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11 results on '"Aghabozorgi, Amirsaeed Sabeti"'

4. Association analysis of premature coronary artery disease and cytochrome P450 2D6 (CYP2D6) C100T and G1846A genetic variants and haplotypes in Iranian population

Author

Bahiraee, Alireza, primary, Nejatizadeh, Azim, additional, Farshidi, Hossein, additional, Malekzadeh, Keyanoosh, additional, Emamgholipour, Solaleh, additional, Ebrahimi, Reyhane, additional, Aghabozorgi, Amirsaeed Sabeti, additional, Yazdany, Mahdy, additional, and Shekari, Mohammad, additional

Published
2020
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6. Circulating and Tissue microRNAs as Biomarkers for Ovarian Cancer Prognosis

Author

Parizadeh, Seyed Mostafa, primary, Jafarzadeh-Esfehani, Reza, additional, Ghandehari, Maryam, additional, Hasanzadeh, Malihe, additional, Parizadeh, Seyed Mohammad Reza, additional, Hassanian, Seyed Mahdi, additional, Rezaei-Kalat, Afsaneh, additional, Aghabozorgi, Amirsaeed Sabeti, additional, Rahimi-Kakhki, Rana, additional, Zargaran, Bita, additional, Ferns, Gordon A, additional, and Avan, Amir, additional

Published
2019
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10. The role of miRNA gene variants in susceptibility and pharmacogenetics of colorectal cancer

Author

Aghabozorgi, Amirsaeed Sabeti, Sharif, Samaneh, Jafarzadeh-Esfehani, Reza, Vakili, Saba, and Abbaszadegan, Mohammad Reza

Abstract

Colorectal cancer (CRC) is one of the most significant challenges in the field of cancer pathology. MiRNAs are among the genetic factors associated with the disease. Although many studies have reviewed the expression patterns of various miRNAs in CRC, few studies have focused on different variants of miRNA. In the present review, miRNA variants have been categorized into three subgroups, including miRNA variants that predict susceptibility to CRC, miRNA variants that predict the clinical parameters of CRC and finally, miRNA variants that predict the pharmacological aspects of CRC. Moreover, a comprehensive review of potentially functional miRNA-associated SNPs as well as their importance as candidate cancer biomarkers are discussed.

Published
2021
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11. Role of Abelson Helper Integration Site 1, Nebulin, and Paired Box 3 Genes in the Development of Nonsyndromic Strabismus in a Series of Iranian Families: Sequence Analysis and Systematic Review of the Genetics of Nonsyndromic Strabismus.

Author

Rahpeyma M, Sabermoghaddam A, Kiarudi MY, Aghabozorgi AS, and Pasdar A

Abstract

Purpose: To look for causative genetic mutations in a series of Iranian families with strabismus. In addition, we systematically reviewed all the published articles regarding the role of genetic variations in primary and nonsyndromic comitant strabismus., Methods: Four families with a history of multiple cases of primary and nonsyndromic comitant strabismus were enrolled in this study. Polymerase chain reaction and Sanger sequencing of exons 23, 11, and 3 of the Abelson helper integration site 1 ( AHI1 ), nebulin ( NEB ), and paired box 3 ( PAX3 ) genes were performed, respectively. One offspring of a consanguineous marriage underwent whole-exome sequencing (WES) to look for possible causative variants. To conduct a systematic review, we thoroughly searched PubMed, Scopus, and ISI Web of Knowledge extracting relevant publications, released by April 2021., Results: We examined four Iranian strabismus pedigrees with multiple affected offspring in different generations. Among these 17 participants, 10 family members had strabismus and 7 were healthy. Sanger sequencing did not reveal a causative mutation. Therefore, to further investigate, one affected offspring was chosen for WES. The WES study demonstrated two possible variants in MYO5B and DHODH genes. These genetic variants showed high allele frequency in our population and are thought to be polymorphisms in our series of Iranian families., Conclusions: We demonstrated that mutations in AHI1 , NEB , and PAX3 genes were not common in a series of Iranian patients with familial strabismus. Moreover, by performing WES, we revealed that two variants of uncertain significance as possible causative variants for strabismus are not related to this disease in our population., Competing Interests: There are no conflicts of interest., (Copyright: © 2024 Journal of Current Ophthalmology.)

Published
2024
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