13 results on '"Aggoune S"'
Search Results
2. Клинико-терапевтические аспекты серповидноклеточной анемии в трех клинических случаях
- Author
-
Aggoune , S.
- Subjects
гостра анемія ,osteonecrosis ,остеонекроз ,инсульт ,sickle cell disease ,серповидноклеточная анемия ,acute anemia ,серповидноклітинна анемія ,інсульт ,stroke ,острая анемия - Abstract
One of the reasons of high pediatric mortality in developing countries, sickle cell disease is gradually emerging and is becoming a public health problem in many countries where it is rife. In Algeria the incidence is 2.7%. The management of sickle cell disease is increasingly better codified now thanks to better knowledge of the condition. It takes into account not only currently accepted universal principles but also the realities specific to our country. Purpose: to share with health care professionals our therapeutic attitude during main acute complications as well as during the inter3critical phase of sickle cell disease in Algerian children. Clinical cases. In this article, we presented three clinical cases concerning two adolescents and a two3year3old infant, carriers of major sickle cell syndrome, who were hospitalized for severe forms. Conclusions. Providing right care for children with sickle cell disease could help prevent or improve many complications associated with this disease and allow them to lead healthier and more productive lives. Our patients were presented late. These cases revealed the problematic nature of early diagnosis, regular follow-up and early detection of complications in SCD patients especially with asymptomatic osteonecrosis of the femoral head. The research was carried out in accordance with the principles of the Helsinki declaration. The informed consent of the patients was obtained for conducting the studies. No conflict of interest was declared by the author., Одним из заболеваний, приводящих к высокой смертности среди детей в развивающихся странах, является серповидноклеточная анемия, которая постепенно распространяется и становится одной из проблем общественного здравоохранения во многих странах. В Алжире заболеваемость составляет 2,7%. Ведение пациентов с серповидноклеточной анемией теперь намного лучше систематизировано благодаря более глубокому пониманию этого состояния. Оно принимает во внимание принятые ныне универсальные принципы, а также реалии, характерные для нашей страны. Цель — поделиться с медицинскими работниками нашей терапевтической позицией во время основных острых осложнений, а также во время межкритической фазы серповидноклеточной анемии среди алжирских детей. Клинические случаи. Представлены три клинических случая у двоих подростков и двухлетнего ребенка, страдающих серповидноклеточным синдром, госпитализированных по поводу тяжелых форм заболевания. Выводы. Оказание надлежащего ухода за детьми с серповидноклеточной анемией может помочь предупредить или облегчить течение многих осложнений, связанных с этим заболеванием, и может позволить им вести более здоровую жизнь. Пациенты, описанные в статье, поступили поздно. Эти случаи выявили проблемы ранней диагностики, диспансерного наблюдения и раннего выявления осложнений у больных с серповидноклеточной анемией, особенно в случае бессимптомного остеонекроза головки бедренной кости. Исследование выполнено в соответствии с принципами Хельсинкской декларации. На проведение исследований получено информированное согласие родителей, пациентов. Автор заявляет об отсутствии конфликта интересов., Однією з хвороб, що призводить до високої смертності серед дітей у країнах, що розвиваються, є серпоподібноклітинна анемія, яка поступово набирає поширення і стає однією з проблем громадської охорони здоров'я в багатьох країнах. В Алжирі захворюваність становить 2,7%. Ведення пацієнтів з серпоподібноклітинною анемією тепер набагато краще систематизоване завдяки більш глибокому розумінню цього стану. Воно бере до уваги прийняті нині універсальні принципи, а також реалії, характерні для нашої країни. Мета — поділитися з медичними працівниками терапевтичною позицією під час основних гострих ускладнень, а також під час міжкритичної фази серпоподібноклітинної анемії серед алжирських дітей. Клінічні випадки. У цій статті наведено три клінічні випадки у двох підлітків та дворічної дитини, що страждають на серпоподібноклітинний синдром, і госпіталізовані з приводу тяжких форм захворювання. Висновки. Надання належного догляду за дітьми з серпоподібноклітинною анемією може допомогти запобігти або полегшити перебіг багатьох ускладнень, пов'язаних з цим захворюванням, та може дозволити їм вести здоровіше та продуктивніше життя. Пацієнти, описані в статті, були госпіталізовані пізно. Ці випадки виявили проблеми ранньої діагностики, диспансерного спостереження та раннього виявлення ускладнень у хворих на серпоподібноклітинну анемію, особливо у випадку безсимптомного остеонекрозу головки стегнової кістки. Дослідження проводилося відповідно до принципів Гельсінської декларації. На проведення досліджень отримано інформовану згоду батьків, пацієнтів. Автор заявляє про відсутність конфлікту інтересів.
