinz, Gunter, Marc J., and Jenab, Mazda
Published: 2024
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2. Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries

Author: Tong, Tammy Y. N., Clarke, Robert, Schmidt, Julie A., Huybrechts, Inge, Noor, Urwah, Forouhi, Nita G., Imamura, Fumiaki, Travis, Ruth C., Weiderpass, Elisabete, Aleksandrova, Krasimira, Dahm, Christina C., van der Schouw, Yvonne T., Overvad, Kim, Kyrø, Cecilie, Tjønneland, Anne, Kaaks, Rudolf, Katzke, Verena, Schiborn, Catarina, Schulze, Matthias B., Mayen-Chacon, Ana-Lucia, Masala, Giovanna, Sieri, Sabina, de Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda M. A., Verschuren, W. M. Monique, Brustad, Magritt, Nøst, Therese Haugdahl, Crous-Bou, Marta, Petrova, Dafina, Amiano, Pilar, Huerta, José María, Moreno-Iribas, Conchi, Engström, Gunnar, Melander, Olle, Johansson, Kristina, Lindvall, Kristina, Aglago, Elom K., Heath, Alicia K., Butterworth, Adam S., Danesh, John, and Key, Timothy J.
Published: 2024
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3. Nutritional quality of diet characterized by the Nutri-Score profiling system and cardiovascular disease risk: a prospective study in 7 European countries

Author: Deschasaux-Tanguy, Mélanie, Huybrechts, Inge, Julia, Chantal, Hercberg, Serge, Sarda, Barthélémy, Fialon, Morgane, Arnault, Nathalie, Srour, Bernard, Kesse-Guyot, Emmanuelle, Fezeu, Léopold K., Biessy, Carine, Casagrande, Corinne, Hemon, Bertrand, Weiderpass, Elisabete, Pinho, Maria G.M., Murphy, Neil, Freisling, Heinz, Ferrari, Pietro, Tjønneland, Anne, Nielsen Petersen, Kristina Elin, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Ricceri, Fulvio, Verschuren, W.M.Monique, Boer, Jolanda M.A., van der Schouw, Yvonne T., Skeie, Guri, Agudo, Antonio, Molina-Montes, Esther, Huerta, José María, Moreno-Iribas, Conchi, Ericson, Ulrika, Sonestedt, Emily, Strid, Anna, Oskarsson, Viktor, Tong, Tammy Y.N., Heath, Alicia K., Aglago, Elom K., Danesh, John, Riboli, Elio, Gunter, Marc J., and Touvier, Mathilde
Published: 2024
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4. Folate intake and colorectal cancer risk according to genetic subtypes defined by targeted tumor sequencing

Author: Aglago, Elom K, Qu, Conghui, Harlid, Sophia, Phipps, Amanda I, Steinfelder, Robert S, Ogino, Shuji, Thomas, Claire E, Hsu, Li, Toland, Amanda E, Brenner, Hermann, Berndt, Sonja I, Buchanan, Daniel D, Campbell, Peter T, Cao, Yin, Chan, Andrew T, Drew, David A, Figueiredo, Jane C, French, Amy J, Gallinger, Steven, Georgeson, Peter, Giannakis, Marios, Goode, Ellen L, Gruber, Stephen B, Gunter, Marc J, Harrison, Tabitha A, Hoffmeister, Michael, Huang, Wen-Yi, Hullar, Meredith AJ, Huyghe, Jeroen R, Jenkins, Mark A, Lynch, Brigid M, Moreno, Victor, Murphy, Neil, Newton, Christina C, Nowak, Jonathan A, Obón-Santacana, Mireia, Sun, Wei, Ugai, Tomotaka, Um, Caroline Y, Zaidi, Syed H, Tsilidis, Konstantinos K, van Guelpen, Bethany, and Peters, Ulrike
Published: 2024
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5. A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort

Author: Christakoudi, Sofia, Tsilidis, Konstantinos K., Dossus, Laure, Rinaldi, Sabina, Weiderpass, Elisabete, Antoniussen, Christian S., Dahm, Christina C., Tjønneland, Anne, Mellemkjær, Lene, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, May, Anne M., Monninkhof, Evelyn M., Quirós, J. Ramón, Bonet, Catalina, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Rosendahl, Ann H., Stocks, Tanja, Perez-Cornago, Aurora, Tin Tin, Sandar, Heath, Alicia K., Aglago, Elom K., Peruchet-Noray, Laia, Freisling, Heinz, and Riboli, Elio
Published: 2023
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6. Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses

Author: Dimou, Niki, Kim, Andre E., Flanagan, Orlagh, Murphy, Neil, Diez-Obrero, Virginia, Shcherbina, Anna, Aglago, Elom K., Bouras, Emmanouil, Campbell, Peter T., Casey, Graham, Gallinger, Steven, Gruber, Stephen B., Jenkins, Mark A., Lin, Yi, Moreno, Victor, Ruiz-Narvaez, Edward, Stern, Mariana C., Tian, Yu, Tsilidis, Kostas K., Arndt, Volker, Barry, Elizabeth L., Baurley, James W., Berndt, Sonja I., Bézieau, Stéphane, Bien, Stephanie A., Bishop, D. Timothy, Brenner, Hermann, Budiarto, Arif, Carreras-Torres, Robert, Cenggoro, Tjeng Wawan, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Chen, Xuechen, Conti, David V., Dampier, Christopher H., Devall, Matthew, Drew, David A., Figueiredo, Jane C., Giles, Graham G., Gsur, Andrea, Harrison, Tabitha A., Hidaka, Akihisa, Hoffmeister, Michael, Huyghe, Jeroen R., Jordahl, Kristina, Kawaguchi, Eric, Keku, Temitope O., Larsson, Susanna C., Le Marchand, Loic, Lewinger, Juan Pablo, Li, Li, Mahesworo, Bharuno, Morrison, John, Newcomb, Polly A., Newton, Christina C., Obon-Santacana, Mireia, Ose, Jennifer, Pai, Rish K., Palmer, Julie R., Papadimitriou, Nikos, Pardamean, Bens, Peoples, Anita R., Pharoah, Paul D. P., Platz, Elizabeth A., Potter, John D., Rennert, Gad, Scacheri, Peter C., Schoen, Robert E., Su, Yu-Ru, Tangen, Catherine M., Thibodeau, Stephen N., Thomas, Duncan C., Ulrich, Cornelia M., Um, Caroline Y., van Duijnhoven, Franzel J. B., Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, White, Emily, Wolk, Alicja, Woods, Michael O., Qu, Conghui, Kundaje, Anshul, Hsu, Li, Gauderman, W. James, Gunter, Marc J., and Peters, Ulrike
Published: 2023
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7. Body size and risk of colorectal cancer molecular defined subtypes and pathways: Mendelian randomization analyses

Author: Papadimitriou, Nikos, Qu, Conghui, Harrison, Tabitha A., Bever, Alaina M., Martin, Richard M., Tsilidis, Konstantinos K., Newcomb, Polly A., Thibodeau, Stephen N., Newton, Christina C., Um, Caroline Y., Obón-Santacana, Mireia, Moreno, Victor, Brenner, Hermann, Mandic, Marko, Chang-Claude, Jenny, Hoffmeister, Michael, Pellatt, Andrew J., Schoen, Robert E., Harlid, Sophia, Ogino, Shuji, Ugai, Tomotaka, Buchanan, Daniel D., Lynch, Brigid M., Gruber, Stephen B., Cao, Yin, Hsu, Li, Huyghe, Jeroen R., Lin, Yi, Steinfelder, Robert S., Sun, Wei, Van Guelpen, Bethany, Zaidi, Syed H., Toland, Amanda E., Berndt, Sonja I., Huang, Wen-Yi, Aglago, Elom K., Drew, David A., French, Amy J., Georgeson, Peter, Giannakis, Marios, Hullar, Meredith, Nowak, Johnathan A., Thomas, Claire E., Le Marchand, Loic, Cheng, Iona, Gallinger, Steven, Jenkins, Mark A., Gunter, Marc J., Campbell, Peter T., Peters, Ulrike, Song, Mingyang, Phipps, Amanda I., and Murphy, Neil
Published: 2024
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8. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses

Author: Sofianopoulou, Eleni, Kaptoge, Stephen K, Afzal, Shoaib, Jiang, Tao, Gill, Dipender, Gundersen, Thomas E, Bolton, Thomas R, Allara, Elias, Arnold, Matthew G, Mason, Amy M, Chung, Ryan, Pennells, Lisa A M, Shi, Fanchao, Sun, Luanluan, Willeit, Peter, Forouhi, Nita G, Langenberg, Claudia, Sharp, Stephen J, Panico, Salvatore, Engström, Gunnar, Melander, Olle, Tong, Tammy Y N, Perez-Cornago, Aurora, Norberg, Margareta, Johansson, Ingegerd, Katzke, Verena, Srour, Bernard, Sánchez, María José, Redondo-Sánchez, Daniel, Olsen, Anja, Dahm, Christina C, Overvad, Kim, Brustad, Magritt, Skeie, Guri, Moreno-Iribas, Conchi, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Tsilidis, Konstantinos K, Heath, Alicia K, Agnoli, Claudia, Krogh, Vittorio, de Boer, Ian H, Kobylecki, Camilla Jannie, Çolak, Yunus, Zittermann, Armin, Sundström, Johan, Welsh, Paul, Weiderpass, Elisabete, Aglago, Elom K, Ferrari, Pietro, Clarke, Robert, Boutron, Marie-Christine, Severi, Gianluca, MacDonald, Conor, Providencia, Rui, Masala, Giovanna, Zamora Ros, Raul, Boer, Jolanda, Verschuren, Wm Monique, Cawthon, Peggy, Schierbeck, Louise L, Cooper, Cyrus, Schulze, Matthias B, Bergmann, Manuela M, Hannemann, Anke, Kiechl, Stefan, Brenner, Hermann, van Schoor, Natasja M, Albertorio, Juan R, Sacerdote, Carlotta, Linneberg, Allan, Kårhus, LineL, Huerta, José María, Imaz, Liher, Joergensen, Christel, Ben-Shlomo, Yoav, Lundqvist, Annamari, Gallacher, John, Sattar, Naveed, Wood, Angela M, Wareham, Nicholas J, Nordestgaard, Børge G, Di Angelantonio, Emanuele, Danesh, John, Butterworth, Adam S, and Burgess, Stephen
Published: 2024
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9. Dietary intake of total, heme and non-heme iron and the risk of colorectal cancer in a European prospective cohort study

Author: Aglago, Elom K., Cross, Amanda J., Riboli, Elio, Fedirko, Veronika, Hughes, David J., Fournier, Agnes, Jakszyn, Paula, Freisling, Heinz, Gunter, Marc J., Dahm, Christina C., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Boutron-Ruault, Marie-Christine, Rothwell, Joseph A., Severi, Gianluca, Katzke, Verena, Srour, Bernard, Schulze, Matthias B., Wittenbecher, Clemens, Palli, Domenico, Sieri, Sabina, Pasanisi, Fabrizio, Tumino, Rosario, Ricceri, Fulvio, Bueno-de-Mesquita, Bas, Derksen, Jeroen W. G., Skeie, Guri, Jensen, Torill Enget, Lukic, Marko, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra, Barricarte, Aurelio, Ericson, Ulrika, van Guelpen, Bethany, Papier, Keren, Knuppel, Anika, Casagrande, Corinne, Huybrechts, Inge, Heath, Alicia K., Tsilidis, Konstantinos K., and Jenab, Mazda
Published: 2023
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10. Monitoring food environments and systems for sustainable diets in Africa

Author: Laar, Amos, primary, Osei-Kwasi, Hibbah Araba, additional, Laar, Matilda Essandoh, additional, Bosu, William K., additional, Nanema, Silver, additional, Asiki, Gershim, additional, Spires, Mark, additional, Diouf, Adama, additional, Manga, Julien Sodiba, additional, Moubarac, Jean Claude, additional, Aglago, Elom K., additional, Jafri, Ali, additional, Ohene-Agyei, Phyllis, additional, Holdsworth, Michelle, additional, and Vandevijvere, Stefanie, additional
Published: 2022
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11. Factors associated with serum ferritin levels and iron excess: results from the EPIC-EurGast study

Author: Iglesias-Vázquez, Lucía, Arija, Victoria, Aranda, Núria, Aglago, Elom K., Cross, Amanda J., Schulze, Matthias B., Quintana Pacheco, Daniel, Kühn, Tilman, Weiderpass, Elisabete, Tumino, Rosario, Redondo-Sánchez, Daniel, de Magistris, Maria Santucci, Palli, Domenico, Ardanaz, Eva, Laouali, Nasser, Sonestedt, Emily, Drake, Isabel, Rizzolo, Lucía, Santiuste, Carmen, Sacerdote, Carlotta, Quirós, Ramón, Amiano, Pilar, Agudo, Antonio, and Jakszyn, Paula
Published: 2022
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12. Participatory cooking demonstrations for mothers improve feeding practices of young children in southern Benin

Author: Mizehoun-Adissoda, Carmelle, primary, Morou, Karimou, additional, Edjrokinto, Hortis, additional, Padonou, Géraud S.R., additional, Mahounou, Joel R., additional, Flénon, Aubierge, additional, Wiafe, Michael A., additional, and Aglago, Elom K., additional
Published: 2024
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13. Supplemental Table 1 from Epidemiologic Factors in Relation to Colorectal Cancer Risk and Survival by Genotoxic Colibactin Mutational Signature

