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This paper studies the bounded confidence model on growing fully-mixed populations. In this model, in addition to the usual opinion clusters, significant secondary clusters of smaller size appear systematically, while those secondary clusters appear erratically and include much fewer agents when the population is fixed. Through simulations, we derive the bifurcation diagram of the growing population model and compare it to the diagram obtained with an evolving probability density instead of agents, and with their equivalent having a fixed population. Our tests, when changing the usual bounded confidence function into a smooth bounded confidence function, suggest that these secondary clusters are mainly generated by a different mechanism when the population is growing than when it is fixed. [ABSTRACT FROM AUTHOR]

Cognitive economics uses cognitive science to understand economic decision-making. We review research streams that conceptualize both minds and markets as complex adaptive systems. Narrative theories of decision-making examine the cognitive and social representations and processes that govern decision-making under uncertainty. Agent-based cognitive models study how cognitive mechanisms at the individual level can contribute to emergent systems-level phenomena. Post-cognitivist approaches such as the Market Mind Hypothesis consider minds and markets to be one continuous complex system. Coordination Dynamics is one useful framework for analyzing this system. Cognitive economics is an emerging interdisciplinary field that uses the tools of cognitive science to study economic and social decision-making. Although most strains of cognitive economics share commitments to bridging levels of analysis (cognitive, behavioral, and systems) and embracing interdisciplinary approaches, we review a newer strand of cognitive economic thinking with a further commitment: conceptualizing minds and markets each as complex adaptive systems. We describe three ongoing research programs that strive toward these goals: (i) studying narratives as a cognitive and social representation used to guide decision-making; (ii) building cognitively informed agent-based models; and (iii) understanding markets as an extended mind – the Market Mind Hypothesis – analyzed using the concepts, methods, and tools of Coordination Dynamics. [ABSTRACT FROM AUTHOR]

Understanding how genetically encoded rules drive and guide complex neuronal growth processes is essential to comprehending the brain’s architecture, and agent-based models (ABMs) offer a powerful simulation approach to further develop this understanding. However, accurately calibrating these models remains a challenge. Here, we present a novel application of Approximate Bayesian Computation (ABC) to address this issue. ABMs are based on parametrized stochastic rules that describe the time evolution of small components–the so-called agents–discretizing the system, leading to stochastic simulations that require appropriate treatment. Mathematically, the calibration defines a stochastic inverse problem. We propose to address it in a Bayesian setting using ABC. We facilitate the repeated comparison between data and simulations by quantifying the morphological information of single neurons with so-called morphometrics and resort to statistical distances to measure discrepancies between populations thereof. We conduct experiments on synthetic as well as experimental data. We find that ABC utilizing Sequential Monte Carlo sampling and the Wasserstein distance finds accurate posterior parameter distributions for representative ABMs. We further demonstrate that these ABMs capture specific features of pyramidal cells of the hippocampus (CA1). Overall, this work establishes a robust framework for calibrating agent-based neuronal growth models and opens the door for future investigations using Bayesian techniques for model building, verification, and adequacy assessment. [ABSTRACT FROM AUTHOR]

Introduced and invasive species make excellent natural experiments for investigating rapid evolution. Here, we describe the effects of genetic drift and rapid genetic adaptation in pink salmon (Oncorhynchus gorbuscha) that were accidentally introduced to the Great Lakes via a single introduction event 31 generations ago. Using whole‐genome resequencing for 134 fish spanning five sample groups across the native and introduced range, we estimate that the source population's effective population size was 146,886 at the time of introduction, whereas the founding population's effective population size was just 72—a 2040‐fold decrease. As expected with a severe founder event, we show reductions in genome‐wide measures of genetic diversity, specifically a 37.7% reduction in the number of SNPs and an 8.2% reduction in observed heterozygosity. Despite this decline in genetic diversity, we provide evidence for putative selection at 47 loci across multiple chromosomes in the introduced populations, including missense variants in genes associated with circadian rhythm, immunological response and maturation, which match expected or known phenotypic changes in the Great Lakes. For one of these genes, we use a species‐specific agent‐based model to rule out genetic drift and conclude our results support a strong response to selection occurring in a period gene (per2) that plays a predominant role in determining an organism's daily clock, matching large day length differences experienced by introduced salmon during important phenological periods. Together, these results inform how populations might evolve rapidly to new environments, even with a small pool of standing genetic variation. [ABSTRACT FROM AUTHOR]

