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2. Bothersome Gynecomastia Following Neoadjuvant GnRH Agonists and Stereotactic Body Radiotherapy for Localized Prostate Cancer

Author

Jatar, S.S., primary, Shah, S., additional, Hsueh, J., additional, Gallagher, L., additional, Danner, M., additional, Zwart, A., additional, Ayoob, M.J., additional, Yung, T., additional, Kumar, D., additional, Leger, P., additional, Aghdam, N., additional, Dawson, N., additional, Suy, S., additional, and Collins, S.P., additional

Published
2023
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3. Bothersome Hot Flashes Following Neoadjuvant Androgen Deprivation Therapy and Stereotactic Body Radiotherapy for Localized Prostate Cancer

Author

Shah, S., primary, Jatar, S.S., additional, Hsueh, J., additional, Gallagher, L., additional, Pepin, A., additional, Danner, M., additional, Zwart, A., additional, Ayoob, M.J., additional, Yung, T., additional, Kumar, D., additional, Aghdam, N., additional, Leger, P., additional, Dawson, N., additional, Suy, S., additional, and Collins, S.P., additional

Published
2023
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7. Weeds Associated Bacterial Endophyte Producing Pantocin against Pectobacterium carotovorum subsp. carotovorum.

Author

Aghdam, N. Mohammad-Nejad, Baghaee-Ravari, S., and Shiri, A.

Subjects
*ERWINIA, *WEEDS, *PEPTIDE antibiotics, *POTATOES, *POTATO storage, *TUBERS, *POTATO diseases & pests
Abstract

In the present study, bacterial endophytes were obtained from weeds of potato fields. Their antagonistic activity was screened against potato storage pathogen, Pectobacterium carotovorum subsp. carotovorum (Pcc) (JX029052), in the maceration assay. An endophytic strain, PC-2B was isolated from Convolvulus arvensis L. as a dominant weed of potato fields. In vivo application of this strain led to 58.8% reduction in tuber decay. This motile strain that can produce amylase was identified as Pantoea sp. using phenotypic features and 16S rRNA sequencing. Following PC-2B treatment, 56.7% Reduction in Disease Incidence (RDI) was obtained in preventative and 52% in curative challenges under semi-practical storage trails. Anti-Pcc bioactive compounds of Pantoea sp. was extracted and identified based on H NMR and FT-IR techniques. Two peptide antibiotics including Pantocin A and B with inhibitory effect against Pcc were characterized. These results might indicate that the tested Pantoea strain could be a promising candidate to protect potato tubers against soft rot disease caused by Pcc. However, large-scale complementary trials have to be conducted to validate these results before any recommendations. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Adjuvant Stereotactic Body Radiation Therapy (ASBRT) for Early-Stage Breast Cancer: Symptomatic Fat Necrosis is Associated with Consecutive Daily Treatments

Author

Cantalino, J.M., primary, Pernia, M., additional, Obayomi-Davies, O., additional, Aghdam, N., additional, Danner, M., additional, Suy, S., additional, Conroy, D., additional, Collins, S.P., additional, Salvatore, M., additional, Makariou, E.V., additional, Rudra, S., additional, Lischalk, J.W., additional, and Collins, B.T., additional

Published
2022
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9. Correlation between Obesity and Treatment Failure Following Stereotactic Body Radiation Therapy (SBRT) for Clinically Localized Prostate Cancer

Author

Conroy, D., primary, Sholklapper, T., additional, Lawlor, M.K., additional, Cantalino, J.M., additional, Zwart, A., additional, Ayoob, M.J., additional, Danner, M., additional, Yung, T., additional, Collins, B.T., additional, Lei, S., additional, Rashid, A., additional, Kumar, D., additional, Suy, S., additional, Aghdam, N., additional, and Collins, S.P., additional

Published
2022
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12. Early PSA Kinetics in Patients Treated with Prostate SBRT with Intra-Prostatic Boost.

Author

Aghdam, N., Bhargava, N., Hurwitz, M., Bennett, L., Aronovitz, J.A., Schmidt, D.R., and Kaplan, I.D.

