403 results on '"Agabiti, N"'
Search Results
2. How audit&feedback can bridge the gap between scientific evidence and clinical practice: reflections from the EASY-NET network programme
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De Belvis, Antonio, Acampora, Anna, D'Agostino, M., Angioletti, C., Colais, P., Agabiti, N., Davoli, Marina, de Belvis A. (ORCID:0000-0003-4456-1937), Acampora A., Davoli M., De Belvis, Antonio, Acampora, Anna, D'Agostino, M., Angioletti, C., Colais, P., Agabiti, N., Davoli, Marina, de Belvis A. (ORCID:0000-0003-4456-1937), Acampora A., and Davoli M.
- Abstract
Il divario tra ricerca e pratica si riferisce ai casi in cui la ricerca fatica a essere applicabile in contesti concreti, come quello sanitario, con un notevole impatto sull’organizzazione dell’assistenza, sull’erogazione dei servizi e sugli esiti di salute. Questo aspetto si somma, nei sistemi sanitari come quello italiano, a una forte variabilità nell’accesso ad assistenza di qualità e negli esiti di salute tra le Regioni e nello stesso territorio. Viene usata l’espressione “trasferimento della conoscenza”1 per spiegare il processo iterativo di sintesi e scambio dai risultati della ricerca sanitaria al miglioramento della qualità nella pratica clinica. Comprendere e applicare tutto ciò risulta essenziale per implementare con tempestività ed efficacia le evidenze scientifiche.
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- 2024
3. Determinants Of Antipsychotic Drugs Prescription Among Community-Living Older Adults With Dementia: A Population-Based Study Using Health Information Systems In The Lazio Region, Italy
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Bargagli AM, Cascini S, Agabiti N, Kirchmayer U, Marino C, and Davoli M
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dementia ,antipsychotics ,health information systems ,older adults ,Geriatrics ,RC952-954.6 - Abstract
Anna Maria Bargagli, Silvia Cascini, Nera Agabiti, Ursula Kirchmayer, Claudia Marino, Marina Davoli Department of Epidemiology, Regional Health Service Lazio Region, Rome, ItalyCorrespondence: Silvia CasciniDepartment of Epidemiology, Regional Health Service Lazio Region, Via Cristoforo Colombo, Rome 112 - 00147, ItalyTel +39 06 9972 2130Fax +39 06 9972 2111Email s.cascini@deplazio.itIntroduction: Despite recommendations from associations of geriatric and psychiatry societies and warnings from drug agencies, antipsychotic (AP) drugs are frequently used to control behavioral and psychological symptoms of dementia. APs are associated with a range of potential adverse events, including increased risk of cerebrovascular events and mortality. Evidence suggests limited efficacy of APs for aggression and psychosis. Our objectives were to investigate patterns and predictors for prescription of APs among older adults with dementia residing in a large region of central Italy, and to identify patient characteristics related to typical or atypical APs prescribing.Methods: This is a retrospective population-based cohort study using data from regional health information systems (HIS). We included dementia patients aged ≥65 years residing in the Lazio region. The exposure was defined as new use vs non-use of APs. Dementia patients with incident use of APs during 2015 were followed-up from the date of first prescription to the earliest among discontinuation of use, death, or end of study (December 31, 2016).Results: We enrolled 24,735 dementia patients, 1727 (6.7%) new users and 23,008 non-users of APs. Forty-four percent of AP users were treated for more than 3 months, and among these about 60% received APs continuously for at least 12 months. Individuals using antidepressant or anti-dementia drugs had higher odds of being prescribed with APs (OR: 1.67 and OR: 1.86, respectively). Patients exposed to polypharmacy were less likely to receive APs (OR: 0.82). Cardiovascular risk factors and comorbidities were not associated with APs use. Low socio-economic position was associated with lower odds of atypical AP prescribing (OR: 0.57).Conclusion: The study showed that a not negligible proportion of patients had a period of AP use longer than recommended by guidelines. We identified socio-demographic and clinical factors associated with first use of APs, providing insight into prescribing practices in a community setting and useful information to address areas of potential inappropriateness.Keywords: dementia, antipsychotics, health information systems, older adults
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- 2019
4. Audit&Feedback in emergency care: a pre-post intervention study in Lazio (Italy)
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Agabiti, N, primary, Angelici, L, additional, Acampora, A, additional, Angioletti, C, additional, de Mattia, E, additional, Pinnarelli, L, additional, Colais, P, additional, De Belvis, A G, additional, and Davoli, M, additional
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- 2023
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- View/download PDF
5. Population-based cohort study on comparative effectiveness and safety of biologics in inflammatory bowel disease
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Di Domenicantonio R, Trotta F, Cascini S, Agabiti N, Kohn A, Gasbarrini A, Davoli M, and Addis A
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Biologics ,Real-World Effectiveness ,Inflammatory bowel disease. ,Infectious and parasitic diseases ,RC109-216 - Abstract
Riccardo Di Domenicantonio,1 Francesco Trotta,1 Silvia Cascini,1 Nera Agabiti,1 Anna Kohn,2 Antonio Gasbarrini,3 Marina Davoli,1 Antonio Addis1 1Department of Epidemiology, Lazio Regional Health Service, Rome, Italy; 2IBD Unit, AO San Camillo Forlanini, Rome, Italy; 3Department of Internal Medicine, Agostino Gemelli University Hospital, Catholic University of Sacred Heart, Rome, Italy Background: The comparison of effectiveness and safety of anti-tumor necrosis factor-alpha agents for the treatment of inflammatory bowel disease (IBD) is relevant for clinical practice and stakeholders. Objective: The objective of this study was to compare the risk of abdominal surgery, steroid utilization, and hospitalization for infection in Crohn’s disease (CD) or ulcerative colitis (UC) patients newly treated with infliximab (IFX) or adalimumab (ADA). Methods: A retrospective population-based cohort study was performed using health information systems data from Lazio region, Italy. Patients with CD or UC diagnosis were enrolled at first prescription of IFX or ADA during 2008–2014 (index date). Only new drug users were followed for 2 years from the index date. IFX versus ADA adjusted hazard ratios were calculated applying “intention-to-treat” approach, controlling for several characteristics and stratifying the analysis on steroid use according to previous drug utilization. Sensitivity analyses were performed according to “as-treated” approach, adjusting for propensity score, censoring at switching or discontinuation, and evaluating different lengths of follow-up periods. Results: We enrolled 1,432 IBD patients (42% and 83% exposed to IFX for CD and UC, respectively). In both diseases, treatment effects did not differ in any outcome considered, and sensitivity analyses confirmed the results from the main analysis. Conclusion: In our population-based cohort study, effectiveness and safety data in new users of ADA or IFX with CD or UC were comparable for the outcomes we tested. Keywords: biologics, real-world effectiveness, inflammatory bowel disease
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- 2018
6. Audit and Feedback in the Hospitals of the Emergency Networks in the Lazio Region, Italy: A Cross-Sectional Evaluation of the State of Implementation
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Angioletti, C., Pinnarelli, Luigi, Colais, P., Angelici, L., De Mattia, Egidio, Davoli, Marina, De Belvis, Antonio, Agabiti, N., Acampora, Anna, Pinnarelli L., de Mattia E., Davoli M., de Belvis A. (ORCID:0000-0003-4456-1937), Acampora A., Angioletti, C., Pinnarelli, Luigi, Colais, P., Angelici, L., De Mattia, Egidio, Davoli, Marina, De Belvis, Antonio, Agabiti, N., Acampora, Anna, Pinnarelli L., de Mattia E., Davoli M., de Belvis A. (ORCID:0000-0003-4456-1937), and Acampora A.