Author: Thomas, Claire E., primary, Georgeson, Peter, primary, Qu, Conghui, primary, Steinfelder, Robert S., primary, Buchanan, Daniel D., primary, Song, Mingyang, primary, Harrison, Tabitha A., primary, Um, Caroline Y., primary, Hullar, Meredith A., primary, Jenkins, Mark A., primary, Van Guelpen, Bethany, primary, Lynch, Brigid M., primary, Melaku, Yohannes Adama, primary, Huyghe, Jeroen R., primary, Aglago, Elom K., primary, Berndt, Sonja I., primary, Boardman, Lisa A., primary, Campbell, Peter T., primary, Cao, Yin, primary, Chan, Andrew T., primary, Drew, David A., primary, Figueiredo, Jane C., primary, French, Amy J., primary, Giannakis, Marios, primary, Goode, Ellen L., primary, Gruber, Stephen B., primary, Gsur, Andrea, primary, Gunter, Marc J., primary, Hoffmeister, Michael, primary, Hsu, Li, primary, Huang, Wen-Yi, primary, Moreno, Victor, primary, Murphy, Neil, primary, Newcomb, Polly A., primary, Newton, Christina C., primary, Nowak, Jonathan A., primary, Obón-Santacana, Mireia, primary, Ogino, Shuji, primary, Sun, Wei, primary, Toland, Amanda E., primary, Trinh, Quang M., primary, Ugai, Tomotaka, primary, Zaidi, Syed H., primary, Peters, Ulrike, primary, and Phipps, Amanda I., primary
Published: 2024
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14. Supplemental Table 2 from Epidemiologic Factors in Relation to Colorectal Cancer Risk and Survival by Genotoxic Colibactin Mutational Signature

Author: Thomas, Claire E., primary, Georgeson, Peter, primary, Qu, Conghui, primary, Steinfelder, Robert S., primary, Buchanan, Daniel D., primary, Song, Mingyang, primary, Harrison, Tabitha A., primary, Um, Caroline Y., primary, Hullar, Meredith A., primary, Jenkins, Mark A., primary, Van Guelpen, Bethany, primary, Lynch, Brigid M., primary, Melaku, Yohannes Adama, primary, Huyghe, Jeroen R., primary, Aglago, Elom K., primary, Berndt, Sonja I., primary, Boardman, Lisa A., primary, Campbell, Peter T., primary, Cao, Yin, primary, Chan, Andrew T., primary, Drew, David A., primary, Figueiredo, Jane C., primary, French, Amy J., primary, Giannakis, Marios, primary, Goode, Ellen L., primary, Gruber, Stephen B., primary, Gsur, Andrea, primary, Gunter, Marc J., primary, Hoffmeister, Michael, primary, Hsu, Li, primary, Huang, Wen-Yi, primary, Moreno, Victor, primary, Murphy, Neil, primary, Newcomb, Polly A., primary, Newton, Christina C., primary, Nowak, Jonathan A., primary, Obón-Santacana, Mireia, primary, Ogino, Shuji, primary, Sun, Wei, primary, Toland, Amanda E., primary, Trinh, Quang M., primary, Ugai, Tomotaka, primary, Zaidi, Syed H., primary, Peters, Ulrike, primary, and Phipps, Amanda I., primary
Published: 2024
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15. Data from Epidemiologic Factors in Relation to Colorectal Cancer Risk and Survival by Genotoxic Colibactin Mutational Signature

Author: Thomas, Claire E., primary, Georgeson, Peter, primary, Qu, Conghui, primary, Steinfelder, Robert S., primary, Buchanan, Daniel D., primary, Song, Mingyang, primary, Harrison, Tabitha A., primary, Um, Caroline Y., primary, Hullar, Meredith A., primary, Jenkins, Mark A., primary, Van Guelpen, Bethany, primary, Lynch, Brigid M., primary, Melaku, Yohannes Adama, primary, Huyghe, Jeroen R., primary, Aglago, Elom K., primary, Berndt, Sonja I., primary, Boardman, Lisa A., primary, Campbell, Peter T., primary, Cao, Yin, primary, Chan, Andrew T., primary, Drew, David A., primary, Figueiredo, Jane C., primary, French, Amy J., primary, Giannakis, Marios, primary, Goode, Ellen L., primary, Gruber, Stephen B., primary, Gsur, Andrea, primary, Gunter, Marc J., primary, Hoffmeister, Michael, primary, Hsu, Li, primary, Huang, Wen-Yi, primary, Moreno, Victor, primary, Murphy, Neil, primary, Newcomb, Polly A., primary, Newton, Christina C., primary, Nowak, Jonathan A., primary, Obón-Santacana, Mireia, primary, Ogino, Shuji, primary, Sun, Wei, primary, Toland, Amanda E., primary, Trinh, Quang M., primary, Ugai, Tomotaka, primary, Zaidi, Syed H., primary, Peters, Ulrike, primary, and Phipps, Amanda I., primary
Published: 2024
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16. Pre‐diagnostic plasma advanced glycation end‐products and soluble receptor for advanced glycation end‐products and mortality in colorectal cancer patients.

Author: Li, Jinze, Roshelli Baker, Jacqueline, Aglago, Elom K., Zhao, Zhiwei, Jiao, Li, Freisling, Heinz, Hughes, David J., Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Pala, Valeria, Pasanisi, Fabrizio, Tumino, Rosario, Padroni, Lisa, Vermeulen, Roel C. H., and Gram, Inger T.
Subjects: CANCER-related mortality, COLORECTAL cancer, LIQUID chromatography, CHRONIC diseases, CANCER patients
Abstract: Advanced glycation end‐products (AGEs), formed endogenously or obtained exogenously from diet, may contribute to chronic inflammation, intracellular signaling alterations, and pathogenesis of several chronic diseases including colorectal cancer (CRC). However, the role of AGEs in CRC survival is less known. The associations of pre‐diagnostic circulating AGEs and their soluble receptor (sRAGE) with CRC‐specific and overall mortality were estimated using multivariable‐adjusted Cox proportional hazards regression among 1369 CRC cases in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Concentrations of major plasma AGEs, Nε‐[carboxy‐methyl]lysine (CML), Nε‐[carboxy‐ethyl]lysine (CEL) and Nδ‐[5‐hydro‐5‐methyl‐4‐imidazolon‐2‐yl]‐ornithine (MG‐H1), were measured using ultra‐performance liquid chromatography mass‐spectrometry. sRAGE was assessed by enzyme‐linked immunosorbent assay. Over a mean follow‐up period of 96 months, 693 deaths occurred of which 541 were due to CRC. Individual and combined AGEs were not statistically significantly associated with CRC‐specific or overall mortality. However, there was a possible interaction by sex for CEL (Pinteraction =.05). Participants with higher sRAGE had a higher risk of dying from CRC (HRQ5vs.Q1 = 1.67, 95% CI: 1.21–2.30, Ptrend =.02) or any cause (HRQ5vs.Q1 = 1.38, 95% CI: 1.05–1.83, Ptrend =.09). These associations tended to be stronger among cases with diabetes (Pinteraction =.03) and pre‐diabetes (Pinteraction <.01) before CRC diagnosis. Pre‐diagnostic AGEs were not associated with CRC‐specific and overall mortality in individuals with CRC. However, a positive association was observed for sRAGE. Our findings may stimulate further research on the role of AGEs and sRAGE in survival among cancer patients with special emphasis on potential effect modifications by sex and diabetes. [ABSTRACT FROM AUTHOR]
Published: 2024
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17. Plasma concentration of 36 (poly)phenols and prospective body weight change in participants from the EPIC cohort

Author: Gil-Lespinard, Mercedes, Almanza-Aguilera, Enrique, Castañeda, Jazmín, Guiñón-Fort, Daniel, Eriksen, Anne Kirstine, Tjønneland, Anne, Rothwell, Joseph A., Shah, Sanam, Cadeau, Claire, Katzke, Verena, Johnson, Theron, Schulze, Matthias B., Oliverio, Andreina, Pasanisi, Fabrizio, Tumino, Rosario, Manfredi, Luca, Masala, Giovana, Skeie, Guri, Lundblad, Marie Wasmuth, Brustad, Magritt, Lasheras, Cristina, Crous-Bou, Marta, Molina-Montes, Esther, Colorado-Yohar, Sandra, Guevara, Marcela, Amiano, Pilar, Johansson, Ingegerd, Hultdin, Johan, Forouhi, Nita G., Freisling, Heinz, Merdas, Mira, Debras, Charlotte, Heath, Alicia K., Aglago, Elom K., Aune, Dagfinn, Zamora-Ros, Raul, Gil-Lespinard, Mercedes, Almanza-Aguilera, Enrique, Castañeda, Jazmín, Guiñón-Fort, Daniel, Eriksen, Anne Kirstine, Tjønneland, Anne, Rothwell, Joseph A., Shah, Sanam, Cadeau, Claire, Katzke, Verena, Johnson, Theron, Schulze, Matthias B., Oliverio, Andreina, Pasanisi, Fabrizio, Tumino, Rosario, Manfredi, Luca, Masala, Giovana, Skeie, Guri, Lundblad, Marie Wasmuth, Brustad, Magritt, Lasheras, Cristina, Crous-Bou, Marta, Molina-Montes, Esther, Colorado-Yohar, Sandra, Guevara, Marcela, Amiano, Pilar, Johansson, Ingegerd, Hultdin, Johan, Forouhi, Nita G., Freisling, Heinz, Merdas, Mira, Debras, Charlotte, Heath, Alicia K., Aglago, Elom K., Aune, Dagfinn, and Zamora-Ros, Raul
Abstract: Introduction: Dietary intake of (poly)phenols has been linked to reduced adiposity and body weight (BW) in several epidemiological studies. However, epidemiological evidence on (poly)phenol biomarkers, particularly plasma concentrations, is scarce. We aimed to investigate the associations between plasma (poly)phenols and prospective BW change in participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: This study included 761 participants with data on BW at baseline and after 5 years of follow-up. Plasma concentrations of 36 (poly)phenols were measured at baseline using liquid chromatography-tandem mass spectrometry. Associations were assessed through general linear mixed models and multinomial logistic regression models, using change in BW as a continuous or as a categorical variable (BW loss, maintenance, gain), respectively. Plasma (poly)phenols were assessed as log2-transformed continuous variables. The false discovery rate (FDR) was used to control for multiple comparisons. Results: Doubling plasma (poly)phenol concentrations showed a borderline trend towards a positive association with BW loss. Plasma vanillic acid showed the strongest association (−0.53 kg/5 years; 95% confidence interval [CI]: −0.99, −0.07). Similar results were observed for plasma naringenin comparing BW loss versus BW maintenance (odds ratio: 1.1; 95% CI: 1.0, 1.2). These results did not remain significant after FDR correction. Conclusion: Higher concentrations of plasma (poly)phenols suggested a tendency towards 5-year BW maintenance or loss. While certain associations seemed promising, they did not withstand FDR correction, indicating the need for caution in interpreting these results. Further studies using (poly) phenol biomarkers are needed to confirm these suggestive protective trends.
Published: 2024
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18. Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries

Author: Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Tong, Tammy Y.N., Clarke, Robert, Schmidt, Julie A., Huybrechts, Inge, Noor, Urwah, Forouhi, Nita G., Imamura, Fumiaki, Travis, Ruth C., Weiderpass, Elisabete, Aleksandrova, Krasimira, Dahm, Christina C., van der Schouw, Yvonne T., Overvad, Kim, Kyrø, Cecilie, Tjønneland, Anne, Kaaks, Rudolf, Katzke, Verena, Schiborn, Catarina, Schulze, Matthias B., Mayen-Chacon, Ana Lucia, Masala, Giovanna, Sieri, Sabina, de Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda M.A., Verschuren, W. M.Monique, Brustad, Magritt, Nøst, Therese Haugdahl, Crous-Bou, Marta, Petrova, Dafina, Amiano, Pilar, Huerta, José María, Moreno-Iribas, Conchi, Engström, Gunnar, Melander, Olle, Johansson, Kristina, Lindvall, Kristina, Aglago, Elom K., Heath, Alicia K., Butterworth, Adam S., Danesh, John, Key, Timothy J., Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Tong, Tammy Y.N., Clarke, Robert, Schmidt, Julie A., Huybrechts, Inge, Noor, Urwah, Forouhi, Nita G., Imamura, Fumiaki, Travis, Ruth C., Weiderpass, Elisabete, Aleksandrova, Krasimira, Dahm, Christina C., van der Schouw, Yvonne T., Overvad, Kim, Kyrø, Cecilie, Tjønneland, Anne, Kaaks, Rudolf, Katzke, Verena, Schiborn, Catarina, Schulze, Matthias B., Mayen-Chacon, Ana Lucia, Masala, Giovanna, Sieri, Sabina, de Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda M.A., Verschuren, W. M.Monique, Brustad, Magritt, Nøst, Therese Haugdahl, Crous-Bou, Marta, Petrova, Dafina, Amiano, Pilar, Huerta, José María, Moreno-Iribas, Conchi, Engström, Gunnar, Melander, Olle, Johansson, Kristina, Lindvall, Kristina, Aglago, Elom K., Heath, Alicia K., Butterworth, Adam S., Danesh, John, and Key, Timothy J.
Published: 2024