In this paper, we present a first modelization of Allen's argument on the British industrial revolution with a history-friendly model heuristic. To do so, we use a macroeconomic micro-founded framework with heterogeneous agents—households, firms, and institutions—interacting through a decentralized matching process presenting standard features across five markets—labor, food, goods, services, and government bonds. We study the dynamics of the model using computer simulation. With the appropriate calibration, macroeconomic properties emerge such as endogenous business cycles and nominal GDP growth, while reproducing important stylized economic facts like the industrial revolution and Engel's Pause. [ABSTRACT FROM AUTHOR]

Copyright of People & Nature is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Traditional models of opinion dynamics provide a simplified approach to understanding human behavior in basic social scenarios. However, when it comes to issues such as polarization and extremism, a more nuanced understanding of human biases and cognitive tendencies are required. This paper proposes an approach to modeling opinion dynamics by integrating mental models and assumptions of individuals agents using Bayesian-inspired methods. By exploring the relationship between human rationality and Bayesian theory, this paper demonstrates the usefulness of these methods in describing how opinions evolve. The analysis here builds upon the basic idea in the Continuous Opinions and Discrete Actions (CODA) model, by applying Bayesian-inspired rules to account for key human behaviors such as confirmation bias, motivated reasoning, and human reluctance to change opinions. Through this, This paper updates rules that are compatible with known human biases. The current work sheds light on the role of human biases in shaping opinion dynamics. I hope that by making the model more realistic this might lead to more accurate predictions of real-world scenarios. [ABSTRACT FROM AUTHOR]

The social epistemology of science has adopted agent-based computer simulations as one of its core methods for investigating the dynamics of scientific inquiry. The epistemic status of these highly idealized models is currently under active debate in which they are often associated either with predictive or the argumentative functions. These two functions roughly correspond to interpreting simulations as virtual experiments or formalized thought experiments, respectively. This paper advances the argumentative account of modeling by proposing that models serve as a means to (re)conceptualize the macro-level dynamics of complex social epistemic interactions. I apply results from the epistemology of scientific modeling and the psychology of mental simulation to the ongoing debate in the social epistemology of science. Instead of considering simulation models as predictive devices, I view them as artifacts that exemplify abstract hypothetical properties of complex social epistemic processes in order to advance scientific understanding, hypothesis formation, and communication. Models need not be accurate representations to serve these purposes. They should be regarded as pragmatic cognitive tools that engender rather than replace intuitions in philosophical reasoning and argumentation. Furthermore, I aim to explain why the community tends to converge around few model templates: Since models have the potential to transform our intuitive comprehension of the subject of inquiry, successful models may literally capture the imagination of the modeling community. [ABSTRACT FROM AUTHOR]