- Abstract
Audit and Feedback (A&F) is an effective multidimensional strategy for improving the quality of care. The optimal methods for its implementation remain unclear. This study aimed to map the state of art of A&F strategies in the hospitals involved in a time-dependent emergency network. For these purposes, a structured questionnaire was defined and discussed within the research group. This consists of 29 questions in three sections: (1) characteristics of the structure, (2) internal feedback systems, and (3) external feedback systems. All structures involved in the network were invited to participate in the e-survey by indicating a Health Management representative and a clinical representative for the Cardiovascular (CaV) and/or for the Cerebrovascular area (CeV). Of 20 structures invited, a total of 13 (65%) responded to the survey, 11 for the CaV area and 8 for the CeV area. A total of 10 of 11 (91%) facilities for the CaV area and 8/11 (75%) for the CeV area reported that they perform A&F activities. All facilities perform at least one of the activities defined as “assimilating A&F procedures.” The most frequent is the presentation and discussion of clinical cases (82% CaV and 88% CeV) and the least is the identification of responsible for improvement actions (45% CaV and 38% CeV). In 4/10 (40%) facilities for the CaV area and 4/8 (50%) for the CEV area, corrective actions are suggested or planned when the feedback is returned. These results confirm the need to define, in a synergistic way with the relevant stakeholders, an effective and agreed A&F intervention to improve the level of implementation of A&F strategies.
- Published
- 2023
7. One-year survival after acute myocardial infarction (AMI): the effect of care pathway in Italy: Martina Ventura
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Belleudi, V, Agabiti, N, Sciattella, P, Di Martino, M, Davoli, M, Fusco, D, and Ventura, M
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- 2017
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8. Antidepressants and the risk of arrhythmia in elderly affected by a previous cardiovascular disease: a real-life investigation from Italy
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Biffi, A., Rea, F., Scotti, L., Mugelli, A., Lucenteforte, E., Bettiol, A., Chinellato, A., Onder, G., Vitale, C., Agabiti, N., Trifirò, G., Roberto, G., Corrao, G., and on behalf of the Italian Group for Appropriate Drug prescription in the Elderly (I-GrADE)
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- 2017
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9. COVID-19 restrictions and NUTS-3 deprivation: multilevel approach in Italy during the second wave
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Dei Bardi, L, primary, Acampora, A, additional, Di Martino, M, additional, Davoli, M, additional, Agabiti, N, additional, and Cesaroni, G, additional
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- 2022
- Full Text
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10. Mortality differences between migrants and Italians residing in Rome before, during, and in the aftermath of the great recession. A longitudinal cohort study from 2001 to 2015
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Trappolini, E, Marino, C, Agabiti, N, Giudici, C, Davoli, M, Cacciani, L, Trappolini E., Marino C., Agabiti N., Giudici C., Davoli M., Cacciani L., Trappolini, E, Marino, C, Agabiti, N, Giudici, C, Davoli, M, Cacciani, L, Trappolini E., Marino C., Agabiti N., Giudici C., Davoli M., and Cacciani L.
- Abstract
Background: In Europe, one of the most consistent findings is that of migrant mortality advantage in high-income countries. Furthermore, the literature shows that economic shocks, which bring worse health outcomes, can severely affect the most disadvantaged individuals. We analyse differences and changes in all-cause mortality between Italians and migrants residing in Rome before, during, and in the aftermath of the Great Recession (2001–2015) by birth-cohort. Methods: The analysis is a longitudinal open cohort study. Mortality data come from the Register of the Causes of Death (58,637 deaths) and the population denominator (n = 2,454,410) comes from the Municipal Register of Rome. By comparing three time-periods (2001–2005, 2006–2010, and 2011–2015), we analyse all-cause mortality of Rome residents born, respectively, in the intervals 1937–1976, 1942–1981, 1947–1986 (aged 25–64 years at entry into observation). Computing birth-cohort-specific death rates and applying parametric survival models with age as the time-scale, we compare mortality differences between migrants and Italians by gender, area of origin, and time-period. Results: Overall, we find a lower risk of dying for migrants than Italians regardless of gender (Women: HR = 0.61, 95% CI 0.56–0.66; Men: HR = 0.49, 95% CI 0.45–0.53), and a lower death risk over time for the total population. Nevertheless, such a pattern changes according to gender and migrants’ area of origin. Conclusion: Given the relevance of international migrations in Europe, studying migrants’ health has proved increasingly important. The deterioration in migrant health and the gradual weakening of migrants’ mortality advantage is likely to become a public health issue with important consequences for the healthcare system of all European countries.
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- 2021
11. Prevalence of schizophrenia spectrum disorders among adults in the Lazio region, Italy: use of an algorithm based on health information systems
- Author
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Forastiere, A., primary, Cascini, S., additional, Calandrini, E., additional, Agabiti, N., additional, Davoli, M., additional, and Bargagli, A., additional
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- 2022
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12. Inequality in 30-day mortality and the wait for surgery after hip fracture: the impact of the regional health care evaluation program in Lazio (Italy)
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COLAIS, P., AGABITI, N., FUSCO, D., PINNARELLI, L., SORGE, C., PERUCCI, C.A., and DAVOLI, M.
