621 results on '"Agache P"'
Search Results
2. A Look Into Training Large Language Models on Next Generation Datacenters
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Gherghescu, Alexandru M., Bădoiu, Vlad-Andrei, Agache, Alexandru, Dumitru, Mihai-Valentin, Vasilescu, Iuliu, Mantu, Radu, and Raiciu, Costin
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Computer Science - Distributed, Parallel, and Cluster Computing ,Computer Science - Computation and Language ,Computer Science - Machine Learning ,Computer Science - Networking and Internet Architecture - Abstract
Is it still worth doing computer networking research? What are relevant problems in this space given the supremacy of hyperscalers in deployed large networks? We take an unconventional approach to finding relevant research directions, by starting from Microsoft's plans to build a $100 billion datacenter for ML. Our goal is to understand what models could be trained in such a datacenter, as well as the high-level challenges one may encounter in doing so. We first examine the constraints imposed by cooling and power requirements for our target datacenter and find that it is infeasible to build in a single location. We use LLM scaling laws to determine that we could train models of 50T or 100T. Finally, we examine how distributed training might work for these models, and what the networking requirements are. We conclude that building the datacenter and training such models is technically possible, but this requires a novel NIC-based multipath transport along with a redesign of the entire training stack, outlining a research agenda for our community in the near future.
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- 2024
3. Driving Towards Sustainable Transportation Systems: A bottom-up Traffic Modal Choices Analysis Using Responsible Management for Future Development Planning
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Andrei AGACHE, Timea CSMA, Marian MOCAN, and Larisa IVASCU
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green mobility ,traffic ,sustainable transportation ,sustainable development ,responsible management ,Transportation engineering ,TA1001-1280 - Abstract
The transportation sector wields substantial influence on society, encompassing economic, social and environmental dimensions of sustainability. Recognising environmentally conscious actions initiated by individuals, particularly at grassroots levels, fosters the development of a pro-environmental social identity. The article aims to analyse the transportation systems from a bottom-up perspective within a municipality. Consequently, three objectives are proposed for this research paper: investigate citizen behaviour regarding transportation, assess the strengths and weaknesses of communities based on citizen perspectives and generate ideas for improving transit through responsible management principles using a bottom-up approach. It has been determined that private car is the most commonly used mode of transportation. The number of cars is the only variable that influences the choice of transportation. A significant positive relationship has been identified between the number of cars and car travels, while a negative relationship has been observed between the number of cars and travels by transit, pedestrian or bicycle. In addition to this, other significant relationships were determined. Regarding the second objective, the majority of the interviewees perceive that the commune lacks any significant strengths. In terms of enhancement opportunities, respondents express a desire for improvements in pedestrian and cyclist infrastructure, transit facilities and the addition of more lanes and roads.
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- 2024
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4. Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK‐air study
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Bernardo Sousa‐Pinto, Gilles Louis, Rafael J. Vieira, Wienczyslawa Czarlewski, Josep M. Anto, Rita Amaral, Ana Sá‐Sousa, Luisa Brussino, G. Walter Canonica, Claudia Chaves Loureiro, Alvaro A. Cruz, Bilun Gemicioglu, Tari Haahtela, Maciej Kupczyk, Violeta Kvedariene, Desirée E. Larenas‐Linnemann, Nhân Pham‐Thi, Francesca Puggioni, Frederico S. Regateiro, Jan Romantowski, Joaquin Sastre, Nicola Scichilone, Luis Taborda‐Barata, Maria Teresa Ventura, Ioana Agache, Anna Bedbrook, Alida Benfante, Karl C. Bergmann, Sinthia Bosnic‐Anticevich, Matteo Bonini, Louis‐Philippe Boulet, Guy Brusselle, Roland Buhl, Lorenzo Cecchi, Denis Charpin, Elisio M. Costa, Stefano Del Giacco, Marek Jutel, Ludger Klimek, Piotr Kuna, Daniel Laune, Mika Makela, Mario Morais‐Almeida, Rachel Nadif, Marek Niedoszytko, Nikolaos G. Papadopoulos, Alberto Papi, Oliver Pfaar, Daniela Rivero‐Yeverino, Nicolas Roche, Boleslaw Samolinski, Mohamed H. Shamji, Aziz Sheikh, Charlotte Suppli Ulrik, Omar S. Usmani, Arunas Valiulis, Arzu Yorgancioglu, Torsten Zuberbier, Joao A. Fonseca, Benoit Pétré, Renaud Louis, Jean Bousquet, and MASK‐air think tank
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asthma ,diagnosis ,dyspnea ,mHealth ,wheezing ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Rationale It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods In this cross‐sectional study, we assessed real‐world data using the MASK‐air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e‐DASTHMA score). Results were validated in a sample of patients with a physician‐established diagnosis of asthma. Measurement and Main Results We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e‐DASTHMA. Consistent results were observed when assessing patients with a physician‐made diagnosis of asthma. Conclusions Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.
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- 2024
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5. Comparative analysis of the manoeuvrability performance for a 9000 tdw chemical/oil tanker
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Ana Maria Agache and Radu Bosoancă
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manoeuvrability, turning circle, preliminary, estimation, sea trials ,Ocean engineering ,TC1501-1800 ,Naval architecture. Shipbuilding. Marine engineering ,VM1-989 - Abstract
The concept of manoeuvrability is very important for efficient ship operation but also in ship safety. The aim of this paper is to test and perform a comparative analysis of manoeuvrability performance of a 9000 tdw chemical/oil tanker. The comparative analysis has been performed between the results obtained based from two software’s, namely PHP and MPP, but also between the results obtained in the sea trials with the output data from MPP. In this way it will be shown the differences (if any) in terms of manoeuvrability., and if the two used platforms are effective for providing preliminary determination of performances of manoeuvrability.
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- 2023
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6. Additional Value of Ultrasound in Patients with Psoriatic Arthritis within Treatment Target
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Mihaela Agache, Claudiu C. Popescu, Luminița Enache, Corina Mogoșan, Emilio Filippucci, and Cătălin Codreanu
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psoriatic arthritis ,ultrasound ,enthesitis ,Medicine - Abstract
Background: In psoriatic arthritis (PsA), musculoskeletal ultrasound is a complementary tool to physical examination, useful even in patients in remission to detect subclinical activity. Objectives: The objective of the study was to assess the ultrasound prevalence of active enthesitis and synovitis in patients who reached the therapeutic target. Methods: This cross-sectional study included patients with at least 6 months of therapy with a targeted synthetic or biological disease-modifying antirheumatic drug who were in treatment target (i.e., DAPSA < 14). Patients underwent bilateral clinical and ultrasound examination of the elbow lateral epicondyle, quadriceps insertion, distal patellar tendon insertion, and Achilles enthesis for assessing enthesitis, and hand and foot joints for assessing synovitis. Enthesitis and synovitis were considered active if the power Doppler signal showed at least a score of one. Results: The study included 51 PsA patients, women (52.9%), with an average age of 55 years. Although the patients were within the DAPSA treatment target, 21.6% had at least one painful enthesis at clinical examination, 19.6% had ultrasound evidence of at least one active enthesitis and 15.7% had ultrasound signs of at least one active synovitis. Conclusions: Among PsA patients thought to be within the therapeutic target, ultrasound detected a non-negligible percentage of active enthesitis and synovitis.
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- 2024
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7. Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation
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Ioana Agache, Cezmi Akdis, Mubeccel Akdis, Ali Al-Hemoud, Isabella Annesi-Maesano, John Balmes, Lorenzo Cecchi, Athanasios Damialis, Tari Haahtela, Adam L. Haber, Jaime E. Hart, Marek Jutel, Yasutaka Mitamura, Blandina T. Mmbaga, Jae-Won Oh, Abbas Ostadtaghizadeh, Ruby Pawankar, Mary Prunicki, Harald Renz, Mary B. Rice, Nelson Augusto Rosario Filho, Vanitha Sampath, Chrysanthi Skevaki, Francis Thien, Claudia Traidl-Hoffmann, Gary W. K. Wong, and Kari C. Nadeau
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air pollution ,immune diseases ,allergy ,asthma ,biodiversity ,climate change ,Science - Abstract
Global warming and climate change have increased the pollen burden and the frequency and intensity of wildfires, sand and dust storms, thunderstorms, and heatwaves—with concomitant increases in air pollution, heat stress, and flooding. These environmental stressors alter the human exposome and trigger complex immune responses. In parallel, pollutants, allergens, and other environmental factors increase the risks of skin and mucosal barrier disruption and microbial dysbiosis, while a loss of biodiversity and reduced exposure to microbial diversity impairs tolerogenic immune development. The resulting immune dysregulation is contributing to an increase in immune-mediated diseases such as asthma and other allergic diseases, autoimmune diseases, and cancer. It is now abundantly clear that multisectoral, multidisciplinary, and transborder efforts based on Planetary Health and One Health approaches (which consider the dependence of human health on the environment and natural ecosystems) are urgently needed to adapt to and mitigate the effects of climate change. Key actions include reducing emissions and improving air quality (through reduced fossil fuel use), providing safe housing (e.g., improving weatherization), improving diets (i.e., quality and diversity) and agricultural practices, and increasing environmental biodiversity and green spaces. There is also a pressing need for collaborative, multidisciplinary research to better understand the pathophysiology of immune diseases in the context of climate change. New data science techniques, biomarkers, and economic models should be used to measure the impact of climate change on immune health and disease, to inform mitigation and adaptation efforts, and to evaluate their effectiveness. Justice, equity, diversity, and inclusion (JEDI) considerations should be integral to these efforts to address disparities in the impact of climate change.
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- 2024
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8. Inertial and viscous flywheel sensing of nanoparticles
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Katsikis, Georgios, Collis, Jesse F., Knudsen, Scott M., Agache, Vincent, Sader, John E., and Manalis, Scott R.
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Physics - Fluid Dynamics - Abstract
Rotational dynamics often challenge physical intuition while enabling unique realizations, from the rotor of a gyroscope that maintains its orientation regardless of the outer gimbals, to a tennis racket that rotates around its handle when tossed face-up in the air. In the context of inertial mass sensing, which can measure mass with atomic precision, rotational dynamics are normally considered a complication hindering measurement interpretation. Here, we exploit the rotational dynamics of a microfluidic device to develop a new modality in inertial resonant sensing. Combining theory with experiments, we show that this modality normally measures the volume of the particle while being insensitive to its density. Paradoxically, particle density only emerges when fluid viscosity becomes dominant over inertia. We explain this paradox via a viscosity-driven, hydrodynamic coupling between the fluid and the particle that activates the rotational inertia of the particle, converting it into a viscous flywheel. This modality now enables the simultaneous measurement of particle volume and mass in fluid, using a single, high-throughput measurement., Comment: 20 pages, 4 figures, 12 s. figures, 2 s. tables
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- 2020
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9. Classroom Quality, Classroom Composition, and Age at Entry: Experiences in Early Childhood Education and Care and Single and Dual Language Learners' German Vocabulary
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Kohl, Katharina, Willard, Jessica A., Agache, Alexandru, Bihler, Lilly-Marlen, and Leyendecker, Birgit
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We examined independent and interactive links among three central characteristics of children's experiences in early childhood education and care and the German receptive vocabulary of single language learners and dual language learners (DLLs). We allowed for possible differential effects depending on children's language background. Our sample included 2,231 children (n = 1,555 single language learners, n = 371 DLLs from families in which German was frequently spoken, n = 305 DLLs from families in which German was less frequently spoken). Children attended 177 classrooms in 95 early childhood education and care centers and were 30 to 80 months old. We found that classroom process quality predicted German vocabulary only for DLLs with low exposure to German in the family. An earlier age at entry was linked to a larger German vocabulary for all children, but the link was stronger for DLLs from families with low exposure to German. Classroom composition did not predict German vocabulary.