Abstract Current approaches to project spatial biodiversity responses to climate change mainly focus on the direct effects of climate on species while regarding land use and land cover as constant or prescribed by global land‐use scenarios. However, local land‐use decisions are often affected by climate change and biodiversity on top of socioeconomic and policy drivers. To realistically understand and predict climate impacts on biodiversity, it is, therefore, necessary to integrate both direct and indirect effects (via climate‐driven land‐use change) of climate change on biodiversity. In this perspective paper, we outline how biodiversity models could be better integrated with regional, climate‐driven land‐use models. We initially provide a short, non‐exhaustive review of empirical and modelling approaches to land‐use and land‐cover change (LU) and biodiversity (BD) change at regional scales, which forms the base for our perspective about improved integration of LU and BD models. We consider a diversity of approaches, with a special emphasis on mechanistic models. We also look at current levels of integration and at model properties, such as scales, inputs and outputs, to further identify integration challenges and opportunities. We find that LU integration in BD models is more frequent than the other way around and has been achieved at different levels: from overlapping predictions to simultaneously coupled simulations (i.e. bidirectional effects). Of the integrated LU‐BD socio‐ecological models, some studies included climate change effects on LU, but the relative contribution of direct vs. indirect effects of climate change on BD remains a key research challenge. Important research avenues include concerted efforts in harmonizing spatial and temporal resolution, disentangling direct and indirect effects of climate change on biodiversity, explicitly accounting for bidirectional feedbacks, and ultimately feeding socio‐ecological systems back into climate predictions. These avenues can be navigated by matching models, plugins for format and resolution conversion, and increasing the land‐use forecast horizon with adequate uncertainty. Recent developments of coupled models show that such integration is achievable and can lead to novel insights into climate–land use–biodiversity relations. Read the free Plain Language Summary for this article on the Journal blog.

Computational models of tumor growth are valuable for simulating the dynamics of cancer progression and treatment responses. In particular, agent-based models (ABMs) tracking individual agents and their interactions are useful for their flexibility and ability to model complex behaviors. However, ABMs have often been confined to small domains or, when scaled up, have neglected crucial aspects like vasculature. Additionally, the integration into tumor ABMs of precise radiation dose calculations using gold-standard Monte Carlo (MC) methods, crucial in contemporary radiotherapy, has been lacking. Here, we introduce AMBER, an Agent-based fraMework for radioBiological Effects in Radiotherapy that computationally models tumor growth and radiation responses. AMBER is based on a voxelized geometry, enabling realistic simulations at relevant pre-clinical scales by tracking temporally discrete states stepwise. Its hybrid approach, combining traditional ABM techniques with continuous spatiotemporal fields of key microenvironmental factors such as oxygen and vascular endothelial growth factor, facilitates the generation of realistic tortuous vascular trees. Moreover, AMBER is integrated with TOPAS, an MC-based particle transport algorithm that simulates heterogeneous radiation doses. The impact of radiation on tumor dynamics considers the microenvironmental factors that alter radiosensitivity, such as oxygen availability, providing a full coupling between the biological and physical aspects. Our results show that simulations with AMBER yield accurate tumor evolution and radiation treatment outcomes, consistent with established volumetric growth laws and radiobiological understanding. Thus, AMBER emerges as a promising tool for replicating essential features of tumor growth and radiation response, offering a modular design for future expansions to incorporate specific biological traits. [ABSTRACT FROM AUTHOR]

Traditional models of opinion dynamics provide a simplified approach to understanding human behavior in basic social scenarios. However, when it comes to issues such as polarization and extremism, a more nuanced understanding of human biases and cognitive tendencies are required. This paper proposes an approach to modeling opinion dynamics by integrating mental models and assumptions of individuals agents using Bayesian-inspired methods. By exploring the relationship between human rationality and Bayesian theory, this paper demonstrates the usefulness of these methods in describing how opinions evolve. The analysis here builds upon the basic idea in the Continuous Opinions and Discrete Actions (CODA) model, by applying Bayesian-inspired rules to account for key human behaviors such as confirmation bias, motivated reasoning, and human reluctance to change opinions. Through this, This paper updates rules that are compatible with known human biases. The current work sheds light on the role of human biases in shaping opinion dynamics. I hope that by making the model more realistic this might lead to more accurate predictions of real-world scenarios.

Abstract This research introduces a novel global sensitivity analysis (GSA) framework for agent-based models (ABMs) that explicitly handles their distinctive features, such as multi-level structure and temporal dynamics. The framework uses Grassmannian diffusion maps to reduce output data dimensionality and sparse polynomial chaos expansion (PCE) to compute sensitivity indices for stochastic input parameters. To demonstrate the versatility of the proposed GSA method, we applied it to a non-linear system dynamics model and epidemiological and economic ABMs, depicting different dynamics. Unlike traditional GSA approaches, the proposed method enables a more general estimation of parametric sensitivities spanning from the micro level (individual agents) to the macro level (entire population). The new framework encourages the use of manifold-based techniques in uncertainty quantification, enhances understanding of complex spatio-temporal processes, and equips ABM practitioners with robust tools for detailed model analysis. This empowers them to make more informed decisions when developing, fine-tuning, and verifying models, thereby advancing the field and improving routine practice for GSA in ABMs.

