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1,149 results on '"Agarwal, Anupam"'

8. Analysing Statistical methods for Automatic Detection of Image Forgery

Author

Masud, Umar and Agarwal, Anupam

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Image manipulation and forgery detection have been a topic of research for more than a decade now. New-age tools and large-scale social platforms have given space for manipulated media to thrive. These media can be potentially dangerous and thus innumerable methods have been designed and tested to prove their robustness in detecting forgery. However, the results reported by state-of-the-art systems indicate that supervised approaches achieve almost perfect performance but only with particular datasets. In this work, we analyze the issue of out-of-distribution generalisability of the current state-of-the-art image forgery detection techniques through several experiments. Our study focuses on models that utilise handcrafted features for image forgery detection. We show that the developed methods fail to perform well on cross-dataset evaluations and in-the-wild manipulated media. As a consequence, a question is raised about the current evaluation and overestimated performance of the systems under consideration. Note: This work was done during a summer research internship at ITMR Lab, IIIT-Allahabad under the supervision of Prof. Anupam Agarwal.

Published
2021

15. UAB-UCSD O’Brien Center for Acute Kidney Injury Research

Author

Curtis, Lisa M, George, James, Vallon, Volker, Barnes, Stephen, Darley-Usmar, Victor, Vaingankar, Sucheta, Cutter, Gary R, Gutierrez, Orlando M, Seifert, Michael, Ix, Joachim H, Mehta, Ravindra L, Sanders, Paul W, and Agarwal, Anupam

Subjects
Clinical Research, Kidney Disease, Renal and urogenital, Acute Kidney Injury, Alabama, Biomarkers, Biomedical Research, California, Humans, Universities, acute kidney injury, acute renal failure, core, kidney disease, O'Brien Center, Physiology, Clinical Sciences, Medical Physiology, Urology & Nephrology
Abstract

Acute kidney injury (AKI) remains a significant clinical problem through its diverse etiologies, the challenges of robust measurements of injury and recovery, and its progression to chronic kidney disease (CKD). Bridging the gap in our knowledge of this disorder requires bringing together not only the technical resources for research but also the investigators currently endeavoring to expand our knowledge and those who might bring novel ideas and expertise to this important challenge. The University of Alabama at Birmingham-University of California-San Diego O'Brien Center for Acute Kidney Injury Research brings together technical expertise and programmatic and educational efforts to advance our knowledge in these diverse issues and the required infrastructure to develop areas of novel exploration. Since its inception in 2008, this O'Brien Center has grown its impact by providing state-of-the-art resources in clinical and preclinical modeling of AKI, a bioanalytical core that facilitates measurement of critical biomarkers, including serum creatinine via LC-MS/MS among others, and a biostatistical resource that assists from design to analysis. Through these core resources and with additional educational efforts, our center has grown its investigator base to include >200 members from 51 institutions. Importantly, this center has translated its pilot and catalyst funding program with a $37 return per dollar invested. Over 500 publications have resulted from the support provided with a relative citation ratio of 2.18 ± 0.12 (iCite). Through its efforts, this disease-centric O'Brien Center is providing the infrastructure and focus to help the development of the next generation of researchers in the basic and clinical science of AKI. This center creates the promise of the application at the bedside of the advances in AKI made by current and future investigators.

Published
2021

18. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Author

Klionsky, Daniel J, Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie H, Abudu, Yakubu Princely, Acevedo-Arozena, Abraham, Adamopoulos, Iannis E, Adeli, Khosrow, Adolph, Timon E, Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat B, Agnello, Maria, Agostinis, Patrizia, Agrewala, Javed N, Agrotis, Alexander, Aguilar, Patricia V, Ahmad, S Tariq, Ahmed, Zubair M, Ahumada-Castro, Ulises, Aits, Sonja, Aizawa, Shu, Akkoc, Yunus, Akoumianaki, Tonia, Akpinar, Hafize Aysin, Al-Abd, Ahmed M, Al-Akra, Lina, Al-Gharaibeh, Abeer, Alaoui-Jamali, Moulay A, Alberti, Simon, Alcocer-Gómez, Elísabet, Alessandri, Cristiano, Ali, Muhammad, Al-Bari, M Abdul Alim, Aliwaini, Saeb, Alizadeh, Javad, Almacellas, Eugènia, Almasan, Alexandru, Alonso, Alicia, Alonso, Guillermo D, Altan-Bonnet, Nihal, Altieri, Dario C, Álvarez, Élida MC, Alves, Sara, da Costa, Cristine Alves, Alzaharna, Mazen M, Amadio, Marialaura, Amantini, Consuelo, Amaral, Cristina, Ambrosio, Susanna, Amer, Amal O, Ammanathan, Veena, An, Zhenyi, Andersen, Stig U, Andrabi, Shaida A, Andrade-Silva, Magaiver, Andres, Allen M, Angelini, Sabrina, Ann, David, Anozie, Uche C, Ansari, Mohammad Y, Antas, Pedro, Antebi, Adam, Antón, Zuriñe, Anwar, Tahira, Apetoh, Lionel, Apostolova, Nadezda, Araki, Toshiyuki, Araki, Yasuhiro, Arasaki, Kohei, Araújo, Wagner L, Araya, Jun, Arden, Catherine, Arévalo, Maria-Angeles, Arguelles, Sandro, Arias, Esperanza, Arikkath, Jyothi, Arimoto, Hirokazu, Ariosa, Aileen R, Armstrong-James, Darius, Arnauné-Pelloquin, Laetitia, Aroca, Angeles, Arroyo, Daniela S, Arsov, Ivica, Artero, Rubén, Asaro, Dalia Maria Lucia, Aschner, Michael, Ashrafizadeh, Milad, Ashur-Fabian, Osnat, Atanasov, Atanas G, Au, Alicia K, Auberger, Patrick, Auner, Holger W, and Aurelian, Laure