Subjects
*PROSTATE cancer patients, *SEMINAL vesicles, *STEREOTACTIC radiotherapy, *HORMONE therapy, *PROSTATE-specific antigen, *PROSTATE cancer
Abstract

SBRT is a standard of care treatment for localized prostate cancer. Intra-prostatic boost (IPB) may improve biochemical control. Additionally, the prognostic impact of early PSA nadir has been described by ICECaP collaborative. In the present series, we report early PSA kinetics for patients with intermediate risk disease who received IPB treated with SBRT with and without short course of hormone therapy. From October 2018 to June 2023, 280 patients with intermediate risk prostate cancer were treated with a robotic stereotactic body radiotherapy platform with fiducial tracking. Intra-prostatic nodules were delineated using diagnostic and treatment planning MRI by the treating radiation oncologist. Patients received the standard dose of 36.25Gy to the prostate and proximal seminal vesicles with isotropic expansion margin of 5mm, except posteriorly towards the rectum, where the margin was 3mm. GTV received 40 Gy. For assessing PSA kinetics, each patient's PSA value at diagnosis and follow-up, defined as 6-12 months after completion of treatment, were considered. PSA values were retrospectively extracted from each patient's medical records and the percentage of patients with PSA values <0.1 ng/mL, <0.2 ng/mL, and <0.5 ng/mL within 6-12 months of completion of treatment was determined. Patients were compared based on the use of short term (4-6 months) hormone therapy with SBRT. Of 280 patients, 157 patients received hormone therapy and 123 did not. The median and ranges of PSA values at diagnosis for each group were 6.9 (0.8-19.5) and 6.8 (2-19.9), respectively. Of patients who received hormone therapy with SBRT and IPB, 36.9% achieved PSA<0.1ng/mL compared to 1.6% for those who did not receive hormone therapy. Respectively, 58.0% and 4.1% achieved PSA<0.2mg/mL and 86.0% and 15.4% achieved PSA<0.5ng/mL within 12 months of treatment completion. SBRT is a safe and effective treatment for patients with localized prostate cancer. To our knowledge, this report is the largest series describing early PSA kinetics for patients treated with SBRT with IPB in the context of established PSA nadirs reported by ICECaP collaborative group. Long-term follow up is needed to determine the prognostic significance of these findings. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Patterns and Predictors of Distant Failure After Stereotactic Body Radiation Therapy for Localized Prostate Cancer: A Retrospective Multi-Institutional Analysis

Author

Shabsovich, D., primary, Xiang, M., additional, Katz, A.W., additional, Mantz, C.A., additional, Fuller, D.B., additional, van Dams, R., additional, Philipson, R., additional, Juarez, J.E., additional, Ma, T.M., additional, Pepin, A., additional, Suy, S., additional, Stephans, K.L., additional, Murthy, V., additional, Nickols, N.G., additional, Miszczyk, L., additional, Aghdam, N., additional, Glicksman, R., additional, Collins, S.P., additional, Loblaw, D.A., additional, and Kishan, A.U., additional

Published
2021
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16. Working Towards a New Definition of Biochemical Failure in the Era of Stereotactic Body Radiation Therapy for Prostate Cancer

Author

Ma, T.M., primary, Roy, S., additional, Mantz, C.A., additional, Fuller, D.B., additional, Miszczyk, L., additional, Napieralska, A., additional, Namysł-Kaletka, A.J., additional, Bagshaw, H.P., additional, Buyyounouski, M.K., additional, Glicksman, R., additional, Loblaw, D.A., additional, Katz, A.J., additional, Nickols, N.G., additional, Steinberg, M.L., additional, Philipson, R., additional, Aghdam, N., additional, Suy, S., additional, Pepin, A., additional, Collins, S.P., additional, and Kishan, A.U., additional

Published
2021
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23. Impact of Anatomic Tumor Location on Clinical Outcomes: A Long-Term Analysis of Early Stage Non-Small Cell Lung Cancer Treated with Stereotactic Body Radiation Therapy and Fiducial Tracking