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- 2013
13. All-cause mortality and antipsychotic use among elderly persons with high baseline cardiovascular and cerebrovascular risk: a multi-center retrospective cohort study in Italy
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Sultana J., Giorgianni F., REA, FEDERICO, Lucenteforte E., Lombardi N., Mugelli A., Vannacci A., Liperoti R., Kirchmayer U., Vitale C., Chinellato A., Roberto G., Corrao G., Trifiro G., Agabiti N., Bartolini C., Bernabei R., Bettiol A., Bonassi S., Caputi A. P., Cascini S., Cipriani F., Davoli M., Fini M., Gini R., Lapi F., Onder G., Sorge C., Tari M., Vetrano D. L., Sultana, J, Giorgianni, F, Rea, F, Lucenteforte, E, Lombardi, N, Mugelli, A, Vannacci, A, Liperoti, R, Kirchmayer, U, Vitale, C, Chinellato, A, Roberto, G, Corrao, G, Trifiro, G, Agabiti, N, Bartolini, C, Bernabei, R, Bettiol, A, Bonassi, S, Caputi, A, Cascini, S, Cipriani, F, Davoli, M, Fini, M, Gini, R, Lapi, F, Onder, G, Sorge, C, Tari, M, and Vetrano, D
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Male ,Pediatrics ,medicine.medical_treatment ,Toxicology ,030226 pharmacology & pharmacy ,Cohort Studies ,Antipsychotic ,0302 clinical medicine ,Retrospective Studie ,Risk Factors ,Cardiovascular Disease ,80 and over ,Antipsychotics ,Medicine ,Drug Interactions ,Aged, 80 and over ,Incidence ,Incidence (epidemiology) ,General Medicine ,Italy ,Cardiovascular Diseases ,030220 oncology & carcinogenesis ,Cerebrovascular Disorder ,Female ,cohort study ,drug interactions ,elderly ,mortality ,Antipsychotic Agents ,Human ,Cohort study ,medicine.medical_specialty ,03 medical and health sciences ,Elderly persons ,Humans ,Cerebrovascular risk ,Proportional Hazards Models ,Retrospective Studies ,Aged ,Pharmacology ,drug interaction ,urogenital system ,business.industry ,Proportional hazards model ,Settore MED/09 - MEDICINA INTERNA ,Retrospective cohort study ,equipment and supplies ,Cerebrovascular Disorders ,Antipsychotic Agent ,Proportional Hazards Model ,Cohort Studie ,business ,All cause mortality - Abstract
Background: Little is known about the comparative risk of death with atypical or conventional antipsychotics (APs) among persons with cardiovascular or cerebrovascular disease (CCD). Research design and methods: A cohort study was conducted using five Italian claims databases. New atypical AP users with CCD aged ≥65 (reference) were matched to new conventional AP users. Mortality per 100 person-years (PYs) and hazard ratios (HR), estimated using Cox models, were reported. Incidence and risk of death were estimated for persons having drug–drug interactions. Outcome occurrence was evaluated 180 days after AP initiation. Results: Overall 24,711 and 27,051 elderly new conventional and atypical AP users were identified. The mortality rate was 51.3 and 38.5 deaths per 100 PYs for conventional and atypical AP users. Mortality risk was 1.33 (95%CI: 1.27–1.39) for conventional APs. There was no increased mortality risk with single drug–drug interactions (DDIs) vs. no DDI. AP users with ≥1 DDI had a 29% higher mortality risk compared to no DDI in the first 90 days of treatment (HR: 1.29 (95% CI: 1.00–1.67)). Conclusions: Conventional APs had a higher risk of death than atypical APs among elderly persons with CCD. Having ≥1 DDI was associated with an increased risk of death.
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- 2019
14. Additional file 1 of Socio-economic inequalities in the use of drugs for the treatment of chronic diseases in Italy
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Di Filippo, A., Perna, S., Pierantozzi, A., Milozzi, F., Fortinguerra, F., Caranci, N., Moro, L., Agabiti, N., Belleudi, V., Cesaroni, G., Nardi, A., Spadea, T., Gnavi, R., and Trotta, F.
- Abstract
Additional file 1:eTable 1. Therapeutic categories and exposure for single chronic disease. eFigure 1. Provincial deprivation index map. eFigure 2. Medicine consumption rate (DDD per capita) for lipid-lowering agent in adults (aged ≥ 18 years) by province, standardized: (A) by age only; (B) by age and deprivation tertile. eFigure 3. Medicine consumption rate (DDD per capita) for antiosteoporotic drugs in adults (aged ≥ 18 years) by province, standardized: (A) by age only; (B) by age and deprivation tertile. eFigure 4. Medicine consumption rate (DDD per capita) for drugs for obstructive airway diseases in adults (aged ≥ 18 years) by province†, standardized: (A) by age only; (B) by age and deprivation tertile. eFigure 5. Adherence and persistence to treatment at 12 months (%) in adults (≥ 18 years) by province adjusted by age.
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- 2022
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15. The association of socioeconomic disadvantage with postoperative complications after major elective cardiovascular surgery
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Italian Study Group on Inequalities in Health Care, Agabiti, N, Cesaroni, G, Picciotto, S, Bisanti, L, Caranci, N, Costa, G, Forastiere, F, Marinacci, C, Pandolfi, P, Russo, A, and Perucci, C A
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- 2008
16. A Systematic Review of Case-Identification Algorithms for 18 Conditions Based on Italian Healthcare Administrative Databases: A Study Protocol
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Canova, C, Simonato, L, Barbiellini Amidei, C, Baldi, I, Dalla Zuanna, T, Gregori, D, Danieli, S, Buja, A, Lorenzoni, G, Pitter, G, Costa, G, Gnavi, R, Corrao, G, Rea, F, Gini, R, Hyeraci, G, Roberto, G, Spini, A, Lucenteforte, E, Agabiti, N, Davoli, M, Di Domenicantonio, R, Cappai, G, Canova C., Simonato L., Barbiellini Amidei C., Baldi I., Dalla Zuanna T., Gregori D., Danieli S., Buja A., Lorenzoni G., Pitter G., Costa G., Gnavi R., Corrao G., Rea F., Gini R., Hyeraci G., Roberto G., Spini A., Lucenteforte E., Agabiti N., Davoli M., Di Domenicantonio R., Cappai G., Canova, C, Simonato, L, Barbiellini Amidei, C, Baldi, I, Dalla Zuanna, T, Gregori, D, Danieli, S, Buja, A, Lorenzoni, G, Pitter, G, Costa, G, Gnavi, R, Corrao, G, Rea, F, Gini, R, Hyeraci, G, Roberto, G, Spini, A, Lucenteforte, E, Agabiti, N, Davoli, M, Di Domenicantonio, R, Cappai, G, Canova C., Simonato L., Barbiellini Amidei C., Baldi I., Dalla Zuanna T., Gregori D., Danieli S., Buja A., Lorenzoni G., Pitter G., Costa G., Gnavi R., Corrao G., Rea F., Gini R., Hyeraci G., Roberto G., Spini A., Lucenteforte E., Agabiti N., Davoli M., Di Domenicantonio R., and Cappai G.