19. Consumption of Fish and Long-chain n-3 Polyunsaturated Fatty Acids Is Associated With Reduced Risk of Colorectal Cancer in a Large European Cohort

Author: Aglago, Elom K., Huybrechts, Inge, Murphy, Neil, Casagrande, Corinne, Nicolas, Genevieve, Pischon, Tobias, Fedirko, Veronika, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Fournier, Agnès, Katzke, Verena, Kühn, Tilman, Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Overvad, Kim, Lasheras, Cristina, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Huerta, José Maria, Ardanaz, Eva, Perez-Cornago, Aurora, Trichopoulou, Antonia, Karakatsani, Anna, Martimianaki, Georgia, Palli, Domenico, Pala, Valeria, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Bueno-de-Mesquita, Bas, May, Anne, Derksen, Jeroen W.G., Hellstrand, Sophie, Ohlsson, Bodil, Wennberg, Maria, Van Guelpen, Bethany, Skeie, Guri, Brustad, Magritt, Weiderpass, Elisabete, Cross, Amanda J., Ward, Heather, Riboli, Elio, Norat, Teresa, Chajes, Veronique, and Gunter, Marc J.
Published: 2020
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20. Epidemiologic Factors in Relation to Colorectal Cancer Risk and Survival by Genotoxic Colibactin Mutational Signature

Author: Thomas, Claire E., primary, Georgeson, Peter, additional, Qu, Conghui, additional, Steinfelder, Robert S., additional, Buchanan, Daniel D., additional, Song, Mingyang, additional, Harrison, Tabitha A., additional, Um, Caroline Y., additional, Hullar, Meredith A., additional, Jenkins, Mark A., additional, Van Guelpen, Bethany, additional, Lynch, Brigid M., additional, Melaku, Yohannes Adama, additional, Huyghe, Jeroen R., additional, Aglago, Elom K., additional, Berndt, Sonja I., additional, Boardman, Lisa A., additional, Campbell, Peter T., additional, Cao, Yin, additional, Chan, Andrew T., additional, Drew, David A., additional, Figueiredo, Jane C., additional, French, Amy J., additional, Giannakis, Marios, additional, Goode, Ellen L., additional, Gruber, Stephen B., additional, Gsur, Andrea, additional, Gunter, Marc J., additional, Hoffmeister, Michael, additional, Hsu, Li, additional, Huang, Wen-Yi, additional, Moreno, Victor, additional, Murphy, Neil, additional, Newcomb, Polly A., additional, Newton, Christina C., additional, Nowak, Jonathan A., additional, Obón-Santacana, Mireia, additional, Ogino, Shuji, additional, Sun, Wei, additional, Toland, Amanda E., additional, Trinh, Quang M., additional, Ugai, Tomotaka, additional, Zaidi, Syed H., additional, Peters, Ulrike, additional, and Phipps, Amanda I., additional
Published: 2024
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21. Development and validation of a lifestyle-based model for colorectal cancer risk prediction: the LiFeCRC score

Author: Aleksandrova, Krasimira, Reichmann, Robin, Kaaks, Rudolf, Jenab, Mazda, Bueno-de-Mesquita, H. Bas, Dahm, Christina C., Eriksen, Anne Kirstine, Tjønneland, Anne, Artaud, Fanny, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Hüsing, Anika, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Panico, Salvatore, Masala, Giovanna, Grioni, Sara, Sacerdote, Carlotta, Tumino, Rosario, Elias, Sjoerd G., May, Anne M., Borch, Kristin B., Sandanger, Torkjel M., Skeie, Guri, Sánchez, Maria-Jose, Huerta, José María, Sala, Núria, Gurrea, Aurelio Barricarte, Quirós, José Ramón, Amiano, Pilar, Berntsson, Jonna, Drake, Isabel, van Guelpen, Bethany, Harlid, Sophia, Key, Tim, Weiderpass, Elisabete, Aglago, Elom K., Cross, Amanda J., Tsilidis, Konstantinos K., Riboli, Elio, and Gunter, Marc J.
Published: 2021
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22. Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study

Author: Cordova, Reynalda, primary, Viallon, Vivian, additional, Fontvieille, Emma, additional, Peruchet-Noray, Laia, additional, Jansana, Anna, additional, Wagner, Karl-Heinz, additional, Kyrø, Cecilie, additional, Tjønneland, Anne, additional, Katzke, Verena, additional, Bajracharya, Rashmita, additional, Schulze, Matthias B., additional, Masala, Giovanna, additional, Sieri, Sabina, additional, Panico, Salvatore, additional, Ricceri, Fulvio, additional, Tumino, Rosario, additional, Boer, Jolanda M.A., additional, Verschuren, W.M.Monique, additional, van der Schouw, Yvonne T., additional, Jakszyn, Paula, additional, Redondo-Sánchez, Daniel, additional, Amiano, Pilar, additional, Huerta, José María, additional, Guevara, Marcela, additional, Borné, Yan, additional, Sonestedt, Emily, additional, Tsilidis, Konstantinos K., additional, Millett, Christopher, additional, Heath, Alicia K., additional, Aglago, Elom K., additional, Aune, Dagfinn, additional, Gunter, Marc J., additional, Ferrari, Pietro, additional, Huybrechts, Inge, additional, and Freisling, Heinz, additional
Published: 2023
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23. Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries

Author: Tong, Tammy Y. N., primary, Clarke, Robert, additional, Schmidt, Julie A., additional, Huybrechts, Inge, additional, Noor, Urwah, additional, Forouhi, Nita G., additional, Imamura, Fumiaki, additional, Travis, Ruth C., additional, Weiderpass, Elisabete, additional, Aleksandrova, Krasimira, additional, Dahm, Christina C., additional, van der Schouw, Yvonne T., additional, Overvad, Kim, additional, Kyrø, Cecilie, additional, Tjønneland, Anne, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Schiborn, Catarina, additional, Schulze, Matthias B., additional, Mayen-Chacon, Ana-Lucia, additional, Masala, Giovanna, additional, Sieri, Sabina, additional, de Magistris, Maria Santucci, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Boer, Jolanda M. A., additional, Verschuren, W. M. Monique, additional, Brustad, Magritt, additional, Nøst, Therese Haugdahl, additional, Crous-Bou, Marta, additional, Petrova, Dafina, additional, Amiano, Pilar, additional, Huerta, José María, additional, Moreno-Iribas, Conchi, additional, Engström, Gunnar, additional, Melander, Olle, additional, Johansson, Kristina, additional, Lindvall, Kristina, additional, Aglago, Elom K., additional, Heath, Alicia K., additional, Butterworth, Adam S., additional, Danesh, John, additional, and Key, Timothy J., additional
Published: 2023
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24. Associations between Fatty Acid Intakes and Plasma Phospholipid Fatty Acid Concentrations in the European Prospective Investigation into Cancer and Nutrition

Author: Huybrechts, Inge, primary, Jacobs, Inarie, additional, Aglago, Elom K., additional, Yammine, Sahar, additional, Matta, Michèle, additional, Schmidt, Julie A., additional, Casagrande, Corinne, additional, Nicolas, Geneviève, additional, Biessy, Carine, additional, Van Puyvelde, Heleen, additional, Scalbert, Augustin, additional, Derksen, Jeroen W. G., additional, van der Schouw, Yvonne T., additional, Grioni, Sara, additional, Amiano, Pilar, additional, Halkjær, Jytte, additional, Tjønneland, Anne, additional, Huerta, José M., additional, Luján-Barroso, Leila, additional, Palli, Domenico, additional, Gunter, Marc J., additional, Perez-Cornago, Aurora, additional, and Chajès, Véronique, additional
Published: 2023
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25. Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries

Author: Tong, Tammy Y.N., primary, Clarke, Robert, additional, Schmidt, Julie A., additional, Huybrechts, Inge, additional, Noor, Urwah, additional, Forouhi, Nita G., additional, Imamura, Fumiaki, additional, Travis, Ruth C., additional, Weiderpass, Elisabete, additional, Aleksandrova, Krasimira, additional, Dahm, Christina C., additional, van der Schouw, Yvonne T., additional, Overvad, Kim, additional, Kyrø, Cecilie, additional, Tjønneland, Anne, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Schiborn, Catarina, additional, Schulze, Matthias B., additional, Mayen-Chacon, Ana-Lucia, additional, Masala, Giovanna, additional, Sieri, Sabina, additional, de Magistris, Maria Santucci, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Boer, Jolanda M.A., additional, Verschuren, W.M. Monique, additional, Brustad, Magritt, additional, Nøst, Therese Haugdahl, additional, Crous-Bou, Marta, additional, Petrova, Dafina, additional, Amiano, Pilar, additional, Huerta, José María, additional, Moreno-Iribas, Conchi, additional, Engström, Gunnar, additional, Melander, Olle, additional, Johansson, Kristina, additional, Lindvall, Kristina, additional, Aglago, Elom K., additional, Heath, Alicia K., additional, Butterworth, Adam S., additional, Danesh, John, additional, and Key, Timothy J., additional
Published: 2023
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26. Intake of the Total, Classes, and Subclasses of (Poly)Phenols and Risk of Prostate Cancer: A Prospective Analysis of the EPIC Study

Author: Almanza-Aguilera, Enrique, primary, Guiñón-Fort, Daniel, additional, Perez-Cornago, Aurora, additional, Martínez-Huélamo, Miriam, additional, Andrés-Lacueva, Cristina, additional, Tjønneland, Anne, additional, Eriksen, Anne Kirstine, additional, Katzke, Verena, additional, Bajracharya, Rashmita, additional, Schulze, Matthias B., additional, Masala, Giovanna, additional, Oliverio, Andreina, additional, Tumino, Rosario, additional, Manfredi, Luca, additional, Lasheras, Cristina, additional, Crous-Bou, Marta, additional, Sánchez, Maria-José, additional, Amiano, Pilar, additional, Colorado-Yohar, Sandra M., additional, Guevara, Marcela, additional, Sonestedt, Emily, additional, Bjartell, Anders, additional, Thysell, Elin, additional, Weiderpass, Elisabete, additional, Aune, Dagfinn, additional, Aglago, Elom K., additional, Travis, Ruth C., additional, and Zamora-Ros, Raul, additional
Published: 2023
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27. Data from A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk

Author: Aglago, Elom K., primary, Kim, Andre, primary, Lin, Yi, primary, Qu, Conghui, primary, Evangelou, Marina, primary, Ren, Yu, primary, Morrison, John, primary, Albanes, Demetrius, primary, Arndt, Volker, primary, Barry, Elizabeth L., primary, Baurley, James W., primary, Berndt, Sonja I., primary, Bien, Stephanie A., primary, Bishop, D. Timothy, primary, Bouras, Emmanouil, primary, Brenner, Hermann, primary, Buchanan, Daniel D., primary, Budiarto, Arif, primary, Carreras-Torres, Robert, primary, Casey, Graham, primary, Cenggoro, Tjeng Wawan, primary, Chan, Andrew T., primary, Chang-Claude, Jenny, primary, Chen, Xuechen, primary, Conti, David V., primary, Devall, Matthew, primary, Diez-Obrero, Virginia, primary, Dimou, Niki, primary, Drew, David, primary, Figueiredo, Jane C., primary, Gallinger, Steven, primary, Giles, Graham G., primary, Gruber, Stephen B., primary, Gsur, Andrea, primary, Gunter, Marc J., primary, Hampel, Heather, primary, Harlid, Sophia, primary, Hidaka, Akihisa, primary, Harrison, Tabitha A., primary, Hoffmeister, Michael, primary, Huyghe, Jeroen R., primary, Jenkins, Mark A., primary, Jordahl, Kristina, primary, Joshi, Amit D., primary, Kawaguchi, Eric S., primary, Keku, Temitope O., primary, Kundaje, Anshul, primary, Larsson, Susanna C., primary, Marchand, Loic Le, primary, Lewinger, Juan Pablo, primary, Li, Li, primary, Lynch, Brigid M., primary, Mahesworo, Bharuno, primary, Mandic, Marko, primary, Obón-Santacana, Mireia, primary, Moreno, Victor, primary, Murphy, Neil, primary, Nan, Hongmei, primary, Nassir, Rami, primary, Newcomb, Polly A., primary, Ogino, Shuji, primary, Ose, Jennifer, primary, Pai, Rish K., primary, Palmer, Julie R., primary, Papadimitriou, Nikos, primary, Pardamean, Bens, primary, Peoples, Anita R., primary, Platz, Elizabeth A., primary, Potter, John D., primary, Prentice, Ross L., primary, Rennert, Gad, primary, Ruiz-Narvaez, Edward, primary, Sakoda, Lori C., primary, Scacheri, Peter C., primary, Schmit, Stephanie L., primary, Schoen, Robert E., primary, Shcherbina, Anna, primary, Slattery, Martha L., primary, Stern, Mariana C., primary, Su, Yu-Ru, primary, Tangen, Catherine M., primary, Thibodeau, Stephen N., primary, Thomas, Duncan C., primary, Tian, Yu, primary, Ulrich, Cornelia M., primary, van Duijnhoven, Franzel JB, primary, Van Guelpen, Bethany, primary, Visvanathan, Kala, primary, Vodicka, Pavel, primary, Wang, Jun, primary, White, Emily, primary, Wolk, Alicja, primary, Woods, Michael O., primary, Wu, Anna H., primary, Zemlianskaia, Natalia, primary, Hsu, Li, primary, Gauderman, W. James, primary, Peters, Ulrike, primary, Tsilidis, Konstantinos K., primary, and Campbell, Peter T., primary
Published: 2023
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28. Supplementary Data from A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk

