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3. High levels of HPV16-L1 antibody but not HPV16 DNA load or integration predict oropharyngeal patient outcome: The Papillophar study

Author

Prétet, Jean-Luc, Dalstein, Véronique, Touzé, Antoine, Beby-Defaux, Agnès, Soussan, Patrick, Jacquin, Élise, Birembaut, Philippe, Clavel, Christine, Mougin, Christiane, Rousseau, Alexandra, Lacau Saint Guily, Jean, Agius, G., Albert, S., Babin, E., Badet, J., Badoual, C., Baglin, A., Blanc-Fournier, K., Cassagneau, E., Debry, C., de Raucourt, D., Diebold, M., Dufour, X., Hourseau, M., Lacave, R., Zalcman, E. Lechapt, Lefevre, M., Levillain, P., Malard, O., Mauvais, O., Mechine, A., Merol, J., Mirghani, H., Morinière, S., Périé, S., Rousselot, C., Simon, T., Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250 (P3CELL), Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Reims (CHU Reims), Infectiologie et Santé Publique (UMR ISP), Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire Inflammation, Tissus épithéliaux et Cytokines (LITEC), Université de Poitiers, Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de virologie [Hôpital Tenon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Unité de Recherche Clinique de l’Est Parisien [CHU Saint-Antoine] (URC-EST), Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (CHNO)-CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Direction de la Recherche Clinique et de l'Innovation [AP-HP] (DRCI), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Oto-Rhino-Laryngologie Chirurgie cervico-faciale [CHU Tenon], Fondation Ophtalmologique Adolphe de Rothschild [Paris], and This work was funded by the Programme Hospitalier de Recherche Clinique, French Ministry of Health (Grant Numbers AOM 08104, AOM 11 293).

Subjects
stomatognathic diseases, Oropharyngeal cancer, viruses, [SDV]Life Sciences [q-bio], virus diseases, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biomarker, General Medicine, Papillomavirus, Prognosis, neoplasms, female genital diseases and pregnancy complications, General Biochemistry, Genetics and Molecular Biology
Abstract

International audience; The incidence of oropharyngeal cancers (OPC) is increasing in the world. Among OPC, those induced by human papillomaviruses have a better prognosis than non-HPV-associated OPC. The objective of this study was to highlight the relevance of HPV16 load, HPV16 DNA integration and HPV16-L1 serology on progression-free survival and overall survival of OPC patients. The PAPILLOPHAR cohort consists of 362 patients with oropharyngeal squamous cell carcinomas prospectively followed up for 5 years after treatment. Tumor biopsies and sera were collected at inclusion to investigate tumor HPV DNA/RNA characteristics and HPV16 L1 serology, respectively. Twenty-seven percent of tumor biopsies were HPV DNA- and RNA-positive and HPV16 represented 93% of HPV-positive cases. Among them, neither HPV16 viral load nor HPV16 DNA integration was associated with overall survival (OS) or progression-free survival (PFS). In contrast, high anti-HPV16 L1 antibody titers were significantly associated with a better OS and PFS. This study reveals that HPV16 load and integration are not relevant prognosis biomarkers in OPC patients. Clinical Relevance: High levels of HPV16 L1 antibodies may be useful to predict OPC patient outcome following treatment. ClinicalTrials.gov Identifier: NCT00918710, May 2017.

Published
2021
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5. High levels of HPV16-L1 antibody but not HPV16 DNA load or integration predict oropharyngeal patient outcome: The Papillophar study.

Author

Prétet, Jean-Luc, Dalstein, Véronique, Touzé, Antoine, Beby-Defaux, Agnès, Soussan, Patrick, Jacquin, Élise, Birembaut, Philippe, Clavel, Christine, Mougin, Christiane, Rousseau, Alexandra, Lacau Saint Guily, Jean, for the Papillophar Study Group, Agius, G., Albert, S., Babin, E., Badet, J. M., Badoual, C., Baglin, A. C., Blanc-Fournier, K., and Cassagneau, E.

Subjects
HUMAN papillomavirus, PROGRAMMED cell death 1 receptors, DNA, PROGRESSION-free survival, OROPHARYNGEAL cancer, OVERALL survival
Abstract

The incidence of oropharyngeal cancers (OPC) is increasing in the world. Among OPC, those induced by human papillomaviruses have a better prognosis than non-HPV-associated OPC. The objective of this study was to highlight the relevance of HPV16 load, HPV16 DNA integration and HPV16-L1 serology on progression-free survival and overall survival of OPC patients. The PAPILLOPHAR cohort consists of 362 patients with oropharyngeal squamous cell carcinomas prospectively followed up for 5 years after treatment. Tumor biopsies and sera were collected at inclusion to investigate tumor HPV DNA/RNA characteristics and HPV16 L1 serology, respectively. Twenty-seven percent of tumor biopsies were HPV DNA- and RNA-positive and HPV16 represented 93% of HPV-positive cases. Among them, neither HPV16 viral load nor HPV16 DNA integration was associated with overall survival (OS) or progression-free survival (PFS). In contrast, high anti-HPV16 L1 antibody titers were significantly associated with a better OS and PFS. This study reveals that HPV16 load and integration are not relevant prognosis biomarkers in OPC patients. Clinical Relevance: High levels of HPV16 L1 antibodies may be useful to predict OPC patient outcome following treatment. ClinicalTrials.gov Identifier: NCT00918710, May 2017. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Clinical severity and molecular characteristics of circulating and emerging rotaviruses in young children attending hospital emergency departments in France