Subjects
Biochemistry and Cell Biology, Biological Sciences, Animals, Autophagosomes, Autophagy, Autophagy-Related Proteins, Biological Assay, Biomarkers, Humans, Lysosomes, English, grammar, spelling, writing, Autophagosome, cancer, flux, LC3, lysosome, macroautophagy, neurodegeneration, phagophore, stress, vacuole, Biochemistry & Molecular Biology, Biochemistry and cell biology
Abstract

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.

Published
2021

22. An Improved Approach for Removal of Salt and Pepper Noise in MR Images

Author

Jyotiyana, Monika, Kesswani, Nishtha, Agarwal, Anupam, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Troiano, Luigi, editor, Vaccaro, Alfredo, editor, Tagliaferri, Roberto, editor, Kesswani, Nishtha, editor, Díaz Rodriguez, Irene, editor, Brigui, Imene, editor, and Parente, Domenico, editor

Published
2022
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39. Contributors

Author

Agarwal, Anupam, primary, Ashley, Sophie L., additional, Asthana, Amish, additional, Atala, Anthony, additional, Babickova, Janka, additional, Baird, David P., additional, Basile, David P., additional, Bedzow, Ira, additional, Bhattacharya, Rohan, additional, Blank, Ulrich, additional, Bonventre, Joseph V., additional, Borradaile, Nica M., additional, Celikoyar, Selin, additional, Charles, Nicolas, additional, Cheung, Matthew D., additional, Choi, Hoon Young, additional, Crunk, Amanda E., additional, Daugas, Eric, additional, Dekel, Benjamin, additional, Demaria, Marco, additional, Diegisser, Danielle, additional, Ding, Feng, additional, Dirice, Ercument, additional, Doyle, Ross, additional, Ebert, Thomas, additional, Erman, Elise N., additional, Ferenbach, David A., additional, Fogo, Agnes B., additional, Francipane, Maria Giovanna, additional, George, James F., additional, Godson, Catherine, additional, Golestaneh, Ladan, additional, Goligorsky, Michael S., additional, Haber, Dylan, additional, He, John Cijiang, additional, Heller, Daniel A., additional, Holmes, Jordan A., additional, Hukriede, Neil A., additional, Hunsberger, Joshua, additional, Izpisua Belmonte, Juan Carlos, additional, Jaimes, Edgar A., additional, Ji, Jing, additional, Kahraman, Sevim, additional, Kalejaiye, Titilola D., additional, Kapadia, Chintan, additional, Kretzler, Matthias, additional, La Pointe, Catherine, additional, Lasagni, Laura, additional, Lee, Jason J., additional, Lee, Kyung, additional, Lerman, Lilach O., additional, Li, Li, additional, Li, Xuezhu, additional, Mahler, Gretchen J., additional, Marino, Domenica Ida, additional, Mazzinghi, Benedetta, additional, Melk, A., additional, Muir, Sean, additional, Musah, Samira, additional, Nath, Meryl C., additional, Nehme, Jamil, additional, Neugarten, Joel, additional, Nicolas, Paola, additional, Okusa, Mark D., additional, Orlando, Giuseppe, additional, Osafune, Kenji, additional, Park, Hyeong Cheon, additional, Pickering, J. Geoffrey, additional, Pleniceanu, Oren, additional, Przepiorski, Aneta, additional, Rabadi, May M., additional, Ratliff, Brian B., additional, Romagnani, Paola, additional, Schaub, Jennifer A., additional, Schmitt, R., additional, Somara, Sita, additional, Stenvinkel, Peter, additional, Varela-Eirin, Marta, additional, Williams, Ryan M., additional, Wilson, Rachel B., additional, Woolf, Adrian S., additional, Xia, Yun, additional, Yang, Hai-Chun, additional, Yang, Li, additional, Yoder, Mervin C., additional, Zhang, Stephanie, additional, Zhang, Yuanyuan, additional, and Zhu, Xiang Yang, additional

Published
2022
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41. Acute kidney injury results in long-term alterations of kidney lymphatics in mice.

