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1. Cerebral microbleeds and risk of symptomatic hemorrhagic transformation following mechanical thrombectomy for large vessel ischemic stroke

Author

Agbonon, Rémi, Forestier, Géraud, Bricout, Nicolas, Benhassen, Wagih, Turc, Guillaume, Bretzner, Martin, Pasi, Marco, benzakoun, Joseph, Seners, Pierre, Derraz, Imad, Legrand, Laurence, Trystram, Denis, Rodriguez-Regent, Christine, Charidimou, Andreas, Rost, Natalia S., Bracard, Serge, Cordonnier, Charlotte, Eker, Omer F., Oppenheim, Catherine, Naggara, Olivier, Henon, Hilde, and Boulouis, Grégoire

Published
2024
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3. Evaluation of the performance of advantage P.f. malaria Card® and advantage malaria Pan + Pf Card®, two rapid diagnostic tests for parasitological confirmation of malaria cases in field situation in Togo

Author

Diwaba Carmel Teou, Ameyo Monique Dorkenoo, Essoham Ataba, Smaila Alidou, Kossi Yakpa, Agueregna Abdou-Kerim, Issaka Maman, and Amegnona Agbonon

Subjects
RDT, Malaria, Performance, Microscopy, PCR, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background In Togo, malaria remains a major public health problem, and the management of suspected cases requires confirmation with appropriate biological methods. Malaria diagnosis has been improved by the introduction of rapid diagnostic tests (RDTs), recommended by the World Health Organization (WHO) for areas where microscopy is not available. To be used, these RDTs must meet performance criteria defined by the WHO. This study was conducted to evaluate the diagnostic performance of two RDTs: Advantage P.f. Malaria Card® detecting HRP2 antigen and Advantage Malaria Pan + Pf Card® detecting both HRP2 and pLDH antigens. Methods This was a cross-sectional analytical study conducted from December 2019 to February 2020 on malaria-suspected cases received in three sentinel sites in Togo and from whom capillary blood was collected to perform the two RDTs according to the manufacturer's instructions. Sensitivity and specificity were estimated by comparing to thick/thin blood smear, the gold standard, and to PCR, which is a more sensitive. Results A total of 390 participants (54.9% female) with a median age of 18 (± 0.8) years were included in the study. The sensitivity of both Advantage P.f. Malaria Card® and Advantage Malaria Pan + Pf Card® compared to thick/thin blood smear was 91.8% and 91.3%, respectively, and for both the specificity was 94.7%. Compared to PCR, the sensitivity was 84.2% and 83.8%, respectively, and the specificity 96.5%. Conclusions The performances of the Advantage P.f. Malaria Card® and Advantage Malaria PAN + Pf Card® compared to microscopy, considered the gold standard, were acceptable under the field conditions found in Togo. They can therefore be used for the biological diagnosis of malaria. Graphical Abstract

Published
2023
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6. Effect of Vernonia amygdalina leaf meal on growth performance, intestinal mucosa activity, digestive enzymes, absorption capacity, and immunity in broiler chickens

Author

B.M. Tokofai, B.M. Orounladji, K. Idoh, O.E. Oke, and A. Agbonon

Subjects
Vernonia amygdalina, enzymes, immunity, gut, broilers, Agriculture, Animal culture, SF1-1100
Abstract

Gut health is multifaceted and is largely influenced by the rearing environment and the diet. The use of phytochemicals rich in phenolics and flavonoids can improve the digestive health of chickens and lead to better growth performance. The aim of this study was to examine the effects of dietary Vernonia amygdalina leaf meal (VALM) on growth performance, digestive enzyme activities, absorption function, organ weights and immunity of broilers. Two hundred and forty, one-day-old male Cobb 500 broiler chicks were randomly divided into four groups: an unsupplemented control and VA-1, VA-3 and VA-5 receiving VALM incorporation at concentrations of 1, 3 and 5 g/kg, respectively. Each treatment had six replicates of 10 chickens. On d 42, six chickens per replicate were isolated and euthanised. Digesta from the jejunal segments (10 cm) was collected for analysis of the digestive enzymes. The remaining digesta was then washed out with ice-cold phosphate-buffered saline before the jejunal segments (10 cm) were opened longitudinally to collect the mucosa by scraping. For the preparation of the homogenate, intestinal mucosa samples were homogenised with 154 mmol/l of ice-cold sodium chloride solution and centrifuged at 4 °C for 900 s. To determine immunoglobulins, glutathione and D-xylose, the supernatant was extracted and stored at -20 °C. Supplementation with VALM did not significantly influence the relative weights of organs in the different treatments. However, VALM at 3 g/kg caused a significant increase in amylase and trypsin concentration (P

Published
2023
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7. Small vessel disease and collaterals in ischemic stroke patients treated with thrombectomy

Author

Forestier, Géraud, Agbonon, Rémi, Bricout, Nicolas, Benhassen, Wagih, Turc, Guillaume, Bretzner, Martin, Pasi, Marco, Benzakoun, Joseph, Seners, Pierre, Personnic, Thomas, Legrand, Laurence, Trystram, Denis, Rodriguez-Regent, Christine, Charidimou, Andreas, Rost, Natalia S., Bracard, Serge, Clarençon, Frédéric, Eker, Omer F., Nighoghossian, Norbert, Cordonnier, Charlotte, Oppenheim, Catherine, Naggara, Olivier, Henon, Hilde, and Boulouis, Grégoire

Published
2022
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9. Knowledge and practices of female students at University of Kara regarding sexually transmitted infections in Togo, 2021

Author

Gatibe Y.S. Gnatou, Fifonsi A. Gbeasor-Komlanvi, Arnold J. Sadio, Yao R. Konu, Martin K. Tchankoni, Wendpouiré I.C. Zida-Compaore, Amegnona Agbonon, and Didier K. Ekouevi

Subjects
sti, female students, university of kara, togo, Public aspects of medicine, RA1-1270
Abstract

A good knowledge of sexually transmitted infections (STI) in female students is an important element in the prevention of STI transmission. The objective of this study is to describe the level of knowledge and practices on STI among female students at the University of Kara. A cross-sectional study was conducted at the University of Kara from July to September 2021. Data were collected using a standard, digitalised, selfadministered questionnaire. Logistic regression analysis was used to describe factors associated with the level of knowledge of STIs. A total of 1,055 female students with a median age of 21 years (interquartile range: 20-24) participated in the study. More than one-third (33.7%) of the students had good knowledge of STI. Having already been tested for HIV (aOR=3.25; 95% CI 2.36-4.52), having already had sex (aOR=1.56; 95% CI 1.10-2.24) and the level of education (AOR=3.46; 95% CI 2.10-5.85) were significantly associated with good STIs knowledge. Among the 723 female students (68.5%) who already had sex, 32.5% reported inconsistent use of condoms during sexual intercourse and 18.9% reported having multiple sexual partners. The results of this study highlight the importance of intensifying STIs prevention efforts (awareness, screening, and vaccination) among female students at the University of Kara.

Published
2022
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10. Knowledge and practices among healthcare workers regarding dengue in Togo

Author

Wendpouiré I.C. Zida-Compaore, Fifonsi A. Gbeasor-Komlanvi, Martin K. Tchankoni, Arnold J. Sadio, Yao R. Konu, Amegnona Agbonon, and Didier K. Ekouevi

Subjects
dengue, healthcare workers, knowledge and practices, togo, Public aspects of medicine, RA1-1270
Abstract

In Togo where malaria is endemic, because main signs of malaria and dengue are similar, the use of malarial drugs first could contribute to a delay in the diagnosis of dengue and the dissemination of the disease. Thus, it is important that healthcare workers (HCW) have a good knowledge of these diseases. To assess the knowledge, and practices regarding dengue infection among HCW in Togo. A cross-sectional study was carried out from November 2020 to March 2021 among HCW in Togo. A pre-tested digital questionnaire was used for data collection. Based on clinical signs of dengue, preventive measures, infection type and disease type, a knowledge score was constructed with eight questions. A total of 334 HCW with median age 32 years, IQR:(28-38) responded to the survey and the sex ratio male/female was 5.9. The majority (94.0%) of HCW have heard about dengue through training (73.3%), internet (38.0%) and media (33.2%). Compared with lower executive HCW, senior manager were more knowledgeable about the causative agent, the symptoms and preventive methods of dengue infection (p0.001). Globally, good knowledge (score ≥6) about dengue was found for 47.1% of HCW. More than 9 out of 10 HCW (91.3%) reported the lack of dengue diagnostic tools. Providing health structures with dengue diagnostic tools and training health personnel in their use in any febrile patient with a negative or positive malaria test would help prevent dengue epidemic.