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- 2019
10. A rare association of multiple sclerosis and systemic lupus erythematosus - A case report
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Luana Stanciu, Silviu Stanciu, Simona Petrescu, Mihaela Agache, Claudiu Popescu, and Catalin Codreanu
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systemic lupus erythematosus ,multiple sclerosis ,autoimmune ,interferon ,systemic ,Medicine ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Although both systemic lupus erythematosus (SLE) and multiple sclerosis (MS) are autoimmune diseases, their simultaneous presence in the same patient is rare. Case report. We present the case of a 26-year-old woman who was diagnosed with MS and underwent treatment with interferon beta 1-alfa. After 2 years, she developed cutaneous lesions subsequent to a systemic disorder. After multiple serological tests were conducted, the diagnosis of SLE was established and hydroxychloroquine was added to the patient’s treatment. Conclusion. The presented case report is one of only a few cases published on the association of the two autoimmune diseases.
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- 2023
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11. Does Variation in Early Childhood Education Matter More for Dual Language Learners' than for Monolingual Children's Language Development?
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Willard, Jessica A., Leyendecker, Birgit, Kohl, Katharina, Bihler, Lilly-Marlen, and Agache, Alexandru
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Can early childhood education (ECE) support the societal language development of children from linguistically diverse backgrounds? This study examined how existing variation in classroom interaction quality (CLASS Pre-K), classroom composition (percentages of children from low-income backgrounds and dual language learners [DLLs]), and duration of attending German ECE were related to language trajectories from 30 to 73 months of age (n = 519 children in 154 classrooms). DLL status served as a focal moderator and parental education was considered as an additional moderator. Age-based growth models revealed interactions between DLL status and ECE characteristics. There were numerous intercept effects that endured over the age span studied. Interaction quality (emotional support) and classroom composition (percentage of DLLs) were related only to DLLs' German language growth. Parental education did not moderate ECE effects. Hence, the observed range of variation in German ECE may matter for DLLs' societal language development but may be of less relevance for monolingual children.
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- 2022
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12. Do Peers Matter? Peer Effects on Young Children's Vocabulary Gains in German Classrooms
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Kohl, Katharina, Bihler, Lilly-Marlen, Agache, Alexandru, Leyendecker, Birgit, and Willard, Jessica A.
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Children in early childhood education and care (ECEC) spend a considerable amount of time interacting with their peers. However, open questions remain on whether and how children influence their peers' language development. The present study examined effects of peers' German receptive vocabulary (n = 1,871) on individual children's (n = 431) receptive vocabulary gains. Target children were between 30 and 48 months old at the beginning of the study. Findings revealed no links between peers' vocabulary skills and individual children's vocabulary gains, neither for all children nor depending on children's prior vocabulary skills. However, for children with lower prior skills, there was a negative association between the percentage of dual language learners in the classroom and children's vocabulary gains. This link was not attributable to peers' vocabulary skills. A number of possible mediators and moderators for peer effects were examined but none of them proved to be significant. In sum, these (null-) findings inform future research on compositional and peer effects as well as their underlying processes. Moreover, they have important practical implications for policymakers and ECEC professionals.
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- 2022
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13. Depression in Rheumatoid Arthritis: Prevalence and Effects on Disease Activity
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Cătălina-Elena Ionescu, Claudiu Costinel Popescu, Mihaela Agache, Georgiana Dinache, and Cătălin Codreanu
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rheumatoid arthritis ,depression ,mental health ,disease activity ,Medicine - Abstract
Background:The primary objective of this study was to estimate depression’s prevalence in a cohort of rheumatoid arthritis (RA) patients, and the secondary objective was to evaluate the impact of depression on disease activity over time. Methods: We included all patients with RA presenting to our clinic from 2019 to 2020, who had three follow-up visits available. Depression prevalence was calculated using the patient’s history of diagnosed depression, and disease activity was assessed using the disease activity score for 28 joints (DAS28) and its components: tender joint count (TJC), swollen joint count (SJC), pain value on a visual analog scale (VAS), and inflammatory markers. Results: A total of 400 RA patients were included, 75 of whom had diagnosed depression, generating a prevalence of 18.8%. The mean values of DAS28 and its components were higher, with statistical significance, in the depression subgroup at all three follow-ups (p < 0.001). Conclusions: Depression is prevalent in the RA population, and leads to higher disease activity in dynamic evaluations. Assessing depression could be a psychological marker for RA prognosis with an important outcome in controlling disease activity.
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- 2024
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14. Longitudinal Interrelations between Nonword Repetition and Vocabulary from Age Three to Five: Evidence for Within-Child Processes?
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Willard, Jessica A., Agache, Alexandru, Kohl, Katharina, Bihler, Lilly-Marlen, and Leyendecker, Birgit
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The relation between nonword repetition and vocabulary has been the focus of a theoretical controversy for several decades. The point of contention is whether the ability underlying nonword repetition drives vocabulary growth or vice versa. The present study examines longitudinal interrelations between nonword repetition and vocabulary from age 3 to 5 with random intercept cross-lagged panel models (RI-CLPMs). RI-CLPMs have the advantage of separating within-child dynamic processes from more stable differences between children, including time-stable unmeasured confounders. For n = 260 monolingual German-speaking children assessed at three time points with a lag of eleven months, RI-CLPM and, for comparison purposes, "classical" cross-lagged panel models (CLPMs) were estimated. The ill-fitting CLPMs in which cross-lagged effects combine within-child processes and stable differences between children yielded evidence consistent with reciprocal effects between nonword repetition and vocabulary (without covariates) or from nonword repetition to vocabulary (with covariates). Adding a random intercept markedly improved model fit. All within-child cross-lagged effects in the RI-CLPM were nonsignificant. Thus, the results provided no evidence consistent with within-child processes such as nonword repetition affecting vocabulary or vice versa for preschool-age children. Instead, results are more consistent with, for example, third variable explanations, within-child processes fading out by age 3 or occurring on a time frame that is not captured with a lag of approximately 1 year.
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- 2021
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15. Adverse events in children and adolescents undergoing allergen immunotherapy for respiratory allergies—Report from the Allergen Immunotherapy Adverse Events Registry (ADER), a European Academy of Allergy and Clinical Immunology taskforce
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Julijana Asllani, Dimitrios Mitsias, George Konstantinou, Eris Mesonjesi, Fatmira Xhixha, Esmeralda Shehu, George Christoff, Katia Noleva, Michael Makris, Xenofon Aggelidis, Mirjana Turkalj, Erceg Damir, Ioana Agache, Vesna Tomic‐Spiric, Rajica Stosovic, Zeynep Misirligil, Mitja Kosnik, Todor A. Popov, Moises Calderon, Nikolaos G. Papadopoulos, and ADER study group
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adverse events ,allergen immunotherapy ,real‐life settings ,risk factors ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Background Although it has been shown that allergen immunotherapy (AIT) is well‐tolerated in children, systematic and prospective surveillance of AIT safety in real life settings is needed. Methods The multinational Allergen Immunotherapy Adverse Events Registry (ADER) was designed to address AIT safety in real life clinical practice. Data on children ≤18 years old with respiratory allergies undergoing AIT were retrieved. Patient‐ and AIT‐related features were collected and analyzed. The characteristics of adverse events (AE) and risk factors were evaluated. Results A total of 851 patients, 11.3 ± 3.4 years old, with rhinitis only (47.6%); asthma and rhinitis (44.5%); asthma (7.9%), receiving 998 AIT courses were analyzed. Sublingual immunotherapy (SLIT) accounted for 51% of the courses. In 84.5% of patients only one AIT treatment was prescribed. Pollen was the most frequent sensitizer (57.1%), followed by mites (53.4%), molds (18.2%) and epithelia (16.7%). Local and systemic AEs were reported in 85 patients (9.9%). Most AEs (83.1%) were mild and occurred in
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- 2023
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16. Transcriptomics reveals a distinct metabolic profile in T cells from severe allergic asthmatic patients
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Carmela Pablo-Torres, Carlota Garcia-Escribano, Martina Romeo, Cristina Gomez-Casado, Ricardo Arroyo Solera, José Luis Bueno-Cabrera, M. del Mar Reaño Martos, Alfredo Iglesias-Cadarso, Carlos Tarín, Ioana Agache, Tomás Chivato, Domingo Barber, María M. Escribese, and Elena Izquierdo
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t cells ,CD3+cells ,allergy ,transcriptomics ,metabolism ,severe phenotype ,Immunologic diseases. Allergy ,RC581-607 - Abstract
The reasons behind the onset and continuation of chronic inflammation in individuals with severe allergies are still not understood. Earlier findings indicated that there is a connection between severe allergic inflammation, systemic metabolic alterations and impairment of regulatory functions. Here, we aimed to identify transcriptomic alterations in T cells associated with the degree of severity in allergic asthmatic patients. T cells were isolated from severe (n = 7) and mild (n = 9) allergic asthmatic patients, and control (non-allergic, non-asthmatic healthy) subjects (n = 8) to perform RNA analysis by Affymetrix gene expression. Compromised biological pathways in the severe phenotype were identified using significant transcripts. T cells' transcriptome of severe allergic asthmatic patients was distinct from that of mild and control subjects. A higher count of differentially expressed genes (DEGs) was observed in the group of individuals with severe allergic asthma vs. control (4,924 genes) and vs. mild (4,232 genes) groups. Mild group also had 1,102 DEGs vs. controls. Pathway analysis revealed alterations in metabolism and immune response in the severe phenotype. Severe allergic asthmatic patients presented downregulation in genes related to oxidative phosphorylation, fatty acid oxidation and glycolysis together with increased expression of genes coding inflammatory cytokines (e.g. IL-19, IL-23A and IL-31). Moreover, the downregulation of genes involved in TGFβ pathway together with a decreased tendency on the percentage of T regulatory cell (CD4 + CD25+), suggest a compromised regulatory function in severe allergic asthmatic patients. This study demonstrates a transcriptional downregulation of metabolic and cell signalling pathways in T cells of severe allergic asthmatic patients associated with diminished regulatory T cell function. These findings support a link between energy metabolism of T cells and allergic asthmatic inflammation.
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- 2023
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17. Correction: Agache et al. Nail Ultrasound in Psoriasis and Psoriatic Arthritis—A Narrative Review. Diagnostics 2023, 13, 2236
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Mihaela Agache, Claudiu C. Popescu, Luminita Enache, Bianca M. Dumitrescu, and Catalin Codreanu
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n/a ,Medicine (General) ,R5-920 - Abstract
In the original publication [...]