Author: Aglago, Elom K., primary, Kim, Andre, primary, Lin, Yi, primary, Qu, Conghui, primary, Evangelou, Marina, primary, Ren, Yu, primary, Morrison, John, primary, Albanes, Demetrius, primary, Arndt, Volker, primary, Barry, Elizabeth L., primary, Baurley, James W., primary, Berndt, Sonja I., primary, Bien, Stephanie A., primary, Bishop, D. Timothy, primary, Bouras, Emmanouil, primary, Brenner, Hermann, primary, Buchanan, Daniel D., primary, Budiarto, Arif, primary, Carreras-Torres, Robert, primary, Casey, Graham, primary, Cenggoro, Tjeng Wawan, primary, Chan, Andrew T., primary, Chang-Claude, Jenny, primary, Chen, Xuechen, primary, Conti, David V., primary, Devall, Matthew, primary, Diez-Obrero, Virginia, primary, Dimou, Niki, primary, Drew, David, primary, Figueiredo, Jane C., primary, Gallinger, Steven, primary, Giles, Graham G., primary, Gruber, Stephen B., primary, Gsur, Andrea, primary, Gunter, Marc J., primary, Hampel, Heather, primary, Harlid, Sophia, primary, Hidaka, Akihisa, primary, Harrison, Tabitha A., primary, Hoffmeister, Michael, primary, Huyghe, Jeroen R., primary, Jenkins, Mark A., primary, Jordahl, Kristina, primary, Joshi, Amit D., primary, Kawaguchi, Eric S., primary, Keku, Temitope O., primary, Kundaje, Anshul, primary, Larsson, Susanna C., primary, Marchand, Loic Le, primary, Lewinger, Juan Pablo, primary, Li, Li, primary, Lynch, Brigid M., primary, Mahesworo, Bharuno, primary, Mandic, Marko, primary, Obón-Santacana, Mireia, primary, Moreno, Victor, primary, Murphy, Neil, primary, Nan, Hongmei, primary, Nassir, Rami, primary, Newcomb, Polly A., primary, Ogino, Shuji, primary, Ose, Jennifer, primary, Pai, Rish K., primary, Palmer, Julie R., primary, Papadimitriou, Nikos, primary, Pardamean, Bens, primary, Peoples, Anita R., primary, Platz, Elizabeth A., primary, Potter, John D., primary, Prentice, Ross L., primary, Rennert, Gad, primary, Ruiz-Narvaez, Edward, primary, Sakoda, Lori C., primary, Scacheri, Peter C., primary, Schmit, Stephanie L., primary, Schoen, Robert E., primary, Shcherbina, Anna, primary, Slattery, Martha L., primary, Stern, Mariana C., primary, Su, Yu-Ru, primary, Tangen, Catherine M., primary, Thibodeau, Stephen N., primary, Thomas, Duncan C., primary, Tian, Yu, primary, Ulrich, Cornelia M., primary, van Duijnhoven, Franzel JB, primary, Van Guelpen, Bethany, primary, Visvanathan, Kala, primary, Vodicka, Pavel, primary, Wang, Jun, primary, White, Emily, primary, Wolk, Alicja, primary, Woods, Michael O., primary, Wu, Anna H., primary, Zemlianskaia, Natalia, primary, Hsu, Li, primary, Gauderman, W. James, primary, Peters, Ulrike, primary, Tsilidis, Konstantinos K., primary, and Campbell, Peter T., primary
Published: 2023
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29. Table 2 from A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk

Author: Aglago, Elom K., primary, Kim, Andre, primary, Lin, Yi, primary, Qu, Conghui, primary, Evangelou, Marina, primary, Ren, Yu, primary, Morrison, John, primary, Albanes, Demetrius, primary, Arndt, Volker, primary, Barry, Elizabeth L., primary, Baurley, James W., primary, Berndt, Sonja I., primary, Bien, Stephanie A., primary, Bishop, D. Timothy, primary, Bouras, Emmanouil, primary, Brenner, Hermann, primary, Buchanan, Daniel D., primary, Budiarto, Arif, primary, Carreras-Torres, Robert, primary, Casey, Graham, primary, Cenggoro, Tjeng Wawan, primary, Chan, Andrew T., primary, Chang-Claude, Jenny, primary, Chen, Xuechen, primary, Conti, David V., primary, Devall, Matthew, primary, Diez-Obrero, Virginia, primary, Dimou, Niki, primary, Drew, David, primary, Figueiredo, Jane C., primary, Gallinger, Steven, primary, Giles, Graham G., primary, Gruber, Stephen B., primary, Gsur, Andrea, primary, Gunter, Marc J., primary, Hampel, Heather, primary, Harlid, Sophia, primary, Hidaka, Akihisa, primary, Harrison, Tabitha A., primary, Hoffmeister, Michael, primary, Huyghe, Jeroen R., primary, Jenkins, Mark A., primary, Jordahl, Kristina, primary, Joshi, Amit D., primary, Kawaguchi, Eric S., primary, Keku, Temitope O., primary, Kundaje, Anshul, primary, Larsson, Susanna C., primary, Marchand, Loic Le, primary, Lewinger, Juan Pablo, primary, Li, Li, primary, Lynch, Brigid M., primary, Mahesworo, Bharuno, primary, Mandic, Marko, primary, Obón-Santacana, Mireia, primary, Moreno, Victor, primary, Murphy, Neil, primary, Nan, Hongmei, primary, Nassir, Rami, primary, Newcomb, Polly A., primary, Ogino, Shuji, primary, Ose, Jennifer, primary, Pai, Rish K., primary, Palmer, Julie R., primary, Papadimitriou, Nikos, primary, Pardamean, Bens, primary, Peoples, Anita R., primary, Platz, Elizabeth A., primary, Potter, John D., primary, Prentice, Ross L., primary, Rennert, Gad, primary, Ruiz-Narvaez, Edward, primary, Sakoda, Lori C., primary, Scacheri, Peter C., primary, Schmit, Stephanie L., primary, Schoen, Robert E., primary, Shcherbina, Anna, primary, Slattery, Martha L., primary, Stern, Mariana C., primary, Su, Yu-Ru, primary, Tangen, Catherine M., primary, Thibodeau, Stephen N., primary, Thomas, Duncan C., primary, Tian, Yu, primary, Ulrich, Cornelia M., primary, van Duijnhoven, Franzel JB, primary, Van Guelpen, Bethany, primary, Visvanathan, Kala, primary, Vodicka, Pavel, primary, Wang, Jun, primary, White, Emily, primary, Wolk, Alicja, primary, Woods, Michael O., primary, Wu, Anna H., primary, Zemlianskaia, Natalia, primary, Hsu, Li, primary, Gauderman, W. James, primary, Peters, Ulrike, primary, Tsilidis, Konstantinos K., primary, and Campbell, Peter T., primary
Published: 2023
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30. Table 1 from A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk

Author: Aglago, Elom K., primary, Kim, Andre, primary, Lin, Yi, primary, Qu, Conghui, primary, Evangelou, Marina, primary, Ren, Yu, primary, Morrison, John, primary, Albanes, Demetrius, primary, Arndt, Volker, primary, Barry, Elizabeth L., primary, Baurley, James W., primary, Berndt, Sonja I., primary, Bien, Stephanie A., primary, Bishop, D. Timothy, primary, Bouras, Emmanouil, primary, Brenner, Hermann, primary, Buchanan, Daniel D., primary, Budiarto, Arif, primary, Carreras-Torres, Robert, primary, Casey, Graham, primary, Cenggoro, Tjeng Wawan, primary, Chan, Andrew T., primary, Chang-Claude, Jenny, primary, Chen, Xuechen, primary, Conti, David V., primary, Devall, Matthew, primary, Diez-Obrero, Virginia, primary, Dimou, Niki, primary, Drew, David, primary, Figueiredo, Jane C., primary, Gallinger, Steven, primary, Giles, Graham G., primary, Gruber, Stephen B., primary, Gsur, Andrea, primary, Gunter, Marc J., primary, Hampel, Heather, primary, Harlid, Sophia, primary, Hidaka, Akihisa, primary, Harrison, Tabitha A., primary, Hoffmeister, Michael, primary, Huyghe, Jeroen R., primary, Jenkins, Mark A., primary, Jordahl, Kristina, primary, Joshi, Amit D., primary, Kawaguchi, Eric S., primary, Keku, Temitope O., primary, Kundaje, Anshul, primary, Larsson, Susanna C., primary, Marchand, Loic Le, primary, Lewinger, Juan Pablo, primary, Li, Li, primary, Lynch, Brigid M., primary, Mahesworo, Bharuno, primary, Mandic, Marko, primary, Obón-Santacana, Mireia, primary, Moreno, Victor, primary, Murphy, Neil, primary, Nan, Hongmei, primary, Nassir, Rami, primary, Newcomb, Polly A., primary, Ogino, Shuji, primary, Ose, Jennifer, primary, Pai, Rish K., primary, Palmer, Julie R., primary, Papadimitriou, Nikos, primary, Pardamean, Bens, primary, Peoples, Anita R., primary, Platz, Elizabeth A., primary, Potter, John D., primary, Prentice, Ross L., primary, Rennert, Gad, primary, Ruiz-Narvaez, Edward, primary, Sakoda, Lori C., primary, Scacheri, Peter C., primary, Schmit, Stephanie L., primary, Schoen, Robert E., primary, Shcherbina, Anna, primary, Slattery, Martha L., primary, Stern, Mariana C., primary, Su, Yu-Ru, primary, Tangen, Catherine M., primary, Thibodeau, Stephen N., primary, Thomas, Duncan C., primary, Tian, Yu, primary, Ulrich, Cornelia M., primary, van Duijnhoven, Franzel JB, primary, Van Guelpen, Bethany, primary, Visvanathan, Kala, primary, Vodicka, Pavel, primary, Wang, Jun, primary, White, Emily, primary, Wolk, Alicja, primary, Woods, Michael O., primary, Wu, Anna H., primary, Zemlianskaia, Natalia, primary, Hsu, Li, primary, Gauderman, W. James, primary, Peters, Ulrike, primary, Tsilidis, Konstantinos K., primary, and Campbell, Peter T., primary
Published: 2023
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31. A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort

Author: Christakoudi, Sofia, Tsilidis, Konstantinos K., Muller, David C., Freisling, Heinz, Weiderpass, Elisabete, Overvad, Kim, Söderberg, Stefan, Häggström, Christel, Pischon, Tobias, Dahm, Christina C., Zhang, Jie, Tjønneland, Anne, Halkjær, Jytte, MacDonald, Conor, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Kaaks, Rudolf, Schulze, Matthias B., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Quirós, J. Ramón, Agudo, Antonio, Sánchez, Maria-Jose, Cirera, Lluís, Barricarte-Gurrea, Aurelio, Amiano, Pilar, Memarian, Ensieh, Sonestedt, Emily, Bueno-de-Mesquita, Bas, May, Anne M., Khaw, Kay-Tee, Wareham, Nicholas J., Tong, Tammy Y. N., Huybrechts, Inge, Noh, Hwayoung, Aglago, Elom K., Ellingjord-Dale, Merete, Ward, Heather A., Aune, Dagfinn, and Riboli, Elio
Published: 2020
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32. A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk

Author: Aglago, Elom K., primary, Kim, Andre, additional, Lin, Yi, additional, Qu, Conghui, additional, Evangelou, Marina, additional, Ren, Yu, additional, Morrison, John, additional, Albanes, Demetrius, additional, Arndt, Volker, additional, Barry, Elizabeth L., additional, Baurley, James W., additional, Berndt, Sonja I., additional, Bien, Stephanie A., additional, Bishop, D. Timothy, additional, Bouras, Emmanouil, additional, Brenner, Hermann, additional, Buchanan, Daniel D., additional, Budiarto, Arif, additional, Carreras-Torres, Robert, additional, Casey, Graham, additional, Cenggoro, Tjeng Wawan, additional, Chan, Andrew T., additional, Chang-Claude, Jenny, additional, Chen, Xuechen, additional, Conti, David V., additional, Devall, Matthew, additional, Diez-Obrero, Virginia, additional, Dimou, Niki, additional, Drew, David, additional, Figueiredo, Jane C., additional, Gallinger, Steven, additional, Giles, Graham G., additional, Gruber, Stephen B., additional, Gsur, Andrea, additional, Gunter, Marc J., additional, Hampel, Heather, additional, Harlid, Sophia, additional, Hidaka, Akihisa, additional, Harrison, Tabitha A., additional, Hoffmeister, Michael, additional, Huyghe, Jeroen R., additional, Jenkins, Mark A., additional, Jordahl, Kristina, additional, Joshi, Amit D., additional, Kawaguchi, Eric S., additional, Keku, Temitope O., additional, Kundaje, Anshul, additional, Larsson, Susanna C., additional, Marchand, Loic Le, additional, Lewinger, Juan Pablo, additional, Li, Li, additional, Lynch, Brigid M., additional, Mahesworo, Bharuno, additional, Mandic, Marko, additional, Obón-Santacana, Mireia, additional, Moreno, Victor, additional, Murphy, Neil, additional, Nan, Hongmei, additional, Nassir, Rami, additional, Newcomb, Polly A., additional, Ogino, Shuji, additional, Ose, Jennifer, additional, Pai, Rish K., additional, Palmer, Julie R., additional, Papadimitriou, Nikos, additional, Pardamean, Bens, additional, Peoples, Anita R., additional, Platz, Elizabeth A., additional, Potter, John D., additional, Prentice, Ross L., additional, Rennert, Gad, additional, Ruiz-Narvaez, Edward, additional, Sakoda, Lori C., additional, Scacheri, Peter C., additional, Schmit, Stephanie L., additional, Schoen, Robert E., additional, Shcherbina, Anna, additional, Slattery, Martha L., additional, Stern, Mariana C., additional, Su, Yu-Ru, additional, Tangen, Catherine M., additional, Thibodeau, Stephen N., additional, Thomas, Duncan C., additional, Tian, Yu, additional, Ulrich, Cornelia M., additional, van Duijnhoven, Franzel JB, additional, Van Guelpen, Bethany, additional, Visvanathan, Kala, additional, Vodicka, Pavel, additional, Wang, Jun, additional, White, Emily, additional, Wolk, Alicja, additional, Woods, Michael O., additional, Wu, Anna H., additional, Zemlianskaia, Natalia, additional, Hsu, Li, additional, Gauderman, W. James, additional, Peters, Ulrike, additional, Tsilidis, Konstantinos K., additional, and Campbell, Peter T., additional
Published: 2023
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33. Genotoxic colibactin mutational signature in colorectal cancer is associated with clinicopathological features, specific genomic alterations and better survival