In a networked anagram game, players are provided letters with possible actions of requesting letters from their neighbours, replying to letter requests, or forming words. The objective is to form as many words as possible as a team. The experimental data show that behaviours among players can vary significantly. However, simulations using agent-based models (ABM) in the literature often have not incorporated proper uncertainty quantification methods to characterise diverse behaviours of players. In this work, we propose an uncertainty quantification framework to build, exercise, and evaluate agent behaviour models and simulations for networked group anagram games. Specifically, using the data of game experiments, the proposed framework considers the clustering of game players based on their performance to reflect players' heterogeneity. Moreover, we also quantify uncertainty within each cluster through statistical modelling and inference. Numerical studies of networked game configurations are conducted to demonstrate the merits of the proposed framework. [ABSTRACT FROM AUTHOR]

Many bees visit just one flower species during a foraging trip, i.e. they show flower constancy. Flower constancy is important for plant reproduction but it could lead to an unbalanced diet, especially in biodiversity-depleted landscapes. It is assumed that flower constancy does not reduce dietary diversity in social bees, such as honeybees or bumblebees, but this has not yet been tested. We used computer simulations to investigate the effects of flower constancy on colony diet in plant species-rich and species-poor landscapes. We also explored if communication about food sources, which is used by many social bees, further reduces forage diversity. Our simulations reveal an extensive loss of forage diversity owing to flower constancy in both species-rich and species-poor environments. Small flower-constant colonies often discovered only 30–50% of all available plant species, thereby increasing the risk of nutritional deficiencies. Communication often interacted with flower constancy to reduce forage diversity further. Finally, we found that food source clustering, but not habitat fragmentation impaired dietary diversity. These findings highlight the nutritional challenges flower-constant bees face in different landscapes and they can aid in the design of measures to increase forage diversity and improve bee nutrition in human-modified landscapes. [ABSTRACT FROM AUTHOR]

In this paper, we introduce a new method based on a library of chemical reactions for constructing a system of ordinary differential equations from stochastic simulations arising from an agent-based model. The advantage of this approach is that this library respects any coupling between systems components, whereas the SINDy algorithm (introduced by Brunton et al.) treats the individual components as decoupled from one another. Another advantage of our approach is that we can use a non-negative least squares algorithm to find the non-negative rate constants in a very robust, stable and simple manner. We illustrate our ideas on an agent-based model of tumour growth on a 2D lattice. [ABSTRACT FROM AUTHOR]

Simple Summary: Targeted therapies can induce strong tumor regression, but they typically fail to eradicate metastatic cancers. The elucidation of the causes that enable cancers to survive within a residual disease is essential for finding eradication strategies. The ability of cancers to survive eradication reflects not only cell-intrinsic sensitivities, but also microenvironmental effects. Paracrine signals produced by fibroblast, non-neoplastic cells that make tumor stroma, can provide strong but spatially limited therapy protection. Even though this phenomenon is well-established, its contribution to the ability of tumors to escape eradication remains poorly understood. To address this gap of knowledge, we developed an in silico model that recapitulates the effect of stroma on therapy responses in tumor tissues. This model enabled us to evaluate the contribution of spatial aspects of stroma-mediated resistance. Our analyses reveal that stroma dispersal might be the most important yet overlooked aspect of stromal resistance that determines the overall tumor responses to therapy. The response of tumors to anti-cancer therapies is defined not only by cell-intrinsic therapy sensitivities but also by local interactions with the tumor microenvironment. Fibroblasts that make tumor stroma have been shown to produce paracrine factors that can strongly reduce the sensitivity of tumor cells to many types of targeted therapies. Moreover, a high stroma/tumor ratio is generally associated with poor survival and reduced therapy responses. However, in contrast to advanced knowledge of the molecular mechanisms responsible for stroma-mediated resistance, its effect on the ability of tumors to escape therapeutic eradication remains poorly understood. To a large extent, this gap of knowledge reflects the challenge of accounting for the spatial aspects of microenvironmental resistance, especially over longer time frames. To address this problem, we integrated spatial inferences of proliferation-death dynamics from an experimental animal model of targeted therapy responses with spatial mathematical modeling. With this approach, we dissected the impact of tumor/stroma distribution, magnitude and distance of stromal effects. While all of the tested parameters affected the ability of tumor cells to resist elimination, spatial patterns of stroma distribution within tumor tissue had a particularly strong impact. [ABSTRACT FROM AUTHOR]