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- 2024
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18. Erratum to: Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA
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Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Białoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guérin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Lodrup Carlsen, K. C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Kaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Maggio, M., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Siciliano, P., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Tsartara, S. I., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van den Berge, M., Vandenplas, O., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wickman, M., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and de Oliveira-Alves, B.
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- 2023
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19. Development and validation of an electronic daily control score for asthma (e-DASTHMA): a real-world direct patient data study
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Bernardo Sousa-Pinto, PhD, Cristina Jácome, PhD, Ana Margarida Pereira, MD, Frederico S Regateiro, MD, Rute Almeida, PhD, Wienczyslawa Czarlewski, MD, Marek Kulus, ProfMD, Mohamed H Shamji, ProfMD, Louis-Philippe Boulet, ProfMD, Matteo Bonini, MD, Luisa Brussino, MD, G Walter Canonica, ProfMD, Alvaro A Cruz, MD, Bilun Gemicioglu, ProfMD, Tari Haahtela, ProfMD, Maciej Kupczyk, MD, Violeta Kvedariene, MD, Desirée Larenas-Linnemann, MD, Renaud Louis, ProfMD, Marek Niedoszytko, ProfMD, Nhân Pham-Thi, MD, Francesca Puggioni, MD, Jan Romantowski, MD, Joaquin Sastre, ProfMD, Nicola Scichilone, ProfMD, Luis Taborda-Barata, ProfMD, Maria Teresa Ventura, MD, Rafael José Vieira, MD, Ioana Agache, ProfMD, Anna Bedbrook, BSc, Karl C Bergmann, MD, Rita Amaral, PhD, Luís Filipe Azevedo, PhD, Sinthia Bosnic-Anticevich, ProfPhD, Guy Brusselle, ProfMD, Roland Buhl, ProfMD, Lorenzo Cecchi, MD, Denis Charpin, MD, Claudia Chaves Loureiro, MD, Frédéric de Blay, ProfMD, Stefano Del Giacco, ProfMD, Philippe Devillier, ProfMD, Ewa Jassem, ProfMD, Guy Joos, ProfMD, Marek Jutel, ProfMD, Ludger Klimek, MD, Piotr Kuna, ProfMD, Daniel Laune, PhD, Jorge Luna Pech, MD, Mika Makela, ProfMD, Mario Morais-Almeida, MD, Rachel Nadif, PhD, Hugo E Neffen, MD, Ken Ohta, ProfMD, Nikolaos G Papadopoulos, ProfMD, Alberto Papi, ProfMD, Benoit Pétré, MD, Oliver Pfaar, MD, Daniela Rivero Yeverino, MD, Carlos Robalo Cordeiro, ProfMD, Nicolas Roche, ProfMD, Ana Sá-Sousa, PhD, Boleslaw Samolinski, ProfMD, Aziz Sheikh, ProfMD, Charlotte Suppli Ulrik, ProfMD, Omar S Usmani, ProfMD, Arunas Valiulis, ProfMD, Olivier Vandenplas, ProfMD, Pedro Vieira-Marques, PhD, Arzu Yorgancioglu, ProfMD, Torsten Zuberbier, ProfMD, Josep M Anto, ProfMD, João A Fonseca, PhD, and Jean Bousquet, ProfMD
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Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Summary: Background: Validated questionnaires are used to assess asthma control over the past 1–4 weeks from reporting. However, they do not adequately capture asthma control in patients with fluctuating symptoms. Using the Mobile Airways Sentinel Network for airway diseases (MASK-air) app, we developed and validated an electronic daily asthma control score (e-DASTHMA). Methods: We used MASK-air data (freely available to users in 27 countries) to develop and assess different daily control scores for asthma. Data-driven control scores were developed based on asthma symptoms reported by a visual analogue scale (VAS) and self-reported asthma medication use. We included the daily monitoring data from all MASK-air users aged 16–90 years (or older than 13 years to 90 years in countries with a lower age of digital consent) who had used the app in at least 3 different calendar months and had reported at least 1 day of asthma medication use. For each score, we assessed construct validity, test–retest reliability, responsiveness, and accuracy. We used VASs on dyspnoea and work disturbance, EQ-5D-VAS, Control of Allergic Rhinitis and Asthma Test (CARAT), CARAT asthma, and Work Productivity and Activity Impairment: Allergy Specific (WPAI:AS) questionnaires as comparators. We performed an internal validation using MASK-air data from Jan 1 to Oct 12, 2022, and an external validation using a cohort of patients with physician-diagnosed asthma (the INSPIRERS cohort) who had had their diagnosis and control (Global Initiative for Asthma [GINA] classification) of asthma ascertained by a physician. Findings: We studied 135 635 days of MASK-air data from 1662 users from May 21, 2015, to Dec 31, 2021. The scores were strongly correlated with VAS dyspnoea (Spearman correlation coefficient range 0·68–0·82) and moderately correlated with work comparators and quality-of-life-related comparators (for WPAI:AS work, we observed Spearman correlation coefficients of 0·59–0·68). They also displayed high test–retest reliability (intraclass correlation coefficients range 0·79–0·95) and moderate-to-high responsiveness (correlation coefficient range 0·69–0·79; effect size measures range 0·57–0·99 in the comparison with VAS dyspnoea). The best-performing score displayed a strong correlation with the effect of asthma on work and school activities in the INSPIRERS cohort (Spearman correlation coefficients 0·70; 95% CI 0·61–0·78) and good accuracy for the identification of patients with uncontrolled or partly controlled asthma according to GINA (area under the receiver operating curve 0·73; 95% CI 0·68–0·78). Interpretation: e-DASTHMA is a good tool for the daily assessment of asthma control. This tool can be used as an endpoint in clinical trials as well as in clinical practice to assess fluctuations in asthma control and guide treatment optimisation. Funding: None.
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- 2023
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20. Family Literacy Activities and Their Interplay with Family and Preschool Language Environments: Links to Gains in Dual Language Learners' German Vocabulary
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Willard, Jessica A., Kohl, Katharina, Bihler, Lilly-Marlen, Agache, Alexandru, and Leyendecker, Birgit
- Abstract
Research Findings: Are family literacy activities linked to gains in preschool-aged dual language learners' (DLLs') societal language vocabulary? To understand connections between literacy activities and vocabulary, we separately considered literacy activities in the respective heritage language and in the societal language, German, and accounted for heterogeneity in DLLs' family and preschool language environment. DLLs (n = 115) were administered the German PPVT-4 twice (at 40 and 51 months). Literacy activities as well as other family language environment variables were reported by mothers. Classroom language stimulation was observed with the CLASS Pre-K language modeling scale. Two different models of change revealed that family literacy activities in the heritage language predicted gains in German vocabulary for children with low levels of classroom language stimulation (albeit at the p = 0.10-level in one set of models). There was no evidence that literacy activities in German were positively connected to gains in German vocabulary. Practice or Policy: This study suggests that family literacy activities in the heritage language may have the potential to support societal language vocabulary. More research is needed to understand under what circumstances family literacy activities in the societal language are supportive of DLLs' societal language vocabulary.
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- 2021
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21. Macrophage Activated Syndrome associated with Adult Onset Still Disease
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Mihaela Agache, Corina Mogosan, Claudiu Popescu, Stefan Gabriel, and Catalin Codreanu
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haemophagocytic lymphohistiocytosis ,adult onset still disease ,macrophage activation syndrome ,Medicine ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Haemophagocytic lymphohistiocytosis (HLH) is an underrecognized hyperinflammatory condition with a high mortality, characterized by inappropriate survival of histiocytes and cytotoxic T cells (CTLs), leading to a cytokine storm, haemophagocytosis and multi-organ damage (1). The currently accepted terminology includes two forms of HLH: the primary or familial HLH (fHLH) and the secondary HLH (sHLH) (2). The sHLH associated with rheumatic conditions is known as macrophage activation syndrome (MAS). MAS can develop at any time during the evolution of the rheumatic diseases: at the beginning, during flare of the disease or during intercurrent infections – mostly with viral trigger. We present a case of MAS in an patient with adult-onset Still Disease. It is of great importance to be recognized in early stages, because if promptly treated it might respond well to combination therapy of glucocorticoids and IL1- blockers.
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- 2022
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22. Linking Quantity and Quality of Early Childhood Education and Care to Children's Socio-Emotional Adjustment: A German Cross-Sectional Study
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Kohl, Katharina, Bihler, Lilly-Marlen, Willard, Jessica A., Agache, Alexandru, and Leyendecker, Birgit
- Abstract
This study examined how quantity and quality of early childhood education and care (ECEC) are related to the socio-emotional adjustment of children born in Germany (30-48 months old, N = 395). Previous research focused on a small set of ECEC features, used broad measures, and yielded inconclusive results. We assessed ECEC quantity (age at entry, hours per week), process quality (CLASS Pre-K), structural quality (child-teacher ratio), and classroom composition (percentage of immigrant children). Controlling for child, family, and teacher characteristics, we tested main and interaction effects in regression analyses. Research Findings: More hours per week predicted lower adjustment only on specific indicators (hyperactivity, conduct problems) and only in classrooms with a high percentage of immigrant children or a high child-teacher ratio. In addition, a higher child-teacher ratio predicted more conduct problems, but only for children who entered ECEC at a very young age. Process quality did not predict adjustment. Practice or policy: In sum, this implies that German ECEC does not pose a major risk for children's socio-emotional adjustment, as only certain aspects of quantity and structural quality are linked to very specific socio-emotional outcomes under very specific circumstances.
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- 2020
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23. Long-term safety and exploratory efficacy of fevipiprant in patients with inadequately controlled asthma: the SPIRIT randomised clinical trial
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Jorge Maspero, Ioana Octavia Agache, Tadashi Kamei, Makoto Yoshida, Bryan Boone, James M. Felser, Fernando Kawakami, Barbara Knorr, David Lawrence, Thomas Lehmann, Wei Wang, and Andrew J. Pedinoff
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Adverse event ,DP2 receptor ,Fevipiprant ,Safety ,Uncontrolled asthma ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background The prostaglandin D2 (PGD2) receptor 2 (DP2 receptor) pathway is an important regulator of the inflammatory cascade in asthma, which can be stimulated by allergic or non-allergic triggers. Fevipiprant is an oral, non-steroidal, highly selective, reversible antagonist of the DP2 receptor that inhibits the binding of PGD2 and its metabolites. Methods SPIRIT, a 2-treatment period (52-week, double-blind and optional 104-week single-blind), randomised, placebo-controlled, multicentre, parallel-group study, assessed the long-term safety of fevipiprant (150 mg and 450 mg o.d.) added to standard of care in patients ≥ 12 years with uncontrolled asthma. Stratified block randomisation was used. Patients were randomised in an approximate ratio of 3:3:1 (fevipiprant 150 mg, fevipiprant 450 mg or placebo). Patients were either newly enrolled or had participated in a previous fevipiprant Phase 3 trial. Primary endpoints were: time-to-first treatment emergent adverse event (AE); serious AE; and AE leading to discontinuation from study treatment. Data from both treatment periods were combined for analyses. Data were collected during study site visits. Results In total, 1093 patients were randomised to receive fevipiprant 150 mg, 1085 to fevipiprant 450 mg, and 360 to placebo. Overall, 1184 patients had ≥ 52 weeks’ treatment, while 163 received ≥ 104 weeks’ treatment. Both doses were well tolerated, with a safety profile similar to placebo both in new patients and in those enrolled from previous studies. In exploratory analyses, reduced rates of moderate-to-severe asthma exacerbations, increased time-to-first moderate-to-severe asthma exacerbation and improved FEV1 were observed for both doses of fevipiprant versus placebo; these were without multiplicity adjustment and should be interpreted with caution. SPIRIT was terminated early, on 16 December 2019, by the Sponsor. Conclusions In patients with uncontrolled asthma, the addition of fevipiprant had a favourable long-term safety profile. Trial registration Clinicaltrials.gov, NCT03052517, prospectively registered 23 January 2017, https://clinicaltrials.gov/ct2/show/NCT03052517 .