Author: Georgeson, Peter, primary, Steinfelder, Robert S., additional, Harrison, Tabitha A., additional, Pope, Bernard J., additional, Zaidi, Syed H., additional, Qu, Conghui, additional, Lin, Yi, additional, Joo, Jihoon E., additional, Mahmood, Khalid, additional, Clendenning, Mark, additional, Walker, Romy, additional, Aglago, Elom K, additional, Berndt, Sonja I., additional, Brenner, Hermann, additional, Campbell, Peter T., additional, Cao, Yin, additional, Chan, Andrew T., additional, Chang-Claude, Jenny, additional, Dimou, Niki, additional, Doheny, Kimberly F., additional, Drew, David A., additional, Figueiredo, Jane C., additional, French, Amy J., additional, Gallinger, Steven, additional, Giannakis, Marios, additional, Giles, Graham G., additional, Goode, Ellen L, additional, Gruber, Stephen B, additional, Gsur, Andrea, additional, Gunter, Marc J., additional, Harlid, Sophia, additional, Hoffmeister, Michael, additional, Hsu, Li, additional, Huang, Wen-Yi, additional, Huyghe, Jeroen R, additional, Manson, JoAnn E., additional, Moreno, Victor, additional, Murphy, Neil, additional, Nassir, Rami, additional, Newton, Christina C., additional, Nowak, Jonathan A., additional, Obón-Santacana, Mireia, additional, Ogino, Shuji, additional, Pai, Rish K., additional, Papadimitrou, Nikos, additional, Potter, John D., additional, Schoen, Robert E., additional, Song, Mingyang, additional, Sun, Wei, additional, Toland, Amanda E., additional, Trinh, Quang M., additional, Tsilidis, Kostas, additional, Ugai, Tomotaka, additional, Um, Caroline Y, additional, Macrae, Finlay A., additional, Rosty, Christophe, additional, Hudson, Thomas J., additional, Winship, Ingrid M., additional, Phipps, Amanda I., additional, Jenkins, Mark A., additional, Peters, Ulrike, additional, and Buchanan, Daniel D., additional
Published: 2023
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34. Body mass index and molecular subtypes of colorectal cancer

Author: Murphy, Neil, Newton, Christina C., Song, Mingyang, Papadimitriou, Nikos, Hoffmeister, Michael, Phipps, Amanda I., Harrison, Tabitha A., Newcomb, Polly A., Aglago, Elom K., Berndt, Sonja I., Brenner, Hermann, Buchanan, Daniel D., Cao, Yin, Chan, Andrew T., Chen, Xuechen, Cheng, Iona, Chang-Claude, Jenny, Dimou, Niki, Drew, David, Farris, Alton B., French, Amy J., Gallinger, Steven, Georgeson, Peter, Giannakis, Marios, Giles, Graham G., Gruber, Stephen B., Harlid, Sophia, Hsu, Li, Huang, Wen-Yi, Jenkins, Mark A., Laskar, Ruhina S., Le Marchand, Loic, Limburg, Paul, Lin, Yi, Mandic, Marko, Nowak, Johnathan A., Obon-Santacana, Mereia, Ogino, Shuji, Qu, Conghui, Sakoda, Lori C., Schoen, Robert E., Southey, Melissa C., Stadler, Zsofia K., Steinfelder, Robert S., Sun, Wei, Thibodeau, Stephen N., Toland, Amanda E., Trinh, Quang M., Tsilidis, Kostas K., Ugai, Tomotaka, van Guelpen, Bethany, Wang, Xiaoliang, Woods, Michael O., Zaidi, Syed H., Gunter, Marc J., Peters, Ulrike, Campbell, Peter T., Murphy, Neil, Newton, Christina C., Song, Mingyang, Papadimitriou, Nikos, Hoffmeister, Michael, Phipps, Amanda I., Harrison, Tabitha A., Newcomb, Polly A., Aglago, Elom K., Berndt, Sonja I., Brenner, Hermann, Buchanan, Daniel D., Cao, Yin, Chan, Andrew T., Chen, Xuechen, Cheng, Iona, Chang-Claude, Jenny, Dimou, Niki, Drew, David, Farris, Alton B., French, Amy J., Gallinger, Steven, Georgeson, Peter, Giannakis, Marios, Giles, Graham G., Gruber, Stephen B., Harlid, Sophia, Hsu, Li, Huang, Wen-Yi, Jenkins, Mark A., Laskar, Ruhina S., Le Marchand, Loic, Limburg, Paul, Lin, Yi, Mandic, Marko, Nowak, Johnathan A., Obon-Santacana, Mereia, Ogino, Shuji, Qu, Conghui, Sakoda, Lori C., Schoen, Robert E., Southey, Melissa C., Stadler, Zsofia K., Steinfelder, Robert S., Sun, Wei, Thibodeau, Stephen N., Toland, Amanda E., Trinh, Quang M., Tsilidis, Kostas K., Ugai, Tomotaka, van Guelpen, Bethany, Wang, Xiaoliang, Woods, Michael O., Zaidi, Syed H., Gunter, Marc J., Peters, Ulrike, and Campbell, Peter T.
Abstract: Background: Obesity is an established risk factor for colorectal cancer (CRC), but the evidence for the association is inconsistent across molecular subtypes of the disease. Methods: We pooled data on body mass index (BMI), tumor microsatellite instability status, CpG island methylator phenotype status, BRAF and KRAS mutations, and Jass classification types for 11 872 CRC cases and 11 013 controls from 11 observational studies. We used multinomial logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusted for covariables. Results: Higher BMI was associated with increased CRC risk (OR per 5 kg/m(2) = 1.18, 95% CI = 1.15 to 1.22). The positive association was stronger for men than women but similar across tumor subtypes defined by individual molecular markers. In analyses by Jass type, higher BMI was associated with elevated CRC risk for types 1-4 cases but not for type 5 CRC cases (considered familial-like/Lynch syndrome microsatellite instability-H, CpG island methylator phenotype-low or negative, BRAF-wild type, KRAS-wild type, OR = 1.04, 95% CI = 0.90 to 1.20). This pattern of associations for BMI and Jass types was consistent by sex and design of contributing studies (cohort or case-control). Conclusions: In contrast to previous reports with fewer study participants, we found limited evidence of heterogeneity for the association between BMI and CRC risk according to molecular subtype, suggesting that obesity influences nearly all major pathways involved in colorectal carcinogenesis. The null association observed for the Jass type 5 suggests that BMI is not a risk factor for the development of CRC for individuals with Lynch syndrome.
Published: 2023
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35. Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts

Author: Karavasiloglou, Nena, Hughes, David J., Murphy, Neil, Schomburg, Lutz, Sun, Qian, Seher, Vartiter, Rohrmann, Sabine, Weiderpass, Elisabete, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kaaks, Rudolf, Kuhn, Tilman, Schulze, Matthias B., Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Pala, Valeria, Sacerdote, Carlotta, Derksen, Jeroen W G, Skeie, Guri, Hjartåker, Anette, Lasheras, Cristina, Agudo, Antonio, Sánchez, Maria-José, Chirlaque, Maria-Dolores, Ardanaz, Eva, Amiano, Pilar, van Guelpen, Bethany, Gylling, Björn, Bradbury, Kathryn E., Papier, Keren, Freisling, Heinz, Aglago, Elom K., Cross, Amanda J., Riboli, Elio, Aune, Dagfinn, Gunter, Marc J., Jenab, Mazda, Karavasiloglou, Nena, Hughes, David J., Murphy, Neil, Schomburg, Lutz, Sun, Qian, Seher, Vartiter, Rohrmann, Sabine, Weiderpass, Elisabete, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kaaks, Rudolf, Kuhn, Tilman, Schulze, Matthias B., Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Pala, Valeria, Sacerdote, Carlotta, Derksen, Jeroen W G, Skeie, Guri, Hjartåker, Anette, Lasheras, Cristina, Agudo, Antonio, Sánchez, Maria-José, Chirlaque, Maria-Dolores, Ardanaz, Eva, Amiano, Pilar, van Guelpen, Bethany, Gylling, Björn, Bradbury, Kathryn E., Papier, Keren, Freisling, Heinz, Aglago, Elom K., Cross, Amanda J., Riboli, Elio, Aune, Dagfinn, Gunter, Marc J., and Jenab, Mazda
Abstract: BACKGROUND: Higher dietary calcium consumption is associated with lower colorectal cancer (CRC) risk. However, little data are available on the association between circulating calcium concentrations and CRC risk. OBJECTIVES: To explore the association between circulating calcium concentrations and CRC risk using data from 2 large European prospective cohort studies. METHODS: Conditional logistic regression models were used to calculate multivariable-adjusted ORs and 95% CIs in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC; n-cases = 947, n-controls = 947) and the UK Biobank (UK-BB; n-cases = 2759, n-controls = 12,021) cohorts. RESULTS: In EPIC, nonalbumin-adjusted total serum calcium (a proxy of free calcium) was not associated with CRC (OR: 0.94; 95% CI: 0.85, 1.03; modeled as continuous variable, per 1 mg/dL increase), colon cancer (OR: 0.93; 95% CI: 0.82, 1.05) or rectal cancer (OR: 1.01; 95% CI: 0.84, 1.20) risk in the multivariable adjusted model. In the UK-BB, serum ionized calcium (free calcium, most active form) was inversely associated with the risk of CRC (OR: 0.85; 95% CI: 0.76, 0.95; per 1 mg/dL) and colon cancer (OR: 0.78; 95% CI: 0.68, 0.90), but not rectal cancer (OR: 1.02; 95% CI: 0.83, 1.24) in multivariable adjusted models. Meta-analysis of EPIC and UK-BB CRC risk estimates showed an inverse risk association for CRC in the multivariable adjusted model (OR: 0.90; 95%CI: 0.84, 0.97). In analyses by quintiles, in both cohorts, higher levels of serum calcium were associated with reduced CRC risk (EPIC: ORQ5vs.Q1: 0.69; 95% CI: 0.47, 1.00; P-trend = 0.03; UK-BB: ORQ5vs.Q1: 0.82; 95% CI: 0.72, 0.94; P-trend < 0.01). Analyses by anatomical subsite showed an inverse cancer risk association in the colon (EPIC: ORQ5vs.Q1: 0.63, 95% CI: 0.39, 1.02; P-trend = 0.05; UK-BB: ORQ5vs.Q1: 0.75; 95% CI: 0.64, 0.88; P-trend < 0.01) but not the rectum. CONCLUSIONS: In UK-BB, higher serum ionized calcium
Published: 2023
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36. Intake of the total, classes, and subclasses of (poly)phenols and risk of prostate cancer : a prospective analysis of the EPIC study