- Abstract
BACKGROUND: there has been a long-standing, consistent use worldwide of Healthcare Administrative Databases (HADs) for epidemiological purposes, especially to identify acute and chronic health conditions. These databases are able to reflect health-related conditions at a population level through disease-specific case-identification algorithms that combine information coded in multiple HADs. In Italy, in the past 10 years, HAD-based case-identification algorithms have experienced a constant increase, with a significant extension of the spectrum of identifiable diseases. Besides estimating incidence and/or prevalence of diseases, these algorithms have been used to enroll cohorts, monitor quality of care, assess the effect of environmental exposure, and identify health outcomes in analytic studies. Despite the rapid increase in the use of case-identification algorithms, information on their accuracy and misclassification rate is currently unavailable for most conditions. OBJECTIVES: to define a protocol to systematically review algorithms used in Italy in the past 10 years for the identification of several chronic and acute diseases, providing an accessible overview to future users in the Italian and international context. METHODS: PubMed will be searched for original research articles, published between 2007 and 2017, in Italian or English. The search string consists of a combination of free text and MeSH terms with a common part on HADs and a disease-specific part. All identified papers will be screened for eligibility by two independent reviewers. All articles that used/defined an algorithm for the identification of each disease of interest using Italian HADs will be included. Algorithms with exclusive use of death certificates, pathology register, general practitioner or pediatrician data will be excluded. Pertinent papers will be classified according to the objective for which the algorithm was used, and only articles that used algorithms with "primary objectives"
- Published
- 2019
17. All-cause mortality and antipsychotic use among elderly persons with high baseline cardiovascular and cerebrovascular risk: a multi-center retrospective cohort study in Italy
- Author
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Sultana, J, Giorgianni, F, Rea, F, Lucenteforte, E, Lombardi, N, Mugelli, A, Vannacci, A, Liperoti, R, Kirchmayer, U, Vitale, C, Chinellato, A, Roberto, G, Corrao, G, Trifiro, G, Agabiti, N, Bartolini, C, Bernabei, R, Bettiol, A, Bonassi, S, Caputi, A, Cascini, S, Cipriani, F, Davoli, M, Fini, M, Gini, R, Lapi, F, Onder, G, Sorge, C, Tari, M, Vetrano, D, Sultana J., Giorgianni F., REA, FEDERICO, Lucenteforte E., Lombardi N., Mugelli A., Vannacci A., Liperoti R., Kirchmayer U., Vitale C., Chinellato A., Roberto G., Corrao G., Trifiro G., Agabiti N., Bartolini C., Bernabei R., Bettiol A., Bonassi S., Caputi A. P., Cascini S., Cipriani F., Davoli M., Fini M., Gini R., Lapi F., Onder G., Sorge C., Tari M., Vetrano D. L., Sultana, J, Giorgianni, F, Rea, F, Lucenteforte, E, Lombardi, N, Mugelli, A, Vannacci, A, Liperoti, R, Kirchmayer, U, Vitale, C, Chinellato, A, Roberto, G, Corrao, G, Trifiro, G, Agabiti, N, Bartolini, C, Bernabei, R, Bettiol, A, Bonassi, S, Caputi, A, Cascini, S, Cipriani, F, Davoli, M, Fini, M, Gini, R, Lapi, F, Onder, G, Sorge, C, Tari, M, Vetrano, D, Sultana J., Giorgianni F., REA, FEDERICO, Lucenteforte E., Lombardi N., Mugelli A., Vannacci A., Liperoti R., Kirchmayer U., Vitale C., Chinellato A., Roberto G., Corrao G., Trifiro G., Agabiti N., Bartolini C., Bernabei R., Bettiol A., Bonassi S., Caputi A. P., Cascini S., Cipriani F., Davoli M., Fini M., Gini R., Lapi F., Onder G., Sorge C., Tari M., and Vetrano D. L.
- Abstract
Background: Little is known about the comparative risk of death with atypical or conventional antipsychotics (APs) among persons with cardiovascular or cerebrovascular disease (CCD). Research design and methods: A cohort study was conducted using five Italian claims databases. New atypical AP users with CCD aged ≥65 (reference) were matched to new conventional AP users. Mortality per 100 person-years (PYs) and hazard ratios (HR), estimated using Cox models, were reported. Incidence and risk of death were estimated for persons having drug–drug interactions. Outcome occurrence was evaluated 180 days after AP initiation. Results: Overall 24,711 and 27,051 elderly new conventional and atypical AP users were identified. The mortality rate was 51.3 and 38.5 deaths per 100 PYs for conventional and atypical AP users. Mortality risk was 1.33 (95%CI: 1.27–1.39) for conventional APs. There was no increased mortality risk with single drug–drug interactions (DDIs) vs. no DDI. AP users with ≥1 DDI had a 29% higher mortality risk compared to no DDI in the first 90 days of treatment (HR: 1.29 (95% CI: 1.00–1.67)). Conclusions: Conventional APs had a higher risk of death than atypical APs among elderly persons with CCD. Having ≥1 DDI was associated with an increased risk of death.
- Published
- 2019
18. Audit and feedback strategies: study protocol and preliminary results from the EASY-NET project
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Agabiti, N, primary, Grilli, R, additional, Valent, F, additional, Ciccone, G, additional, Marchesini Reggiani, G, additional, Marenzi, G, additional, Di Carlo, C, additional, Bramanti, P, additional, and Davoli, M, additional
- Published
- 2021
- Full Text
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19. Risk of SARS-CoV-2 infection in people living with Multiple Sclerosis in the Lazio region, Italy
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Acampora, A, primary, Cascini, S, additional, Calandrini, E, additional, Agabiti, N, additional, Davoli, M, additional, and Bargagli, AM, additional
- Published
- 2021
- Full Text
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20. Short Term Respiratory Effects of Acute Exposure to Chlorine Due to a Swimming Pool Accident
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Agabiti, N., Ancona, C., Forastiere, F., Di Napoli, A., Presti, E. Lo, Corbo, G. M., D'Orsi, F., and Perucci, C. A.
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- 2001
21. The fibroblast growth factor-23 and Vitamin D emerge as nontraditional risk factors and may affect cardiovascular risk
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Masson, S., Agabiti, N., Vago, T., Miceli, M., Mayer, F., Letizia, T., Wienhues-Thelen, U., Mureddu, G. F., Davoli, M., Boccanelli, A., and Latini, R.
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- 2015
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22. Adherence to Antidepressants and Mortality in Elderly Patients with Cardiovascular Disease
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Biffi, A, Scotti, L, Rea, F, Lucenteforte, E, Chinellato, A, Vetrano, Dl, Vitale, C, Agabiti, N, Sultana, J, Roberto, G, Mugelli, A, G Agabiti N, Corrao, Bartolini, C, Bernabei, R, Bettiol, A, Bonassi, S, Caputi, Ap, Cascini, S, Cipriani, F, Corrao, G, Davoli, M, Fini, M, Gini, R, Giorgianni, F, Kirchmayer, U, Lapi, F, Lombardi, N, Onder, G, Sorge, C, Tari, M, Trifirò, G, Vannacci, A, Vitale, C., Biffi, A, Scotti, L, Rea, F, Lucenteforte, E, Chinellato, A, Vetrano, D, Vitale, C, Agabiti, N, Sultana, J, Roberto, G, Mugelli, A, and Corrao, G
- Subjects
Male ,medicine.medical_specialty ,Databases, Factual ,MEDLINE ,Antidepressant ,Disease ,030204 cardiovascular system & hematology ,Medication Adherence ,Cohort Studies ,03 medical and health sciences ,Databases ,0302 clinical medicine ,Pharmacotherapy ,Internal medicine ,80 and over ,Medicine ,Humans ,Pharmacology (medical) ,030212 general & internal medicine ,Medical prescription ,Mortality ,Factual ,Antihypertensive Agents ,Aged ,Aged, 80 and over ,Antidepressive Agents ,Cardiovascular Diseases ,Female ,Follow-Up Studies ,Italy ,business.industry ,Proportional hazards model ,General Medicine ,Cardiovascular disease ,Adherence ,Cohort ,business ,Cohort study - Abstract
Background and Objective: Conflicting findings from studies evaluating the association between use of antidepressant drugs and mortality have been reported. We tested the hypothesis that better adherence to antidepressant therapy may reduce mortality. Methods: The cohort included 29,845 individuals aged ≥ 65 years from several Italian health units who were newly treated with antidepressant drugs after hospital discharge with a diagnosis for cardiovascular disease during 2008–2010. These individuals were observed from the first prescription until the end of data availability (i.e. 2012–2014, depending on the local database). During this period, information on (1) prescription of antidepressants and other medications and (2) death from any cause (outcome) was recorded. Proportional hazards models were fitted to estimate the association between better adherence to antidepressants (defined as proportion of days covered ≥ 75%) and outcome, by adjusting and stratifying for several covariates. Results: Patients with better adherence to antidepressants had a reduced mortality of 9% (95% CI 3–14). Patients who did not use other medicaments during follow-up had reduced mortality associated with better adherence to antidepressants of 21% (− 1–38), 14% (7–20), 20% (13–26) and 13% (7–19) for no users of antihypertensive agents, lipid-lowering agents, other cardiovascular drugs and antidiabetics, respectively. Conclusions: Better adherence to antidepressants is associated with reduced all-cause mortality, mainly in patients who did not use other pharmacological treatments. Behavioural changes to enhance adherence among the elderly with cardiovascular disease might offer important benefits in reducing their mortality.