- Published
- 2021
3. Numerical study of the expansion of metallic vapor plasma by a nanosecond laser pulse
- Author
-
Aggoune, S., Vidal, F., and Amara, E. H.
- Published
- 2010
- Full Text
- View/download PDF
4. Simulation by temperature gradient adaption of wavelength effect in metal laser cutting
- Author
-
Amara, E. H., primary, Aoudjit, T., additional, Kheloufi, K., additional, Tamsaout, T., additional, Aggoune, S., additional, Ahmanache, A., additional, Hamadi, F., additional, and Bougherara, K., additional
- Published
- 2017
- Full Text
- View/download PDF
5. On the Vortex Formation Effect During the Application of a Nitrogen-Gas Assisted Laser-Fusion Cutting Technique to Stainless Steel
- Author
-
Aggoune, S., Abid, C., Amara, E. H., Pouliquen, Olivier, Institut universitaire des systèmes thermiques industriels (IUSTI), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[PHYS]Physics [physics] ,Physics::Fluid Dynamics ,Condensed Matter::Superconductivity ,[PHYS] Physics [physics] - Abstract
International audience; This paper focuses on the vortex formation effect during the application of a laser-fusion cutting technique. This industrial technique is typically associated with the ejection of a film of molten stainless steel blown off by a subsonic laminar jet of nitrogen gas used to assist the process. Without taking into account the transverse movement of the workpiece, we consider a 4 mm thick stainless steel plate. The resulting molten metal flow is assumed to be laminar, steady, viscous and incompressible. The numerical results reveal vortex structures adjacent to the walls at the entrance of the kerf, and a pair of eddies outside the kerf. Remarkably, these vortex structures can produce a separation point in the molten film, and thereby they can affect the surface quality of the processed material. The problem is investigated in the framework of a numerical technique available in the Fluent software, based on a volume of fluid (VOF) surface-tracking strategy and the enthalpy method to account for material solidification or melting.
- Published
- 2015
6. Dynamical Study of a Molten Boundary Layer Ejected by Laminar Gas Flow
- Author
-
Aggoune, S., primary and Amara, El Hachemi, additional
- Published
- 2014
- Full Text
- View/download PDF
7. Modelling of Laser Beam Distribution Effects for Metal Laser Cutting.
- Author
-
AMARA, E. H., KHELOUFI, K., TAMSAOUT, T., and AGGOUNE, S.
- Subjects
LASER beam cutting ,SPATIAL distribution (Quantum optics) ,FINITE volume method ,SOLIDIFICATION ,ELECTRIC discharges - Abstract
We develop a study on laser cutting of metals with assist gas jet, the aim is to investigate the effect of the beam shape spatial distribution when a top-hat or a Gaussian beam distributions are considered. A three-dimensional (3-D) numerical model is developed for assumed normal atmospheric conditions, where the treated metallic sample is subjected to irradiation with a continuous wave (CW) Nd:YAG laser beam. The finite volume method (FVM) is used to discretize the differential governing conservation equations, which are numerically solved. The solid-air and liquid-air interfaces are tracked by implementation of the volume of fluid (VOF) method, whereas an enthalpy approach allows to take into account the melting and re-solidification phenomena. The cut formation is simulated by inserting the related laser deposited energy, for the considered beam distribution, as a volumetric source term in the energy conservation equation, the results show that the used beam distribution may play an important role in reducing the striation formation. [ABSTRACT FROM AUTHOR]
- Published
- 2016
8. Numerical study of the radiation effect on the flowing of mixed convection along a vertical channel
- Author
-
Aggoune, S., primary, Amara, E. H., additional, and Hamadi, F., additional
- Published
- 2008
- Full Text
- View/download PDF
9. Thin Films Deposition By Chemically Reacting Laminar Flows
- Author
-
Aggoune, S., primary, Amara, E. H., additional, Amara, El-Hachemi, additional, Boudjemai, Saïd, additional, and Doumaz, Djamila, additional