Published
2022
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11. Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients

Author

Abbassi, Abdelhamid, Debure, Alain, Guerraoui, Abdallah, Benmoussa, Abdelatif, Hamani, Abdelaziz, Ziane, Abdelaziz, Nefti, Abdelhamid, Hadj, Abdelkader, El Amari, Abderrahim, Ghazali, Abderrahmane, Abd El Fatah Mohamed, Abo Bakr, Laradi, Achour, Ben Ahmed, Adel, Sahar, Adel, Pillet, Adele, Lacraz, Adeline, Moinat, Adnan, Massoumi, Afshin, Pardon, Agathe, Beaudoin, Agnes Caillette, Debout, Agnes Chapelet, Mariot, Agnes, Rachi, Ahmed, Afiani, Aida, Boula, Aime Remy, Jalaby, Al, Cremault, Alain, Fournier, Alain, Jeanson, Alain, Lyon, Alain, Nony, Alain, Robert, Alain, Slingeneyer, Alain, Labatide, Alanor Agnes, Sartorius, Albane Brodin, Bensman, Albert, Fournier, Albert, Ranlin, Alex, Sandor, Alex Vido, Colombo, Alexandra, Duhem, Alexandra, Stancu, Alexandra, Dufay, Alexandre, Dumoulin, Alexandre, Ebel, Alexandre, Klein, Alexandre, Martin, Alexandre, Mouneimne, Alexandre, Seidowsky, Alexandre, De Martin, Alfio, Zannier, Alfredo, Aizel, Ali, Hafi, Ali, Diddaoui, Ali Zineddine, Heyani, Alim, Mocanu, Alina, Preda, Alina, Hafi, Aline, Talaszka, Aline, Duquesne, Alyette, Amaouche, Amar, Ghemmour, Amel, Simon, Amelie, Skalli, Amina, Boukadida, Amine, Ragab Eid, Amr Ekhlas, Fedorca, Ana, Baillet, Anabelle, Poyet, Anais, Giorgita, Ancuta Bouffandeau, Ratsimbazafy, Anderson, Pruna, Andre, Argiles, Angel, Testa, Angelo, Vandooren, Ann Karolien, Jolivot, Anne, Labadens, Anne Kolko, Lataste, Anne, Maisin, Anne, Paris, Anne, Sechet, Anne, Wuillai, Anne, Heng, Anne Elisabeth, Josse, Anne Gaelle, Querard, Anne Helene, Reboux, Anne Helene, Adra, Anne Laure, Faller, Anne Laure, Leclerc, Anne Laure, Poitou, Anne Laure, Manucci, Annie Lahoche, Jacquet, Antoine, Pommereau, Antoine, Thierry, Antoine, Adem, Arezki, Chapelet, Arielle, Del Bello, Arnaud, Delezire, Arnaud, Garnier, Arnaud, Guerard, Arnaud, Klisnick, Arnaud, Lionet, Arnaud, Roccabianca, Arnaud, Stolz, Arnaud, Capdeville, Arthur, Allal, Asma, Alrifai, Assem, Diarrassouba, Assetou, Djema, Assia, Carre, Assia Ferhat, Dubrasquet, Astrid Godron, Elmrabet, Atman Haddj, Jegado, Audrey, Thomas, Aurelia Bertholet, Salandre, Aurelie Davourie, Pajot, Aurelie, Lorthioir, Aurelien, Tiple, Aurelien, Sury, Aurore, Abokasem, Ayman, Sarraj, Ayman, Henaoui, Bachir, Chaghouri, Baher, Wehbe, Bassem, Ball, Beatrice, Viron, Beatrice, Issad, Belkassem, Corne, Benedicte Hodemon, Janbon, Benedicte, Deroure, Benjamin, Savenkoff, Benjamin, Jonon, Benoit, Vendrely, Benoit, Djelaleddine, Benyakoub, Ohry, Bernard, Painchart, Bernard, Strullu, Bernard, Temperville, Bernard, Ebikili, Bertin, Hacq, Bertrand, Morel, Bertrand, Aoun, Bilal, Muniz, Blanca, Chlih, Bouchra, Amara, Brahim, Mayor, Brice, Gilson, Brigitte, Llanas, Brigitte, Zins, Brigitte, Bourgeon, Bruno, Coevoet, Bruno, Guery, Bruno, Legallicier, Bruno, Paris, Bruno, Ranchin, Bruno, Seigneuric, Bruno, Dita, Camelia Ghiciuc, Prelipcean, Camelia, Hottelart, Carine Achard, Diet, Carine, Frangie, Carlos, Vela, Carlos, Muresan, Carmina, Deprele, Carole, Araujo, Caroline, Bidault, Caroline, Creput, Caroline, Delclaux, Caroline, Du Halgouet, Caroline, Favennec, Caroline, Freguin, Caroline, Vercel, Caroline Gourraud, Mesguen, Caroline, Obama, Caroline Ndomo, Poitou, Caroline, Dirhold, Caroline Preissig, Roubiou, Caroline, Albert, Catherine, Bessin, Catherine, De Marion Gaja, Catherine, Godart, Catherine, Lasseur, Catherine, Leocardi, Catherine, Lumbroso, Catherine, Melander, Catherine, Michel, Catherine, Maurouard, Catherine Quere, Rouannet, Catherine, Taddei, Catherine, Verove, Cathy, Guiraud, Cecile, Tafelin, Cecile, Baron, Cecile Turc, Formet, Cedric, Pinier, Cedric, De Ste Foy, Celia Lessore, Granolleras, Celine, Bennini, Chaouki, Cartou, Charles, Chazot, Charles, Jouzel, Charlotte, Badid, Cherif, Roubicek, Christa, Viaud, Christel, Verrier, Christelle, Chuet, Christian, Combe, Christian, Dabot, Christian, Duvic, Christian, Emond, Christian, Lagarde, Christian, Lamotte, Christian, Pain, Christian, Mousson, Christiane, Lorriaux, Christie, Beauchamp, Christine, Fumeron, Christine, Le Gurun, Christine, Leroy, Christine, Pietrement, Christine, Richer, Christine, Bouaka, Christophe, Charasse, Christophe, Goupy, Christophe, Ridel, Christophe, Castrale, Cindy, Detourne, Cindy, Francois, Clair, Presne, Claire, Trivin, Claire, Von Kotze, Clarissa, Bernard, Claude, Bonniol, Claude, Desvergnes, Claude, Raharivelina, Claude, Nistor, Claudia, Gueret, Claudine, Lloret, Claudine, Saltiel, Claudine, Rosati, Clelia, Rabate, Clementine, Stanescu, Corina, Ferrandini, Corinne, Guibergia, Corinne, Lemoine, Corinne, Passeron, Corinne, Kahil, Cynthia, Garrouste, Cyril, Van, Cyril Vo, Jolimoy, Cyrille, Kesraoui, Dalila, Jolly, Damien, Thibaudin, Damien, Teboulle, Dan, Daubresse, Daniel, Louvet, Daniel, Rasamimanantsoa, Daniel, Toledano, Daniel, Babici, Daniela, David, Daniela, Dincu, Daniela, Bruno, Danielle, May, Delia, Haussaire, Delphine, Viprey, Delphine Henriet, Bugnon, Denis, Fouque, Denis, Morin, Denis, Nour, Derradji, Mahmoud, Diab Mohamed, Cristescu, Diana Istrati, Aguilera, Didier, Coste, Didier, Hamel, Didier, Le Chapois, Didier, Testou, Didier, Erbilgin, Dilaver, Dahmane, Djamal, Quang, Doan Bui, Bertrand, Dominique, Besnier, Dominique, Blanchier, Dominique, Briffa, Dominique, Caux, Dominique, Durand, Dominique, Fleury, Dominique, Guerrot, Dominique, Hestin, Dominique, Jaubert, Dominique, Joly, Dominique, Lombart, Dominique, Pagniez, Dominique, Pierre, Dominique, Schohn, Dominique, Ikonga, Donatien, Visanica, Dorina, Bazin, Dorothee, Boury, Edouard, Maksour, Edouard, Agbonon, Ekoue, Harrami, Elarbi, Marcu, Elena, Tudorache, Elena, Caniot, Elisabeth, Semjen, Elisabeth, Tomkiewicz, Elisabeth, Scheidt, Elise, Gaboriau, Elke, Lamouroux, Elodie, Guiard, Elsa, Passos, Elsa Martin, Nsembani, Emerson, Fache, Emilie, Kalbacher, Emilie, Pambrun, Emilie, Pincon, Emilie, Launay, Emma Allain, Baron, Emmanuel, Dupuis, Emmanuel, Villar, Emmanuel, Charlin, Emmanuelle, Hecquet, Emmanuelle, Kohler, Emmanuelle, Laurain, Emmanuelle, Rosier, Emmanuelle, Figueroa, Enrique, Azoulay, Eric, Canivet, Eric, Daugas, Eric, Gauthier, Eric, Laruelle, Eric, Le Guen, Eric, Legrand, Eric, Moumas, Eric, Postec, Eric, Prinz, Eric, Renaudineau, Eric, Desport, Estelle, Sutra, Estelle Ricard, Berard, Etienne, Ged, Etienne, Robin, Etienne, Vilaine, Eve, Bargas, Evelyne, Namara, Evelyne Mac, Combarnous, François, Yazbeck, Fatima, Gerard, Fabien, Metivier, Fabien, Parazols, Fabien, Soulis, Fabien, Garnier, Fabrice, Messaoudene, Fadhila