- Published
- 2018
23. A Systematic Review of Case-Identification Algorithms for 18 Conditions Based on Italian Healthcare Administrative Databases: A Study Protocol
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Canova C., Simonato L., Barbiellini Amidei C., Baldi I., Dalla Zuanna T., Gregori D., Danieli S., Buja A., Lorenzoni G., Pitter G., Costa G., Gnavi R., Corrao G., Rea F., Gini R., Hyeraci G., Roberto G., Spini A., Lucenteforte E., Agabiti N., Davoli M., Di Domenicantonio R., Cappai G., Canova, C, Simonato, L, Barbiellini Amidei, C, Baldi, I, Dalla Zuanna, T, Gregori, D, Danieli, S, Buja, A, Lorenzoni, G, Pitter, G, Costa, G, Gnavi, R, Corrao, G, Rea, F, Gini, R, Hyeraci, G, Roberto, G, Spini, A, Lucenteforte, E, Agabiti, N, Davoli, M, Di Domenicantonio, R, and Cappai, G
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Databases, Factual ,Italy ,Research Design ,Acute Disease ,Chronic Disease ,Humans ,Algorithms, Healthcare administrative database ,Algorithms ,Health Services Administration ,Systematic Reviews as Topic - Abstract
BACKGROUND: there has been a long-standing, consistent use worldwide of Healthcare Administrative Databases (HADs) for epidemiological purposes, especially to identify acute and chronic health conditions. These databases are able to reflect health-related conditions at a population level through disease-specific case-identification algorithms that combine information coded in multiple HADs. In Italy, in the past 10 years, HAD-based case-identification algorithms have experienced a constant increase, with a significant extension of the spectrum of identifiable diseases. Besides estimating incidence and/or prevalence of diseases, these algorithms have been used to enroll cohorts, monitor quality of care, assess the effect of environmental exposure, and identify health outcomes in analytic studies. Despite the rapid increase in the use of case-identification algorithms, information on their accuracy and misclassification rate is currently unavailable for most conditions. OBJECTIVES: to define a protocol to systematically review algorithms used in Italy in the past 10 years for the identification of several chronic and acute diseases, providing an accessible overview to future users in the Italian and international context. METHODS: PubMed will be searched for original research articles, published between 2007 and 2017, in Italian or English. The search string consists of a combination of free text and MeSH terms with a common part on HADs and a disease-specific part. All identified papers will be screened for eligibility by two independent reviewers. All articles that used/defined an algorithm for the identification of each disease of interest using Italian HADs will be included. Algorithms with exclusive use of death certificates, pathology register, general practitioner or pediatrician data will be excluded. Pertinent papers will be classified according to the objective for which the algorithm was used, and only articles that used algorithms with "primary objectives" (I disease occurrence; II population/cohort selection; III outcome identification) will be considered for algorithm extraction. The HADs used (hospital discharge records, drug prescriptions, etc.), ICD-9 and ICD-10 codes, ATC classification of drugs, follow-back periods, and age ranges applied by the algorithms will be collected. Further information on specific accuracy measures from external validations, sensitivity analyses, and the contribution of each source will be recorded. This protocol will be applied for 16 different systematic reviews concerning eighteen diseases (Hypothyroidism, Hyperthyroidism, Diabetes mellitus, Type 1 diabetes mellitus, Acute myocardial infarction, Ischemic heart disease, Stroke, Hypertension, Heart failure, Congenital heart anomalies, Parkinson's disease, Multiple sclerosis, Epilepsy, Chronic obstructive pulmonary disease, Asthma, Inflammatory bowel disease, Celiac disease, Chronic kidney failure). CONCLUSION: this protocol defines a standardized approach to extensively examine and compare all experiences of case identification algorithms in Italy, on the 18 abovementioned diseases. The methodology proposed may be applied to other systematic reviews concerning diseases not included in this project, as well as other settings, including international ones. Considering the increasing availability of healthcare data, developing standard criteria to describe and update characteristics of published algorithms would be of great use to enhance awareness in the choice of algorithms and provide a greater comparability of results.
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- 2019
24. Antidepressants and the risk of arrhythmia in elderly affected by a previous cardiovascular disease: a real-life investigation from Italy
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Biffi, A, Rea, F, Scotti, L, Mugelli, A, Lucenteforte, E, Bettiol, A, Chinellato, A, Onder, G, Vitale, C, Agabiti, N, Trifirã2, G, Roberto, G, Corrao, G, Biffi, A., Rea, F., Scotti, L., Mugelli, A., Lucenteforte, E., Bettiol, A., Chinellato, A., Onder, G., Vitale, C., Agabiti, N., TrifirÃ2, G., Roberto, G., Corrao, G., Biffi, A, Rea, F, Scotti, L, Mugelli, A, Lucenteforte, E, Bettiol, A, Chinellato, A, Onder, G, Vitale, C, Agabiti, N, Trifirã2, G, Roberto, G, Corrao, G, Biffi, A., Rea, F., Scotti, L., Mugelli, A., Lucenteforte, E., Bettiol, A., Chinellato, A., Onder, G., Vitale, C., Agabiti, N., TrifirÃ2, G., Roberto, G., and Corrao, G.
- Abstract
Purpose: The study aimed to fill existing knowledge gaps on the safety of antidepressant drugs (ADs) by estimating the risk of hospitalization for arrhythmia associated with use of selective serotonin reuptake inhibitors (SSRIs) and newer atypical ADs (NAAs) among elderly with previous cardiovascular (CV) events. Methods: The cohort was composed by 199,569 individuals aged ≥ 65 years from five Italian healthcare territorial units who were discharged for cardiovascular outcomes in the years 2008–2010. The 17,277 patients who experienced hospital admission for arrhythmia during follow-up were included as cases. Odds of current ADs use among cases (i.e., 14 days before hospital admission) was compared with (i) odds of current use of 1:5 matched controls (between-patients case-control) and with (ii) odds of previous use during 1:5 matched control periods (within-patient case-crossover). The risk of arrhythmia associated with ADs current use was modelled fitting a conditional logistic regression. A set of sensitivity analyses was performed to account for sources of systematic uncertainty. Results: Current users of SSRIs and NAAs were at increased risk of arrhythmia with case-control odds ratios (OR) of 1.37 (95% confidence interval, CI 1.18 to 1.58) and 1.41 (1.16 to 1.71) and case-crossover OR of 1.48 (1.20 to 1.81) and 1.72 (1.31 to 2.27). An increased risk of arrhythmia was associated with current use of trazodone (NAA) consistently in case-control and case-crossover designs. Conclusions: Evidence that current use of SSRIs and NAAs is associated to an increased risk of arrhythmia among elderly with CV disease was consistently supplied by two observational approaches.
