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1. Elevated plasma IL-6 and CRP levels are associated with adverse clinical outcomes and death in critically ill SARS-CoV-2 patients: inflammatory response of SARS-CoV-2 patients

Author

Jean-Rémi Lavillegrand, Marc Garnier, Agathe Spaeth, Nathalie Mario, Geoffroy Hariri, Antoine Pilon, Enora Berti, Fabienne Fieux, Sara Thietart, Tomas Urbina, Matthieu Turpin, Lucie Darrivière, Muriel Fartoukh, Franck Verdonk, Guillaume Dumas, Alain Tedgui, Bertrand Guidet, Eric Maury, Yannick Chantran, Guillaume Voiriot, and Hafid Ait-Oufella

Subjects
SARS-CoV-2, Covid-19, Cytokine, Inflammation, Outcome, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background SARS coronavirus 2 (SARS-CoV-2) is responsible for high morbidity and mortality worldwide, mostly due to the exacerbated inflammatory response observed in critically ill patients. However, little is known about the kinetics of the systemic immune response and its association with survival in SARS-CoV-2+ patients admitted in ICU. We aimed to compare the immuno-inflammatory features according to organ failure severity and in-ICU mortality. Methods Six-week multicentre study (N = 3) including SARS-CoV-2+ patients admitted in ICU. Analysis of plasma biomarkers at days 0 and 3–4 according to organ failure worsening (increase in SOFA score) and 60-day mortality. Results 101 patients were included. Patients had severe respiratory diseases with PaO2/FiO2 of 155 [111–251] mmHg), SAPS II of 37 [31–45] and SOFA score of 4 [3–7]. Eighty-three patients (83%) required endotracheal intubation/mechanical ventilation and among them, 64% were treated with prone position. IL-1β was barely detectable. Baseline IL-6 levels positively correlated with organ failure severity. Baseline IL-6 and CRP levels were significantly higher in patients in the worsening group than in the non-worsening group (278 [70–622] vs. 71 [29–153] pg/mL, P

Published
2021
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2. Correction to: Elevated plasma IL-6 and CRP levels are associated with adverse clinical outcomes and death in critically ill SARS-CoV-2 patients: infammatory response of SARS-CoV-2 patients

Author

Jean-Rémi Lavillegrand, Marc Garnier, Agathe Spaeth, Nathalie Mario, Geofroy Hariri, Antoine Pilon, Enora Berti, Fabienne Fieux, Sara Thietart, Tomas Urbina, Matthieu Turpin, Lucie Darrivere, Muriel Fartoukh, Franck Verdonk, Guillaume Dumas, Alain Tedgui, Bertrand Guidet, Eric Maury, Yannick Chantran, Guillaume Voiriot, and Hafd Ait-Oufella

Subjects
Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

An amendment to this paper has been published and can be accessed via the original article.

Published
2021
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6. Correction to: Elevated plasma IL-6 and CRP levels are associated with adverse clinical outcomes and death in critically ill SARS-CoV-2 patients: infammatory response of SARS-CoV-2 patients

Author

Matthieu Turpin, Sara Thietart, Bertrand Guidet, Yannick Chantran, Agathe Spaeth, Fabienne Fieux, Alain Tedgui, Muriel Fartoukh, Antoine Pilon, Lucie Darrivere, Guillaume Voiriot, Hafd Ait-Oufella, Eric Maury, Guillaume Dumas, Geofroy Hariri, Jean Rémi Lavillegrand, Enora Berti, Franck Verdonk, Tomas Urbina, Marc Garnier, and Nathalie Mario

Subjects
medicine.medical_specialty, biology, RC86-88.9, business.industry, Critically ill, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Medical emergencies. Critical care. Intensive care. First aid, Critical Care and Intensive Care Medicine, Intensive care, Internal medicine, biology.protein, Medicine, business, Interleukin 6
Abstract

An amendment to this paper has been published and can be accessed via the original article.

Published
2021

7. Elevated plasma IL-6 and CRP levels are associated with adverse clinical outcomes and death in critically ill SARS-CoV-2 patients: inflammatory response of SARS-CoV-2 patients

Author

Matthieu Turpin, Bertrand Guidet, Muriel Fartoukh, Enora Berti, Eric Maury, Tomas Urbina, Guillaume Dumas, Hafid Ait-Oufella, Antoine Pilon, Lucie Darrivere, Agathe Spaeth, Geoffroy Hariri, Alain Tedgui, Yannick Chantran, Sara Thietart, Fabienne Fieux, Guillaume Voiriot, Marc Garnier, Nathalie Mario, Franck Verdonk, Jean-Rémi Lavillegrand, Service de Réanimation Médicale [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Service de biochimie [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Pneumologie - Oncologie Thoracique - Maladies Pulmonaires Rares [CHU Tenon], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Service de rhumatologie [CHU Saint-Antoine], Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Laboratoire d'Hématologie et d'Immunologie [CHU Saint-Antoine], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Service de Pneumologie = Pneumologie - Oncologie Thoracique - Maladies Pulmonaires Rares [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), and Gestionnaire, HAL Sorbonne Université 5

Subjects
medicine.medical_specialty, Lymphocyte, medicine.medical_treatment, Critical Care and Intensive Care Medicine, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Anesthesiology, Medicine, 030212 general & internal medicine, Respiratory system, Interleukin 6, Cytokine, 030304 developmental biology, Outcome, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Mechanical ventilation, Inflammation, 0303 health sciences, biology, business.industry, SARS-CoV-2, Research, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Correction, lcsh:RC86-88.9, 3. Good health, Prone position, medicine.anatomical_structure, SAPS II, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, biology.protein, SOFA score, business, Covid-19
Abstract

Background SARS coronavirus 2 (SARS-CoV-2) is responsible for high morbidity and mortality worldwide, mostly due to the exacerbated inflammatory response observed in critically ill patients. However, little is known about the kinetics of the systemic immune response and its association with survival in SARS-CoV-2+ patients admitted in ICU. We aimed to compare the immuno-inflammatory features according to organ failure severity and in-ICU mortality. Methods Six-week multicentre study (N = 3) including SARS-CoV-2+ patients admitted in ICU. Analysis of plasma biomarkers at days 0 and 3–4 according to organ failure worsening (increase in SOFA score) and 60-day mortality. Results 101 patients were included. Patients had severe respiratory diseases with PaO2/FiO2 of 155 [111–251] mmHg), SAPS II of 37 [31–45] and SOFA score of 4 [3–7]. Eighty-three patients (83%) required endotracheal intubation/mechanical ventilation and among them, 64% were treated with prone position. IL-1β was barely detectable. Baseline IL-6 levels positively correlated with organ failure severity. Baseline IL-6 and CRP levels were significantly higher in patients in the worsening group than in the non-worsening group (278 [70–622] vs. 71 [29–153] pg/mL, P P A contrario, kinetics of CRP and lymphocyte count were different between survivors and non-survivors. Conclusions In SARS-CoV-2+ patients admitted in ICU, a systemic pro-inflammatory signature was associated with clinical worsening and 60-day mortality.

Published
2020

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