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21 results on '"Agatsuma, Nobukazu"'

2. THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer

Author

Omatsu, Mayuki, Nakanishi, Yuki, Iwane, Kosuke, Aoyama, Naoki, Duran, Angeles, Muta, Yu, Martinez-Ordoñez, Anxo, Han, Qixiu, Agatsuma, Nobukazu, Mizukoshi, Kenta, Kawai, Munenori, Yamakawa, Go, Namikawa, Mio, Hamada, Kensuke, Fukunaga, Yuichi, Utsumi, Takahiro, Sono, Makoto, Masuda, Tomonori, Hata, Akitaka, Araki, Osamu, Nagao, Munemasa, Yoshikawa, Takaaki, Ogawa, Satoshi, Hiramatsu, Yukiko, Tsuda, Motoyuki, Maruno, Takahisa, Kogame, Toshiaki, Kasashima, Hiroaki, Kakiuchi, Nobuyuki, Nakagawa, Masahiro M., Kawada, Kenji, Yashiro, Masakazu, Maeda, Kiyoshi, Saito, Yasuyuki, Matozaki, Takashi, Fukuda, Akihisa, Kabashima, Kenji, Obama, Kazutaka, Ogawa, Seishi, Sheibani, Nader, Diaz-Meco, Maria T., Moscat, Jorge, and Seno, Hiroshi

Published
2023
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4. Nonrecurrence Rate of Underwater EMR for ≤20-mm Nonampullary Duodenal Adenomas: A Multicenter Prospective Study (D-UEMR Study)

Author

Kanzaki, Hiromitsu, Inoue, Shuntaro, Miyake, Muneaki, Ohmori, Masayasu, Takeuchi, Yoji, Tani, Yasuhiro, Harada, Nobuyuki, Agatsuma, Nobukazu, Okada, Keijirou, Ikenouchi, Maiko, Nakatani, Yasuki, Uenoyama, Yoshito, Yamashita, Yukitaka, Ishikawa, Shigenao, Inaba, Tomoki, Miyahara, Koji, Moritou, Yuki, Nakagawa, Masahiro, Kitae, Hiroaki, Ishida, Tsugitaka, Naito, Yuji, Nishio, Akiyoshi, Shimatani, Masaaki, Kato, Ryo, Taki, Shinya, Mandai, Koichiro, Sanada, Kasumi, Nakase, Kojiro, Nebiki, Hiroko, Saito, Shunsuke, Wakatsuki, Toshiyuki, Nishimura, Naoyuki, Yamasaki, Yasushi, Uedo, Noriya, Akamatsu, Takuji, Kagawa, Tomo, Higashi, Reiji, Dohi, Osamu, Furukawa, Masanori, Takahashi, Yu, Inoue, Takuya, Tanaka, Shouichi, Takenaka, Ryuta, Iguchi, Mikitaka, Kawamura, Takuji, Tsuzuki, Takao, Yamasaki, Tomoaki, Yamashina, Takeshi, Nasu, Junichiro, Mannami, Tomohiko, Yamauchi, Atsushi, Matsueda, Kazuhiro, Aizawa, Shigeyuki, Mitsuhashi, Toshiharu, and Okada, Hiroyuki

Published
2022
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5. Stage at diagnosis of colorectal cancer through diagnostic route: Who should be screened?

Author

Agatsuma, Nobukazu, primary, Utsumi, Takahiro, additional, Nishikawa, Yoshitaka, additional, Horimatsu, Takahiro, additional, Seta, Takeshi, additional, Yamashita, Yukitaka, additional, Tanaka, Yukari, additional, Inoue, Takahiro, additional, Nakanishi, Yuki, additional, Shimizu, Takahiro, additional, Ohno, Mikako, additional, Fukushima, Akane, additional, Nakayama, Takeo, additional, and Seno, Hiroshi, additional

Published
2024
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6. Stage at diagnosis of colorectal cancer through diagnostic route: Who should be screened?