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- 2018
25. Urban health and inequalities in highly socially marginalised settings in Rome // Salute urbana e disuguaglianze a Roma in contesti a elevata marginalità sociale
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Paglione, L., Bargagli, A. M., Agabiti, N., Calandrini, E., Salvatori, L. M., Marceca, M., Baglio, G., Brandimarte, M. A., Iorio, S., Davoli, M., and Cacciani, L.
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urban health ,differentials access to care ,health disparities ,marginalization ,Rome suburb - Published
- 2020
26. Prevalence of chronic kidney disease in the Lazio region, Italy: A classification algorithm based on health information systems
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Marino, C., Ferraro, Pietro Manuel, Bargagli, M., Cascini, S., Agabiti, N., Gambaro, G., Davoli, M., Ferraro P. M. (ORCID:0000-0002-1379-022X), Marino, C., Ferraro, Pietro Manuel, Bargagli, M., Cascini, S., Agabiti, N., Gambaro, G., Davoli, M., and Ferraro P. M. (ORCID:0000-0002-1379-022X)
- Abstract
Background: Estimating CKD prevalence is difficult. Information on CKD prevalence is rather scanty in Italy and available figures come from surveys in selected geographical areas. Administrative data have been already demonstrated to be an effective tool in estimating the epidemiological burden of diseases, however there is limited experience in literature as far as CKD is concerned. Methods: The aim of this study is to develop an algorithm based on regional Health Administrative Databases to identify individuals with CKD and provide estimates of disease prevalence in Lazio Region (Italy); about 5.500.000 inhabitants in 2017. A population-level analysis based on a record-linkage strategy using data from Health Administrative Databases has been applied in Lazio Region. CKD cases were identified between January 1, 2012 and December 31, 2017 using Outpatient Specialist Service Information System, Hospital Discharge Registry, Ticket Exemption Registry and Drug Dispensing Registry. Age-specific and standardized prevalence rates were calculated by gender. CKD cases were classified as higher and lower severity. Results: The algorithm identified 99,457 individuals with CKD (mean age 71 years, 55.8% males). The exclusive contributions of each regional source used were: 35,047 (35.2%) from Outpatient Specialist Service Information System, 27,778 (27.9%) from Hospital Discharge Registry, 4143 (4.2%) from Ticket Exemption Registry and 463 (0.5%) from Drug Dispensing Registry; 5.1% of cases were found in all databases. The standardized prevalence rate at December 31, 2017 was 1.76, 2.06% for males and 1.50% for females. The prevalence increased with age, rising from 0.33% (age 0-18) up to 14.18% (age 85+) among males and from 0.25% up to 8.18% among females. The proportion of CKD individuals with lower severity disease was 78.7% in both genders. Conclusions: The proposed algorithm represents a novel tool to monitor the burden of CKD disease, that can be used by the regional gove
- Published
- 2020
27. High-sensitivity cardiac troponin T for detection of subtle abnormalities of cardiac phenotype in a general population of elderly individuals
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Masson, S., Latini, R., Mureddu, G. F., Agabiti, N., Miceli, M., Cesaroni, G., Forastiere, F., Wienhues-Thelen, U.-H., Block, D., Zaugg, C., Vago, T., and Boccanelli, A.
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- 2013
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28. Calcium Channel Blockers in Secondary Cardiovascular Prevention and Risk of Acute Events: Real-World Evidence from Nested Case-Control Studies on Italian Hypertensive Elderly
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Bettiol, A, Lucenteforte, E, Vannacci, A, Lombardi, N, Onder, G, Agabiti, N, Vitale, C, Trifirò, G, Corrao, G, Roberto, G, Mugelli, A, Chinellato, A, for the Italian Group for Appropriate Drug prescription in the Elderly (I-GrADE), Agabiti N, Bartolini, C, Bernabei, R, Bonassi, S, Caputi, AP, Cascini, S, Davoli, M, Fini, M, Gini, R, Giorgianni, F, Kirchmayer, U, Lapi, F, Rea, F, Sorge, C, Tari, M, Vetrano, DL, Bettiol, A, Lucenteforte, E, Vannacci, A, Lombardi, N, Onder, G, Agabiti, N, Vitale, C, Trifirò, G, Corrao, G, Roberto, G, Mugelli, A, Chinellato, A, for the Italian Group for Appropriate Drug prescription in the Elderly,, Bartolini, C, Bernabei, R, Bonassi, S, Caputi, A, Cascini, S, Davoli, M, Fini, M, Gini, R, Giorgianni, F, Kirchmayer, U, Lapi, F, Rea, F, Sorge, C, Tari, M, and Vetrano, D
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Male ,Risk ,Real-world evidence ,CCBs ,acute events ,medicine.medical_specialty ,DHPS ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Pharmacotherapy ,Internal medicine ,Cardiovascular Disease ,Odds Ratio ,Secondary Prevention ,Humans ,Medicine ,Pharmacology (medical) ,030212 general & internal medicine ,Antihypertensive Agents ,Aged ,Aged, 80 and over ,business.industry ,Case-control study ,General Medicine ,Odds ratio ,Calcium Channel Blockers ,medicine.disease ,Confidence interval ,Antihypertensive Agent ,Cardiovascular Diseases ,Case-Control Studies ,Nested case-control study ,Cohort ,Hypertension ,Female ,Medical emergency ,Cohort Studie ,business ,Calcium Channel Blocker ,Case-Control Studie ,030217 neurology & neurosurgery ,Cohort study ,Human - Abstract
Background and Objectives: Antihypertensive treatment with calcium channel blockers (CCBs) is consolidated in clinical practice; however, different studies observed increased risks of acute events for short-acting CCBs. This study aimed to provide real-world evidence on risks of acute cardiovascular (CV) events, hospitalizations and mortality among users of different CCB classes in secondary CV prevention. Methods: Three case–control studies were nested in a cohort of Italian elderly hypertensive CV-compromised CCBs users. Cases were subjects with CV events (n = 25,204), all-cause hospitalizations (n = 19,237), or all-cause mortality (n = 17,996) during the follow-up. Up to four controls were matched for each case. Current or past exposition to CCBs at index date was defined based on molecule, formulation and daily doses of the last CCB delivery. The odds ratio (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression models. Results: Compared to past users, current CCB users had significant reductions in risks of CV events [OR 0.88 (95% CI: 0.84–0.91)], hospitalization [0.90 (0.88–0.93)] and mortality [0.48 (0.47–0.49)]. Current users of long-acting dihydropyridines (DHPs) had the lowest risk [OR 0.87 (0.84–0.90), 0.86 (0.83–0.90), 0.55 (0.54–0.56) for acute CV events, hospitalizations and mortality], whereas current users of short-acting CCBs had an increased risk of acute CV events [OR 1.77 (1.13–2.78) for short-acting DHPs; 1.19 (1.07–1.31) for short-acting non-DHPs] and hospitalizations [OR 1.84 (0.96–3.51) and 1.23 (1.08–1.42)]. Conclusions: The already-existing warning on short-acting CCBs should be potentiated, addressing clinicians towards the choice of long-acting formulations.