Pech, Haidar, Fadi, Boullenger, Fanny, Lepeytre, Fanny, Leroy, Fanny, Frejate, Fares, Bellahsene, Farid, Bellhasene, Farid, Saidani, Farid, Toure, Fatouma, Kriaa, Faycal, Nemmar, Fazia, Vetromile, Fernando, Chalmin, Florence, Lucats, Florence, Sens, Florence, Villemain, Florence, Plasse, Florent, Lebhour, Fouad, Schillinger, Francis, Berge, Franck, Bourdon, Franck, Bridoux, Franck, Reynaud, Franck, Babinet, Francois, Basse, Francois, Chantrel, Francois, Clair, Francois, Coulomb, Francois, De Cornelissen, Francois, Glowacki, Francois, Marchal, Francois, Maurice, Francois, Nobili, Francois, Pourreau, Francois, Provot, Francois, Amani, Francois Roux, Broux, Francoise, Bulte, Francoise, Heibel, Francoise, Leonetti, Francoise, Schott, Francoise Moussion, Le Roy, Frank, Besson, Frederic, Lavainne, Frederic, Tollis, Frederic, Bocquentin, Frederique, Meeus, Frederique, Vecina, Frederique, Von Ey, Friederike, Balit, Gabriel, Choukroun, Gabriel, Gruget, Gabriel, Huchard, Gabriel, Golea, Gabriella, Duneau, Gabrielle, Lefrancois, Gaelle, Pelle, Gaelle, Lebrun, Gaetan, Dumont, Genevieve, Brillet, Georges, Deschenes, Georges, Mourad, Georges, Stamatakis, Georges, Cazajous, Geraldine, D'ythurbide, Geraldine, Wiart, Geraldine Robitaille, Cardon, Gerard, Champion, Gerard, Deschodt, Gerard, Mangenot, Gerard, Motte, Gerard, Schortgen, Gerard, Boulahia, Ghada, Maakaroun, Ghassan, Michel, Ghylene Bourdat, Zanetta, Gilbert, Hufnagel, Gilles, Messier, Gilles, Piccoli, Giorgina, Desvergnes, Gregoire Couvrat, Bobrie, Guillaume, Bonnard, Guillaume, Clement, Guillaume, Jean, Guillaume, Queffeulou, Guillaume, Seret, Guillaume, Vernin, Guillaume, Delavaud, Guy, Lambrey, Guy, Rostoker, Guy, Poussard, Gwenaelle, Kesler, Gwenaelle Roussey, Leon, H., Aboubekr, Habib, Boulechfar, Hacene, Sekhri, Hacene, Hebibi, Hadia, Benalia, Hadjira, Fessi, Hafed, Atchia, Hafsabhai, Bittar, Haiat, Maiza, Hakim, Mazouz, Hakim, El Ali, Hamid, Bougrida, Hammouche, Van Der Pijl, Hans, Lokmane, Hassan, Izzedine, Hassane, Adda, Hassen, De Preneuf, Helene, Leray, Helene, Philippot, Helene, Boulanger, Henri, Merault, Henri, Renaud, Henri, Bonarek, Herve, Maheut, Herve, Nzeyimana, Hilaire, Mehama, Hocine, Zaidi, Hocine, Weclawiak, Hugo, Flodrops, Hugues, Karaaslan, Huseyin, Haskour, Ibrahim, Belhadj, Ihssen, Almoubarak, Imad, Haddad, Imad, Castellano, Ines, Ferrandiz, Ines, Daniliuc, Ioana, Darie, Ioana, Enache, Ioana, Prunescu, Ionut, Djiconkpode, Irenee, Shahapuni, Irina, Bouchoule, Isabelle, Devriendt, Isabelle, Kazes, Isabelle, Kolb, Isabelle, Landru, Isabelle, Poli, Isabelle, Rey, Isabelle, Segalen, Isabelle, Selcer, Isabelle, Vernier, Isabelle, Vrillon, Isabelle, Guenifi, Ismahane, Gheerbrandt, J. Dominique, Potier, Jacky, Becart, Jacques, Cledes, Jacques, Ducros, Jacques, Duvic, Jacques, Fourcade, Jacques, Gaultier, Jacques, Jurine, Jacques, Lebleu, Jacques, Ollier, Jacques, Charles, Jacques Ibsen, Yazji, Jamal, Mansour, Janette, Arnautou, Jean, Brocard, Jean, Carolfi, Jean, Montoriol, Jean, Gouin, Jean Baptiste, Palcoux, Jean Bernard, Bendini, Jean Christophe, Aldigier, Jean Claude, Alphonse, Jean Claude, Delbet, Jean Daniel, Bonne, Jean Francois, Cantin, Jean Francois, De Fremont, Jean Francois, Dessassis, Jean Francois, Subra, Jean Francois, Valentin, Jean Francois, Verdier, Jean Francois, Dion, Jean Jacques, Haultier, Jean Jacques, Montseny, Jean Jacques, Bacri, Jean Louis, Bouchet, Jean Louis, Mahe, Jean Luc, Chalopin, Jean Marc, Gabriel, Jean Marc, Hurot, Jean Marc, Lanau, Jean Marc, Batho, Jean Marie, Coulibaly, Jean Marie, Hardin, Jean Michel, Marc, Jean Michel, Poux, Jean Michel, Rebibou, Jean Michel, Tivollier, Jean Michel, Ottavioli, Jean Noel, Faucon, Jean Paul, Imiela, Jean Paul, Jaulin, Jean Paul, Masselot, Jean Paul, Ortiz, Jean Paul, Bourdenx, Jean Philippe, Devaux, Jean Philippe, Hammelin, Jean Philippe, Rivory, Jean Pierre, Wauquier, Jean Pierre, Larue, Jean Rene, Mondain, Jean Rene, Borde, Jean Sebastien, Virot, Jean Simon, Bosc, Jean Yves, Achiche, Jedjiga, Parasote, Jennifer, Diolez, Jeremie, Harambat, Jerome, Potier, Jerome, Sampol, Jerome, Mustel, Jihad, Lefevre, Jean Jacques, Maurizi, Jocelyne, Gamberoni, Joel, Claudeon, Joelle, Terzic, Joelle, Rogol, Joffrey, Sayegh, Johnny, Cardozo, Jorge, Brasseur, Jose, Guiserix, Jose, Barsumau, Joseph, Albaret, Julie, Beaume, Julie, Attias, Julie Sohier, Dehay, Julien, Hogan, Julien, Journet, Julien, Ott, Julien, Baleynaud, Juliette, Bacchetta, Justine, Faucher, Justine, Yousfi, Kamel, Dardim, Karim, Clabault, Karine, Moreau, Karine, Thomas, Kedna, Sirajedine, Khaled, Chedid, Khalil, El Kaeoui, Khalil, El Karoui, Khalil, Bouachi, Khedidja, Hue, Kheira, El Nasser, Khuzama, Akposso, Kodso, Kunz, Kristian, Bijak, Krzysztof, Kihal, Lilia, Rasoloarijaona, L., Harbouche, Laid, Bencheikh, Larbi, Lamriben, Larbie, Hanafi, Latifa, Parvez, Laura Braun, Champion, Laure, Croze, Laure, Eprinchard, Laure, Patrier, Laure, Nicolet, Laurence, Vrigneaud, Laurence, Duflot, Laurent, Mackaya, Leandre, Chenine, Leila, Odry, Leon, Tamiji, Lili Taghipour, Bouzar, Lilia Antri, Nga Messi, Liliane Ngango, Le Mouellic, Lionel, Mandart, Lise, Weis, Lise, Pouteau, Lise Marie, Georgieva, Lora, Vitanova, Lorita, Chalabi, Lotfi, Delvallez, Luc, Frimat, Luc, Fromentin, Luc, Marty, Luc, Monjot, Luc, Spataru, Luciana, Bessenay, Lucie, Boissinot, Lucie, Wajsbrot, Lucie, Rakoff, Lucien, Lebourg, Ludivine, Perez, Lydie, Lafage, Lyliane, Azzouz, Lynda, Dumoulin, Madeleine, Ouziala, Messaoud, Joseph, Maan, Brahimi, Mabrouk, Fat, Maeva Wong, Fort, Magalie, Nakhla, Magued, Abtahi, Mahdi, Albadawy, Mahen, Alouach, Mahmoud, Mezghani, Mahmoud, Daroux, Maite, Boukelmoune, Maklouf, Dhib, Malek, Touam, Malik, Dubau, Malina, Balde, Mamadou, Khoa, Man Nguyen, Ismer, Manfred, Mehdi, Manolie, Laforet, Manon, Bouiller, Marc, Eugene, Marc, Fila, Marc, Hazzan, Marc, Kribs, Marc, Ladriere, Marc, Lebot, Marc, Padilla, Marc, Souid, Marc, Marraoui, Marcel, Burbach, Maren, Manescu, Maria, Noguera Gonzalez, Maria Eugenia, Revenco, Mariana, Terrasse, Marianne, Essi, Marie, Macher, Marie Alice, Nogier, Marie Beatrice, Cazin, Marie Cecile, Schweitzer Camoin, Marie Christine, Thouret, Marie Christine, Hannaert, Marie Claude, Servel, Marie France, Chabannier, Marie Helene, Coudert Krier, Marie Jeanne, Catoliquot, Marie Noelle, Guillodo, Marie Paule, Gavard, Marie Sophie, Vairon Codaccioni, Marie Xaviere, Rabec, Marina, Freist, Marine, Gauthier, Marion, Lemaire, Marion, Mehrenberger, Marion, Venot, Marion, Pongas, Marios, Diant, Marlene