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- 2021
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24. Real‐world data using mHealth apps in rhinitis, rhinosinusitis and their multimorbidities
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Bernardo Sousa‐Pinto, Aram Anto, Markus Berger, Stephanie Dramburg, Oliver Pfaar, Ludger Klimek, Marek Jutel, Wienczyslawa Czarlewski, Anna Bedbrook, Arunas Valiulis, Ioana Agache, Rita Amaral, Ignacio J. Ansotegui, Katharina Bastl, Uwe Berger, Karl C. Bergmann, Sinthia Bosnic‐Anticevich, Fulvio Braido, Luisa Brussino, Victoria Cardona, Thomas Casale, G. Walter Canonica, Lorenzo Cecchi, Denis Charpin, Tomás Chivato, Derek K. Chu, Cemal Cingi, Elisio M. Costa, Alvaro A. Cruz, Philippe Devillier, Stephen R. Durham, Motohiro Ebisawa, Alessandro Fiocchi, Wytske J. Fokkens, Bilun Gemicioğlu, Maia Gotua, Maria‐Antonieta Guzmán, Tari Haahtela, Juan Carlos Ivancevich, Piotr Kuna, Igor Kaidashev, Musa Khaitov, Violeta Kvedariene, Désirée E. Larenas‐Linnemann, Brian Lipworth, Daniel Laune, Paolo M. Matricardi, Mario Morais‐Almeida, Joaquim Mullol, Robert Naclerio, Hugo Neffen, Kristoff Nekam, Marek Niedoszytko, Yoshitaka Okamoto, Nikolaos G. Papadopoulos, Hae‐Sim Park, Giovanni Passalacqua, Vincenzo Patella, Simone Pelosi, Nhân Pham‐Thi, Ted A. Popov, Frederico S. Regateiro, Sietze Reitsma, Monica Rodriguez‐Gonzales, Nelson Rosario, Philip W. Rouadi, Boleslaw Samolinski, Ana Sá‐Sousa, Joaquin Sastre, Aziz Sheikh, Charlotte Suppli Ulrik, Luis Taborda‐Barata, Ana Todo‐Bom, Peter Valentin Tomazic, Sanna Toppila‐Salmi, Salvatore Tripodi, Ioanna Tsiligianni, Erkka Valovirta, Maria Teresa Ventura, Antonio A. Valero, Rafael José Vieira, Dana Wallace, Susan Waserman, Sian Williams, Arzu Yorgancioglu, Luo Zhang, Mihaela Zidarn, Jaron Zuberbier, Heidi Olze, Josep M. Antó, Torsten Zuberbier, João A. Fonseca, and Jean Bousquet
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allergic rhinitis ,app ,chronic rhinosinusitis ,mHealth ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Digital health is an umbrella term which encompasses eHealth and benefits from areas such as advanced computer sciences. eHealth includes mHealth apps, which offer the potential to redesign aspects of healthcare delivery. The capacity of apps to collect large amounts of longitudinal, real‐time, real‐world data enables the progression of biomedical knowledge. Apps for rhinitis and rhinosinusitis were searched for in the Google Play and Apple App stores, via an automatic market research tool recently developed using JavaScript. Over 1500 apps for allergic rhinitis and rhinosinusitis were identified, some dealing with multimorbidity. However, only six apps for rhinitis (AirRater, AllergyMonitor, AllerSearch, Husteblume, MASK‐air and Pollen App) and one for rhinosinusitis (Galenus Health) have so far published results in the scientific literature. These apps were reviewed for their validation, discovery of novel allergy phenotypes, optimisation of identifying the pollen season, novel approaches in diagnosis and management (pharmacotherapy and allergen immunotherapy) as well as adherence to treatment. Published evidence demonstrates the potential of mobile health apps to advance in the characterisation, diagnosis and management of rhinitis and rhinosinusitis patients.
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- 2022
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25. Enthesitis in psoriatic arthritis
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Mihaela Agache, Catalina Elena Ionescu, Claudiu Popescu, Luminita Enache, Corina Mogosan, and Catalin Codreanu
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psoriatic arthritis ,enthesitis ,ultrasound ,Medicine ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Enthesitis is a distinctive feature of psoriatic arthritis. New imaging techniques help to better understand the pathophysiology of entheses, being one of the essential factors of the subclinical and prodromal stages of psoriatic arthritis. This paper aims to review the main clinical scores, imaging scores, confounding factors that might influence the interpretation of results and the impact of medication on enthesitis in psoriatic arthritis.
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- 2021
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26. Clinically suspect arthralgia – are we going towards a new shift in the therapeutic paradigm of rheumatoid arthritis?
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Catalina Elena Ionescu, Mihaela Agache, Claudiu Popescu, Luminita Enache, Corina Mogosan, and Catalin Codreanu
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clinically suspect arthralgia ,window of opportunity ,pre-arthritis phase ,Medicine ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Background. There is a time sensitive window of opportunity in rheumatoid arthritis (RA) in which therapeutic intervention is more effective, the disease being more susceptible to the immunomodulatory effects of the remissive medication. The goal is to prevent osteo-articular damage, which causes severe functional deficit, and to raise the chance to lead the disease in remission. Evolution towards RA represents a multi-step process. In other medical fields prevention has the same important role as treatment, so could we in the future switch again the therapeutic paradigm in RA, from early treatment to prevention of RA, by treating patients with high risk of developing disease? Initiating treatment in the pre-RA phases could potentially lead to a better immune modulation or even preventing disease development by acting on less mature pathogenic processes. Treating in the initial symptomatic phase of the disease could potentially be more effective in reducing disease persistence and the development of structural lesions. The clinically suspect arthralgia (CSA) definition offers a support of clinical parameters for future longitudinal studies, where together with para clinical parameters, laboratory studies and imagistic studies, could lead to the development of imminent RA classification criteria. Currently there are more ongoing studies that have the primary objective to prove this concept with different subpopulations and treatments, but most of them have inclusion criteria based on the presence of autoantibodies. The publication of this trials results in the next decade will help to better understand the efficacy of therapeutic intervention with the scope of preventing chronic arthritis and what subset of patients at risk to treat. There are no recommendations for management of CSA, but current practice is symptomatic treatment with nonsteroidal anti-inflammatory drugs, pain relievers and of course monitoring.
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- 2021
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27. Inertial and viscous flywheel sensing of nanoparticles
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Georgios Katsikis, Jesse F. Collis, Scott M. Knudsen, Vincent Agache, John E. Sader, and Scott R. Manalis
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Science - Abstract
Balances for nanoparticles such as resonating fluid-filled cantilevers usually probe only mass through changes in oscillation frequency. Katsikis and Collis et al. tap information from previously ignored rotational motion to simultaneously measure particle mass and volume.
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- 2021
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28. Nail Ultrasound in Psoriasis and Psoriatic Arthritis—A Narrative Review
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Mihaela Agache, Claudiu C. Popescu, Luminița Enache, Bianca M. Dumitrescu, and Cătălin Codreanu
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ultrasound ,psoriatic arthritis ,psoriasis ,nail enthesitis ,Medicine (General) ,R5-920 - Abstract
Ultrasonography has advantages for assessing psoriatic arthritis (PsA) due to its ability to evaluate several targets, including joints, entheses, and tendons, but also skin and nails. Although ultrasound is widely used in PsA, nail ultrasound, despite its potential as a non-invasive method for the early detection of inflammation in the nail apparatus, has low applicability in medical practice, as probes with a higher frequency are needed compared with the frequency of probes usually used. In the present article, we have narratively evaluated the studies published in the last 5 years (19 February 2018–18 February 2023) on nail ultrasound value in the diagnosis and monitoring of PsA. The studies published during this period share common measurement parameters, such as the OMERACT definition of enthesis published in 2018. We included original articles published in PubMed and Web of Science using the following search terms in all possible combinations: psoriatic arthritis, psoriasis, ultrasound, and nail. Articles were declared relevant if they presented data on nail morphology, power Doppler evaluation and nearby structure evaluation, while focusing on digitorum extensor enthesitis. In most of the studies, common morphological parameters were generally increased in patients with psoriasis or PsA and were demonstrated to change with medication. The thickness of the extensor tendon was greater in patients with PsA and psoriasis versus controls and it was correlated with nail clinical changes, especially the presence of onycholysis. The presence of PD showed large variability in healthy individuals. The link between enthesitis and nail involvement is still a subject of controversy, taking into account the latest histological findings. The use of ultrasound in the evaluation of nail and DIP enthesitis remains a challenge and an area of research in the coming years.
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- 2023
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29. Radiographic assessment in rheumatoid arthritis: From daily practice to clinical trials
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Corina Mogosan, Luminita Enache, Bianca Dumitrescu, Mihaela Agache, Catalina Ionescu, Claudiu Popescu, and Catalin Codreanu
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rheumatoid arthritis ,radiographic ,erosion ,joint space narrowing ,Medicine ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Imaging evaluation in rheumatoid arthritis (RA) has evolved significantly in last decades. Even if the modern imaging technics like ultrasound and magnetic resonance imaging have unequivocal place in the assessment of early disease (especially for synovial inflammation, bone oedema, erosions), radiographic evaluation of hands and feet is still the most widely used imaging technic for quantification of joint damage in RA. In the current review we aim to address some practical issues related to the radiographic evaluation in RA from daily practice perspective, followed by a broader approach from the clinical trials point of view.