Author

10963332, 60878362, 40511829, 40838679, 70217933, 90335266, Agatsuma, Nobukazu, Utsumi, Takahiro, Nishikawa, Yoshitaka, Horimatsu, Takahiro, Seta, Takeshi, Yamashita, Yukitaka, Tanaka, Yukari, Inoue, Takahiro, Nakanishi, Yuki, Shimizu, Takahiro, Ohno, Mikako, Fukushima, Akane, Nakayama, Takeo, Seno, Hiroshi, 10963332, 60878362, 40511829, 40838679, 70217933, 90335266, Agatsuma, Nobukazu, Utsumi, Takahiro, Nishikawa, Yoshitaka, Horimatsu, Takahiro, Seta, Takeshi, Yamashita, Yukitaka, Tanaka, Yukari, Inoue, Takahiro, Nakanishi, Yuki, Shimizu, Takahiro, Ohno, Mikako, Fukushima, Akane, Nakayama, Takeo, and Seno, Hiroshi

Abstract

Background: Colorectal cancer (CRC) is a global health concern, with advanced-stage diagnoses contributing to poor prognoses. The efficacy of CRC screening has been well-established; nevertheless, a significant proportion of patients remain unscreened, with > 70% of cases diagnosed outside screening. Although identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources, the association between the diagnostic routes and identification of these subgroups has been less appreciated. In the Japanese cancer registry, the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related symptoms. Aim: To clarify the stage at CRC diagnosis based on diagnostic routes. Methods: We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two hospitals. The diagnostic routes were primarily classified into three groups: Cancer screening, follow-up, and symptomatic. The early-stage was defined as Stages 0 or I. Multivariate and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups, referencing the follow-up group. The adjusted covariates were age, sex, and tumor location. Results: Of the 2083 patients, 715 (34.4%), 1064 (51.1%), and 304 (14.6%) belonged to the follow-up, symptomatic, and cancer screening groups, respectively. Among the 2083 patients, CRCs diagnosed at an early stage were 57.3% (410 of 715), 23.9% (254 of 1064), and 59.5% (181 of 304) in the follow-up, symptomatic, and cancer screening groups, respectively. The symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group [P < 0.001, adjusted odds ratio (aOR), 0.23; 95% confidence interval (95%CI): 0.19-0.29]. The likelihood of diagnosis at an early

Published
2024

8. Medical care costs according to the stage and subtype of breast cancer in a municipal setting: a case study of Hachioji City, Japan

Author

Nishikawa, Yoshitaka, primary, Agatsuma, Nobukazu, additional, Utsumi, Takahiro, additional, Funakoshi, Taro, additional, Mori, Yukiko, additional, Nakamura, Yuki, additional, Hoshino, Nobuaki, additional, Horimatsu, Takahiro, additional, Saito, Takumi, additional, Kashihara, Soichiro, additional, Fukuyoshi, Jun, additional, Goto, Rei, additional, Toi, Masakazu, additional, Takahashi, Yoshimitsu, additional, and Nakayama, Takeo, additional

Published
2023
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10. Efficacy of antimicrobial therapy in patients with uncomplicated acute colonic diverticulitis: an updated systematic review and meta-analysis

Author

Seta, Takeshi, primary, Iwagami, Hiroyoshi, additional, Agatsuma, Nobukazu, additional, Noma, Atsushi, additional, Ikenouchi, Maiko, additional, Kubo, Kenji, additional, Akamatsu, Takuji, additional, Uenoyama, Yoshito, additional, Ito, Daisuke, additional, Yamashita, Yukitaka, additional, and Nakayama, Takeo, additional

Published
2023
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11. THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer

Author

40838679, 10963332, 90967720, 40760567, 90839721, 90335266, Omatsu, Mayuki, Nakanishi, Yuki, Iwane, Kosuke, Aoyama, Naoki, Duran, Angeles, Muta, Yu, Martinez-Ordoñez, Anxo, Han, Qixiu, Agatsuma, Nobukazu, Mizukoshi, Kenta, Kawai, Munenori, Yamakawa, Go, Namikawa, Mio, Hamada, Kensuke, Fukunaga, Yuichi, Utsumi, Takahiro, Sono, Makoto, Masuda, Tomonori, Hata, Akitaka, Araki, Osamu, Nagao, Munemasa, Yoshikawa, Takaaki, Ogawa, Satoshi, Hiramatsu, Yukiko, Tsuda, Motoyuki, Maruno, Takahisa, Kogame, Toshiaki, Kasashima, Hiroaki, Kakiuchi, Nobuyuki, Nakagawa, Masahiro M., Kawada, Kenji, Yashiro, Masakazu, Maeda, Kiyoshi, Saito, Yasuyuki, Matozaki, Takashi, Fukuda, Akihisa, Kabashima, Kenji, Obama, Kazutaka, Ogawa, Seishi, Sheibani, Nader, Diaz-Meco, Maria T., Moscat, Jorge, Seno, Hiroshi, 40838679, 10963332, 90967720, 40760567, 90839721, 90335266, Omatsu, Mayuki, Nakanishi, Yuki, Iwane, Kosuke, Aoyama, Naoki, Duran, Angeles, Muta, Yu, Martinez-Ordoñez, Anxo, Han, Qixiu, Agatsuma, Nobukazu, Mizukoshi, Kenta, Kawai, Munenori, Yamakawa, Go, Namikawa, Mio, Hamada, Kensuke, Fukunaga, Yuichi, Utsumi, Takahiro, Sono, Makoto, Masuda, Tomonori, Hata, Akitaka, Araki, Osamu, Nagao, Munemasa, Yoshikawa, Takaaki, Ogawa, Satoshi, Hiramatsu, Yukiko, Tsuda, Motoyuki, Maruno, Takahisa, Kogame, Toshiaki, Kasashima, Hiroaki, Kakiuchi, Nobuyuki, Nakagawa, Masahiro M., Kawada, Kenji, Yashiro, Masakazu, Maeda, Kiyoshi, Saito, Yasuyuki, Matozaki, Takashi, Fukuda, Akihisa, Kabashima, Kenji, Obama, Kazutaka, Ogawa, Seishi, Sheibani, Nader, Diaz-Meco, Maria T., Moscat, Jorge, and Seno, Hiroshi

Abstract

Mesenchymal activation, characterized by dense stromal infiltration of immune and mesenchymal cells, fuels the aggressiveness of colorectal cancers (CRC), driving progression and metastasis. Targetable molecules in the tumor microenvironment (TME) need to be identified to improve the outcome in CRC patients with this aggressive phenotype. This study reports a positive link between high thrombospondin-1 (THBS1) expression and mesenchymal characteristics, immunosuppression, and unfavorable CRC prognosis. Bone marrow-derived monocyte-like cells recruited by CXCL12 are the primary source of THBS1, which contributes to the development of metastasis by inducing cytotoxic T-cell exhaustion and impairing vascularization. Furthermore, in orthotopically generated CRC models in male mice, THBS1 loss in the TME renders tumors partially sensitive to immune checkpoint inhibitors and anti-cancer drugs. Our study establishes THBS1 as a potential biomarker for identifying mesenchymal CRC and as a critical suppressor of antitumor immunity that contributes to the progression of this malignancy with a poor prognosis.

Published
2023

16. Nonrecurrence Rate of Underwater EMR for ≤20-mm Nonampullary Duodenal Adenomas: A Multicenter Prospective Study (D-UEMR Study)