Author: Almanza-Aguilera, Enrique, Guiñón-Fort, Daniel, Perez-Cornago, Aurora, Martínez-Huélamo, Miriam, Andrés-Lacueva, Cristina, Tjønneland, Anne, Eriksen, Anne Kirstine, Katzke, Verena, Bajracharya, Rashmita, Schulze, Matthias B., Masala, Giovanna, Oliverio, Andreina, Tumino, Rosario, Manfredi, Luca, Lasheras, Cristina, Crous-Bou, Marta, Sánchez, Maria-José, Amiano, Pilar, Colorado-Yohar, Sandra M., Guevara, Marcela, Sonestedt, Emily, Bjartell, Anders, Thysell, Elin, Weiderpass, Elisabete, Aune, Dagfinn, Aglago, Elom K., Travis, Ruth C., Zamora-Ros, Raul, Almanza-Aguilera, Enrique, Guiñón-Fort, Daniel, Perez-Cornago, Aurora, Martínez-Huélamo, Miriam, Andrés-Lacueva, Cristina, Tjønneland, Anne, Eriksen, Anne Kirstine, Katzke, Verena, Bajracharya, Rashmita, Schulze, Matthias B., Masala, Giovanna, Oliverio, Andreina, Tumino, Rosario, Manfredi, Luca, Lasheras, Cristina, Crous-Bou, Marta, Sánchez, Maria-José, Amiano, Pilar, Colorado-Yohar, Sandra M., Guevara, Marcela, Sonestedt, Emily, Bjartell, Anders, Thysell, Elin, Weiderpass, Elisabete, Aune, Dagfinn, Aglago, Elom K., Travis, Ruth C., and Zamora-Ros, Raul
Abstract: Existing epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, in the case of flavonoids, it has been suggested that their intake may increase PCa risk. We investigated the associations between the intake of the total and individual classes and subclasses of (poly)phenols and the risk of PCa, including clinically relevant subtypes. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort included 131,425 adult men from seven European countries. (Poly)phenol intake at baseline was assessed by combining validated center/country-specific dietary questionnaires and the Phenol-Explorer database. Multivariable-adjusted Cox proportional hazards models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI). In total, 6939 incident PCa cases (including 3501 low-grade and 710 high-grade, 2446 localized and 1268 advanced, and 914 fatal Pca cases) were identified during a mean follow-up of 14 years. No associations were observed between the total intake of (poly)phenols and the risk of PCa, either overall (HRlog2 = 0.99, 95% CI 0.94–1.04) or according to PCa subtype. Null associations were also found between all classes (phenolic acids, flavonoids, lignans, and stilbenes) and subclasses of (poly)phenol intake and the risk of PCa, overall and according to PCa subtype. The results of the current large prospective cohort study do not support any association between (poly)phenol intake and PCa incidence.
Published: 2023
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37. A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk

Author: Aglago, Elom K., Kim, Andre, Lin, Yi, Qu, Conghui, Evangelou, Marina, Ren, Yu, Morrison, John, Albanes, Demetrius, Arndt, Volker, Barry, Elizabeth L., Baurley, James W., Berndt, Sonja I., Bien, Stephanie A., Bishop, D Timothy, Bouras, Emmanouil, Brenner, Hermann, Buchanan, Daniel D., Budiarto, Arif, Carreras-Torres, Robert, Casey, Graham, Cenggoro, Tjeng Wawan, Chan, Andrew T., Chang-Claude, Jenny, Chen, Xuechen, Conti, David V., Devall, Matthew, Diez-Obrero, Virginia, Dimou, Niki, Drew, David, Figueiredo, Jane C., Gallinger, Steven, Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Gunter, Marc J., Hampel, Heather, Harlid, Sophia, Hidaka, Akihisa, Harrison, Tabitha A., Hoffmeister, Michael, Huyghe, Jeroen R., Jenkins, Mark A., Jordahl, Kristina, Joshi, Amit D., Kawaguchi, Eric S., Keku, Temitope O., Kundaje, Anshul, Larsson, Susanna C., Marchand, Loic Le, Lewinger, Juan Pablo, Li, Li, Lynch, Brigid M., Mahesworo, Bharuno, Mandic, Marko, Obón-Santacana, Mireia, Moreno, Victor, Murphy, Neil, Nan, Hongmei, Nassir, Rami, Newcomb, Polly A., Ogino, Shuji, Ose, Jennifer, Pai, Rish K., Palmer, Julie R., Papadimitriou, Nikos, Pardamean, Bens, Peoples, Anita R., Platz, Elizabeth A., Potter, John D., Prentice, Ross L., Rennert, Gad, Ruiz-Narvaez, Edward, Sakoda, Lori C., Scacheri, Peter C., Schmit, Stephanie L., Schoen, Robert E., Shcherbina, Anna, Slattery, Martha L., Stern, Mariana C., Su, Yu-Ru, Tangen, Catherine M., Thibodeau, Stephen N., Thomas, Duncan C., Tian, Yu, Ulrich, Cornelia M., van Duijnhoven, Franzel Jb, van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Wang, Jun, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Zemlianskaia, Natalia, Hsu, Li, Gauderman, W James, Peters, Ulrike, Tsilidis, Konstantinos K., Campbell, Peter T., Aglago, Elom K., Kim, Andre, Lin, Yi, Qu, Conghui, Evangelou, Marina, Ren, Yu, Morrison, John, Albanes, Demetrius, Arndt, Volker, Barry, Elizabeth L., Baurley, James W., Berndt, Sonja I., Bien, Stephanie A., Bishop, D Timothy, Bouras, Emmanouil, Brenner, Hermann, Buchanan, Daniel D., Budiarto, Arif, Carreras-Torres, Robert, Casey, Graham, Cenggoro, Tjeng Wawan, Chan, Andrew T., Chang-Claude, Jenny, Chen, Xuechen, Conti, David V., Devall, Matthew, Diez-Obrero, Virginia, Dimou, Niki, Drew, David, Figueiredo, Jane C., Gallinger, Steven, Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Gunter, Marc J., Hampel, Heather, Harlid, Sophia, Hidaka, Akihisa, Harrison, Tabitha A., Hoffmeister, Michael, Huyghe, Jeroen R., Jenkins, Mark A., Jordahl, Kristina, Joshi, Amit D., Kawaguchi, Eric S., Keku, Temitope O., Kundaje, Anshul, Larsson, Susanna C., Marchand, Loic Le, Lewinger, Juan Pablo, Li, Li, Lynch, Brigid M., Mahesworo, Bharuno, Mandic, Marko, Obón-Santacana, Mireia, Moreno, Victor, Murphy, Neil, Nan, Hongmei, Nassir, Rami, Newcomb, Polly A., Ogino, Shuji, Ose, Jennifer, Pai, Rish K., Palmer, Julie R., Papadimitriou, Nikos, Pardamean, Bens, Peoples, Anita R., Platz, Elizabeth A., Potter, John D., Prentice, Ross L., Rennert, Gad, Ruiz-Narvaez, Edward, Sakoda, Lori C., Scacheri, Peter C., Schmit, Stephanie L., Schoen, Robert E., Shcherbina, Anna, Slattery, Martha L., Stern, Mariana C., Su, Yu-Ru, Tangen, Catherine M., Thibodeau, Stephen N., Thomas, Duncan C., Tian, Yu, Ulrich, Cornelia M., van Duijnhoven, Franzel Jb, van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Wang, Jun, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Zemlianskaia, Natalia, Hsu, Li, Gauderman, W James, Peters, Ulrike, Tsilidis, Konstantinos K., and Campbell, Peter T.
Abstract: Colorectal cancer risk can be impacted by genetic, environmental, and lifestyle factors, including diet and obesity. Gene-environment interactions (G × E) can provide biological insights into the effects of obesity on colorectal cancer risk. Here, we assessed potential genome-wide G × E interactions between body mass index (BMI) and common SNPs for colorectal cancer risk using data from 36,415 colorectal cancer cases and 48,451 controls from three international colorectal cancer consortia (CCFR, CORECT, and GECCO). The G × E tests included the conventional logistic regression using multiplicative terms (one degree of freedom, 1DF test), the two-step EDGE method, and the joint 3DF test, each of which is powerful for detecting G × E interactions under specific conditions. BMI was associated with higher colorectal cancer risk. The two-step approach revealed a statistically significant G×BMI interaction located within the Formin 1/Gremlin 1 (FMN1/GREM1) gene region (rs58349661). This SNP was also identified by the 3DF test, with a suggestive statistical significance in the 1DF test. Among participants with the CC genotype of rs58349661, overweight and obesity categories were associated with higher colorectal cancer risk, whereas null associations were observed across BMI categories in those with the TT genotype. Using data from three large international consortia, this study discovered a locus in the FMN1/GREM1 gene region that interacts with BMI on the association with colorectal cancer risk. Further studies should examine the potential mechanisms through which this locus modifies the etiologic link between obesity and colorectal cancer. SIGNIFICANCE: This gene-environment interaction analysis revealed a genetic locus in FMN1/GREM1 that interacts with body mass index in colorectal cancer risk, suggesting potential implications for precision prevention strategies.
Published: 2023
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38. Genome-wide interaction study with smoking for colorectal cancer risk identifies novel genetic loci related to tumor suppression, inflammation, and immune response

Author: Carreras-Torres, Robert, Kim, Andre E., Lin, Yi, Díez-Obrero, Virginia, Bien, Stephanie A., Qu, Conghui, Wang, Jun, Dimou, Niki, Aglago, Elom K., Albanes, Demetrius, Arndt, Volker, Baurley, James W., Berndt, Sonja I., Bézieau, Stéphane, Bishop, D Timothy, Bouras, Emmanouil, Brenner, Hermann, Budiarto, Arif, Campbell, Peter T., Casey, Graham, Chan, Andrew T., Chang-Claude, Jenny, Chen, Xuechen, Conti, David V., Dampier, Christopher H., Devall, Matthew A M, Drew, David A., Figueiredo, Jane C., Gallinger, Steven, Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Gunter, Marc J., Harrison, Tabitha A., Hidaka, Akihisa, Hoffmeister, Michael, Huyghe, Jeroen R., Jenkins, Mark A., Jordahl, Kristina M., Kawaguchi, Eric, Keku, Temitope O., Kundaje, Anshul, Le Marchand, Loic, Lewinger, Juan Pablo, Li, Li, Mahesworo, Bharuno, Morrison, John L., Murphy, Neil, Nan, Hongmei, Nassir, Rami, Newcomb, Polly A., Obón-Santacana, Mireia, Ogino, Shuji, Ose, Jennifer, Pai, Rish K., Palmer, Julie R., Papadimitriou, Nikos, Pardamean, Bens, Peoples, Anita R., Pharoah, Paul D P, Platz, Elizabeth A., Rennert, Gad, Ruiz-Narvaez, Edward, Sakoda, Lori C., Scacheri, Peter C., Schmit, Stephanie L., Schoen, Robert E., Shcherbina, Anna, Slattery, Martha L., Stern, Mariana C., Su, Yu-Ru, Tangen, Catherine M., Thomas, Duncan C., Tian, Yu, Tsilidis, Konstantinos K., Ulrich, Cornelia M., van Duijnhoven, Fränzel J B, van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Cenggoro, Tjeng Wawan, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Woods, Michael O., Hsu, Li, Peters, Ulrike, Moreno, Victor, Gauderman, W. James, Carreras-Torres, Robert, Kim, Andre E., Lin, Yi, Díez-Obrero, Virginia, Bien, Stephanie A., Qu, Conghui, Wang, Jun, Dimou, Niki, Aglago, Elom K., Albanes, Demetrius, Arndt, Volker, Baurley, James W., Berndt, Sonja I., Bézieau, Stéphane, Bishop, D Timothy, Bouras, Emmanouil, Brenner, Hermann, Budiarto, Arif, Campbell, Peter T., Casey, Graham, Chan, Andrew T., Chang-Claude, Jenny, Chen, Xuechen, Conti, David V., Dampier, Christopher H., Devall, Matthew A M, Drew, David A., Figueiredo, Jane C., Gallinger, Steven, Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Gunter, Marc J., Harrison, Tabitha A., Hidaka, Akihisa, Hoffmeister, Michael, Huyghe, Jeroen R., Jenkins, Mark A., Jordahl, Kristina M., Kawaguchi, Eric, Keku, Temitope O., Kundaje, Anshul, Le Marchand, Loic, Lewinger, Juan Pablo, Li, Li, Mahesworo, Bharuno, Morrison, John L., Murphy, Neil, Nan, Hongmei, Nassir, Rami, Newcomb, Polly A., Obón-Santacana, Mireia, Ogino, Shuji, Ose, Jennifer, Pai, Rish K., Palmer, Julie R., Papadimitriou, Nikos, Pardamean, Bens, Peoples, Anita R., Pharoah, Paul D P, Platz, Elizabeth A., Rennert, Gad, Ruiz-Narvaez, Edward, Sakoda, Lori C., Scacheri, Peter C., Schmit, Stephanie L., Schoen, Robert E., Shcherbina, Anna, Slattery, Martha L., Stern, Mariana C., Su, Yu-Ru, Tangen, Catherine M., Thomas, Duncan C., Tian, Yu, Tsilidis, Konstantinos K., Ulrich, Cornelia M., van Duijnhoven, Fränzel J B, van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Cenggoro, Tjeng Wawan, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Woods, Michael O., Hsu, Li, Peters, Ulrike, Moreno, Victor, and Gauderman, W. James
Abstract: BACKGROUND: Tobacco smoking is an established risk factor for colorectal cancer. However, genetically defined population subgroups may have increased susceptibility to smoking-related effects on colorectal cancer. METHODS: A genome-wide interaction scan was performed including 33,756 colorectal cancer cases and 44,346 controls from three genetic consortia. RESULTS: Evidence of an interaction was observed between smoking status (ever vs. never smokers) and a locus on 3p12.1 (rs9880919, P = 4.58 × 10-8), with higher associated risk in subjects carrying the GG genotype [OR, 1.25; 95% confidence interval (CI), 1.20-1.30] compared with the other genotypes (OR <1.17 for GA and AA). Among ever smokers, we observed interactions between smoking intensity (increase in 10 cigarettes smoked per day) and two loci on 6p21.33 (rs4151657, P = 1.72 × 10-8) and 8q24.23 (rs7005722, P = 2.88 × 10-8). Subjects carrying the rs4151657 TT genotype showed higher risk (OR, 1.12; 95% CI, 1.09-1.16) compared with the other genotypes (OR <1.06 for TC and CC). Similarly, higher risk was observed among subjects carrying the rs7005722 AA genotype (OR, 1.17; 95% CI, 1.07-1.28) compared with the other genotypes (OR <1.13 for AC and CC). Functional annotation revealed that SNPs in 3p12.1 and 6p21.33 loci were located in regulatory regions, and were associated with expression levels of nearby genes. Genetic models predicting gene expression revealed that smoking parameters were associated with lower colorectal cancer risk with higher expression levels of CADM2 (3p12.1) and ATF6B (6p21.33). CONCLUSIONS: Our study identified novel genetic loci that may modulate the risk for colorectal cancer of smoking status and intensity, linked to tumor suppression and immune response. IMPACT: These findings can guide potential prevention treatments.
Published: 2023
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39. Intake of the Total, Classes, and Subclasses of (Poly)Phenols and Risk of Prostate Cancer:A Prospective Analysis of the EPIC Study