- Published
- 2008
- Full Text
- View/download PDF
10. Flow cytometry-based diagnostic approach for inborn errors of immunity: experience from Algeria.
- Author
-
Tahiat A, Belbouab R, Yagoubi A, Hakem S, Fernini F, Keddari M, Belhadj H, Touri S, Aggoune S, Stoddard J, Niemela J, Zerifi F, Melzi S, Aboura R, Saad-Djaballah A, Ferhani Y, Ketfi A, Messaoudi H, Bencharif Madani T, Benhacine Z, Dehimi A, Okka K, Amroune F, Fellahi M, Bendahmane C, Khoulani R, Oukil A, Soufane A, Bourelaf I, Boubidi C, Boukhenfouf N, Amine Ifri M, Khelafi N, Boudiaf H, Khelifi Touhami T, Meçabih F, Boucelma M, Zelaci A, Gacem O, Ladj MS, Mekki A, Bensaadi N, Benhalima M, Zeroual Z, Bioud B, Benameur M, Bouhdjila R, Bouzerar Z, Ibsaine O, Maouche H, Kedji L, Smati L, Boukari R, Lambert C, Rosenzweig SD, Notarangelo LD, and Djenouhat K
- Subjects
- Humans, Male, Female, Algeria, Child, Child, Preschool, Infant, Adolescent, Adult, Retrospective Studies, Immunophenotyping, Young Adult, Infant, Newborn, Immunologic Deficiency Syndromes diagnosis, Immunologic Deficiency Syndromes immunology, Immunologic Deficiency Syndromes genetics, Flow Cytometry methods
- Abstract
Purpose: In this study, we retrospectively reviewed the use of flow cytometry (FCM) in the diagnosis of inborn errors of immunity (IEIs) at a single center in Algeria. Sharing insights into our practical experience, we present FCM based diagnostic approaches adapted to different clinical scenarios., Methods: Between May 2017 and February 2024, pediatric and adult patients presenting with clinical features suggestive of immunodeficiency were subjected to FCM evaluation, including lymphocyte subset analysis, detection of specific surface or intracellular proteins, and functional analysis of immune cells., Results: Over a nearly seven-year period, our laboratory diagnosed a total of 670 patients (372 (55.5%) males and 298 (44.5%) females), distributed into 70 different IEIs belonging to 9 different categories of the International Union of Immunological Societies classification. FCM was used to diagnose and categorize IEI in 514 patients (76.7%). It provided direct diagnostic insights for IEIs such as severe combined immunodeficiency, Omenn syndrome, MHC class II deficiency, familial hemophagocytic lymphohistiocytosis, and CD55 deficiency. For certain IEIs, including hyper-IgE syndrome, STAT1-gain of function, autoimmune lymphoproliferative syndrome, and activated PI3K delta syndrome, FCM offered suggestive evidence, necessitating subsequent genetic testing for confirmation. Protein expression and functional assays played a crucial role in establishing definitive diagnoses for various disorders. To setup such diagnostic assays at high and reproducible quality, high level of expertise is required; in house reference values need to be determined and the parallel testing of healthy controls is highly recommended., Conclusion: Flow cytometry has emerged as a highly valuable and cost-effective tool for diagnosing and studying most IEIs, particularly in low-income countries where access to genetic testing can be limited. FCM analysis could provide direct diagnostic insights for most common IEIs, offer clues to the underlying genetic defects, and/or aid in narrowing the list of putative genes to be analyzed., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2024 Tahiat, Belbouab, Yagoubi, Hakem, Fernini, Keddari, Belhadj, Touri, Aggoune, Stoddard, Niemela, Zerifi, Melzi, Aboura, Saad-Djaballah, Ferhani, Ketfi, Messaoudi, Bencharif Madani, Benhacine, Dehimi, Okka, Amroune, Fellahi, Bendahmane, Khoulani, Oukil, Soufane, Bourelaf, Boubidi, Boukhenfouf, Amine Ifri, Khelafi, Boudiaf, Khelifi Touhami, Meçabih, Boucelma, Zelaci, Gacem, Ladj, Mekki, Bensaadi, Benhalima, Zeroual, Bioud, Benameur, Bouhdjila, Bouzerar, Ibsaine, Maouche, Kedji, Smati, Boukari, Lambert, Rosenzweig, Notarangelo and Djenouhat.)
