1. Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome
- Author
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Didier Dewailly, Anne-Laure Barbotin, Agathe Dumont, Sophie Catteau-Jonard, and Geoffroy Robin
- Subjects
anti-müllerian hormone ,polycystic ovary syndrome ,androgens ,follicle ,FSH ,anovulation ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generational transmission of PCOS. For each of those issues, the clinical and experimental evidences currently available are discussed and pathophysiological hypothesis are proposed.
- Published
- 2020
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