Beaubrun, Levannier, Martial, Bertaux, Martine, Jablonski, Mathieu, Sacquepee, Mathieu, Dargelos, Mathilde, Lemoine, Mathilde, Tamain, Mathilde, Monge, Matthieu, Reberolle, Matthieu, Cousin, Maud, Francois, Maud, Baron, Maurice, Hoffmann, Maxime, Ingwiller, Maxime, Touzot, Maxime, Mohajer, Mederick, Maaz, Mehadji, Hanoy, Melanie, Marroc, Melanie, Cuny, Melodie, Van Der Straaten, Menno, Serveaux, Mf., Basteri, Michel, Chong, Michel Fen, Hecht, Michel, Massad, Michel, Normand, Michel, Olmer, Michel, Tolani, Michel, Tsimaratos, Michel, Hemery, Michele, Kessler, Michele, Esposito, Miguel, Shenouda, Milad, Kareche, Mimi, Khalili, Mina, Diaconita, Mirella, Rifard, Mohamad Khair, Aladib, Mohamed, Belmouaz, Mohamed, Brahim, Mohamed, Diouani, Mohamed, Cherif, Mohamed Fodil, Jamali, Mohamed, Maghlaoua, Mohamed, Meddeb, Mohamed, Ramdane, Mohamed, Rifaat, Mohamed, Islam, Mohamed Sharifull, Abbade, Mohamed Adnan, Amrandi, Mokhtar, Chawki, Mokhtar, Ciobotaru, Monica, Indrieis, Monica, Chanas, Monique, Hoarau, Monique, Tomeh, Monzer, Bellou, Moufida, Bouzernidj, Mouloud, Ammor, Mounia, Guergour, Mounir, Benzakour, Mountassir, Hachicha, Mourad, Coulibaly, Moussa, Smati, Mustafa, Al Morabiti, Mustapha, Amirou, Mustapha, Isnard, Myriam, Pastural, Myriam, Pujo, Myriam, Boumendjel, Nourredine, Majbri, Nabil, Goumri, Nabila, Mingat, Nadege, Bassilios, Nader, Kerkeni, Nadia, Sedrati, Nadia, Soltani, Nadia, Maroun, Nadine, Neyrat, Nadine, Luang, Nahn, El Esper, Najeh, Ammar, Naji, Ghali, Nasredine, Hamdini, Nasser, Noel, Natacha, Potelune, Natacha, Maisonneuve, Nathalie, Pertuiset, Nathalie, Raynal, Nathalie, Vittoz, Nathalie, Terki, Nazim, Castin, Nelly, Nankeu, Nestor, Bouvier, Nicolas, Keller, Nicolas, Legros, Nicolas, Peters, Nicolas, Quirin, Nicolas, Lefrancois, Nicole, Monnier, Nicole, Rance, Nicole, Bruckmann, Niels, Mertens, Noel, Lorcy, Nolwenn, Gilbert, Olivia, Coldefy, Olivier, Drouineau, Olivier, Dunand, Olivier, Fritz, Olivier, Imhoff, Olivier, Kourilsky, Olivier, Lavelle, Olivier, Moranne, Olivier, Papin, Olivier, Roques, Olivier, Le Maner, Ophelie, Benbrahim, Oussamah Fikri, Erina Torres, Pablo Antonio, Urena Torres, Pablo Antonio, Malvezzi, Paolo, Bindi, Pascal, Cluzel, Pascal, Fontanier, Pascal, Wheatley, Pascal, Depraetre, Pascale, Dubosq, Pascale, Halin, Pascale, Sebahoun, Pascale, Siohan, Pascale, Testevuide, Pascale, Deteix, Patrice, Nolen, Patrice, Hue, Patricia, Lemarchand, Patricia, Donnadieu, Patrick, Fievet, Patrick, Fohrer, Patrick, Francais, Patrick, Giraud, Patrick, Hallonet, Patrick, Henri, Patrick, Michaut, Patrick, Niaudet, Patrick, Pauly, Patrick, Thomas, Patrick, Deleaval, Patrik, Finielz, Paul, Stroumza, Paul, Yverneau, Paule Hardy, Caillard, Pauline, Palacin, Pedro, Aubertin, Perrine, Attias, Philippe, Brunet, Philippe, Chauveau, Philippe, Coindre, Philippe, Coste, Philippe, Dubot, Philippe, Fournier, Philippe, Hiernaux, Philippe, Jousset, Philippe, Yue Wah, Philippe Lan, Lang, Philippe, Le Cacheux, Philippe, Dupont, Philippe Martin, Michel, Philippe, Mirgaine, Philippe, Moriniere, Philippe, Nicoud, Philippe, Rieu, Philippe, Rousseau, Philippe, Sporer, Philippe, Thorel, Philippe, Vanhille, Philippe, Vigeral, Philippe, Zaoui, Philippe, Bataille, Pierre, Brignon, Pierre, Filipozzi, Pierre, Housset, Pierre, Peyronnet, Pierre, Ramperez, Pierre, Vautrin, Pierre, Michel, Pierre Alexandre, Westeel, Pierre Francois, Carron, Pierre Louis, Durand, Pierre Yves, Parent, Pierrot, Seniuta, Piotr, Kuentz, François, Fraoui, Rabah, Tetaz, Rachel, Amaria, Rachid, Bourouma, Rachid, Djeffal, Rachid, Nebbad, Rachida, Allal, Radia, Dimulescu, Radu, Boustani, Rafaat, Mesbah, Rafik, Makdassi, Raifat, Diab, Raji, Puslenghea, Raluca, Roura, Raoul, Khayat, Rateb, Azar, Raymond, Frayssinet, Raymond, Monkam, Regine, Boulahrouz, Rehouni, Boudet, Remi, Demontis, Renato, Gansey, Renaud, Cuvelier, Rene, Schmitt, Renee, Noordally, Reschad, Binaut, Reynald, Latif, Rezkallah, Dufresne, Richard, Montagnac, Richard, Reade, Richard, Genin, Robert, Novo, Robert, Fickl, Rocsana, Dufresne, Roger, Magnol, Roger, Issautier, Roland, Mortelette, Romain, Delaval, Ronan, Lohro, Ronan, M'barga, Roseline, Beau, S., Dupuis, Clémentine, Vidil, Marie Jacques, Hacini, Sabria, Dahmoune, Said, Lekhal, Saliha, Sakso, Salima Ahriz, Saksi, Salima, Citarda, Salvatore, Boubenider, Samir, Kassis, Samuel, Verhille, Sandra, Genestier, Sandrine, Muller, Sandrine, Krid, Saoussen, Richter, Sarah, Delbes, Sebastien, Mailliez, Sebastien, Veillon, Sebastien, Nony, Sébastien, Benarbia, Seddick, Beaudreuil, Severine, Benyaghla, Sidi Ali, Duquennoy, Simon, Baluta, Simona, Boncila, Simona, Mzoughi, Sonia, Ribal, Sonia, Acamer, Sophie, Chauvet, Sophie, Girerd, Sophie, Ozenne, Sophie, Parahy, Sophie, Duval, Sophie Rubens, Taque, Sophie, Menouer, Soraya, Chargui, Soumaya, Bataille, Stanislas, Barbier, Stephane, Billion, Stephane, Roueff, Stephane, Torner, Stephane, Martin, Stephane Jean, Coupel, Stephanie, Cloarec, Sylvie, Lavaud, Sylvie, Leou, Sylvie, Chatelet, T., Onesta, Tania, Benhabib, Tassadit, Bensalem, Tayeb, Dimulescu, Theodora, Sawadogo, Theophile, Hitze, Thibault Dolley, Baranger, Thierry, Boudemaghe, Thierry, Hannedouche, Thierry, Krummel, Thierry, Lobbedez, Thierry, Milcent, Thierry, Dervaux, Thomas, Guincestre, Thomas, Kofman, Thomas, Raphael, Thomas, Sadreux, Thomas, Ulinski, Tim, Roger, Tiphaine Guyon, Serrato, Tomas, Kofman, Tomek, Wong, Tony, Boubia, Toufik, Gbindoun, Ubald Assogba, Khuzaie, Usama, Caudwell, Valerie, Chatelet, Valerie, Crougneau, Valerie, De Precigout, Valerie, Drouillat, Valerie, Galantine, Valerie, Hugot, Valerie Granveau, Leroy, Valerie, Boubia, Veronique, Falque, Veronique, Fournier, Veronique, Queron, Veronique, Viviani, Veronique, Gueuttin, Victor, Panescu, Victor, Calonge, Victorio Menoyo, Nguyen, Viet, Allot, Vincent, Delattre, Vincent, Leduc, Vincent, Pradier, Vincent, Aglae, Violaine Emal, Badulescu, Viorica, Molina, Virginia, Besson, Virginie, Chaigne, Virginie, Jaber, Waddah, Boudi, Wael, El Haggan, Wael, Guillon, Wen Qin, Aneni, Wided Tabbi, Hanf, William, Kohn, Wladimir, Bellenfant, Xavier, Gaudry, Xavier Moreau, Delmas, Yahsou, Knefati, Yannick, Saingra, Yannick, Tirolien, Yannick, Mann, Youssef, Brunak, Yvan, Dimitrov, Yves, Doussy, Yves, Tanter, Yves, Benabid, Zaid, Soltani, Zaara, Boukerroucha, Zacharia, Takla, Zafer, Ramanantsialonina, Zana, Dickson, Zara, Tubail, Zead, Pour, Zoe Koochaki, Boukhalfa, Zohra, Jacquot, Zohra, Couchoud, Cécile, Bayer, Florian, Ayav, Carole, Béchade, Clémence, Chantrel, François, Galland, Roula, Hourmant, Maryvonne, and Mercadal, Lucile