Author

Forsthoefel, M.K., primary, Aghdam, N., additional, Pernia, M., additional, Krochmal, R., additional, Anderson, E., additional, Campbell, L., additional, Suy, S., additional, Collins, S.P., additional, Lischalk, J.W., additional, and Collins, B.T., additional

Published
2020
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25. Stereotactic Body Radiotherapy for High-Risk Localized Carcinoma of the Prostate (SHARP) Consortium: Analysis of 323 Prospectively Treated Patients

Author

van Dams, R., primary, Jiang, N., additional, King, C.R., additional, Fuller, D.B., additional, Loblaw, D.A., additional, Jiang, T., additional, Romero, T., additional, Katz, A.J., additional, Collins, S.P., additional, Aghdam, N., additional, Suy, S., additional, Stephans, K.L., additional, Kaplan, I.D., additional, Yuan, Y., additional, Nickols, N.G., additional, Murthy, V., additional, Telkhade, T.P., additional, Kupelian, P.A., additional, Steinberg, M.L., additional, and Kishan, A.U., additional

Published
2020
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31. Testosterone Recovery Following Short Course Androgen Deprivation Therapy and Stereotactic Body Radiotherapy Correlates Closely with Improvements in Patient-Reported Hormonal and Sexual Domain Scores

Author

Forsthoefel, M.K., primary, Burlile, J., additional, Lane, S.A., additional, Tsou, H., additional, Kataria, S., additional, Danner, M., additional, Yung, T., additional, Ayoob, M.J., additional, Lischalk, J.W., additional, Collins, B.T., additional, Suy, S., additional, Aghdam, N., additional, and Collins, S.P., additional

Published
2019
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32. Early Stage NSCLC (ES-NSCLC) with Gross Endobronchial Disease (GED) Predicts for Worse Overall Survival (OS) after Treatment with 5-Fraction Stereotactic Body Radiation Therapy (SBRT)

Author

Aghdam, N., primary, Kataria, S., additional, Pernia, M., additional, Hall, C., additional, O'Connor, T., additional, Campbell, L., additional, Suy, S., additional, Collins, S.P., additional, Krochmal, R., additional, Anderson, E., additional, Collins, B.T., additional, and Lischalk, J.W., additional

Published
2019
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37. Reduced PSA Surveillance Following SBRT for Favorable Prostate Cancer Decreases the Incidence of Anxiety-Promoting Benign PSA Bounces without Limiting the Early Detection of Biochemical Failures

Author

Aghdam, N., primary, Smith, C.P., additional, Danner, M., additional, Ayoob, M.J., additional, Yung, T., additional, Lei, S., additional, Collins, B.T., additional, Lischalk, J.W., additional, Dritschilo, A., additional, Suy, S., additional, and Collins, S.P., additional

Published
2018
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38. Poor outcome following percutaneous balloon mitral valvotomy in patients with atrial fibrillation

Author

Aslanabadi A, Mohammadreza Taban, Ahmadzade M, Naser Aslanabadi, Ahmad Separham, Babak Nasiri, Babak Kazemi, Samad Ghaffari, Khezerlouy Aghdam N, and Bahram Sohrabi

Subjects
lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, Percutaneous, 030204 cardiovascular system & hematology, Balloon Mitral Valvotomy, Balloon Mtral Valvotomy, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Atrial Fibrillation, medicine, Sinus rhythm, 030212 general & internal medicine, cardiovascular diseases, Stroke, Mitral regurgitation, business.industry, Mitral Stenosis, Atrial fibrillation, medicine.disease, Surgery, Stenosis, Embolism, lcsh:RC666-701, Cardiology, cardiovascular system, Original Article, Cardiology and Cardiovascular Medicine, Complication, business
Abstract