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- 2021
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30. Screening Criteria for Colorectal Cancer for Patients with Type II Diabetes Mellitus
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Alexandra AGACHE, Sabin BOTEA, Petronel MUSTATEA, Florin BOBIRCA, and Traian PATRASCU
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diabetes ,colorectal cancer ,screening ,Medicine ,Medicine (General) ,R5-920 - Abstract
Colorectal cancer and diabetes mellitus represent a major public health issue, first, by the number of new cases which are at an alarming rate. Secondly, by the negative effect over the quality of life, socio-economic status and lifespan, representing high morbidity and mortality causes. Diabetes Mellitus is the disease of the century with a global prevalence (standardised-age) which doubled since 1980, rising from 4.7% to 8.5% in adult population. In 2012, the estimated number of fatalities caused by diabetes mellitus and other related complications were at 3.7 million, out of which 43% were patients under the age of 70. Neoplasia represents the second cause of death, after cardiovascular disease. Colorectal cancer (CRC) ranks the 3rd regarding the global neoplasia incidence (10.2%) and the second regarding the mortality (9.5% of all cancer deaths). Colorectal cancer screening refers to the periodic evaluation of asymptomatic patients at risk of developing this neoplasia. Colorectal cancer has a number of peculiarities that make it ideal for screening. Since the end of the 19th century, the suspicion has been raised that diabetes mellitus has been involved, through directly etiological mechanisms, in carcinogenesis (breast, endometrium, colorectal, pancreas, liver, non-Hodgkin lymphoma). At the moment, there is already a consensus in the literature on the role of diabetes as an independent risk factor for colorectal cancer. However, despite the existence of numerous experimental evidence, epidemiological studies and meta-analyses, there is currently no adaptation of colorectal cancer screening for these patients. Material and method: Prospective case-control study conducted over a 2-year period including a number of 442 patients presented at „Dr. I Cantacuzino” Clinical Hospital, asymptomatic, who underwent lower digestive endoscopies in order to assess and define using anamnestic, clinical and paraclinical criteria, the profile of the patient with type II diabetes mellitus that should be given an endoscopic examination because diagnosing precursor lesions or even CRC is likely probable. Results: In the analyzed group, statistically significant correlations (p 25, aged over 60 years, with an unbalanced diabetes mellitus counted by HbA1c > 7 mg/dL, with over 5 years of diabetes evolution, in treatment with insulin most likely or combined insulin with oral antidiabetics and with an inflammatory biological profile expressed by PCR> 2 mg/dL threshold values.
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- 2020
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31. Variability of patient and physician global assessment on visual analogue and Likert scales in rheumatoid arthritis
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Claudiu C. Popescu, Laurentiu Cilibiu, Corina Mogosan, Mihaela Agache, Catalina Ionescu, Bianca Dumitrescu, Dragos Minca, Luminita Enache, and Catalin Codreanu
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rheumatoid arthritis ,patient global assessment ,likert scale ,visual analogue scale ,Medicine ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Objective. The study aimed to observe the variability of rheumatoid arthritis (RA) disease activity scores according to the type of patient global assessment (PtGA) and to compare these subjective assessments with objective measurements. Methods. Prospective study in which RA patients four types of assessments in the same day of their inclusion in the study: completing a questionnaire (including PtGA on a 100 mm visual analogue scale – VAS, and a 0-10 Likert scale), clinical interview and joint examination performed by each attending rheumatologist and peripheral venous blood sampling for acute phase reactants. Results. The study included 110 RA patients (57.5 years average age, 9.4 years median disease duration, 90.0% women, 58.2% in remission or low disease activity). There was low concordance and agreement between PtGA and physician global assessment (PhGA): the two evaluations were significantly but poorly correlated, and in 71.8% of cases VAS and Likert PtGA were higher than PhGA with at least 2 points in average. Patients with no tender or swollen joints (27.3%) reported a median VAS-PtGA of 27 cm and a median Likert-PtGA of 4.2 points. Likert-PtGA were higher than VAS-PtGA in the general sample and for patients with normal objective measures (patients in remission according to DAS28-3v-CRP reported a median VAS-PtGA of 5 points, compared to VAS-PtGA of only 2.2 cm). The strongest correlations of PtGA on both VAS and Likert scales were recorded for mHAQ (r = 0.521 and 0.589, p < 0.001), DAS28-3v-CRP (r = 0.419 and 0.422, p < 0.001) and the presence of prolonged morning stiffness (r = 0.361 and 0.485, p < 0.001). Conclusion. Romanian patients with RA seem to favour and understand the Likert scale better than the VAS when reporting PtGA.
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- 2020
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32. STUDY ON THE PRACTICE OF CHESS BY CHILDREN AGED BETWEEN 8 AND 10 YEARS OLD ONLINE THROUGH CONTENTS SPECIFIC TO PHYSICAL EDUCATION
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Agache Gheorghe and Vizitiu Elena
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chess ,online educational platforms ,physical education ,attention ,students ,Education ,Education (General) ,L7-991 - Abstract
In the context of the development of information technology and computers we can talk about equipping schools with internet networks, intranet, computers, tablets and mobile phones which contain software that promotes the development of online education successfully and efficiently. The training of chess-playing students is an essential objective in obtaining good results in competitions. In this sense, the theoretical training must be harmoniously combined with the development of psychomotor qualities, and the teacher-trainer must demonstrate a rigorous ability to select methods and means from physical education and sports, as well as those specific to psychomotor skills, necessary to achieve the proposed objectives for an effective training of chess-playing students, both for classical and online competitions. The research was carried out over a period of two months (October, 2020 - December, 2020) on two groups of children aged between 8 and 10 years old, from School No. 17 Botosani, representing the experiment group (28 students) and the control group ( 28 students, too). The methods used in conducting the study were the observation method, the testing method and the statistical-mathematical method.
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- 2020
33. Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper
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Valerie Hox, Evelijn Lourijsen, Arnout Jordens, Kristian Aasbjerg, Ioana Agache, Isam Alobid, Claus Bachert, Koen Boussery, Paloma Campo, Wytske Fokkens, Peter Hellings, Claire Hopkins, Ludger Klimek, Mika Mäkelä, Ralph Mösges, Joaquim Mullol, Laura Pujols, Carmen Rondon, Michael Rudenko, Sanna Toppila-Salmi, Glenis Scadding, Sophie Scheire, Peter-Valentin Tomazic, Thibaut Van Zele, Martin Wagemann, Job F. M. van Boven, and Philippe Gevaert
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Glucocorticosteroids ,Rhinitis ,Rhinosinusitis ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Because of the inflammatory mechanisms of most chronic upper airway diseases such as rhinitis and chronic rhinosinusitis, systemic steroids have been used for their treatment for decades. However, it has been very well documented that—potentially severe—side-effects can occur with the accumulation of systemic steroid courses over the years. A consensus document summarizing the benefits of systemic steroids for each upper airway disease type, as well as highlighting the potential harms of this treatment is currently lacking. Therefore, a panel of international experts in the field of Rhinology reviewed the available literature with the aim of providing recommendations for the use of systemic steroids in treating upper airway disease.
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- 2020
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34. Prioritizing Research Challenges and Funding for Allergy and Asthma and the Need for Translational Research — The European Strategic Forum on Allergic Diseases
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I. Agache, I. Annesi-Maesano, A. Bonertz, F. Branca, A. Cant, Z. Fras, F. Ingenrieth, L. Namazova-Baranova, M. Odemyr, A. Spanevello, S. Vieths, A. Yorgancioglu, M. Alvaro-Lozano, D. Barber Hernandez, T. Chivato, S. Del Giacco, Z. Diamant, I. Eguiluz-Gracia, R. G. van Wijk, P. Gevaert, A. Graessel, P. Hellings, K. Hoffmann-Sommergruber, M. Jutel, S. Lau, A. Lauerma, J. Maria Olaguibel, L. O’Mahony, C. Ozdemir, O. Palomares, O. Pfaar, J. Sastre, G. Scadding, C. Schmidt-Weber, P. Schmid-Grendelmeier, M. Shamji, I. Skypala, M. Spinola, O. Spranger, M. Torres, A. Vereda, and S. Bonini
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allergic diseases ,asthma ,big data ,environmental health ,exposome ,implementation science ,quality criteria ,translational research ,Pediatrics ,RJ1-570 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The European Academy of Allergy and Clinical Immunology (EAACI) organized the first European Strategic Forum on Allergic Diseases and Asthma. The main aim was to bring together all relevant stakeholders and decision‐makers in the field of allergy, asthma and clinical Immunology around an open debate on contemporary challenges and potential solutions for the next decade. The Strategic Forum was an upscaling of the EAACI White Paper aiming to integrate the Academy’s output with the perspective offered by EAACI’s partners. This collaboration is fundamental for adapting and integrating allergy and asthma care into the context of real‐world problems. The Strategic Forum on Allergic Diseases brought together all partners who have the drive and the influence to make positive change: national and international societies, patients’ organizations, regulatory bodies and industry representatives. An open debate with a special focus on drug development and biomedical engineering, big data and information technology and allergic diseases and asthma in the context of environmental health concluded that connecting science with the transformation of care and a joint agreement between all partners on priorities and needs are essential to ensure a better management of allergic diseases and asthma in the advent of precision medicine together with global access to innovative and affordable diagnostics and therapeutics.
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- 2020
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35. Inertial and viscous flywheel sensing of nanoparticles
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Katsikis, Georgios, Collis, Jesse F., Knudsen, Scott M., Agache, Vincent, Sader, John E., and Manalis, Scott R.
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- 2021
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36. Long-term safety and exploratory efficacy of fevipiprant in patients with inadequately controlled asthma: the SPIRIT randomised clinical trial
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Maspero, Jorge, Agache, Ioana Octavia, Kamei, Tadashi, Yoshida, Makoto, Boone, Bryan, Felser, James M., Kawakami, Fernando, Knorr, Barbara, Lawrence, David, Lehmann, Thomas, Wang, Wei, and Pedinoff, Andrew J.
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- 2021
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37. Highlights and recent developments in skin allergy and related diseases in EAACI journals (2018)
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C. A. Akdis, J. Bousquet, C. E. Grattan, P. A. Eigenmann, K. Hoffmann-Sommergruber, I. Agache, and M. Jutel
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Atopic dermatitis ,Urticaria ,EAACI ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Paediatric Allergy and Immunology as well as Clinical and Translational Allergy. The major goals of EAACI include (i) supporting health promotion in which the prevention of allergy and asthma plays a critical role and (ii) disseminating the knowledge of allergy to all stakeholders including the EAACI junior members. Substantial progress was made in 2018 in the identification of basic mechanisms of atopic dermatitis and urticaria and the translation of these mechanisms into clinics. Many large epidemiologic studies and meta-analyses have been the highlights of the last year.