Published
2020
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12. Predictors of three-month mortality among hospitalized older adults in Togo

Author

Fifonsi Adjidossi Gbeasor-Komlanvi, Martin Kouame Tchankoni, Akila Wimima Bakoubayi, Matthieu Yaovi Lokossou, Arnold Sadio, Wendpouiré Ida Carine Zida-Compaore, Mohaman Djibril, Mofou Belo, Amegnona Agbonon, and Didier Koumavi Ekouevi

Subjects
Ageing, Mortality, Hospital, Associated factors, Togo, Geriatrics, RC952-954.6
Abstract

Abstract Background Assessing hospital mortality and its predictors is important as some of these can be prevented through appropriate interventions. Few studies have reported hospital mortality data among older adults in sub-Saharan Africa. The objective of this study was to assess the mortality and associated factors among hospitalized older adults in Togo. Methods We conducted a prospective cohort study from February 2018 to September 2019 among patients ≥50 years admitted in medical and surgical services of six hospitals in Togo. Data were recorded during hospitalization and through telephone follow-up survey within 90 days after admission. The main outcome was all-cause mortality at 3 months. Survival curves were estimated using the Kaplan-Meier method and Cox regression analyses were performed to assess predictors of mortality. Results The median age of the 650 older adults included in the study period was 61 years, IQR: [55–70] and at least one comorbidity was identified in 59.7% of them. The all-cause mortality rate of 17.2% (95%CI: 14.4–20.4) and the majority of death (93.7%) occurred in hospital. Overall survival rate was 85.5 and 82.8% after 30 and 90 days of follow-up, respectively. Factors associated with 3-month mortality were the hospital level in the health pyramid, hospitalization service, length of stay, functional impairment, depression and malignant diseases. Conclusion Togolese health system needs to adjust its response to an aging population in order to provide the most effective care.

Published
2020
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13. Comparative Physicochemical Screening and Toxicology of Hydroethanol Extracts of the Parts of Pterocarpus santalinoides l’Hér. ex DC. (Fabaceae) in Wistar Rats

Author

Aimé Cézaire T. Ayéna, Kossivi Dosseh, Kokou Idoh, Amegnona Agbonon, and Messanvi Gbeassor

Subjects
Technology, Medicine, Science
Abstract

Aims. The aim of this study was to compare the phytochemical profile and acute and chronic toxicity of hydroethanolic extracts of three parts of P. santalinoides. Methods. Seven major chemical groups (alkaloids, flavonoids, saponosides, coumarins, tannins, triterpenes, and steroids) were studied. The single dose limit test of 5000 mg/kg body weight was used to evaluate the acute toxicity of each organic extract. Subacute toxicity was evaluated after daily oral doses of 500 and 1000 mg/kg body weight were administered to rats for 28 days. Results. At a single dose of 5000 mg/kg, none of the extracts (leaf, trunk bark, and root) caused death in experimental rats. However, the trunk bark extract of P. santalinoides induced coat change and lethargy in treated rats. Macroscopic observation of the internal organs (liver and kidneys) of the rats showed no abnormalities. In the subacute test, only the trunk extracts induced signs of toxicity such as mobility disorders, diarrhea, and loss of body weight at a dose of 1000 mg/kg. Conclusion. This study showed that the hydroethanol extracts of the leaves, trunk bark, and root bark of P. santalinoides divergently concentrated the main chemical groups of interest. Administration of a single dose of extracts from all three P. santalinoides is not toxic to the consumer. However, when used over a long period of time, they can have a harmful effect on the consumer. In view of the different results of the trunk bark extract and in a context of conservation of the species, we recommend the use of the hydroethanolic extract of the leaves in the different treatments in which the three organs are involved.

Published
2022
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14. African swine fever in Benin and prevalence of the disease in Southern Benin: A retrospective study (20142018)

Author

Okri Frejus Hans Ohouko, Koffi Koudouvo, Tossou Jacques Dougnon, Amegnona Agbonon, Issaka Youssao Abdou Karim, Souaïbou Farougou, and Messanvi Gbeassor

Subjects
african swine fever, incidence, risk factors, prevalence, benin, Veterinary medicine, SF600-1100
Abstract

Objective: This study aimed to assess the prevalence and risk factors of African swine fever (ASF) disease in Benin. Materials and methods: A retrospective study was conducted on 70 pig farms from the Departement of Atlantique and Oueme and also by using the data available from the Directorate of Livestock on the spread of ASF in Benin from 2014 to 2018. The prevalence of ASF was assessed with 106 nasal swabs from apparently healthy domestic pigs and 15 organ samples from dead ASF-suspected pigs. ASF virus detection was carried out by conventional polymerase chain reac¬tion using Qiagen Kit for DNA extraction. Data recorded were processed with SAS software (2006). Results: It appears that ASF is an endemic disease in Benin with the Department of Oueme as the hotspot of dissemination of the virus in the country. The losses due to ASF recorded from 2014 to 2018 are evaluated to 884,850,000 CFA Franc by estimating the average cost of a pig at 25,000 FCFA. A prevalence of 1.89% (CI at 95%, 0.713.49) was recorded for live animals with a positive result in organs from all dead pigs suspected of ASF. Breeding practices related to the sharing of breeding males, scavenging pigs, and non-compliance with biosecurity measures were the risk factors identified. Conclusion: The present study sheds light on the areas prone to the ASF virus in Benin. Moreover, the cross-sectional data recorded on the prevalence of ASF will help to better rule on the spread of the disease. It would be interesting for the Beninese Republic to increase its efforts for ASF control. [J Adv Vet Anim Res 2020; 7(3.000): 464-470]

Published
2020
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18. Cryptococcal Meningitis in Kidney Transplant Recipients: A Two-Decade Cohort Study in France

Author

Laurène Tardieu, Gillian Divard, Olivier Lortholary, Anne Scemla, Éric Rondeau, Isabelle Accoceberry, Rémi Agbonon, Alexandre Alanio, Adela Angoulvant, Laetitia Albano, Philippe Attias, Anne Pauline Bellanger, Dominique Bertrand, Julie Bonhomme, Françoise Botterel, Nicolas Bouvier, Matthias Buchler, Taieb Chouaki, Thomas Crépin, Marie-Fleur Durieux, Guillaume Desoubeaux, Gary Doppelt, Loïc Favennec, Arnaud Fekkar, Ophélie Fourdinier, Marie Frimat, Jean-Pierre Gangneux, Claire Garandeau, Lilia Hasseine, Christophe Hennequin, Xavier Iriart, Nassim Kamar, Hannah Kaminski, Raphael Kormann, Laurence Lachaud, Christophe Legendre, Moglie Le Quintrec Donnette, Jordan Leroy, Charlène Levi, Marie Machouart, David Marx, Jean Menotti, Valérie Moal, Florent Morio, Natacha Mrozek, Muriel Nicolas, Philippe Poirier, Marie-Noelle Peraldi, Benjamin Poussot, Stéphane Ranque, Jean-Philippe Rerolle, Boualem Sendid, Renaud Snanoudj, Jérôme Tourret, Marc Vasse, Cécile Vigneau, Odile Villard, Laurent Mesnard, Fanny Lanternier, and Cédric Rafat

Subjects
cryptococcosis, opportunistic infection, transplant associated diseases, renal transplantation, cryptococcal meningitis, graft outcome, Medicine
Abstract

Cryptococcosis is the third most common cause of invasive fungal infection in solid organ transplant recipients and cryptococcal meningitis (CM) its main clinical presentation. CM outcomes, as well as its clinical features and radiological characteristics, have not yet been considered on a large scale in the context of kidney transplantation (KT). We performed a nationwide retrospective study of adult patients diagnosed with cryptococcosis after KT between 2002 and 2020 across 30 clinical centers in France. We sought to describe overall and graft survival based on whether KT patients with cryptococcosis developed CM or not. Clinical indicators of CNS involvement and brain radiological characteristics were assessed. Eighty-eight cases of cryptococcosis were diagnosed during the study period, with 61 (69.3%) cases of CM. Mortality was high (32.8%) at 12 months (M12) but not significantly different whether or not patients presented with CM. Baseline hyponatremia and at least one neurological symptom were independently associated with CM (p < 0.001). Positive serum cryptococcal antigen at diagnosis was also significantly associated with CM (p < 0.001). On magnetic resonance imaging (MRI), three patterns of brain injury were identified: parenchymal, meningeal, and vascular lesions. Although CM does not affect graft function directly, it entails a grim prognosis.