Copyright of Diachronica is the property of John Benjamins Publishing Co. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This research introduces a novel global sensitivity analysis (GSA) framework for agent-based models (ABMs) that explicitly handles their distinctive features, such as multi-level structure and temporal dynamics. The framework uses Grassmannian diffusion maps to reduce output data dimensionality and sparse polynomial chaos expansion (PCE) to compute sensitivity indices for stochastic input parameters. To demonstrate the versatility of the proposed GSA method, we applied it to a non-linear system dynamics model and epidemiological and economic ABMs, depicting different dynamics. Unlike traditional GSA approaches, the proposed method enables a more general estimation of parametric sensitivities spanning from the micro level (individual agents) to the macro level (entire population). The new framework encourages the use of manifold-based techniques in uncertainty quantification, enhances understanding of complex spatio-temporal processes, and equips ABM practitioners with robust tools for detailed model analysis. This empowers them to make more informed decisions when developing, fine-tuning, and verifying models, thereby advancing the field and improving routine practice for GSA in ABMs. [ABSTRACT FROM AUTHOR]

The differential transmission of COVID-19 depending on the socio-economic status of a neighborhood is well established. For example, several studies have shown that COVID-19 transmission was higher in poorer and denser neighborhoods than in wealthier ones. However, what is less well known is how this varied rate of transmission interacted with established health measures, i.e., face masks and lockdowns, in the context of developing countries to reduce pandemic cases and hence resulted in fewer deaths. This study uses an Agent-Based Model (ABM) simulation to examine the context and impacts of COVID-19 mitigation efforts (i.e., lockdowns combined with masks) on the transmission of COVID-19 across a single neighborhood in Ahmedabad, a city in the state of Gujarat, India. The model is parameterized using real-world population data, which allows us to simulate the spread of COVID-19 to find conditions that most closely match the realities of COVID-19 in the spring of 2020. Consequently, the simulation can be used to understand the impact of nation-wide lockdown on the spread of COVID cases across Ahmedabad as a function of housing density. Thus, invaluable insight into the effectiveness of a lockdown as a mitigation measure can be derived. Further information about how the effectiveness of the lockdown varied by neighborhood, as well as other factors that impacted it, can be ascertained. [ABSTRACT FROM AUTHOR]

Social structure may have changed from hierarchical to egalitarian and back along the evolutionary line of humans. Within the tradition of sociophysics, we construct a mathematical model of a society of agents subject to competing cognitive and social navigation constraints and predict, using statistical mechanics methods, that its degree of hierarchy decreases with encephalization and increases with group size, hence suggesting human societies were driven from hierarchical to egalitarian structures by the encephalization during the last few million years and back to hierarchical due to fast demographic changes during the Neolithic. In addition, applied to a different problem, the theory leads to the following predictions for modern pre-literary humans: (i) an intermediate hierarchy degree in mild climates. In harsher climates, societies will be (ii) more egalitarian if organized in small groups (of less than 100 persons) but (iii) more hierarchical if in larger (of more than 1000 persons) groups. The predicted bifurcation, characteristic of a phase transition, is also seen in the empirical cross-cultural record (248 cultures in the Ethnographic Atlas). [ABSTRACT FROM AUTHOR]