Author

Ghajar-Rahimi, Gelare, Barwinska, Daria, Whipple, Grace E., Kamocka, Malgorzata M., Khan, Shehnaz, Winfree, Seth, Lafontaine, Jennifer, Soliman, Reham H., Melkonian, Arin L., Zmijewska, Anna A., Cheung, Matthew D., Traylor, Amie M., Jiang, Yanlin, Yang, Zhengqin, Bolisetty, Subhashini, Zarjou, Abolfazl, Lee, Timmy, George, James F., El-Achkar, Tarek M., and Agarwal, Anupam

Subjects
ACUTE kidney failure, KIDNEY cortex, CHRONIC kidney failure, LYMPHOID tissue, TISSUE remodeling
Abstract

The long-term effects of a single episode of acute kidney injury (AKI) induced by bilateral ischemia-reperfusion injury (BIRI) on kidney lymphatic dynamics are not known. The purpose of this study was to determine if alterations in kidney lymphatics are sustained in the long term and how they relate to inflammation and injury. Mice underwent BIRI as a model of AKI and were followed up to 9 mo. Although kidney function markers normalized following initial injury, histological analysis revealed sustained tissue damage and inflammation for up to 9 mo. Transcriptional analysis showed both acute and late-stage lymphangiogenesis, supported by increased expression of lymphatic markers, with unique signatures at each phase. Expression of Ccl21a was distinctly upregulated during late-stage lymphangiogenesis. Three-dimensional tissue cytometry confirmed increased lymphatic vessel abundance, particularly in the renal cortex, at early and late timepoints postinjury. In addition, the study identified the formation of tertiary lymphoid structures composed of CCR7+ lymphocytes and observed changes in immune cell composition over time, suggesting a complex and dynamic response to AKI involving tissue remodeling and immune cell involvement. This study provides new insights into the role of lymphatics in the progression of AKI to chronic kidney disease. NEW & NOTEWORTHY: Here, we perform the first, comprehensive study of long-term lymphatic dynamics following a single acute kidney injury (AKI) event. Using improved three-dimensional image analysis and an expanded panel of transcriptional markers, we identify multiple stages of lymphatic responses with distinct transcriptional signatures, associations with the immune microenvironment, and collagen deposition. This research advances kidney lymphatic biology, emphasizing the significance of longitudinal studies in understanding AKI and the transition to chronic kidney disease. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Renal control of disease tolerance to malaria

Author

Ramos, Susana, Carlos, Ana Rita, Sundaram, Balamurugan, Jeney, Viktoria, Ribeiro, Ana, Gozzelino, Raffaella, Bank, Claudia, Gjini, Erida, Braza, Faouzi, Martins, Rui, Ademolue, Temitope Wilson, Blankenhaus, Birte, Gouveia, Zélia, Faísca, Pedro, Trujillo, Damian, Cardoso, Sílvia, Rebelo, Sofia, del Barrio, Laura, Zarjou, Abolfazl, Bolisetty, Subhashini, Agarwal, Anupam, and Soares, Miguel P.

Published
2019

45. Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood–brain barrier

Author

Hauptmann, Judith, Johann, Lisa, Marini, Federico, Kitic, Maja, Colombo, Elisa, Mufazalov, Ilgiz A., Krueger, Martin, Karram, Khalad, Moos, Sonja, Wanke, Florian, Kurschus, Florian C., Klein, Matthias, Cardoso, Silvia, Strauß, Judith, Bolisetty, Subhashini, Lühder, Fred, Schwaninger, Markus, Binder, Harald, Bechman, Ingo, Bopp, Tobias, Agarwal, Anupam, Soares, Miguel P., Regen, Tommy, and Waisman, Ari

Published
2020
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46. Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial

Author

Lagae, Lieven, Sullivan, Joseph, Knupp, Kelly, Laux, Linda, Polster, Tilman, Nikanorova, Marina, Devinsky, Orrin, Cross, J Helen, Guerrini, Renzo, Talwar, Dinesh, Miller, Ian, Farfel, Gail, Galer, Bradley S, Gammaitoni, Arnold, Mistry, Arun, Morrison, Glenn, Lock, Michael, Agarwal, Anupam, Lai, Wyman W, and Ceulemans, Berten

Published
2019
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