Published
2022
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19. Effect of Hydromethanolic Extract of Stem Bark of Lannea kerstingii on Anemia and Hepcidin Production

Author

Amegnona Agbonon, Komlatsè Togbenou, Messanh Délagnon Irénée Kueviakoé, and Hèzouwè Magnang

Subjects
General Engineering
Abstract

Introduction: Stem bark of Lannea kerstingii is used in Togo for its anti-anemic effect. The aim of this study was to verify the efficacy of extracts of L. kerstingii’s bark in the treatment of anemia and to explore its mechanism of action. Materials and Method: L. kerstingii stem bark was collected in the city of Kpalimé, located at 120 km northwest of Lomé. Hydromethanolic extract was obtained by evaporation. Two protocols were carried out and 20 twelve-week-old rats that had an average weight of 175.17±16.8 grams were used. The first protocol consisted of inducing anemia in rats by intraperitoneal injection of phenylhydrazine, then force-feeding them with L. kerstingii extract and measuring the effect of this extract on their hemoglobin levels. The second protocol investigated the effect of the extract on the serum hepcidin level, after oral administration of carbon tetrachloride to rats. Hepcidin levels were measured by the ELISA technique. Results: L. kerstingii stem bark extract significantly corrected the anemia induced by phenylhydrazine use: in fact, the anemia of rats that received L. kerstingii extracts was corrected. Control rats that received folic acid had a correction of their anemia too. But, rats that received only saline remained anemic. However, no correlation between the level of extract consumption and the level of hepcidin was established. Conclusion: L. kerstingii bark hydroethanolic extracts increase hemoglobin levels in anemic rats. The main challenge that needs to be solved is determining the minimum dose to be consumed to ensure its effectiveness. Keywords: Lannea kerstingii, anemia, hepcidin, wistar rat.

Published
2023

21. Antidiarrheal Activity of Dialium guineense Willd Fruit Pulp in Wistar Rats

Author

Tcharé Assiki, Aboudoulatif Diallo, Essotolom Badjabaïssi, Mindédé Assih, Tchazou Kpatcha, Kokou Idoh, Kossivi Dosseh, and Amegnona Agbonon

Subjects
Article Subject, General Immunology and Microbiology, General Medicine, General Biochemistry, Genetics and Molecular Biology
Abstract

Objective. This study is aimed at evaluating the effects of Dialium guineense Willd fruit pulp powder on diarrhea induced by castor oil in Wistar rats. Materials and Methods. Three different tests were carried out. A preventive test by administration of a single dose of 250, 500, 1000, 2000, and 4000 mg/kg before the induction of diarrhea by castor oil. Another preventive test after repeated administration of Dialium guineense at 250, 500, and 1000 mg/kg/day for 8 days, before the induction of diarrhea, was done. The third test was a curative test with a single dose of 250, 500, 1000, and 2000 mg/kg after the induction of diarrhea by castor oil. Results. D. guineense fruit pulp at 1000, 2000, and 4000 mg/kg administered before the induction of diarrhea, has significantly delayed diarrhea; reduced the frequency of defecation, reduced the amount of diarrheal stools, and also reduced the purging index, with a degree of inhibition comparable to that of loperamide. But the water content of the stools of the group treated with D. guineense does not change significantly compared to the controls. D. guineense has reduced significantly from 500 mg/kg the diarrhea induced by castor oil after 8 days of treatment. It appears that the doses of 250 and 500 mg/kg, which were not effective with the single-dose preventive test, significantly delayed diarrhea; reduces the frequency of diarrheal stools and also reduces the purging index. D. guineense administered, after the induction of diarrhea, by castor oil has significantly reduced the diarrhea from 250 mg/kg. Conclusion. The fruit pulp of D. guineense has showed antidiarrheal activities in Wistar rats by reducing the frequency of defecation, the amount of diarrheal fecal matter emitted as well as the water content. It also delayed the onset of diarrhea and significantly reduced the purging index like loperamide.

Published
2022

22. Prevalence and factors associated with poor self-rated health among communitydwelling older adults in Lomé (Togo) in 2019

Author

Fifonsi A. Gbeasor-Komlanvi, Martin K. Tchankoni, Ama B. Adjonko, Wendpouire I.C. Zida-Compaore, Nicolas K. Kouakou, Mofou Belo, Amegnona Agbonon, and Didier K. Ekouevi

Subjects
ageing, self-rated health, associated factors, togo, Public aspects of medicine, RA1-1270
Abstract

The number of older adults is increasing worldwide, including in sub-Saharan Africa (SSA). However, there is a paucity of data on the overall health status of older adults living in SSA. To assess the prevalence and factors associated with poor Self-Rated Health (SRH) among community-dwelling older adults in Lomé, Togo, we conducted a cross-sectional study from January to June 2019 in Lomé among community-dwelling older adults aged 50 years and older. A 30- minute questionnaire was used to collect socio-demographic characteristics, medical history, patterns of medication use and use of herbal products and dietary supplements during a face-to-face interview. SRH was assessed using a single item: Overall, you would say that your health is… (1) excellent, (2) very good, (3) good, (4) fair and (5) poor with response fair or poor defining poor SRH. A total of 344 respondents with median age 63 years, (IQR: 55-72) were enrolled in the study. Women represented 57.6% of the sample. Overall prevalence of poor SRH was 56.4% (95%CI: 51.0-61.9) and was the highest among females (62.6% vs 47.9%; P=0.007) and participants 60 years (61.5% vs 51.1%; P=0.021). Female sex, aged ≥60 years, osteoarthritis, hospitalization within the 12 months preceding the survey, polypharmacy, and the use of herbal products were factors associated with poor SRH (P0.05). More than half of community- dwelling older adults had poor SRH in Lomé. Further studies are needed to guide policymakers in their efforts to design and implement meaningful policies to improve older adults health conditions.

Published
2020
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23. Chemical composition and antioxidant activities of different parts of Ficus sur

Author

Kossivi Issa Saloufou, Pakoupati Boyode, Oudjaniyobi Simalou, Kodjo Eloh, Kokou Idoh, Mamatchi Melila, Outéndé Toundou, Kafui Kpegba, and Amegnona Agbonon

Subjects
Ficus sur, Antioxidant, Phenolic compounds, Flavonoids, HPLC-QTOF-HRMS, Medicine (General), R5-920, Therapeutics. Pharmacology, RM1-950
Abstract

Introduction: Ficus sur is a plant widely used in traditional pharmacopoeia in Togo. So, this study aimed the assessment of antioxidant properties and identification of some compounds from the ethanolic extracts of different parts of the plant (leaves, fruits, roots, and barks). Methods: The phenolic and flavonoid contents of the ethanolic extracts of different organs of Ficus sur were assessed using conventional known methods. The DPPH radical scavenging and the ferric-reducing antioxidant power (FRAP) assays were used to highlight the antioxidant activities. The different extract samples were also analysed by liquid chromatography coupled to a quadrupole-time of flight mass detector (ESI-QTOF). Results: Total phenolic contents (TPCs) for 1 mg of dry extract ranged from 489.40 ± 7.48 μg GAE (gallic acid equivalents) for the bark to 62.34 ± 2.66 μg GAE for unripe fruits. The bark exhibited the highest flavonoid content, which was closed to 90.20 ± 3.72 μg QE (quercetin equivalents)/mg of dry extract. The radical scavenging activities of the bark and unripe fruits were 56.50 ± 0.29 and 7.3 ± 0.30 μg QE/mg of dry extract, respectively. In the same order, the FRAP values of the two organs were 104.57 ± 4.75 and 19.61 ± 0.22 μmol FeSO4 Eq/mg of dry extract. Many compounds including notoginsenoside R10; 4’,5,7-trihydroxyflavan-3-ol; catechin; and boviquinone 4 were identified. Conclusion: The various organs of Ficus sur are a source of bioactive compounds especially phenolic compounds and flavonoids with antioxidant activity.