Introduction: Atrial fibrillation (AF) is the most common arrhythmia in patients with mitral stenosis (MS) and it may increase complications and decreases success rates of percutaneous balloon mitral valvotomy (PBMV). This study aimed to investigate the short and long term results of PBMV in patients with AF compared to sinus rhythm (SR). Methods: In this cross sectional study, 1000 patients with MS who had undergone PBMV between 1999 and 2013 were enrolled including 585 and 415 patients with AF and SR respectively. Patients were followed for a mean of 7.27 ± 3.16 years. Clinical, echocardiographic and hemodynamic data were collected. Procedure success, in-hospital and long-term outcome were evaluated. Results: Patients with AF were older and had greater symptoms, mitral regurgitation, mitral echocardiographic score, and mitral pressure gradient before PBMV. PBMV success rate were significantly lower in AF group (P < 0.001). In-hospital complications, including severe mitral regurgitation, emergency mitral valve surgery, peripheral embolism and long-term complications, including mortality, re-valvotomy, mitral replacement surgery and peripheral embolism/stroke were significantly higher in patients with AF. Conclusion: AF leads to worse in-hospital and long-term outcome and lower PBMV success rate. Repeated assessment and early decision to PBMV in patients with MS to reduce AF and AF related complication seems necessary.

Published
2016

40. Supplemental IMRT May Increase the Risk of Rectal Bleeding in Prostate Cancer Patients Treated with Stereotactic Body Radiation Therapy (SBRT)

Author

Paydar, I., primary, Pepin, A., additional, Aghdam, N., additional, Yung, T., additional, Bullock, E., additional, Lei, S., additional, Danner, M., additional, Satinsky, A., additional, Harter, K.W.W., additional, Suy, S., additional, Dritschilo, A., additional, Lynch, J.H., additional, and Collins, S.P., additional

Published
2017
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47. The Relation of Serum Bilirubin Level With Coronary Artery Disease Based on Angiographic Findings

Author

Taban Sadeghi Mohammadreza, Golmohamadi Ali, Parvizi Rezayat, Aghdam Naser Khezerlou, Separham Ahmad, and Hosnavi Zahra

Subjects
Angiography, Atherosclerosis, Bilirubin, Coronary vessels, Medicine
Abstract

Objective: Lipid oxidation and generation of free radicals are important factors contributing to the formation of atherosclerotic plaque. Bilirubin is supposed to play a protective role against atherosclerosis, coronary artery diseases (CAD) and inflammation for its strong antioxidant property. Thus, this study aims at investigating the relationship of bilirubin level with the severity and type of coronary artery stenosis (CAS) in different patient groups. Materials and Methods: In this cross-sectional study 200 consecutive patients, who underwent elective angiography in Madani Heart hospital, Tabriz, Iran, were selected and their blood samples were measured for total, direct, and indirect bilirubin level, with Diazo method using colorimetric technique. Following angiography, comparisons were made between the severity and location of CAS and therapeutic follow-up plan with total, direct, and indirect bilirubin level. Results: Of 200 studied patients, 129 (64.5%) and 71 (35.5%) subjects were male and female, respectively. The cases were classified into 5 subgroups based on angiography results as follows: 59 (29.5%) cases with normal angiography, 11 cases (5.5%) with minimal CAD, 56 cases (28%) with single vessel involvement, 35 (17.5%) cases with two vessel involvement and 39 cases (19.5%) with three vessel involvement. The mean total bilirubin level was 1.47 ± 0.8 mg/dl, 1.27 ± 0.12 mg/dl, 1.27 ± 0.06 mg/dl, 1.6 ± 0.04 mg/dl and 0.98 ± 0.05 mg/dl, respectively for the cases with above order. The mean difference in serum total bilirubin between normal angiography group and three-vessel involvement group was 0.49 mg/dl (P < .0001). There was a significant inverse relation between bilirubin level (total, direct and indirect) and number of involved vessels and involvement intensity increased as serum bilirubin level decreased. Severity of coronary arteries stenosis as well as the number of involved vessels increased as serum bilirubin level decreased. Conclusion: According to results, there was a significant inverse relation between serum bilirubin level and coronary involvement (type and intensity). Higher bilirubin serum levels played a protective role against CAD, even in the presence of other risk factors. Therefore, bilirubin level can be used as a predictor of CAD in the future.

Published
2015

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