In this paper, we present an agent-based model for studying the impact of ‘myside bias’ on the argumentative dynamics in scientific communities. Recent insights in cognitive science suggest that scientific reasoning is influenced by ‘myside bias’. This bias manifests as a tendency to prioritize the search and generation of arguments that support one’s views rather than arguments that undermine them. Additionally, individuals tend to apply more critical scrutiny to opposing stances than to their own. Although myside bias may pull individual scientists away from the truth, its effects on communities of reasoners remain unclear. The aim of our model is two-fold: first, to study the argumentative dynamics generated by myside bias, and second, to explore which mechanisms may act as a mitigating factor against its pernicious effects. Our results indicate that biased communities are epistemically less successful than non-biased ones, and that they also tend to be less polarized than non-biased ones. Moreover, we find that two socio-epistemic mechanisms help communities to mitigate the effect of the bias: the presence of a common filter on weak arguments, which can be interpreted as shared beliefs, and an equal distribution of agents for each alternative at the start of the scientific debate. [ABSTRACT FROM AUTHOR]

Copyright of Social Science Information is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Mexican Journal of Behavioral Analysis / Revista Mexicana de Análisis de la Conducta is the property of Sociedad Mexicana de Analisis de la Conducta and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

A bounded version of the Lotka – Volterra model based on logistic differential equations is suggested to emulate cyclic behaviour in complex evolutionary and other systems. The model provides reasonable approximations for the so-called leaping cycles and other oscillational processes when the main state variables are limited by physical constraints. The model represents a basic model-building block that can be used in system dynamics and other frameworks and applications that require fundamental understanding and modelling of principal features of complex cyclic processes. Two application areas – technological progress and industrial safety – are specifically considered here. The model is shown to emulate techno-economic cycles reasonably well and give an appropriate qualitative description of risk and safety variations in the industrial environment. Simulations using the suggested model are quantitatively compared with the results of agent-based simulations. While a simple model cannot match all details of complex agent-based simulations of the risk and benefit dilemma, the bounded Lotka – Volterra model still gives a reasonable approximation of the process. The conceptual implications of the model are, nevertheless, significant, pointing to common cyclic mechanisms taking place in complex evolutionary systems that may belong to different branches of science. [ABSTRACT FROM AUTHOR]

We provide an in silico study of stochastic viral infection extinction from a pharmacokinetical viewpoint. Our work considers a non-specific antiviral drug that increases the virus clearance rate, and we investigate the effect of this drug on early infection extinction. Infection extinction data are generated by a hybrid multiscale framework that applies both continuous and discrete mathematical approaches. The central result of our paper is the observation, analysis and explanation of a linear relationship between the virus clearance rate and the probability of early infection extinction. The derivation behind this simple relationship is given by merging different mathematical toolboxes.

Social structure may have changed from hierarchical to egalitarian and back along the evolutionary line of humans. Within the tradition of sociophysics, we construct a mathematical model of a society of agents subject to competing cognitive and social navigation constraints and predict, using statistical mechanics methods, that its degree of hierarchy decreases with encephalization and increases with group size, hence suggesting human societies were driven from hierarchical to egalitarian structures by the encephalization during the last few million years and back to hierarchical due to fast demographic changes during the Neolithic. In addition, applied to a different problem, the theory leads to the following predictions for modern pre-literary humans: (i) an intermediate hierarchy degree in mild climates. In harsher climates, societies will be (ii) more egalitarian if organized in small groups (of less than 100 persons) but (iii) more hierarchical if in larger (of more than 1000 persons) groups. The predicted bifurcation, characteristic of a phase transition, is also seen in the empirical cross-cultural record (248 cultures in the Ethnographic Atlas).