Published
2018
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24. A significant antihypertensive effect of Holarrhena floribunda supported by an exploratory phytochemical study

Author

Kafui Kpegba, Etonam Tété Kondo, Oudjaniyobi Simalou, Komlatsè Togbenou, Pakoupati Boyode, Outéndé Toundou, Nagba Yendoubé Gbandjaba, Amegnona Agbonon, and Messanvi Gbeassor

Subjects
Holarrhena floribunda, Phytochemical screening, Antioxidant activity, Antihypertensive activity, Medicine (General), R5-920, Therapeutics. Pharmacology, RM1-950
Abstract

Introduction: Holarrhena floribunda (G.Don) T.Durand & Schinz is a tree that can grow up to 25 m with white latex in its organs. The bark of this plant is commonly used in traditional medicine to treat dysentery, diarrhea, diabetes, malaria, and high blood pressure. In this study, phytochemical groups were widely investigated on trunk bark as well as on leaves of H. floribunda harvested in Danyi (Togo). Antioxidant activity and antihypertensive properties of the plant extracts were also evaluated on sound guinea pigs. Methods: The hydro-ethanolic extract of the trunk bark was prepared and antioxidant activity was evaluated via the DPPH radical-scavenging and the ferric-reducing antioxidant power (FRAP) methods, and via the determination of the total phenolics content. This hydro-ethanolic extract was used to assess the plant extract effect on blood pressure of sound guinea pigs. Results: So, phytochemical screening revealed that H. floribunda contained most of the phytochemical groups. The 50% inhibitive concentration of that extract by DPPH was 29.80 ± 0.001 μg/mL. The equivalent of Fe2+ by FRAP was 1009.9 ± 0.6 μmol/g of dry extract. The content of phenolic compounds was 139 ± 0.053 mg GAE (gallic acid equivalents)/g of dry extract. Intravenous injection of the extract (10, 20, 40, 80 mg/kg) via the invasive method in guinea pigs under normal strain caused a decrease in diastolic blood pressure, systolic blood pressure, and so in mean arterial pressure (MAP) by dose cumulative and time-dependent. Conclusion: The results show that hydro-ethanolic extract of H. floribunda trunk bark has antihypertensive and antioxidant properties. This might be the reason for the use of that extract for the treatment of hypertension in traditional medicine.

Published
2018
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25. Hepatoprotective Effects of Vernonia amygdalina (Astereaceae) Extract on CCl4-Induced Liver Injury in Broiler Chickens

Author

Bemela Mawulom Tokofai, Kokou Idoh, Oyegunle Emmanuel Oke, and Amegnona Agbonon

Subjects
Vernonia amygdalina, CCl4, oxidative stress, hepatoprotection, broilers, Veterinary medicine, SF600-1100, Zoology, QL1-991
Abstract

The aim of this study was to evaluate the effect of Vernonia amygdalina leaf extract (VALE) on the carbon tetrachloride-induced hepatotoxicity (CCl4) in broiler chickens. A total of 360-day-old broilers were divided into 4 treatments of 90 birds each consisting of 6 replicates of 15 birds each. The treatments were birds offered 1 mL/kg BW saline (control group), 100 mg/kg BW VALE, 1 mL/kg BW CCl4 (CCl4-treated group), and 100 mg/kg BW VALE + 1 mL/kg BW CCl4 (VALE + CCl4 group). Blood samples were collected at 42 days of age and analyzed for the liver enzymes: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and selected biochemical parameters. The experiment was laid out in a completely randomized design. The results obtained showed that VALE had the potential to mitigate the adverse effects of CCl4 on protein and lipid metabolism as reflected in the low serum malondialdehyde (MDA) levels, which is a marker of lipid peroxidation. The aqueous extract of Vernonia amygdalina (VA) at a dose of 100 mg/kg body weight showed a moderate hepatoprotective effect by reducing serum AST levels (p < 0.05). The levels of serum AST, ALP, ALT, and GGT were significantly increased in CCl4-treated birds compared to the control group, reflecting carbon tetrachloride-induced liver damage. The VALE + CCl4 group showed a significantly higher amount of ALP compared to birds treated with carbon tetrachloride, suggesting a hepatoprotective effect. To conclude, Vernonia amygdalina aqueous extract can be used to confer protection against hepatotoxicity, which can induce severe hepatocellular damage in birds.

Published
2021
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27. Evaluation of the performance of advantage P.f. malaria Card® and advantage malaria Pan + Pf Card®, two rapid diagnostic tests for parasitological confirmation of malaria cases in field situation in Togo.

Author

Teou, Diwaba Carmel, Dorkenoo, Ameyo Monique, Ataba, Essoham, Alidou, Smaila, Yakpa, Kossi, Abdou-Kerim, Agueregna, Maman, Issaka, and Agbonon, Amegnona

Subjects
RAPID diagnostic tests, MALARIA, INSECTICIDE resistance, RECEIVER operating characteristic curves
Abstract

Background: In Togo, malaria remains a major public health problem, and the management of suspected cases requires confirmation with appropriate biological methods. Malaria diagnosis has been improved by the introduction of rapid diagnostic tests (RDTs), recommended by the World Health Organization (WHO) for areas where microscopy is not available. To be used, these RDTs must meet performance criteria defined by the WHO. This study was conducted to evaluate the diagnostic performance of two RDTs: Advantage P.f. Malaria Card® detecting HRP2 antigen and Advantage Malaria Pan + Pf Card® detecting both HRP2 and pLDH antigens. Methods: This was a cross-sectional analytical study conducted from December 2019 to February 2020 on malaria-suspected cases received in three sentinel sites in Togo and from whom capillary blood was collected to perform the two RDTs according to the manufacturer's instructions. Sensitivity and specificity were estimated by comparing to thick/thin blood smear, the gold standard, and to PCR, which is a more sensitive. Results: A total of 390 participants (54.9% female) with a median age of 18 (± 0.8) years were included in the study. The sensitivity of both Advantage P.f. Malaria Card® and Advantage Malaria Pan + Pf Card® compared to thick/thin blood smear was 91.8% and 91.3%, respectively, and for both the specificity was 94.7%. Compared to PCR, the sensitivity was 84.2% and 83.8%, respectively, and the specificity 96.5%. Conclusions: The performances of the Advantage P.f. Malaria Card® and Advantage Malaria PAN + Pf Card® compared to microscopy, considered the gold standard, were acceptable under the field conditions found in Togo. They can therefore be used for the biological diagnosis of malaria. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Prevalence of Viral Hepatitis B among Women of Childbearing Age in the Kara Region of Togo in 2022

Author

Gnatou, Gatibe Yendu-Suglpak, primary, Diallo, Fatoumata Binta Tidiane, additional, Gbeasor-Komlanvi, Fifonsi Adjidossi, additional, Agoro, Sibabe, additional, Sadio, Arnold Junior, additional, Adoli, Latame Komla, additional, Zida-Compaore, Wendpouire Ida Carine, additional, Konu, Yao Rodion, additional, Tchankoni, Martin Kouame, additional, Agbonon, Amegnona, additional, and Ekouevi, Didier Koumavi, additional

Published
2023
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33. Aqueous Leaf Extract of &lt;i&gt;Moringa oleifera&lt;/i&gt; (Moringaceae) Effectively Treats Induced Hemolytic Anemia in Wistar Rats

Author

Médard, Semado Franck, primary, Pascal, Tchogou Atchadé, additional, Espérance, Medoatinsa Seinde, additional, Félicienne, Agbogba, additional, Yollande, Abissi, additional, Roxane, Kassa, additional, Ezéchiel, Lokonon Jacques, additional, Alban, Houngbeme, additional, Amegnon, Agbonon, additional, Djimon, Gbénou Joachim, additional, Lamine, Baba-Moussa, additional, and Maximin, Senou, additional

Published
2023
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34. Evolution de la condition physique liee a la sante chez les etudiants de premiere annee de l’institut national de la jeunesse et des sports de l’universite de Lome(Togo) : Physical fitness profil related to health evolution in first year students of from national institute of youth and sports of the university of Lome (Togo)

Author

Dosseh, K., Onodje, O., Amah, E., Sedjro, K.G.G, Guinhouya, B.C., and Agbonon , A.

Subjects
physical fitness, health, students, STAPS, sport, Lome (Togo), condition physique, santé, étudiants, STAPS, sport, Lomé (Togo)
Abstract

La condition physique est un déterminant important de la santé tout au long de la vie. Elle peut être fortement influencée par les facteurs environnementaux. C’est dans cette perspective que la présente étude vise à évaluer l’évolution du niveau de la condition physique chez les étudiants des sciences et techniques des activités physiques et sportives de l’Institut National de la Jeunesse et des Sports de l’Université de Lomé après quatre mois d’activités physiques et sportives. Au total, trente-sept étudiants volontaires des deux sexes ont participé à l’étude. Ils ont effectué les tests de Vameval, de souplesse et de détente verticale (Sargent test), trois fois successives avec deux mois d’intervalle. Les résultats de l’étude montrent que la pratique physique des étudiants n’a pas d’influence sur leur indice de masse corporelle (P > 0,05) quel que soit le sexe mais elle a significativement réduit leur masse grasse (P < 0,05). Il a été globalement observé une amélioration de l’aptitude aérobie (P < 0,001) les quatre premiers mois d’activités physiques et sportives chez les deux sexes ainsi que la souplesse chez les étudiantes (P < 0,001). Par contre, il n’y a pas eu de changement au niveau de la force (P > 0,05) et de la puissance musculaire (P > 0,05) de leurs membres inférieurs. Ces résultats suggèrent la nécessité de mettre en place des programmes d’intervention et d’amélioration de tous les aspects de la condition physique chez les étudiants afin de leur garantir un meilleur état de santé. Physical fitness is an important determinant of health throughout life. It can be influenced by environmental factors. The aim of this study was to assess the evolution of physical condition level in students enrolled at physical activities and sports sciences and technology of the National Institute of Youth and Sports of university of Lome after four months of physical and sport activities. A total of thirty-seven first-year volunteer students of both sexes participated in the experiment. They performed the Vam-Eval test, flexibility test and Sargent test, three times in succession with two month intervals. Results of the study show that the physical practice of students did not affect their body mass index (P > 0.05) regardless of gender but significantly decreased students’ total body fat (P < 0.05). Result also increased aerobic performance (P < 0.001) in the first four months of physical activities and sports as well as in flexibility (P < 0.001) in female students. However, there was no change in the strength (P > 0.05) and muscle power (P > 0.05) of their lower limbs. These results suggest the need for intervention and improvement programmes in all aspects of student fitness to ensure better health.