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- 2019
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38. Executive Summary of ARIA 2019: Integrated care pathways for allergic rhinitis in Argentina, Spain and Mexico
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Juan Carlos Ivancevich, Victoria Cardona, Désirée Larenas-Linnemann, Joaquim Mullol, Hugo Neffen, Mario Zernotti, Estrella Asayag, Ariel Eduardo Blua, R. Maximiliano Gómez, Edgardo Jares, Jorge Máspero, Josep M. Anto, Toni Dedeu, Mónica Rodríguez-González, Yunuen Rocío Huerta-Villalobos, José Miguel Fuentes-Pérez, Eréndira Rodríguez-Zagal, Antonio Valero, Joan Bartra, Isam Alobid, José Antonio Castillo-Vizuete, Teresa Dordal, Rafael Hijano, César Picado, Joaquín Sastre, Martín Bedolla-Barajas, María Teresa Burguete-Cabañas, María del Carmen Costa-Domínguez, Margarita Domínguez-Silva, Jesús Guillermo Espinoza-Contreras, José Luis Gálvez-Romero, Cecilia Yvonne García-Cobas, María de la Luz Hortensia García-Cruz, Luiana Hernández-Velázquez, Jorge A. Luna-Pech, Juan José Matta, María Dolores Mogica-Martínez, Daniela Rivero-Yeverino, Lucy Tania Ruiz, Blanca E. Del Río-Navarro, Javier Gómez-Vera, Alejandra Macías-Weinmann, Ionna Agache, Ignacio Ansotegui, Claus Bachert, Anna Bedbrook, Giorgio Walter Canonica, Thomas B. Casale, Álvaro Cruz, Wytske Fokkens, Peter Hellings, Bolesław Samolinski, and Jean Bousquet
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aria ,rinitis alérgica ,vías integradas de atención ,estudios en vida real ,adherencia ,automedicación ,Immunologic diseases. Allergy ,RC581-607 - Abstract
The health and economic impact of allergic diseases are increasing rapidly, and changes in management strategies are required. Its influence reduces the capacity of work and school performance by at least a third. The ICPs of the airways (integrated care pathways for respiratory diseases) are structured multidisciplinary healthcare plans, promoting the recommendations of the guidelines in local protocols and their application to clinical practice. This document presents an executive summary for Argentina, Mexico, and Spain. Next-generation ARIA guidelines are being developed for the pharmacological treatment of allergic rhinitis (AR), using the GRADE-based guidelines for AR, tested with real-life evidence provided by mobile technology with visual analogue scales. It is concluded that in the AR treatment, H1-antihistamines are less effective than intranasal corticosteroids (INCS), in severe AR the INCS represent the first line of treatment, and intranasal combination INCS + anti-H1 is more effective than monotherapy. However, according to the MASK real-life observational study, patients have poor adherence to treatment and often self-medicate, according to their needs.
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- 2019
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39. Lung Damage in Rheumatoid Arthritis—A Retrospective Study
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Georgiana Dinache, Claudiu Costinel Popescu, Corina Mogoșan, Luminita Enache, Mihaela Agache, and Cătălin Codreanu
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interstitial pulmonary fibrosis ,pulmonary nodules ,rheumatoid arthritis ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
The current study aimed to evaluate rheumatoid arthritis (RA) patients with interstitial lung disease (ILD) in clinical practice and whether disease characteristics are associated with X-ray and high-resolution computed tomography (HR-CT) findings. Medical history of RA patients from a tertiary rheumatology clinic was retrieved from its electronic database starting from 1 January 2019 until the study date (8 August 2022) using International Classification of Disease version 10 codes for RA, ILD and exclusion criteria. The study included 78 RA patients (75.6% women, 15.4% active smokers), with average time from RA to ILD of 5.6 years. Regarding chest X-ray findings, men had a higher prevalence of nodules, combined fibrosis and nodules and combined bronchiectasis and nodules, rheumatoid factor (RF)-positive patients had a higher prevalence of fibrosis and anti-cyclic citrullinated peptide antibodies (ACPA)-positive patients had a higher prevalence of bronchiectasis. Regarding HR-CT findings, patients actively treated with methotrexate had a higher prevalence of nodules; a combination of fibrosis and nodules; combination of emphysema and nodules; and combination of fibrosis, emphysema and nodules. ILD develops within approximately 5 years from RA diagnosis, and ILD-associated imaging findings on chest X-rays and HR-CT are more prevalent among men with RA, among patients with positive RA serology (RF and/or ACPA) and RA patients on methotrexate.
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- 2022
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40. Depression in Rheumatoid Arthritis: A Narrative Review—Diagnostic Challenges, Pathogenic Mechanisms and Effects
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Cătălina-Elena Ionescu, Claudiu Costinel Popescu, Mihaela Agache, Georgiana Dinache, and Cătălin Codreanu
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depression ,disease activity ,quality of life ,rheumatoid arthritis ,Medicine (General) ,R5-920 - Abstract
Depression is one of the most frequent comorbidities in rheumatoid arthritis (RA); it takes an important toll on the quality of life of these patients and also leads to a decrease in life expectancy. The current article is a narrative review on depression in RA, with the objective to emphasize and raise awareness on the high prevalence, pathogenic mechanisms, and effects that depression has on RA patients. In RA, the prevalence of depression has been shown to be 2 to 3 times higher than in the general population, with a meta-analysis reporting that 16.8% of RA patients have a major depressive disorder. Future studies are needed to determine the most accurate self-reported depression questionnaires and their ideal threshold for defining depression as compared to diagnostic interview as gold-standard for patients with RA to allow better comparisons across studies. The pathogenesis of depression remains to be fully understood, but recent specialty literature suggests that immune-mediated processes are involved and that there are similarities between the neural networks recruited in inflammation and those implicated in the pathophysiology of depression. Depression in patients with RA is associated with poor long-term outcomes. Multiple studies have shown that depression in RA is associated with increased pain, fatigue, and physical disability. It alters treatment compliance, causes more comorbidities, and leads to higher mortality, partly through increased suicide risk. Depression in RA also increases health service utilization and healthcare costs directly through hospitalization, but also indirectly through loss of work productivity. Assessing depression could be a significant psychomarker of rheumatological outcome in RA.
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- 2022
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41. Impact of retrograde transillumination while securing the airway in obese patients undergoing bariatric surgery
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Godoroja, Daniela D., Copaescu, Catalin A., Agache, Mihaela C., and Biro, Peter
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- 2020
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42. ERS/EAACI statement on adherence to international adult asthma guidelines
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Alexander G. Mathioudakis, Olympia Tsilochristou, Ian M Adcock, Andras Bikov, Leif Bjermer, Enrico Clini, Breda Flood, Felix Herth, Ildiko Horvath, Omer Kalayci, Nikolaos G. Papadopoulos, Dermot Ryan, Silvia Sanchez Garcia, Jaime Correia-de-Sousa, Thomy Tonia, Hillary Pinnock, Ioana Agache, and Christer Janson
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Diseases of the respiratory system ,RC705-779 - Abstract
Guidelines aim to standardise and optimise asthma diagnosis and management. Nevertheless, adherence to guidelines is suboptimal and may vary across different healthcare professional (HCP) groups. Further to these concerns, this European Respiratory Society (ERS)/European Academy of Allergy and Clinical Immunology (EAACI) statement aims to: 1) evaluate the understanding of and adherence to international asthma guidelines by HCPs of different specialties via an international online survey; and 2) assess strategies focused at improving implementation of guideline-recommended interventions, and compare process and clinical outcomes in patients managed by HCPs of different specialties via systematic reviews. The online survey identified discrepancies between HCPs of different specialties which may be due to poor dissemination or lack of knowledge of the guidelines but also a reflection of the adaptations made in different clinical settings, based on available resources. The systematic reviews demonstrated that multifaceted quality improvement initiatives addressing multiple challenges to guidelines adherence are most effective in improving guidelines adherence. Differences in outcomes between patients managed by generalists or specialists should be further evaluated. Guidelines need to consider the heterogeneity of real-life settings for asthma management and tailor their recommendations accordingly. Continuous, multifaceted quality improvement processes are required to optimise and maintain guidelines adherence. Validated referral pathways for uncontrolled asthma or uncertain diagnosis are needed.
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- 2021
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43. Ultrasound Enthesitis in Psoriasis Patients with or without Psoriatic Arthritis, a Cross-Sectional Analysis
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Mihaela Agache, Claudiu C. Popescu, Liliana Popa, and Cătălin Codreanu
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psoriasis ,psoriatic arthritis ,enthesitis ,ultrasound ,Medicine (General) ,R5-920 - Abstract
Background and objectives: The main objective of the current study was to describe the prevalence of enthesitis at different sites in a group of patients with psoriasis with or without psoriatic arthritis (PsA). Materials and Methods: The study included adult patients with psoriasis who underwent clinical examination, laboratory tests and ultrasound examination of the entheses. The enthesitis ultrasound scores (BUSES, MASEI, GUESS) were evaluated; the presence of OMERACT-defined enthesitis was also recorded for each scan site. Results: The study included 16 (57.1%) patients with PsA and 12 (42.9%) patients with psoriasis, with an increased average body mass index (29.3 kg/m2). Compared to psoriasis patients, PsA patients had a higher prevalence of nail psoriasis (68.8% compared to 33.3%; p = 0.063). There were no significant differences regarding the clinical examination of entheses between patients with psoriasis and patients with PsA (p = 0.459). Ultrasound scores, BUSES, GUESS and MASEI proved to have statistically significant higher median values in PsA patients compared to psoriasis patients. Compared to psoriasis patients, PsA patients had a significantly higher prevalence of OMERACT-defined enthesitis of the quadriceps tendon and inferior patellar ligament (both 81.3% compared to 25.0%, p = 0.003). Clinical examination of the lateral epicondyle and of the superior patellar ligament was consistent with their ultrasound examination (κ = 0.357, p = 0.043, respectively, κ = 0.404, p = 0.008). Conclusions: Clinical enthesitis scores do not differ between psoriasis and PsA patients. All analyzed ultrasound scores are significantly higher in patients with PsA. OMERACT-defined enthesitis has the ability to discriminate sonographic enthesitis between the two subgroups for bilateral quadriceps and inferior patellar tendon enthesitis. Bilateral ultrasound damage of entheses can suggest a PsA diagnosis.