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- 2017
29. Socio-demographic differences in adherence to evidence-based drug therapy after hospital discharge from acute myocardial infarction: a population-based cohort study in Rome, Italy
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Kirchmayer, U., Agabiti, N., Belleudi, V., Davoli, M., Fusco, D., Stafoggia, M., Arcà, M., Barone, A. P., and Perucci, C. A.
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- 2012
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30. SP1-90 Socio-demographic and geographic differences in healthcare related outcomes in a cohort of diabetes patients in the Lazio Region, Italy
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Kirchmayer, U, Belleudi, V, Bauleo, L, Agabiti, N, Pinnarelli, L, Fusco, D, Arcà, M, and Davoli, M
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- 2011
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31. Mortality inequalities in Rome: the role of individual education and real estate market
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Cesaroni, G, primary, Venturi, G, additional, Paglione, L, additional, Angelici, L, additional, Marino, C, additional, Davoli, M, additional, and Agabiti, N, additional
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- 2020
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32. Antipsychotics and mortality among elderly with dementia: a population based study in the Lazio region
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Bargagli, A M, primary, Cascini, S, additional, Agabiti, N, additional, Kirchmayer, U, additional, Marino, C, additional, Davoli, M, additional, Vanacore, N, additional, and Canevelli, M, additional
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- 2020
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33. Adherence of Elderly Patients with Cardiovascular Disease to Statins and the Risk of Exacerbation of Chronic Obstructive Pulmonary Disease: Evidence from an Italian Real-World Investigation
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Rea, F, Calusi, G, Franchi, M, Vetrano, Dl, Roberto, G, Bonassi, S, Kirchmayer, U, Chinellato, A, Bettiol, A, Sultana, J, Mugelli, A, Corrao, G, Agabiti, N, Bartolini, C, Bernabei, Rita, Caputi, Ap, Cascini, S, Cipriani, F, Davoli, M, Fini, M, Gini, R, Giorgianni, F, Lapi, F, Lombardi, N, Lucenteforte, E, Onder, G, Sorge, C, Tari, M, Trifirò, G, Vannacci, A, Vitale, C., Rea, F, Calusi, G, Franchi, M, Vetrano, D, Borloni, R, Bonassi, S, Kirchmayer, U, Chinellato, A, Bettiol, A, Sultana, J, Mugelli, A, Corrao, G, Agabiti, N, Bartolini, C, Bernabei, R, Caputi, A, Cascini, S, Cipriani, F, Davoli, M, Fini, M, Gini, R, Giorgianni, F, Lapi, F, Lombardi, N, Lucenteforte, E, Onder, G, Sorge, C, Tari, M, Trifirò, G, Vannacci, A, and Vitale, C
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Male ,medicine.medical_specialty ,Exacerbation ,Disease ,Lower risk ,Medication Adherence ,Geriatrics and Gerontology ,Pharmacology (medical) ,Cohort Studies ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Internal medicine ,Medicine ,Humans ,030212 general & internal medicine ,Aged ,Aged, 80 and over ,Cardiovascular Diseases ,Female ,Hospitalization ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Italy ,Proportional Hazards Models ,business.industry ,Proportional hazards model ,Hazard ratio ,Confidence interval ,030228 respiratory system ,Cohort ,business ,Cohort study - Abstract
Objective: The objective of this study was to investigate the relationship between adherence to statin therapy and the risk of exacerbation among elderly individuals affected by chronic obstructive pulmonary disease and cardiovascular disease. Methods: Using the healthcare utilisation databases of five Italian territorial units accounting for nearly 35% of the Italian population, we recruited a cohort of 6263 elderly persons (i.e. aged 65 years or older) with co-existing chronic obstructive pulmonary disease and cardiovascular disease who initiated statin therapy. Exposure was adherence to statins measured by the proportion of days of follow-up covered. Outcome was the first hospital admission for chronic obstructive pulmonary disease occurring in the period of observation. A proportional hazards model was used to estimate the hazard ratio and 95% confidence intervals for the exposure–outcome association, after adjusting for several covariates. A set of sensitivity analyses was performed to account for sources of systematic uncertainty. Results: During an average follow-up of about 4 years, 1307 cohort members experienced the outcome. Compared with patients with low adherence (proportion of days of follow-up covered ≤ 40%), those with intermediate (proportion of days of follow-up covered 41–80%) and high (proportion of days of follow-up covered > 80%) adherence exhibited a lower risk of exacerbation of 16% (95% confidence interval 3–27) and 23% (95% confidence interval 10–34). Conclusions: In a real-world setting, we observed evidence that adherence to statin therapy markedly reduced the risk of chronic obstructive pulmonary disease exacerbations in elderly patients with co-existing chronic obstructive pulmonary disease and cardiovascular disease. Given the limited and controversial evidence from trials, more randomised controlled trials are urgently needed to better examine the potential benefits of statins as adjunct therapy in chronic obstructive pulmonary disease.
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- 2018
34. NSAIDs utilization for musculoskeletal indications in elderly patients with cerebro/cardiovascular disease
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Roberto, G., Bartolini, C., Rea, Federico, Onder, G., Vitale, C., Trifirò, G., Kirchmayer, U., Chinellato, A., Lucenteforte, E., Corrao, G., Mugelli, A., Lapi, F., Gini, R., Agabiti, N., Bernabei, R., Bettiol, A., Bonassi, S., Caputi, A. P., Cascini, S., Davoli, M., Fini Storchi, Marco, Giorgianni, F., Lombardi, N., Rea, F., Sorge, C., Tari, M., Vannacci, A., Vetrano, D. L., Vitale, Claudia, Roberto, G, Bartolini, C, Rea, F, Onder, G, Vitale, C, Trifirò, G, Kirchmayer, U, Chinellato, A, Lucenteforte, E, Corrao, G, Mugelli, A, Lapi, F, Gini, R, On Behalf Of The Italian Group For Appropriate Drug Prescription In The Elderly (I-Grade): Agabiti, N, Bernabei, R, Bettiol, A, Bonassi, S, Caputi, A, Cascini, S, Davoli, M, Fini, M, Giorgianni, F, Lombardi, N, Sorge, C, Tari, M, Vannacci, A, and Vetrano, D
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Drug Utilization ,medicine.medical_specialty ,Diclofenac ,Pharmacoepidemiology and Prescription ,NSAIDs ,Population ,Psychological intervention ,Cardiovascular risk Coxibs Diclofenac Drug utilization Elderly NSAIDs ,Disease ,030204 cardiovascular system & hematology ,Coxib ,03 medical and health sciences ,0302 clinical medicine ,Elderly ,Internal medicine ,medicine ,Coxibs ,Drug utilization ,Humans ,Pharmacology (medical) ,Musculoskeletal Diseases ,030212 general & internal medicine ,Medical prescription ,education ,Aged ,Aged, 80 and over ,Pharmacology ,education.field_of_study ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,General Medicine ,Cardiovascular risk ,NSAID ,Cardiovascular Diseases ,Cohort ,Female ,business ,Nimesulide ,medicine.drug - Abstract
Objectives To describe NSAID utilization for musculoskeletal conditions in a large cohort of Italian elderly with cerebro/cardiovascular disease, a population in which NSAIDs should be generally avoided due to the prothrombotic potential. Methods Administrative data from five Italian geographic areas were analyzed. Patients aged ≥ 65 with a cerebro/cardiovascular event recorded between 2008 and 2011 (cohort entry) were selected. Prescription NSAIDs reimbursed for musculoskeletal conditions and dispensed during 1 year follow-up were retrieved to describe (i) prevalence of use, (ii) average amount of defined daily doses of NSAIDs claimed by users per day of follow-up, and (iii) distribution of the received daily dose (RDD) among patients with ≥ 2 dispensings. Among new users, i.e., patients without NSAID dispensings during 2 years before cohort entry, the first dispensed NSAID molecule was observed. Results Overall, 511,989 patients were selected. Across the five geographic areas, prevalence of use ranged from 48 to 21% and average consumption ranged between 30 and 67 DDD/1000 users/day. Around 10% of patients in the overall cohort had a RDD > 1. Nimesulide (9.6%) and diclofenac (7.5%) had the highest prevalence of use. The most consumed NSAIDs were nimesulide and coxibs with 10.6 and 7.5 DDD/1000 users/day, respectively. Among new users recruited in 2011, 30% had diclofenac or a coxibs as the first prescription. Conclusions NSAID use was common in the study cohort, particularly in central-southern areas. In contrast with current recommendations, coxibs and diclofenac were among the most prescribed active principles, even in new users. Interventions to promote appropriateness of use are warranted. Electronic supplementary material The online version of this article (10.1007/s00228-018-2411-y) contains supplementary material, which is available to authorized users.