- Published
- 2024
- Full Text
- View/download PDF
11. Inborn Errors of Immunity in Algerian Children and Adults: A Single-Center Experience Over a Period of 13 Years (2008-2021).
- Author
-
Belaid B, Lamara Mahammed L, Drali O, Oussaid AM, Touri NS, Melzi S, Dehimi A, Berkani LM, Merah F, Larab Z, Allam I, Khemici O, Kirane SY, Boutaba M, Belbouab R, Bekkakcha H, Guedouar A, Chelali A, Baamara B, Noui D, Baaziz H, Rezak R, Azzouz SM, Aichaoui M, Moktefi A, Benhatchi RM, Oussalah M, Benaissa N, Laredj A, Bouchetara A, Adria A, Habireche B, Tounsi N, Dahmoun F, Touati R, Boucenna H, Bouferoua F, Sekfali L, Bouhafs N, Aboura R, Kherra S, Inouri Y, Dib S, Medouri N, Khelfaoui N, Redjedal A, Zelaci A, Yahiaoui S, Medjadj S, Touhami TK, Kadi A, Amireche F, Frada I, Houasnia S, Benarab K, Boubidi C, Ferhani Y, Benalioua H, Sokhal S, Benamar N, Aggoune S, Hadji K, Bellouti A, Rahmoune H, Boutrid N, Okka K, Ammour A, Saadoune H, Amroun M, Belhadj H, Ghanem A, Abbaz H, Boudrioua S, Zebiche B, Ayad A, Hamadache Z, Ouaras N, Achour N, Bouchair N, Boudiaf H, Bekkat-Berkani D, Maouche H, Bouzrar Z, Aissat L, Ibsaine O, Bioud B, Kedji L, Dahlouk D, Bensmina M, Radoui A, Bessahraoui M, Bensaadi N, Mekki A, Zeroual Z, Chan KW, Leung D, Tebaibia A, Ayoub S, Mekideche D, Gharnaout M, Casanova JL, Puel A, Lau YL, Cherif N, Ladj S, Smati L, Boukari R, Benhalla N, and Djidjik R
- Subjects
- Adult, Algeria epidemiology, Child, Female, Humans, Male, Retrospective Studies, Immunologic Deficiency Syndromes genetics, Primary Immunodeficiency Diseases genetics, Severe Combined Immunodeficiency
- Abstract
Background: Inborn errors of immunity (IEI) predispose patients to various infectious and non-infectious complications. Thanks to the development and expanding use of flow cytometry and increased awareness, the diagnostic rate of IEI has markedly increased in Algeria the last decade., Aim: This study aimed to describe a large cohort of Algerian patients with probable IEI and to determine their clinical characteristics and outcomes., Methods: We collected and analyzed retrospectively the demographic data, clinical manifestations, immunologic, genetic data, and outcome of Algerian IEI patients - diagnosed in the department of medical immunology of Beni Messous university hospital center, Algiers, from 2008 to 2021., Results: Eight hundred and seven patients with IEI (482 males and 325 females) were enrolled, 9.7% of whom were adults. Consanguinity was reported in 50.3% of the cases and a positive family history in 32.34%. The medium age at disease onset was 8 months and at diagnosis was 36 months. The median delay in diagnosis was 16 months. Combined immunodeficiencies were the most frequent (33.8%), followed by antibody deficiencies (24.5%) and well-defined syndromes with immunodeficiency (24%). Among 287 patients tested for genetic disorders, 129 patients carried pathogenic mutations; 102 having biallelic variants mostly in a homozygous state (autosomal recessive disorders). The highest mortality rate was observed in patients with combined immunodeficiency (70.1%), especially in patients with severe combined immunodeficiency (SCID), Omenn syndrome, or Major Histocompatibility Complex (MHC) class II deficiency., Conclusion: The spectrum of IEI in Algeria is similar to that seen in most countries of the Middle East and North Africa (MENA) region, notably regarding the frequency of autosomal recessive and/or combined