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- 2022
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44. A Formal Approach for the Development of Service-Oriented Applications
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Negreanu, Lorina, Giumale, Cristian, Agache, Alexandru, Muraru, Mihnea, Popovici, Matei, and Dobre, Ciprian
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Computer Science - Software Engineering - Abstract
Please cite this as "Lorina Negreanu, Cristian Giumale, Alexandru Agache, Mihnea Muraru, Matei Popovici, Ciprian Dobre, A Formal Approach for the Development of Service-Oriented Applications, in Proc. of 18th International Conference on Control Systems and Computer Science (CSCS-18), Bucharest, Romania, 2011, pp. 804-810, ISSN: 2066-4451, Politehnica Press", Comment: This article has been withdrawn by the author due to copyright incompatibilities raised by the original publisher. The author(s) ask all interested readers to contact either the authors, or check directly the Proceedings published by the Politehnica Press
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- 2012
45. Management of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank
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Jonathan Grigg, Heather J Zar, David Price, Michael Miligkos, Giuseppe De Carlo, Peter N Le Souëf, Tim Felton, Graham Roberts, Jose A Castro-Rodriguez, Stephen Turner, Alexander G Mathioudakis, Gioulinta S Alimani, Georgios A Mathioudakis, Effie Papageorgiou, Nikolaos G Papadopoulos, Apostolos Beloukas, Ioanna Tsiligianni, Despo Ierodiakonou, Tuomas Jartti, A Deschildre, Wojciech Feleszko, Matteo Bonini, Clare Murray, Adnan Custovic, Mário Morais-Almeida, Wanda Phipatanakul, Mika J Mäkelä, Gunilla Hedlin, Robert F Lemanske, Paraskevi Xepapadaki, James E Gern, Cristina Boccabella, Francine Monique Ducharme, Omer Kalayci, Antonio Nieto Garcia, Ioana Octavia Agache, Leonard Bacharier, Timothy Craig, Zuzana Diamant, Elham M Hossny, Alan Kaplan, Paolo Matricardi, Marina Mitrogiorgou, Karthik Nagaraju, Helena Pité, Paulo M C Pitrez, Petr Pohunek, Susanne Vijverberg, Tonya A Winders, and Gary WK Wong
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Medicine - Abstract
Introduction Clinical recommendations for childhood asthma are often based on data extrapolated from studies conducted in adults, despite significant differences in mechanisms and response to treatments. The Paediatric Asthma in Real Life (PeARL) Think Tank aspires to develop recommendations based on the best available evidence from studies in children. An overview of systematic reviews (SRs) on paediatric asthma maintenance management and an SR of treatments for acute asthma attacks in children, requiring an emergency presentation with/without hospital admission will be conducted.Methods and analysis Standard methodology recommended by Cochrane will be followed. Maintenance pharmacotherapy of childhood asthma will be evaluated in an overview of SRs published after 2005 and including clinical trials or real-life studies. For evaluating pharmacotherapy of acute asthma attacks leading to an emergency presentation with/without hospital admission, we opted to conduct de novo synthesis in the absence of adequate up-to-date published SRs. For the SR of acute asthma pharmacotherapy, we will consider eligible SRs, clinical trials or real-life studies without time restrictions. Our evidence updates will be based on broad searches of Pubmed/Medline and the Cochrane Library. We will use A MeaSurement Tool to Assess systematic Reviews, V.2, Cochrane risk of bias 2 and REal Life EVidence AssessmeNt Tool to evaluate the methodological quality of SRs, controlled clinical trials and real-life studies, respectively.Next, we will further assess interventions for acute severe asthma attacks with positive clinical results in meta-analyses. We will include both controlled clinical trials and observational studies and will assess their quality using the previously mentioned tools. We will employ random effect models for conducting meta-analyses, and Grading of Recommendations Assessment, Development and Evaluation methodology to assess certainty in the body of evidence.Ethics and dissemination Ethics approval is not required for SRs. Our findings will be published in peer reviewed journals and will inform clinical recommendations being developed by the PeARL Think Tank.PROSPERO registration numbers CRD42020132990, CRD42020171624.
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- 2021
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46. ARIA‐EAACI care pathways for allergen immunotherapy in respiratory allergy
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Jean Bousquet, Oliver Pfaar, Ioana Agache, Anna Bedbrook, Cezmi A Akdis, G. Walter Canonica, Tomas Chivato, Mona Al‐Ahmad, Amir H Abdul Latiff, Ignacio J Ansotegui, Claus Bachert, Abdullah Baharuddin, Karl‐Christian Bergmann, Carsten Bindslev‐Jensen, Leif Bjermer, Matteo Bonini, Sinthia Bosnic‐Anticevich, Isabelle Bosse, Helen A. Brough, Luisa Brussino, Moises A Calderon, Luis Caraballo, Victoria Cardona, Pedro Carreiro‐Martins, Tomas Casale, Lorenzo Cecchi, Alfonso M Cepeda Sarabia, Ekaterine Chkhartishvili, Derek K Chu, Ieva Cirule, Alvaro A Cruz, Wienczyslawa Czarlewski, Stefano delGiacco, Pascal Demoly, Philippe Devillier, Dejan Dokic, Stephen L Durham, Motohiro Ebisawa, Yehia El‐Gamal✝, Regina Emuzyte, Amiran Gamkrelidze, Jean Luc Fauquert, Alessandro Fiocchi, Wytske J Fokkens, Joao A Fonseca, Jean‐François Fontaine, Radoslaw Gawlik, Asli Gelincik, Bilun Gemicioglu, Jose E Gereda, Roy Gerth van Wijk, R Maximiliano Gomez, Maia Gotua, Ineta Grisle, Maria‐Antonieta Guzmán, Tari Haahtela, Susanne Halken, Enrico Heffler, Karin Hoffmann‐Sommergruber, Elham Hossny, Martin Hrubiško, Carla Irani, Juan Carlos Ivancevich, Zhanat Ispayeva, Kaja Julge, Igor Kaidashev, Omer Kalayci, Musa Khaitov, Ludger Klimek, Edward Knol, Marek L Kowalski, Helga Kraxner, Inger Kull, Piotr Kuna, Violeta Kvedariene, Vicky Kritikos, Antti Lauerma, Susanne Lau, Daniel Laune, Michael Levin, Desiree E Larenas‐Linnemann, Karin C Lodrup Carlsen, Carlo Lombardi, Olga M Lourenço, Bassam Mahboub, Hans‐Jørgen Malling, Patrick Manning, Gailen D Marshall, Erik Melén, Eli O Meltzer, Neven Miculinic, Branislava Milenkovic, Mostafa Moin, Stephen Montefort, Mario Morais‐Almeida, Charlotte G Mortz, Ralph Mösges, Joaquim Mullol, Leyla Namazova Baranova, Hugo Neffen, Kristof Nekam, Marek Niedoszytko, Mikaëla Odemyr, Robyn E O'Hehir, Markus Ollert, Liam O'Mahony, Ken Ohta, Yoshitaka Okamoto, Kimi Okubo, Giovanni B Pajno, Oscar Palomares, Susanna Palkonen, Petr Panzner, Nikolaos GPapadopoulos, Hae‐Sim Park, Giovanni Passalacqua, Vincenzo Patella, Ruby Pawankar, Nhân Pham‐Thi, Davor Plavec, Todor A Popov, Marysia Recto, Frederico S Regateiro, Carmen Riggioni, Graham Roberts, Monica Rodriguez‐Gonzales, Nelson Rosario, Menachem Rottem, Philip W Rouadi, Dermot Ryan, Boleslaw Samolinski, Mario Sanchez‐Borges✝, Faradiba S Serpa, Joaquin Sastre, Glenis K. Scadding, Mohamed H Shamji, Peter Schmid‐Grendelmeier, Holger J Schünemann, Aziz Sheikh, Nicola Scichilone, Juan Carlos Sisul, Mikhail Sofiev, Dirceu Solé, Talant Sooronbaev, Manuel Soto‐Martinez, Manuel Soto‐Quiros, Milan Sova, Jürgen Schwarze, Isabel Skypala, Charlotte Suppli‐Ulrik, Luis Taborda‐Barata, Ana Todo‐Bom, Maria J Torres, Marylin Valentin‐Rostan, Peter‐Valentin Tomazic, Antonio Valero, Sanna Toppila‐Salmi, Ioanna Tsiligianni, Eva Untersmayr, Marilyn Urrutia‐Pereira, Arunas Valiulis, Erkka Valovirta, Olivier Vandenplas, Maria Teresa Ventura, Pakit Vichyanond, Martin Wagenmann, Dana Wallace, Jolanta Walusiak‐Skorupa, De Yun Wang, Susan Waserman, Gary WK Wong, Arzu Yorgancioglu, Osman M Yusuf, Mario Zernotti, Luo Zhang, Mihaela Zidarn, Torsten Zuberbier, and Marek Jutel
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allergic rhinitis ,asthma ,immunotherapy ,precision medicine ,Immunologic diseases. Allergy ,RC581-607 - Published
- 2021
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47. Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases
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J. Jean Bousquet, Holger J. Schünemann, Alkis Togias, Marina Erhola, Peter W. Hellings, Torsten Zuberbier, Ioana Agache, Ignacio J. Ansotegui, Josep M. Anto, Claus Bachert, Sven Becker, Martin Bedolla-Barajas, Michael Bewick, Sinthia Bosnic-Anticevich, Isabelle Bosse, Louis P. Boulet, Jean Marc Bourrez, Guy Brusselle, Niels Chavannes, Elisio Costa, Alvaro A. Cruz, Wienczyslawa Czarlewski, Wytske J. Fokkens, Joao A. Fonseca, Mina Gaga, Tari Haahtela, Maddalena Illario, Ludger Klimek, Piotr Kuna, Violeta Kvedariene, L. T. T. Le, Desiree Larenas-Linnemann, Daniel Laune, Olga M. Lourenço, Enrica Menditto, Joaquin Mullol, Yashitaka Okamoto, Nikos Papadopoulos, Nhân Pham-Thi, Robert Picard, Hilary Pinnock, Nicolas Roche, Regina E. Roller-Wirnsberger, Christine Rolland, Boleslaw Samolinski, Aziz Sheikh, Sanna Toppila-Salmi, Ioanna Tsiligianni, Arunas Valiulis, Erkka Valovirta, Tuula Vasankari, Maria-Teresa Ventura, Samantha Walker, Sian Williams, Cezmi A. Akdis, Isabella Annesi-Maesano, Sylvie Arnavielhe, Xavier Basagana, Eric Bateman, Anna Bedbrook, K. S. Bennoor, Samuel Benveniste, Karl C. Bergmann, Slawomir Bialek, Nils Billo, Carsten Bindslev-Jensen, Leif Bjermer, Hubert Blain, Mateo Bonini, Philippe Bonniaud, Jacques Bouchard, Vitalis Briedis, Christofer E. Brightling, Jan Brozek, Roland Buhl, Roland Buonaiuto, Giorgo W. Canonica, Victoria Cardona, Ana M. Carriazo, Warner Carr, Christine Cartier, Thomas Casale, Lorenzo Cecchi, Alfonso M. Cepeda Sarabia, Eka Chkhartishvili, Derek K. Chu, Cemal Cingi, Elaine Colgan, Jaime Correia de Sousa, Anne Lise Courbis, Adnan Custovic, Biljana Cvetkosvki, Gennaro D’Amato, Jane da Silva, Carina Dantas, Dejand Dokic, Yves Dauvilliers, Antoni Dedeu, Giulia De Feo, Philippe Devillier, Stefania Di Capua, Marc Dykewickz, Ruta Dubakiene, Motohiro Ebisawa, Yaya El-Gamal, Esben Eller, Regina Emuzyte, John Farrell, Antjie Fink-Wagner, Alessandro Fiocchi, Jean F. Fontaine, Bilun Gemicioğlu, Peter Schmid-Grendelmeir, Amiran Gamkrelidze, Judith Garcia-Aymerich, Maximiliano Gomez, Sandra González Diaz, Maia Gotua, Nick A. Guldemond, Maria-Antonieta Guzmán, Jawad Hajjam, John O’B Hourihane, Marc Humbert, Guido Iaccarino, Despo Ierodiakonou, Juan C. Ivancevich, Guy Joos, Ki-Suck