The paper discusses the history of the development of different logical formalisms, explicitly modelling situations in which disagreement is present. It is structured as follows: (§1) sketches the distinction between two main traditions in logic, that have different relation to disagreement; (§2) presents Jaskowski's discussive logic and its shortcomings; (§3) develops the doctrinal paradox in social choice theory. Then we come to (§4) the probabilistic model of Lehrer-Wagner; (§5) the bounded confidence model of Hegselmann and Krause and (§6) the agent-based model of Douven and Riegler. The aim of the paper is to show that the development of these formalisms raises many questions that are yet not solved in adequate manner. [ABSTRACT FROM AUTHOR]

Computer-based simulations are highly effective in supporting students' deep conceptual understanding of scientific ideas. However, in the unprecedented era of the COVID-19 outbreak, students around the world experienced an induced state anxiety, which may have affected their engagement with the learning environments and ultimately their academic outcomes. This crisis underscores the global need to examine the learning processes and identify means of supporting students' engagement under stressful conditions. With this goal in mind, the current study evaluated the impact of COVID-19 induced anxiety on the learning process of 187 undergraduate students by means of computer-based simulation during a quarantine. Findings show that 56% of the students reported experiencing anxiety following the COVID-19 outbreak. A bivariate parametric analysis demonstrated that this COVID-19 induced anxiety had a negative impact on students' engagement. Indirect model analysis revealed that emotional disaffection in terms of boredom mediated the negative effect of COVID-19 induced anxiety on students' engagement. From a theoretical perspective, these findings highlight the pivotal role of boredom in students' learning processes in times of externally induced anxiety. From a pedagogical perspective, our findings highlight the necessity to implement teaching approaches that attend to boredom to mitigate the negative effects of externally induced anxiety. [ABSTRACT FROM AUTHOR]

Background: The United States is in the midst of an opioid overdose epidemic; 28.3 per 100,000 people died of opioid overdose in 2020. Simulation models can help understand and address this complex, dynamic, and nonlinear social phenomenon. Using the HEALing Communities Study, aimed at reducing opioid overdoses, and an agent-based model, Simulation of Community-Level Overdose Prevention Strategy, we simulated increases in buprenorphine initiation and retention and naloxone distribution aimed at reducing overdose deaths by 40% in New York Counties. Methods: Our simulations covered 2020-2022. The eight counties contrasted urban or rural and high and low baseline rates of opioid use disorder treatment. The model calibrated agent characteristics for opioid use and use disorder, treatments and treatment access, and fatal and nonfatal overdose. Modeled interventions included increased buprenorphine initiation and retention, and naloxone distribution. We predicted a decrease in the rate of fatal opioid overdose 1 year after intervention, given various modeled intervention scenarios. Results: Counties required unique combinations of modeled interventions to achieve a 40% reduction in overdose deaths. Assuming a 200% increase in naloxone from current levels, high baseline treatment counties achieved a 40% reduction in overdose deaths with a simultaneous 150% increase in buprenorphine initiation. In comparison, low baseline treatment counties required 250-300% increases in buprenorphine initiation coupled with 200-1000% increases in naloxone, depending on the county. Conclusions: Results demonstrate the need for tailored county-level interventions to increase service utilization and reduce overdose deaths, as the modeled impact of interventions depended on the county's experience with past and current interventions. [ABSTRACT FROM AUTHOR]

In this paper, we study an agent-based model for multi-round, pay as bid, sealed bid reverse auctions using techniques from partial differential equations and statistical mechanics tools. We assume that in each round a fixed fraction of bidders is awarded, and bidders learn from round to round using simple microscopic rules, adjusting myopically their bid according to their performance. Agent-based simulations show that bidders coordinate in the sense that they tend to bid the same value in the long-time limit. Moreover, this common value is the true cost or the ceiling price of the auction, depending on the level of competition. A discontinuous phase transition occurs when half of the bidders win. We establish the corresponding rate equations, and we obtain a system of ordinary differential equations describing the dynamics. Finally, we derive formally the kinetic equations modeling the dynamics, and we study the asymptotic behavior of solutions of the corresponding first-order, nonlinear partial differential equation satisfied by the distribution of agents. [ABSTRACT FROM AUTHOR]