immunodeficiencies., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Belaid, Lamara Mahammed, Drali, Oussaid, Touri, Melzi, Dehimi, Berkani, Merah, Larab, Allam, Khemici, Kirane, Boutaba, Belbouab, Bekkakcha, Guedouar, Chelali, Baamara, Noui, Baaziz, Rezak, Azzouz, Aichaoui, Moktefi, Benhatchi, Oussalah, Benaissa, Laredj, Bouchetara, Adria, Habireche, Tounsi, Dahmoun, Touati, Boucenna, Bouferoua, Sekfali, Bouhafs, Aboura, Kherra, Inouri, Dib, Medouri, Khelfaoui, Redjedal, Zelaci, Yahiaoui, Medjadj, Touhami, Kadi, Amireche, Frada, Houasnia, Benarab, Boubidi, Ferhani, Benalioua, Sokhal, Benamar, Aggoune, Hadji, Bellouti, Rahmoune, Boutrid, Okka, Ammour, Saadoune, Amroun, Belhadj, Ghanem, Abbaz, Boudrioua, Zebiche, Ayad, Hamadache, Ouaras, Achour, Bouchair, Boudiaf, Bekkat-Berkani, Maouche, Bouzrar, Aissat, Ibsaine, Bioud, Kedji, Dahlouk, Bensmina, Radoui, Bessahraoui, Bensaadi, Mekki, Zeroual, Chan, Leung, Tebaibia, Ayoub, Mekideche, Gharnaout, Casanova, Puel, Lau, Cherif, Ladj, Smati, Boukari, Benhalla and Djidjik.)
- Published
- 2022
- Full Text
- View/download PDF
12. Diagnostic and Predictive Contribution of Autoantibodies Screening in a Large Series of Patients With Primary Immunodeficiencies.
- Author
-
Tahiat A, Yagoubi A, Ladj MS, Belbouab R, Aggoune S, Atek L, Bouziane D, Melzi S, Boubidi C, Drali W, Bendahmane C, Iguerguesdaoune H, Taguemount S, Soufane A, Oukil A, Ketfi A, Messaoudi H, Boukhenfouf N, Ifri MA, Bencharif Madani T, Belhadj H, Benhala KN, Khiari M, Cherif N, Smati L, Arada Z, Zeroual Z, Bouzerar Z, Ibsaine O, Maouche H, Boukari R, and Djenouhat K
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Antinuclear blood, Autoimmune Diseases epidemiology, Autoimmune Diseases immunology, Case-Control Studies, Celiac Disease blood, Child, Child, Preschool, Female, Humans, Immunity, Cellular, Immunity, Humoral, Infant, Inflammatory Bowel Diseases blood, Male, Middle Aged, Predictive Value of Tests, Rheumatoid Factor, Young Adult, Autoantibodies blood, Autoimmunity, Primary Immunodeficiency Diseases blood, Primary Immunodeficiency Diseases epidemiology
- Abstract
Objectives: To evaluate the diagnostic and predictive contribution of autoantibodies screening in patients with primary immunodeficiencies (PIDs)., Methods: In the present study, PID patients and healthy controls have been screened for 54 different autoantibodies. The results of autoantibodies screening in PID patients were correlated to the presence of autoimmune diseases., Results: A total of 299 PID patients were included in this study with a predominance of antibody deficiencies (27.8%) followed by immunodeficiencies affecting cellular and humoral immunity (26.1%) and complement deficiencies (22.7%). Autoimmune manifestations were present in 82 (27.4%) patients. Autoimmune cytopenia (10.4%) was the most common autoimmune disease followed by gastrointestinal disorders (10.0%), rheumatologic diseases (3.7%), and endocrine disorders (3.3%). Autoantibodies were found in 32.4% of PID patients and 15.8% of healthy controls ( P < 0.0005). Anti-nuclear antibodies (ANA) (10.0%), transglutaminase antibody (TGA) (8.4%), RBC antibodies (6.7%), anti-smooth muscle antibody (ASMA) (5.4%), and ASCA (5.0%) were the most common autoantibodies in our series. Sixty-seven out of the 82 patients with autoimmune manifestations (81.7%) were positive for one or more autoantibodies. Eleven out of the 14 patients (78.6%) with immune thrombocytopenia had positive platelet-bound IgM. The frequencies of