Jung, Marek Jutel, Igor Kaidashev, Omer Kalayci, Przemyslaw Kardas, Thomas Keil, Mussa Khaitov, Nikolai Khaltaev, Jorg Kleine-Tebbe, Marek L. Kowalski, Vicky Kritikos, Inger Kull, Lisa Leonardini, Philip Lieberman, Brian Lipworth, Karin C. Lodrup Carlsen, Claudia C. Loureiro, Renaud Louis, Alpana Mair, Gert Marien, Bassam Mahboub, Joao Malva, Patrick Manning, Esteban De Manuel Keenoy, Gailen D. Marshall, Mohamed R. Masjedi, Jorge F. Maspero, Eve Mathieu-Dupas, Poalo M. Matricardi, Eric Melén, Elisabete Melo-Gomes, Eli O. Meltzer, Jacques Mercier, Neven Miculinic, Florin Mihaltan, Branislava Milenkovic, Giuliana Moda, Maria-Dolores Mogica-Martinez, Yousser Mohammad, Steve Montefort, Ricardo Monti, Mario Morais-Almeida, Ralf Mösges, Lars Münter, Antonella Muraro, Ruth Murray, Robert Naclerio, Luigi Napoli, Leila Namazova-Baranova, Hugo Neffen, Kristoff Nekam, Angelo Neou, Enrico Novellino, Dieudonné Nyembue, Robin O’Hehir, Ken Ohta, Kimi Okubo, Gabrielle Onorato, Solange Ouedraogo, Isabella Pali-Schöll, Susanna Palkonen, Peter Panzner, Hae-Sim Park, Jean-Louis Pépin, Ana-Maria Pereira, Oliver Pfaar, Ema Paulino, Jim Phillips, Davor Plavec, Ted A. Popov, Fabienne Portejoie, David Price, Emmanuel P. Prokopakis, Benoit Pugin, Filip Raciborski, Rojin Rajabian-Söderlund, Sietze Reitsma, Xavier Rodo, Antonino Romano, Nelson Rosario, Menahenm Rottem, Dermot Ryan, Johanna Salimäki, Mario M. Sanchez-Borges, Juan-Carlos Sisul, Dirceu Solé, David Somekh, Talant Sooronbaev, Milan Sova, Otto Spranger, Cristina Stellato, Rafael Stelmach, Charlotte Suppli Ulrik, Michel Thibaudon, Teresa To, Ana Todo-Bom, Peter V. Tomazic, Antonio A. Valero, Rudolph Valenta, Marylin Valentin-Rostan, Rianne van der Kleij, Olivier Vandenplas, Giorgio Vezzani, Frédéric Viart, Giovanni Viegi, Dana Wallace, Martin Wagenmann, De Y. Wang, Susan Waserman, Magnus Wickman, Dennis M. Williams, Gary Wong, Piotr Wroczynski, Panayiotis K. Yiallouros, Arzu Yorgancioglu, Osman M. Yusuf, Heahter J. Zar, Stéphane Zeng, Mario Zernotti, Luo Zhang, Nan S. Zhong, Mihaela Zidarn, the ARIA Study Group, and the MASK Study Group
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Health care transformation ,Care pathways ,Rhinitis ,ARIA ,MASK ,POLLAR ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Background In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted “patient activation”, (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Santé as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
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- 2019
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48. Alergijski rinitis in njegov vpliv na astmo (ARIA) – glavni povzetek 2016: Integrirane klinične poti za napovedno medicino v vseh življenjskih obdobjih
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Mihaela Zidarn, Nissera Bajrović, Klemen Jenko, Peter Kopač, Mitja Košnik, Natalija Edelbaher, Maja Jošt, Karmen Kramer Vrščaj, Anja Koren Jeverica, Samo Kreft, Nika Lalek, Bojan Madjar, Antonija Poplas-Susič, Irma Rozman Sinur, Tanja Soklič-Košak, Katja Triller, Nadja Triller, Jure Urbančič, Ioana Agache, Claus Bachert, Anna Bedbrook, Giorgio Walter Canonica, Thomas Casale, Alvaro A Cruz, Wytske J Fokkens, Peter W Hellings, Boleslaw Samolinski, and Jean Bousquet
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alergijski rinitis ,astma ,integrirana klinična pot ,mobilna tehnologija ,bolezni dihalnih poti ,Medicine - Abstract
Pobudo »Alergijski rinitis in njegov vpliv na astmo« – (angl. Allergic Rhinitis and its Impact on Asthma, ARIA) – so leta 1999 ustanovili na delavnici Svetovne zdravstvene organizacije – World Health Organization (WHO). Njeni prvotni cilji so bili: 1. predlagati novo klasifikacijo alergijskega rinitisa, 2. spodbujati koncept večobolevnosti pri astmi in rinitisu ter 3. skupaj z vsemi deležniki razviti smernice, namenjene globalni uporabi v vseh državah in vsem skupinam bolnikov. Pobuda ARIA se uporablja v 70 državah, trenutno pa se osredinja na uporabo novih tehnologij za individualizirano in napovedno medicino. Mreža MASK – nadzorna mreža MACVIA (Proti kroničnim boleznim za aktivno staranje, franc. – Contre les Maladies Chroniques pour un Vieillissement Actif) in ARIA (angl. ARIA Sentinel NetworK) uporablja mobilno tehnologijo za razvoj klinične poti, ki bi bolnikom, multidisciplinarnim ekipam zdravnikov in raziskovalcem omogočila nadzor rinitisa in astme. Mobilna aplikacija (Android in iOS) je na voljo v 20 državah in 15 jezikih. Uporablja vizualno analogno lestvico za oceno nadzora nad simptomi in oceno delovne zmožnosti in ponuja sistem, ki pomaga pri kliničnem odločanju. Aplikacija omogoča povezovanje z zdravnikom ali drugimi zdravstvenimi delavci. Ta strategija upošteva priporočila Evropskega partnerstva za inovacije za aktivno in zdravo staranje (angl. European Innovation Partnership on Active and Healthy Ageing, EIP on AHA). Cilj novega pristopa pobude ARIA je zagotoviti aktivno in zdravo življenje bolnikov z rinitisom ne glede na njihovo starost, spol ali družbenogospodarski položaj zato, da bi se zmanjšali zdravstvena in družbena neenakost, ki sta posledici te bolezni.
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49. Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma
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J. Bousquet, A. Bedbrook, W. Czarlewski, G. L. Onorato, S. Arnavielhe, D. Laune, E. Mathieu-Dupas, J. Fonseca, E. Costa, O. Lourenço, M. Morais-Almeida, A. Todo-Bom, M. Illario, E. Menditto, G. W. Canonica, L. Cecchi, R. Monti, L. Napoli, M. T. Ventura, G. De Feo, W. J. Fokkens, N. H. Chavannes, S. Reitsma, A. A. Cruz, J. da Silva, F. S. Serpa, D. Larenas-Linnemann, J. M. Fuentes Perez, Y. R. Huerta-Villalobos, D. Rivero-Yeverino, E. Rodriguez-Zagal, A. Valiulis, R. Dubakiene, R. Emuzyte, V. Kvedariene, I. Annesi-Maesano, H. Blain, P. Bonniaud, I. Bosse, Y. Dauvilliers, P. Devillier, J. F. Fontaine, J. L. Pépin, N. Pham-Thi, F. Portejoie, R. Picard, N. Roche, C. Rolland, P. Schmidt-Grendelmeier, P. Kuna, B. Samolinski, J. M. Anto, V. Cardona, J. Mullol, H. Pinnock, D. Ryan, A. Sheikh, S. Walker, S. Williams, S. Becker, L. Klimek, O. Pfaar, K. C. Bergmann, R. Mösges, T. Zuberbier, R. E. Roller-Wirnsberger, P. V. Tomazic, T. Haahtela, J. Salimäki, S. Toppila-Salmi, E. Valovirta, T. Vasankari, B. Gemicioğlu, A. Yorgancioglu, N. G. Papadopoulos, E. P. Prokopakis, I. G. Tsiligianni, S. Bosnic-Anticevich, R. O’Hehir, J. C. Ivancevich, H. Neffen, M. E. Zernotti, I. Kull, E. Melén, M. Wickman, C. Bachert, P. W. Hellings, G. Brusselle, S. Palkonen, C. Bindslev-Jensen, E. Eller, S. Waserman, L. P. Boulet, J. Bouchard, D. K. Chu, H. J. Schünemann, M. Sova, G. De Vries, M. van Eerd, I. Agache, I. J. Ansotegui, M. Bewick, T. Casale, M. Dykewick, M. Ebisawa, R. Murray, R. Naclerio, Y. Okamoto, D. V. Wallace, and The MASK study group
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App ,Asthma ,Care pathways ,MASK ,mHealth ,Rhinitis ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Aims Mobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle, whatever their gender or socio-economic status, in order to reduce health and social inequities incurred by the disease and to improve the digital transformation of health and care. The ultimate goal is to change the management strategy in chronic diseases. Methods MASK implements ICT technologies for individualized and predictive medicine to develop novel care pathways by a multi-disciplinary group centred around the patients. Stakeholders Include patients, health care professionals (pharmacists and physicians), authorities, patient’s associations, private and public sectors. Results MASK is deployed in 23 countries and 17 languages. 26,000 users have registered. EU grants (2018) MASK is participating in EU projects (POLLAR: impact of air POLLution in Asthma and Rhinitis, EIT Health, DigitalHealthEurope, Euriphi and Vigour). Lessons learnt (i) Adherence to treatment is the major problem of allergic disease, (ii) Self-management strategies should be considerably expanded (behavioural), (iii) Change management is essential in allergic diseases, (iv) Education strategies should be reconsidered using a patient-centred approach and (v) Lessons learnt for allergic diseases can be expanded to chronic diseases.
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50. Vilnius Declaration on chronic respiratory diseases: multisectoral care pathways embedding guided self-management, mHealth and air pollution in chronic respiratory diseases
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A. Valiulis, J. Bousquet, A. Veryga, U. Suprun, D. Sergeenko, S. Cebotari, D. Borelli, S. Pietikainen, J. Banys, I. Agache, N. E. Billo, A. Bush, I. Chkhaidze, L. Dubey, W. J. Fokkens, J. Grigg, T. Haahtela, K. Julge, O. Katilov, N. Khaltaev, M. Odemyr, S. Palkonen, R. Savli, A. Utkus, V. Vilc, T. Alasevicius, A. Bedbrook, M. Bewick, J. Chorostowska-Wynimko, E. Danila, A. Hadjipanayis, R. Karseladze, V. Kvedariene, E. Lesinskas, L. Münter, B. Samolinski, S. Sargsyan, B. Sitkauskiene, D. Somekh, L. Vaideliene, and P. W. Hellings
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Air pollution ,Asthma ,Chronic respiratory diseases ,Guidelines ,Integrated care pathways ,mHealth ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Background Over 1 billion people suffer from chronic respiratory diseases such as asthma, COPD, rhinitis and rhinosinusitis. They cause an enormous burden and are considered as major non-communicable diseases. Many patients are still uncontrolled and the cost of inaction is unacceptable. A meeting was held in Vilnius, Lithuania (March 23, 2018) under the patronage of the Ministry of Health and several scientific societies to propose multisectoral care pathways embedding guided self-management, mHealth and air pollution in selected chronic respiratory diseases (rhinitis, chronic rhinosinusitis, asthma and COPD). The meeting resulted in the Vilnius Declaration that was developed by the participants of the EU Summit on chronic respiratory diseases under the leadership of Euforea. Conclusion The Vilnius Declaration represents an important step for the fight against air pollution in chronic respiratory diseases globally and has a clear strategic relevance with regard to the EU Health Strategy as it will bring added value to the existing public health knowledge.
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