Author

de Rougemont, A., Kaplon, J., Fremy, C., Legrand-Guillien, M.-C., Minoui-Tran, A., Payan, C., Vabret, A., Mendes-Martins, L., Chouchane, M., Maudinas, R., Huet, F., Dubos, F., Hober, D., Lazrek, M., Bouquignaud, C., Decoster, A., Alain, S., Languepin, J., Gillet, Y., Lina, B., Mekki, Y., Morfin-Sherpa, F., Guigon, A., Guinard, J., Foulongne, V., Rodiere, M., Avettand-Fenoel, V., Bonacorsi, S., Garbarg-Chenon, A., Gendrel, D., Lebon, P., Lorrot, M., Mariani, P., Meritet, J.-F., Schnuriger, A., Agius, G., Beby-Defaux, A., Oriot, D., Colimon, R., Lagathu, G., Mory, O., Pillet, S., Pozzetto, B., Stephan, J.-L., Aho, S., and Pothier, P.

Published
2016
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10. Changing of hepatitis C virus genotype patterns in France at the beginning of the third millenium: The GEMHEP GenoCII Study

Author

Payan, C., Roudot-Thoraval, F., Marcellin, P., Bled, N., Duverlie, G., Fouchard-Hubert, I., Trimoulet, P., Couzigou, P., Cointe, D., Chaput, C., Henquell, C., Abergel, A., Pawlotsky, J. M., Hezode, C., Coudé, M., Blanchi, A., Alain, S., Loustaud-Ratti, V., Chevallier, P., Trepo, C., Gerolami, V., Portal, I., Halfon, P., Bourlière, M., Bogard, M., Plouvier, E., Laffont, C., Agius, G., Silvain, C., Brodard, V., Thiefin, G., Buffet-Janvresse, C., Riachi, G., Grattard, F., Bourlet, T., Stoll-Keller, F., Doffoel, M., Izopet, J., Barange, K., Martinot-Peignoux, M., Branger, M., Rosenberg, A., Sogni, P., Chaix, M. L., Pol, S., Thibault, V., Opolon, P., Charrois, A., Serfaty, L., Fouqueray, B., Grange, J. D., Lefrère, J. J., and Lunel-Fabiani, F.

Published
2005

22. La Tuberculose et le cinéma

Author

Castel, O., primary, Boury, A., additional, Underner, M., additional, Agius, G., additional, Burucoa, C., additional, and Thévenot, S., additional

Published
2013
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25. CL020 - Diversité génotypique des rotavirus aux urgences pédiatriques en France entre 2006 et 2009

Author

De Rougemont, A., primary, Kaplon, J., additional, Pillet, S., additional, Stephan, J.L., additional, Gagneur, A., additional, Payan, C., additional, Lebon, P., additional, Huet, F., additional, Coste-Burel, M., additional, Mollat, C., additional, Lorrot, M., additional, Bingen, E., additional, Rodiere, M., additional, Foulongne, V., additional, Floret, D., additional, Lina, B., additional, Parez, N., additional, Garbag-Chenon, A., additional, Fourcade, L., additional, Alain, S., additional, Oriot, D., additional, Agius, G., additional, Hober, D., additional, Martinot, A., additional, Colimon, R., additional, Fontana, C., additional, Gendrel, D., additional, and Pothier, P., additional

Published
2010
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26. OP5-6 Evaluation of human papillomavirus (HPV) by quantification and typing in paired urine and cervical samples of women with abnormal cytology

Author

Ducancelle, A., primary, Hantz, S., additional, Legrand, M.-C., additional, Alain, S., additional, Beby-Defaux, A., additional, Malbois, C., additional, Avenel, M., additional, De Brux, M.-A., additional, Charles, F., additional, Aspeele, F., additional, Catala, L., additional, Descamps, P., additional, Postec, E., additional, Collet, M., additional, Agius, G., additional, Lunel, F., additional, and Payan, C., additional

Published
2009
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31. Surveillance Network for Herpes Simplex Virus Resistance to Antiviral Drugs: 3-Year Follow-Up

Author

Danve-Szatanek, C., primary, Aymard, M., additional, Thouvenot, D., additional, Morfin, F., additional, Agius, G., additional, Bertin, I., additional, Billaudel, S., additional, Chanzy, B., additional, Coste-Burel, M., additional, Finkielsztejn, L., additional, Fleury, H., additional, Hadou, T., additional, Henquell, C., additional, Lafeuille, H., additional, Lafon, M. E., additional, Le Faou, A., additional, Legrand, M. C., additional, Maille, L., additional, Mengelle, C., additional, Morand, P., additional, Morinet, F., additional, Nicand, E., additional, Omar, S., additional, Picard, B., additional, Pozzetto, B., additional, Puel, J., additional, Raoult, D., additional, Scieux, C., additional, Segondy, M., additional, Seigneurin, J. M., additional, Teyssou, R., additional, and Zandotti, C., additional

Published
2004
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