Author

Yamasaki, Yasushi, primary, Uedo, Noriya, additional, Akamatsu, Takuji, additional, Kagawa, Tomo, additional, Higashi, Reiji, additional, Dohi, Osamu, additional, Furukawa, Masanori, additional, Takahashi, Yu, additional, Inoue, Takuya, additional, Tanaka, Shouichi, additional, Takenaka, Ryuta, additional, Iguchi, Mikitaka, additional, Kawamura, Takuji, additional, Tsuzuki, Takao, additional, Yamasaki, Tomoaki, additional, Yamashina, Takeshi, additional, Nasu, Junichiro, additional, Mannami, Tomohiko, additional, Yamauchi, Atsushi, additional, Matsueda, Kazuhiro, additional, Aizawa, Shigeyuki, additional, Mitsuhashi, Toshiharu, additional, Okada, Hiroyuki, additional, Kanzaki, Hiromitsu, additional, Inoue, Shuntaro, additional, Miyake, Muneaki, additional, Ohmori, Masayasu, additional, Takeuchi, Yoji, additional, Tani, Yasuhiro, additional, Harada, Nobuyuki, additional, Agatsuma, Nobukazu, additional, Okada, Keijirou, additional, Ikenouchi, Maiko, additional, Nakatani, Yasuki, additional, Uenoyama, Yoshito, additional, Yamashita, Yukitaka, additional, Ishikawa, Shigenao, additional, Inaba, Tomoki, additional, Miyahara, Koji, additional, Moritou, Yuki, additional, Nakagawa, Masahiro, additional, Kitae, Hiroaki, additional, Ishida, Tsugitaka, additional, Naito, Yuji, additional, Nishio, Akiyoshi, additional, Shimatani, Masaaki, additional, Kato, Ryo, additional, Taki, Shinya, additional, Mandai, Koichiro, additional, Sanada, Kasumi, additional, Nakase, Kojiro, additional, Nebiki, Hiroko, additional, Saito, Shunsuke, additional, Wakatsuki, Toshiyuki, additional, and Nishimura, Naoyuki, additional

Published
2022
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18. Factors associated with inaccurate size estimation of colorectal polyps: A multicenter cross‐sectional study.

Author

Utsumi, Takahiro, Horimatsu, Takahiro, Nishikawa, Yoshitaka, Teramoto, Akira, Hirata, Daizen, Iwatate, Mineo, Tanaka, Shinwa, Ikezawa, Nobuaki, Esaki, Masaya, Osera, Shozo, Ebisutani, Chikara, Agatsuma, Nobukazu, Saito, Hiroaki, Sano, Yasushi, and Seno, Hiroshi

Subjects
COLON polyps, CROSS-sectional method, LOGISTIC regression analysis, POLYPS, ODDS ratio
Abstract

Background and Aim: Accurate polyp size estimation is essential in deciding the therapeutic strategy of colorectal polyps and endoscopic surveillance intervals. However, many endoscopists frequently make incorrect size estimations without being aware of their errors. This cross‐sectional study aimed to clarify the characteristics of endoscopists associated with inaccurate estimation. Methods: We previously conducted a web trial involving 261 endoscopists in 51 institutions in Japan to assess their ability to estimate polyp size. Participants answered questions about polyp size using visual estimates in a test involving images of 30 polyps. Here, we investigated the relationships between inaccurate size estimation and the backgrounds of participants. The rates of overestimation and underestimation of polyp size were also compared to clarify any trends in the answers of participants with low accuracy (< 50%). Results: Multivariable logistic regression analysis revealed that the number of colonoscopic procedures in the past year was the only factor associated with a low accuracy of polyp size estimation (odds ratio 0.750, 95% confidence interval 0.609–0.925; P = 0.007). Endoscopists with low accuracy had a greater tendency to overestimate polyp size (42.3% overestimation and 21.2% underestimation, P < 0.001) compared with other endoscopists (16.6% overestimation and 17.9% underestimation, P = 0.951). Conclusions: Endoscopists with limited experience of colonoscopy in the past year were more likely to make frequent errors in size estimation. Furthermore, endoscopists making inaccurate size estimations had a propensity to overestimate polyp size. [ABSTRACT FROM AUTHOR]

Published
2021
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21. A novel endoscopy training system by video-based asynchronous communication.

Author

Inoue T, Utsumi T, Agatsuma N, Nishikawa Y, Soshi M, Sano Y, and Seno H

Subjects
Humans, Communication, Video Recording, Endoscopy education, Endoscopy, Gastrointestinal
Abstract

Competing Interests: M. Soshi is the chief executive officer and a shareholder of BonBon Inc. T. Inoue, T. Utsumi, N. Agatsuma, Y. Nishikawa, Y. Sano, and H. Seno declare that they have no conflict of interest.

Published
2023
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