ASCA and ANCA among patients with IBD were 47.4% and 21.0% respectively. All patients with celiac disease had TGA-IgA, while six out of the 11 patients with rheumatologic diseases had ANA (54.5%). Almost one third of patients (30/97) with positive autoantibodies had no autoimmune manifestations. ANA, rheumatoid factor, ASMA, anti-phospholipid antibodies and ANCA were often detected while specific AID was absent. Despite the low positive predictive value of TGA-IgA and ASCA for celiac disease and inflammatory bowel disease respectively, screening for these antibodies identified undiagnosed disease in four patients with positive TGA-IgA and two others with positive ASCA., Conclusion: The present study provides valuable information about the frequency and the diagnostic/predictive value of a large panel of autoantibodies in PIDs. Given the frequent association of some AIDs with certain PIDs, screening for corresponding autoantibodies would be recommended. However, positivity for autoantibodies should be interpreted with caution in patients with PIDs due to their low positive predictive value., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Tahiat, Yagoubi, Ladj, Belbouab, Aggoune, Atek, Bouziane, Melzi, Boubidi, Drali, Bendahmane, Iguerguesdaoune, Taguemount, Soufane, Oukil, Ketfi, Messaoudi, Boukhenfouf, Ifri, Bencharif Madani, Belhadj, Benhala, Khiari, Cherif, Smati, Arada, Zeroual, Bouzerar, Ibsaine, Maouche, Boukari and Djenouhat.)
- Published
- 2021
- Full Text
- View/download PDF
13. Variable expressivity of HJV related hemochromatosis: "Juvenile" hemochromatosis?
- Author
-
Hamdi-Rozé H, Ben Ali Z, Ropert M, Detivaud L, Aggoune S, Simon D, Pelletier G, Deugnier Y, David V, and Bardou-Jacquet E
- Subjects
- Adult, Age of Onset, Child, Female, Genetic Variation, Hemochromatosis Protein, Hepcidins deficiency, Humans, Iron Overload, Male, Transferrin, Young Adult, GPI-Linked Proteins, Hemochromatosis congenital, Hemochromatosis diagnosis
- Abstract
Juvenile hemochromatosis is a rare autosomal recessive disease due to variants in the Hemojuvelin (HJV) gene. Although biological features mimic HFE hemochromatosis, clinical presentation is worst with massive iron overload diagnosed during childhood. Our study describes clinical features and results of genetic testing for a group of patients initially referred for a hepcidino-deficiency syndrome and for whom HJV hemochromatosis was finally diagnosed. 662 patients with iron overload and high serum transferrin saturation were tested, and five genes (HFE, HJV, HAMP, TFR2, SLC40A1) were sequenced. Among our cohort, ten unrelated patients were diagnosed with HJV hemochromatosis. Genetic testing revealed five previously published and five undescribed variants: p.Arg41Pro, p.His180Arg, p.Lys299Glu, p.Cys361Arg and p.Ala384Val. Surprisingly, this study revealed a late age of onset in some patients, contrasting with the commonly accepted definition of "juvenile" hemochromatosis. Five of our patients were 30 years old or older, including two very late discoveries. Biological features and severity of iron overload were similar in younger and older patients. Our study brings new insight on HJV hemochromatosis showing that mild phenotype and late onset are possible. Genetic testing for HJV variants should thus be performed for all patients displaying a non-p.Cys282Tyr homozygous HFE hemochromatosis with hepcidin deficiency phenotype., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.