Author: Almanza-Aguilera, Enrique, Guiñón-Fort, Daniel, Perez-Cornago, Aurora, Martínez-Huélamo, Miriam, Andrés-Lacueva, Cristina, Tjønneland, Anne, Eriksen, Anne Kirstine, Katzke, Verena, Bajracharya, Rashmita, Schulze, Matthias B., Masala, Giovanna, Oliverio, Andreina, Tumino, Rosario, Manfredi, Luca, Lasheras, Cristina, Crous-Bou, Marta, Sánchez, Maria José, Amiano, Pilar, Colorado-Yohar, Sandra M., Guevara, Marcela, Sonestedt, Emily, Bjartell, Anders, Thysell, Elin, Weiderpass, Elisabete, Aune, Dagfinn, Aglago, Elom K., Travis, Ruth C., Zamora-Ros, Raul, Almanza-Aguilera, Enrique, Guiñón-Fort, Daniel, Perez-Cornago, Aurora, Martínez-Huélamo, Miriam, Andrés-Lacueva, Cristina, Tjønneland, Anne, Eriksen, Anne Kirstine, Katzke, Verena, Bajracharya, Rashmita, Schulze, Matthias B., Masala, Giovanna, Oliverio, Andreina, Tumino, Rosario, Manfredi, Luca, Lasheras, Cristina, Crous-Bou, Marta, Sánchez, Maria José, Amiano, Pilar, Colorado-Yohar, Sandra M., Guevara, Marcela, Sonestedt, Emily, Bjartell, Anders, Thysell, Elin, Weiderpass, Elisabete, Aune, Dagfinn, Aglago, Elom K., Travis, Ruth C., and Zamora-Ros, Raul
Abstract: first_pagesettingsOrder Article Reprints Open AccessArticle Intake of the Total, Classes, and Subclasses of (Poly)Phenols and Risk of Prostate Cancer: A Prospective Analysis of the EPIC Study by Enrique Almanza-Aguilera 1ORCID,Daniel Guiñón-Fort 1,Aurora Perez-Cornago 2,Miriam Martínez-Huélamo 3,4ORCID,Cristina Andrés-Lacueva 3,4ORCID,Anne Tjønneland 5,6ORCID,Anne Kirstine Eriksen 5,Verena Katzke 7,Rashmita Bajracharya 7ORCID,Matthias B. Schulze 8,9ORCID,Giovanna Masala 10ORCID,Andreina Oliverio 11ORCID,Rosario Tumino 12ORCID,Luca Manfredi 13,Cristina Lasheras 14,Marta Crous-Bou 1,Maria-José Sánchez 15,16,17,18ORCID,Pilar Amiano 17,19,20,Sandra M. Colorado-Yohar 17,21,22ORCID,Marcela Guevara 17,23,24ORCID,add Show full author list 1 Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain 2 Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK 3 Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Nutrition and Food Safety Research Institute (INSA), Food Innovation Network (XIA), Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain 4 Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain 5 Danish Cancer Society Research Center, Danish Cancer Society, 2100 Copenhagen, Denmark 6 Department of Public Health, University of Copenhagen, 2177 Copenhagen, Denmark 7 Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany 8 Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany 9 Institute of Nutritional Science, University of Potsdam, 14558 Nuthet, Existing epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, in the case of flavonoids, it has been suggested that their intake may increase PCa risk. We investigated the associations between the intake of the total and individual classes and subclasses of (poly)phenols and the risk of PCa, including clinically relevant subtypes. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort included 131,425 adult men from seven European countries. (Poly)phenol intake at baseline was assessed by combining validated center/country-specific dietary questionnaires and the Phenol-Explorer database. Multivariable-adjusted Cox proportional hazards models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI). In total, 6939 incident PCa cases (including 3501 low-grade and 710 high-grade, 2446 localized and 1268 advanced, and 914 fatal Pca cases) were identified during a mean follow-up of 14 years. No associations were observed between the total intake of (poly)phenols and the risk of PCa, either overall (HRlog2 = 0.99, 95% CI 0.94–1.04) or according to PCa subtype. Null associations were also found between all classes (phenolic acids, flavonoids, lignans, and stilbenes) and subclasses of (poly)phenol intake and the risk of PCa, overall and according to PCa subtype. The results of the current large prospective cohort study do not support any association between (poly)phenol intake and PCa incidence.
Published: 2023

40. Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study

Author: Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 1, Cordova, Reynalda, Viallon, Vivian, Fontvieille, Emma, Peruchet-Noray, Laia, Jansana, Anna, Wagner, Karl-Heinz, Kyrø, Cecilie, Tjønneland, Anne, Katzke, Verena, Bajracharya, Rashmita, Schulze, Matthias B, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Ricceri, Fulvio, Tumino, Rosario, Boer, Jolanda M A, Verschuren, W M Monique, van der Schouw, Yvonne T, Jakszyn, Paula, Redondo-Sánchez, Daniel, Amiano, Pilar, Huerta, José María, Guevara, Marcela, Borné, Yan, Sonestedt, Emily, Tsilidis, Konstantinos K, Millett, Christopher, Heath, Alicia K, Aglago, Elom K, Aune, Dagfinn, Gunter, Marc J, Ferrari, Pietro, Huybrechts, Inge, Freisling, Heinz, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 1, Cordova, Reynalda, Viallon, Vivian, Fontvieille, Emma, Peruchet-Noray, Laia, Jansana, Anna, Wagner, Karl-Heinz, Kyrø, Cecilie, Tjønneland, Anne, Katzke, Verena, Bajracharya, Rashmita, Schulze, Matthias B, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Ricceri, Fulvio, Tumino, Rosario, Boer, Jolanda M A, Verschuren, W M Monique, van der Schouw, Yvonne T, Jakszyn, Paula, Redondo-Sánchez, Daniel, Amiano, Pilar, Huerta, José María, Guevara, Marcela, Borné, Yan, Sonestedt, Emily, Tsilidis, Konstantinos K, Millett, Christopher, Heath, Alicia K, Aglago, Elom K, Aune, Dagfinn, Gunter, Marc J, Ferrari, Pietro, Huybrechts, Inge, and Freisling, Heinz
Published: 2023

41. Dietary intake of total, heme and non-heme iron and the risk of colorectal cancer in a European prospective cohort study

Author: Epi Kanker Team B, Cancer, Aglago, Elom K., Cross, Amanda J., Riboli, Elio, Fedirko, Veronika, Hughes, David J., Fournier, Agnes, Jakszyn, Paula, Freisling, Heinz, Gunter, Marc J., Dahm, Christina C., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Boutron-Ruault, Marie Christine, Rothwell, Joseph A., Severi, Gianluca, Katzke, Verena, Srour, Bernard, Schulze, Matthias B., Wittenbecher, Clemens, Palli, Domenico, Sieri, Sabina, Pasanisi, Fabrizio, Tumino, Rosario, Ricceri, Fulvio, Bueno-de-Mesquita, Bas, Derksen, Jeroen W.G., Skeie, Guri, Jensen, Torill Enget, Lukic, Marko, Sánchez, Maria Jose, Amiano, Pilar, Colorado-Yohar, Sandra, Barricarte, Aurelio, Ericson, Ulrika, van Guelpen, Bethany, Papier, Keren, Knuppel, Anika, Casagrande, Corinne, Huybrechts, Inge, Heath, Alicia K., Tsilidis, Konstantinos K., Jenab, Mazda, Epi Kanker Team B, Cancer, Aglago, Elom K., Cross, Amanda J., Riboli, Elio, Fedirko, Veronika, Hughes, David J., Fournier, Agnes, Jakszyn, Paula, Freisling, Heinz, Gunter, Marc J., Dahm, Christina C., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Boutron-Ruault, Marie Christine, Rothwell, Joseph A., Severi, Gianluca, Katzke, Verena, Srour, Bernard, Schulze, Matthias B., Wittenbecher, Clemens, Palli, Domenico, Sieri, Sabina, Pasanisi, Fabrizio, Tumino, Rosario, Ricceri, Fulvio, Bueno-de-Mesquita, Bas, Derksen, Jeroen W.G., Skeie, Guri, Jensen, Torill Enget, Lukic, Marko, Sánchez, Maria Jose, Amiano, Pilar, Colorado-Yohar, Sandra, Barricarte, Aurelio, Ericson, Ulrika, van Guelpen, Bethany, Papier, Keren, Knuppel, Anika, Casagrande, Corinne, Huybrechts, Inge, Heath, Alicia K., Tsilidis, Konstantinos K., and Jenab, Mazda
Published: 2023

42. Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts

Author: Epi Kanker Team B, Cancer, Karavasiloglou, Nena, Hughes, David J, Murphy, Neil, Schomburg, Lutz, Sun, Qian, Seher, Vartiter, Rohrmann, Sabine, Weiderpass, Elisabete, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kaaks, Rudolf, Kuhn, Tilman, Schulze, Matthias B, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Pala, Valeria, Sacerdote, Carlotta, Derksen, Jeroen W G, Skeie, Guri, Hjartåker, Anette, Lasheras, Cristina, Agudo, Antonio, Sánchez, Maria-José, Chirlaque, Maria-Dolores, Ardanaz, Eva, Amiano, Pilar, Van Guelpen, Bethany, Gylling, Björn, Bradbury, Kathryn E, Papier, Keren, Freisling, Heinz, Aglago, Elom K, Cross, Amanda J, Riboli, Elio, Aune, Dagfinn, Gunter, Marc J, Jenab, Mazda, Epi Kanker Team B, Cancer, Karavasiloglou, Nena, Hughes, David J, Murphy, Neil, Schomburg, Lutz, Sun, Qian, Seher, Vartiter, Rohrmann, Sabine, Weiderpass, Elisabete, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kaaks, Rudolf, Kuhn, Tilman, Schulze, Matthias B, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Pala, Valeria, Sacerdote, Carlotta, Derksen, Jeroen W G, Skeie, Guri, Hjartåker, Anette, Lasheras, Cristina, Agudo, Antonio, Sánchez, Maria-José, Chirlaque, Maria-Dolores, Ardanaz, Eva, Amiano, Pilar, Van Guelpen, Bethany, Gylling, Björn, Bradbury, Kathryn E, Papier, Keren, Freisling, Heinz, Aglago, Elom K, Cross, Amanda J, Riboli, Elio, Aune, Dagfinn, Gunter, Marc J, and Jenab, Mazda
Published: 2023

43. Associations between Fatty Acid Intakes and Plasma Phospholipid Fatty Acid Concentrations in the European Prospective Investigation into Cancer and Nutrition

Author: Epi Kanker Team B, Cancer, Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Huybrechts, Inge, Jacobs, Inarie, Aglago, Elom K., Yammine, Sahar, Matta, Michèle, Schmidt, Julie A., Casagrande, Corinne, Nicolas, Geneviève, Biessy, Carine, Van Puyvelde, Heleen, Scalbert, Augustin, Derksen, Jeroen W.G., van der Schouw, Yvonne T., Grioni, Sara, Amiano, Pilar, Halkjær, Jytte, Tjønneland, Anne, Huerta, José M., Luján-Barroso, Leila, Palli, Domenico, Gunter, Marc J., Perez-Cornago, Aurora, Chajès, Véronique, Epi Kanker Team B, Cancer, Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Huybrechts, Inge, Jacobs, Inarie, Aglago, Elom K., Yammine, Sahar, Matta, Michèle, Schmidt, Julie A., Casagrande, Corinne, Nicolas, Geneviève, Biessy, Carine, Van Puyvelde, Heleen, Scalbert, Augustin, Derksen, Jeroen W.G., van der Schouw, Yvonne T., Grioni, Sara, Amiano, Pilar, Halkjær, Jytte, Tjønneland, Anne, Huerta, José M., Luján-Barroso, Leila, Palli, Domenico, Gunter, Marc J., Perez-Cornago, Aurora, and Chajès, Véronique
Published: 2023

44. A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort

Author: Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team C, Christakoudi, Sofia, Tsilidis, Konstantinos K, Dossus, Laure, Rinaldi, Sabina, Weiderpass, Elisabete, Antoniussen, Christian S, Dahm, Christina C, Tjønneland, Anne, Mellemkjær, Lene, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, May, Anne M, Monninkhof, Evelyn M, Quirós, J Ramón, Bonet, Catalina, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Rosendahl, Ann H, Stocks, Tanja, Perez-Cornago, Aurora, Tin Tin, Sandar, Heath, Alicia K, Aglago, Elom K, Peruchet-Noray, Laia, Freisling, Heinz, Riboli, Elio, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team C, Christakoudi, Sofia, Tsilidis, Konstantinos K, Dossus, Laure, Rinaldi, Sabina, Weiderpass, Elisabete, Antoniussen, Christian S, Dahm, Christina C, Tjønneland, Anne, Mellemkjær, Lene, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, May, Anne M, Monninkhof, Evelyn M, Quirós, J Ramón, Bonet, Catalina, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Rosendahl, Ann H, Stocks, Tanja, Perez-Cornago, Aurora, Tin Tin, Sandar, Heath, Alicia K, Aglago, Elom K, Peruchet-Noray, Laia, Freisling, Heinz, and Riboli, Elio
Published: 2023

45. Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases:a multinational cohort study

Author: Cordova, Reynalda, Viallon, Vivian, Fontvieille, Emma, Peruchet-Noray, Laia, Jansana, Anna, Wagner, Karl Heinz, Kyrø, Cecilie, Tjønneland, Anne, Katzke, Verena, Bajracharya, Rashmita, Schulze, Matthias B., Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Ricceri, Fulvio, Tumino, Rosario, Boer, Jolanda M.A., Verschuren, W. M.Monique, van der Schouw, Yvonne T., Jakszyn, Paula, Redondo-Sánchez, Daniel, Amiano, Pilar, Huerta, José María, Guevara, Marcela, Borné, Yan, Sonestedt, Emily, Tsilidis, Konstantinos K., Millett, Christopher, Heath, Alicia K., Aglago, Elom K., Aune, Dagfinn, Gunter, Marc J., Ferrari, Pietro, Huybrechts, Inge, Freisling, Heinz, Cordova, Reynalda, Viallon, Vivian, Fontvieille, Emma, Peruchet-Noray, Laia, Jansana, Anna, Wagner, Karl Heinz, Kyrø, Cecilie, Tjønneland, Anne, Katzke, Verena, Bajracharya, Rashmita, Schulze, Matthias B., Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Ricceri, Fulvio, Tumino, Rosario, Boer, Jolanda M.A., Verschuren, W. M.Monique, van der Schouw, Yvonne T., Jakszyn, Paula, Redondo-Sánchez, Daniel, Amiano, Pilar, Huerta, José María, Guevara, Marcela, Borné, Yan, Sonestedt, Emily, Tsilidis, Konstantinos K., Millett, Christopher, Heath, Alicia K., Aglago, Elom K., Aune, Dagfinn, Gunter, Marc J., Ferrari, Pietro, Huybrechts, Inge, and Freisling, Heinz
Abstract: Background It is currently unknown whether ultra-processed foods (UPFs) consumption is associated with a higher incidence of multimorbidity. We examined the relationship of total and subgroup consumption of UPFs with the risk of multimorbidity defined as the co-occurrence of at least two chronic diseases in an individual among first cancer at any site, cardiovascular disease, and type 2 diabetes. Methods This was a prospective cohort study including 266,666 participants (60% women) free of cancer, cardiovascular disease, and type 2 diabetes at recruitment from seven European countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Foods and drinks consumed over the previous 12 months were assessed at baseline by food-frequency questionnaires and classified according to their degree of processing using Nova classification. We used multistate modelling based on Cox regression to estimate cause-specific hazard ratios (HR) and their 95% confidence intervals (CI) for associations of total and subgroups of UPFs with the risk of multimorbidity of cancer and cardiometabolic diseases. Findings After a median of 11.2 years of follow-up, 4461 participants (39% women) developed multimorbidity of cancer and cardiometabolic diseases. Higher UPF consumption (per 1 standard deviation increment, ∼260 g/day without alcoholic drinks) was associated with an increased risk of multimorbidity of cancer and cardiometabolic diseases (HR: 1.09, 95% CI: 1.05, 1.12). Among UPF subgroups, associations were most notable for animal-based products (HR: 1.09, 95% CI: 1.05, 1.12), and artificially and sugar-sweetened beverages (HR: 1.09, 95% CI: 1.06, 1.12). Other subgroups such as ultra-processed breads and cereals (HR: 0.97, 95% CI: 0.94, 1.00) or plant-based alternatives (HR: 0.97, 95% CI: 0.91, 1.02) were not associated with risk. Interpretation Our findings suggest that higher consumption of UPFs increases the risk of, Background: It is currently unknown whether ultra-processed foods (UPFs) consumption is associated with a higher incidence of multimorbidity. We examined the relationship of total and subgroup consumption of UPFs with the risk of multimorbidity defined as the co-occurrence of at least two chronic diseases in an individual among first cancer at any site, cardiovascular disease, and type 2 diabetes. Methods: This was a prospective cohort study including 266,666 participants (60% women) free of cancer, cardiovascular disease, and type 2 diabetes at recruitment from seven European countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Foods and drinks consumed over the previous 12 months were assessed at baseline by food-frequency questionnaires and classified according to their degree of processing using Nova classification. We used multistate modelling based on Cox regression to estimate cause-specific hazard ratios (HR) and their 95% confidence intervals (CI) for associations of total and subgroups of UPFs with the risk of multimorbidity of cancer and cardiometabolic diseases. Findings: After a median of 11.2 years of follow-up, 4461 participants (39% women) developed multimorbidity of cancer and cardiometabolic diseases. Higher UPF consumption (per 1 standard deviation increment, ∼260 g/day without alcoholic drinks) was associated with an increased risk of multimorbidity of cancer and cardiometabolic diseases (HR: 1.09, 95% CI: 1.05, 1.12). Among UPF subgroups, associations were most notable for animal-based products (HR: 1.09, 95% CI: 1.05, 1.12), and artificially and sugar-sweetened beverages (HR: 1.09, 95% CI: 1.06, 1.12). Other subgroups such as ultra-processed breads and cereals (HR: 0.97, 95% CI: 0.94, 1.00) or plant-based alternatives (HR: 0.97, 95% CI: 0.91, 1.02) were not associated with risk. Interpretation: Our findings suggest that higher consumption of UPFs increases the risk of cancer and cardiometabolic multimor
Published: 2023

46. Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response

Author: Carreras-Torres, Robert, primary, Kim, Andre E., additional, Lin, Yi, additional, Díez-Obrero, Virginia, additional, Bien, Stephanie A., additional, Qu, Conghui, additional, Wang, Jun, additional, Dimou, Niki, additional, Aglago, Elom K., additional, Albanes, Demetrius, additional, Arndt, Volker, additional, Baurley, James W., additional, Berndt, Sonja I., additional, Bézieau, Stéphane, additional, Bishop, D. Timothy, additional, Bouras, Emmanouil, additional, Brenner, Hermann, additional, Budiarto, Arif, additional, Campbell, Peter T., additional, Casey, Graham, additional, Chan, Andrew T., additional, Chang-Claude, Jenny, additional, Chen, Xuechen, additional, Conti, David V., additional, Dampier, Christopher H., additional, Devall, Matthew A.M., additional, Drew, David A., additional, Figueiredo, Jane C., additional, Gallinger, Steven, additional, Giles, Graham G., additional, Gruber, Stephen B., additional, Gsur, Andrea, additional, Gunter, Marc J., additional, Harrison, Tabitha A., additional, Hidaka, Akihisa, additional, Hoffmeister, Michael, additional, Huyghe, Jeroen R., additional, Jenkins, Mark A., additional, Jordahl, Kristina M., additional, Kawaguchi, Eric, additional, Keku, Temitope O., additional, Kundaje, Anshul, additional, Le Marchand, Loic, additional, Lewinger, Juan Pablo, additional, Li, Li, additional, Mahesworo, Bharuno, additional, Morrison, John L., additional, Murphy, Neil, additional, Nan, Hongmei, additional, Nassir, Rami, additional, Newcomb, Polly A., additional, Obón-Santacana, Mireia, additional, Ogino, Shuji, additional, Ose, Jennifer, additional, Pai, Rish K., additional, Palmer, Julie R., additional, Papadimitriou, Nikos, additional, Pardamean, Bens, additional, Peoples, Anita R., additional, Pharoah, Paul D.P., additional, Platz, Elizabeth A., additional, Rennert, Gad, additional, Ruiz-Narvaez, Edward, additional, Sakoda, Lori C., additional, Scacheri, Peter C., additional, Schmit, Stephanie L., additional, Schoen, Robert E., additional, Shcherbina, Anna, additional, Slattery, Martha L., additional, Stern, Mariana C., additional, Su, Yu-Ru, additional, Tangen, Catherine M., additional, Thomas, Duncan C., additional, Tian, Yu, additional, Tsilidis, Konstantinos K., additional, Ulrich, Cornelia M., additional, van Duijnhoven, Fränzel J.B., additional, Van Guelpen, Bethany, additional, Visvanathan, Kala, additional, Vodicka, Pavel, additional, Cenggoro, Tjeng Wawan, additional, Weinstein, Stephanie J., additional, White, Emily, additional, Wolk, Alicja, additional, Woods, Michael O., additional, Hsu, Li, additional, Peters, Ulrike, additional, Moreno, Victor, additional, and Gauderman, W. James, additional
Published: 2023
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47. Factors Associated With Delayed Pre-Hospital Times During Trauma-Related Mass Casualty Incidents: A Systematic Review

Author: Alruqi, Fayez, primary, Aglago, Elom K., additional, Cole, Elaine, additional, and Brohi, Karim, additional
Published: 2023
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48. Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts

Author: Karavasiloglou, Nena, primary, Hughes, David J., additional, Murphy, Neil, additional, Schomburg, Lutz, additional, Sun, Qian, additional, Seher, Vartiter, additional, Rohrmann, Sabine, additional, Weiderpass, Elisabete, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Boutron-Ruault, Marie-Christine, additional, Mancini, Francesca Romana, additional, Mahamat-Saleh, Yahya, additional, Kaaks, Rudolf, additional, Kuhn, Tilman, additional, Schulze, Matthias B., additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Masala, Giovanna, additional, Pala, Valeria, additional, Sacerdote, Carlotta, additional, Derksen, Jeroen W.G., additional, Skeie, Guri, additional, Hjartåker, Anette, additional, Lasheras, Cristina, additional, Agudo, Antonio, additional, Sánchez, Maria-José, additional, Chirlaque, Maria-Dolores, additional, Ardanaz, Eva, additional, Amiano, Pilar, additional, Van Guelpen, Bethany, additional, Gylling, Björn, additional, Bradbury, Kathryn E., additional, Papier, Keren, additional, Freisling, Heinz, additional, Aglago, Elom K., additional, Cross, Amanda J., additional, Riboli, Elio, additional, Aune, Dagfinn, additional, Gunter, Marc J., additional, and Jenab, Mazda, additional
Published: 2022
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49. Body mass index and molecular subtypes of colorectal cancer

Author: Murphy, Neil, primary, Newton, Christina C, additional, Song, Mingyang, additional, Papadimitriou, Nikos, additional, Hoffmeister, Michael, additional, Phipps, Amanda I, additional, Harrison, Tabitha A, additional, Newcomb, Polly A, additional, Aglago, Elom K, additional, Berndt, Sonja I, additional, Brenner, Hermann, additional, Buchanan, Daniel D, additional, Cao, Yin, additional, Chan, Andrew T, additional, Chen, Xuechen, additional, Cheng, Iona, additional, Chang-Claude, Jenny, additional, Dimou, Niki, additional, Drew, David, additional, Farris, Alton B, additional, French, Amy J, additional, Gallinger, Steven, additional, Georgeson, Peter, additional, Giannakis, Marios, additional, Giles, Graham G, additional, Gruber, Stephen B, additional, Harlid, Sophia, additional, Hsu, Li, additional, Huang, Wen-Yi, additional, Jenkins, Mark A, additional, Laskar, Ruhina S, additional, Le Marchand, Loic, additional, Limburg, Paul, additional, Lin, Yi, additional, Mandic, Marko, additional, Nowak, Johnathan A, additional, Obón-Santacana, Mereia, additional, Ogino, Shuji, additional, Qu, Conghui, additional, Sakoda, Lori C, additional, Schoen, Robert E, additional, Southey, Melissa C, additional, Stadler, Zsofia K, additional, Steinfelder, Robert S, additional, Sun, Wei, additional, Thibodeau, Stephen N, additional, Toland, Amanda E, additional, Trinh, Quang M, additional, Tsilidis, Kostas K, additional, Ugai, Tomotaka, additional, Van Guelpen, Bethany, additional, Wang, Xiaoliang, additional, Woods, Michael O, additional, Zaidi, Syed H, additional, Gunter, Marc J, additional, Peters, Ulrike, additional, and Campbell, Peter T, additional
Published: 2022
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50. Pre-Diagnostic Circulating Resistin Concentrations Are Not Associated with Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Study

Author: Pham, Thu-Thi, primary, Nimptsch, Katharina, additional, Aleksandrova, Krasimira, additional, Jenab, Mazda, additional, Reichmann, Robin, additional, Wu, Kana, additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Schulze, Matthias B., additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Palli, Domenico, additional, Pasanisi, Fabrizio, additional, Ricceri, Fulvio, additional, Tumino, Rosario, additional, Krogh, Vittorio, additional, Roodhart, Jeanine, additional, Castilla, Jesús, additional, Sánchez, Maria-Jose, additional, Colorado-Yohar, Sandra Milena, additional, Harbs, Justin, additional, Rutegård, Martin, additional, Papier, Keren, additional, Aglago, Elom K., additional, Dimou, Niki, additional, Mayen-Chacon, Ana-Lucia, additional, Weiderpass, Elisabete, additional, and Pischon, Tobias, additional
Published: 2022
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