Published
2023

39. Estimation of yellow fever incidence in Togo between 2010 and 2020

Author

Zida-Compaore, Wendpouiré Ida Carine, primary, Gbeasor-Komlanvi, Fifonsi Adjidossi, additional, Tchankoni, Martin Kouame, additional, Halatoko, Wemboo Afiwa, additional, Sadio, Arnold Junior, additional, Konu, Yao Rodion, additional, Gnatou, Gatibe Yendu-Suglpak, additional, Koba, Adjaho Komla, additional, Agbonon, Amegnona, additional, and Ekouevi, Didier Koumavi, additional

Published
2022
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42. Evaluation of the performance of 'Advantage P.f. Malaria Card® ' and ' Advantage Malaria Pan+Pf Card® ' two rapid diagnostic tests for biological confirmation of malaria cases in field situation in Togo

Author

Diwaba Carmel TEOU, Ameyo Monique DORKENOO, Essoham ATABA, Kossi YAKPA, Agueregna ABDOU-KERIM, Issaka MAMAN, and Amegnona AGBONON

Abstract

Background In Togo, malaria remains a major public health problem and the management of suspected cases requires confirmation with appropriate biological methods. Indeed, malaria diagnosis has been improved through the introduction of rapid diagnostic tests (RDTs), recommended by the World Health Organization (WHO) for areas where microscopy is not available. To be used, these RDTs must meet performance criteria defined by the WHO. This study was conducted to evaluate the diagnostic performance of two RDTs: Advantage P.f. Malaria Card® detecting HRP2 antigen and Advantage Malaria Pan + Pf Card® detecting both HRP2 and pLDH antigens. Methods This was a cross sectional analytical study conducted from December 2019 to February 2020 on malaria suspected cases seen in three sentinel sites in Togo and from whom capillary blood was collected to perform the two RDTs according to the procedures described by the manufacturer. The performance was estimated comparing to thick/thin blood smear and molecular biology (PCR), considered as gold standard. Results The sensitivity of both Advantage P.f. Malaria Card® and Advantage Malaria Pan + Pf Card® compared to thick /thin blood smear was 91.8% and 91.3% respectively and for both the specificity was 94.7%. Compared to PCR, the sensitivity decreased to 89.4% and 88.9% respectively and their specificity to 72.2%. Conclusion The performance of the Advantage P.f. Malaria Card® and Advantage Malaria PAN + Pf Card® compared to microscopy, considered as the gold standard, according to WHO criteria were acceptable. They can therefore be used for the biological diagnosis of malaria.

Published
2022

44. Corrigendum: Étude ethnobotanique des plantes utilisées dans le traitement du diabète dans la médecine traditionnelle de la région Maritime du Togo

Author

Holaly Efui Gbekley, Damintoti Simplice Karou, Charlemagne Gnoula, Kodjovi, Agbodeka Kokou Anani, Tchadjobo Tchacondo, Amegnona Agbonon, Komlan Batawila, and Jacques Simpore

Subjects
corrigendum, diabète, ethnopharmacologie, plantes médicinales, phytomédicaments, togo, Medicine
Abstract

Ce Corrigendum modifie l�article original � Étude ethnobotanique des plantes utilisées dans le traitement du diabète dans la médecine traditionnelle de la région Maritime du Togo �. The Pan African Medical Journal. 2015;20:437. doi:10.11604/pamj.2015.20.437.5660.

Published
2018
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46. Effects of Rourea coccinea ethanolic root extract on ovalbumin-induced allergic asthma in rats

Author

null Kossivi DOSSEH, null Kokou IDOH, null Wilfrid Kpèdétin Dieudonné AGBODJOGBE, and null Amegnona AGBONON

Subjects
Rourea coccinea, Ovalbumin, Asthma, TNF-Α, Inflammatory Cells, Histamine, General Medicine
Abstract

Rourea coccinea (syn. Byrsocarpus coccineus)Schum. and Thonn. (Connaraceae) is a medicinal plant that is being used for the treatment of various disorders in Tropical Africa. Previously, we reported anti-inflammatory and antioxidant effects of ethanolic extract ofR. coccinearoot bark (EERc). The present study aimed to test protective potential effects of EERc treatments against ovalbumin-induced airway lung inflammatory and to investigate some of its possible underlying mechanism on allergic asthma. Rats were sensitized and challenged with ovalbumin (OVA), and were orally treated daily with EERc at 200, 400 and 800 mg/kg from day 24 to day 27 post sensitization. The number of total and differential inflammatory cells, leakage of Evans blue dye tracer, histamine and TNF-α level in bronchoalveolar lavage (BAL) fluid were measured. OVA instillation induced airway lung inflammation, which was significantly suppressed by pre-treatment with EERc. Analysis of bronchoalveolar lavage (BAL) revealed that EERc pre-treatment significantly inhibited leukocytosis and reduced Evans blue dye content in the BAL fluid. EERc also significantly decreased the production and release of histamine and TNF-α. Our study shows that EERc possesses significant anti-allergic activity which might be attributed to reduction of histamine, TNF-α in the BAL fluid.

Published
2022
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49. Diuretic effects and subacute toxicity of Trema orientalis Linn leave extract in wistar rats.

Author

Kpoti, Tokou Labite, Komlatsè, Togbenou, Kossivi, Dosseh, Kokou, Idoh, Tchazou, Kpatcha, and Amégnona, Agbonon

Subjects
LABORATORY rats, LEUKOCYTE count, DIURETICS, PRECIPITATION (Chemistry), FUROSEMIDE
Abstract

Trema Orientalis is a medicinal plant used in the treatment of cardiovascular diseases including hypertension. The present study was undertaken to investigate phytochemical compounds, diuretic activity and subacute toxicity of the hydromethanolic leaf extracts of Trema orientalis. Phytochemical analysis carried out through color and precipitation reactions revealed the presence of many metabolites. The measurement of diuretic activity carried out by saline overload with 0.9% NaCl at a dose of 50 mL/kg in wistar rats showed that the hydromethanolic extract of Trema orientalis leaves had diuretic activity at a dose of 200 mg/kg of body weight. However, this diuretic activity was relatively low compared to the action of the reference molecule, furosemide. The study of the subacute toxicity of the extract took place over 28 days. No significant difference was recorded in the body weights during the 28 days of the study. Likewise, the weight of the organs collected after sacrifice of the rats and their macroscopic aspects did not show any significant difference with those of the control group. The extract increased the count of white and red blood cells as wells as platelets, practically at the two doses used and caused a decrease in ALT at the dose of 500 mg/kg. The extract could have a beneficial effect like a boosting immunity and would not present any toxicity at these doses. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Knowledge and Practices of Female Students at University of Kara Regarding Sexually Transmitted Infections in Togo, 2021

Author

Gatibe Yendu-Suglpak Gnatou, Fifonsi Adjidossi Gbeasor-Komlanvi, Arnold Junior Sadio, Yao Rodion Konu, Martin Kouame Tchankoni, Wendpouiré Ida Carine Zida-Compaore, Amegnona Agbonon, and Didier Koumavi Ekouevi

Subjects
Community and Home Care, Health (social science), Public Health, Environmental and Occupational Health
Abstract

Background: A good knowledge of sexually transmitted infections (STI) in female students is an important element in the prevention of STI transmission. Objective: Describe the level of knowledge and practices on STI among female students at the University of Kara. Methods: A cross-sectional study was conducted at the University of Kara from July to September 2021. Data were collected using a standard, digitalised, self-administered questionnaire. Logistic regression analysis was used to describe factors associated with the level of knowledge of STIs. Results: A total of 1,055 female students with a median age of 21 years (interquartile range: 20-24) participated in the study. More than one-third (33.7%) of the students had good knowledge of STI. Having already been tested for HIV (aOR = 3.25; 95% CI [2.36-4.52]), having already had sex (aOR = 1.56; 95% CI [1.10-2.24]) and the level of education (AOR = 3.46; 95% CI [2.10-5.85]) were significantly associated with good STIs knowledge. Among the 723 female students (68.5%) who already had sex, 32.5% reported an inconsistent use of condoms during sexual intercourse and 18.9% reported having multiple sexual partners. Conclusion: The results of this study highlight the importance of intensifying STIs prevention efforts (awareness, screening, and vaccination) among female students at the University of Kara.

Published
2022

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