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- 2018
35. Zinc supplementation and plasma lipid peroxides in an elderly population
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Fortes, C, Agabiti, N, Fano, V, Pacifici, R, Forastiere, F, Virgili, F, Zuccaro, P, Perruci, CA, and Ebrahim, S
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- 1997
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36. The association of socioeconomic disadvantage with postoperative complications after major elective cardiovascular surgery
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Agabiti, N, Cesaroni, G, Picciotto, S, Bisanti, L, Caranci, N, Costa, G, Forastiere, F, Marinacci, C, Pandolfi, P, Russo, A, and Perucci, C A
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- 2008
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37. Number of offspring and maternal allergy
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Forastiere, F., Sunyer, J., Farchi, S., Corbo, G., Pistelli, R., Baldacci, S., Simoni, M., Agabiti, N., Perucci, C. A., and Viegi, G.
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- 2005
38. Bisphosphonates and cardiovascular risk in elderly patients with previous cardiovascular disease: a population-based nested case-control study in Italy
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Kirchmayer, U, Sorge, C, Sultana, J, Lapi, F, Onder, G, Agabiti, N, Cascini, S, Roberto, G, Corrao, G, Vitale, C, Lucenteforte, E, Mugelli, A, Davoli, M, Kirchmayer, Ursula, Sorge, Chiara, Sultana, Janet, Lapi, Francesco, Onder, Graziano, Agabiti, Nera, Cascini, Silvia, Roberto, Giuseppe, Corrao, Giovanni, Vitale, Cristiana, Lucenteforte, Ersilia, Mugelli, Alessandro, Davoli, Marina, Kirchmayer, U, Sorge, C, Sultana, J, Lapi, F, Onder, G, Agabiti, N, Cascini, S, Roberto, G, Corrao, G, Vitale, C, Lucenteforte, E, Mugelli, A, Davoli, M, Kirchmayer, Ursula, Sorge, Chiara, Sultana, Janet, Lapi, Francesco, Onder, Graziano, Agabiti, Nera, Cascini, Silvia, Roberto, Giuseppe, Corrao, Giovanni, Vitale, Cristiana, Lucenteforte, Ersilia, Mugelli, Alessandro, and Davoli, Marina
- Abstract
Background: In a globally aging population, chronic conditions with a high impact on healthcare costs and quality of life, such as osteoporosis and associated fractures, are a matter of concern. For osteoporosis, several drug treatments are available, but evidence on adverse cardiovascular and cerebrovascular (CCV) events, and in particular the risk of atrial fibrillation (AF), related to anti-osteoporotic drug use is inconclusive. The objective of this study was to evaluate the association between the use of bisphosphonates (BPs), strontium ranelate (SR), and other anti-osteoporosis drugs and the risk of AF and CCV events in a large cohort of patients affected by CCV diseases. Methods: Based on a cohort of patients aged 65 years and over, discharged from the hospitals of five large Italian areas after a CCV event between 2008 and 2011, two nested case-control studies were conducted. Cases were patients with a subsequent hospital admission for AF or CCV; four controls for each case were randomly selected and matched by age group, sex and follow-up time. A total of three exposure measures were tested: ever use, adherence and recency of use. In the conditional logistic regression models, patients not treated with any anti-osteoporotic medication were considered as the reference category. Results: The initial cohort accounted for 657,246 patients. Neither BPs nor SR use was associated with an increased risk of AF regardless of the adherence and recency of use. Overall BP and SR use was associated with a slightly increased risk of CCV; however, results reversed when considering higher adherence: odds ratio (OR) 0.81, 95% confidence interval (CI) 0.71-0.92 for BPs and OR 0.71, 95% CI 0.52-0.97 for SR. Conclusions: BPs do not increase cardiovascular risk and can be prescribed to elderly patients for osteoporosis treatment. However, patients with pre-existing cerebrovascular/cardiovascular conditions should be carefully monitored.
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- 2019
39. All-cause mortality and antipsychotic use among elderly persons with high baseline cardiovascular and cerebrovascular risk: a multi-center retrospective cohort study in Italy
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Sultana, J., Giorgianni, F., Rea, F., Lucenteforte, E., Lombardi, N., Mugelli, A., Vannacci, A., Liperoti, Rosa, Kirchmayer, U., Vitale, C., Chinellato, A., Roberto, G., Corrao, G., Trifiro, G., Agabiti, N., Bartolini, C., Bernabei, Roberto, Bettiol, A., Bonassi, S., Caputi, A. P., Cascini, S., Cipriani, Fabrizio, Davoli, M., Fini, M., Gini, R., Lapi, F., Onder, Graziano, Sorge, C., Tari, M., Vetrano, D. L., Liperoti R. (ORCID:0000-0003-3740-1687), Bernabei R. (ORCID:0000-0002-9197-004X), Cipriani F., Onder G. (ORCID:0000-0003-3400-4491), Sultana, J., Giorgianni, F., Rea, F., Lucenteforte, E., Lombardi, N., Mugelli, A., Vannacci, A., Liperoti, Rosa, Kirchmayer, U., Vitale, C., Chinellato, A., Roberto, G., Corrao, G., Trifiro, G., Agabiti, N., Bartolini, C., Bernabei, Roberto, Bettiol, A., Bonassi, S., Caputi, A. P., Cascini, S., Cipriani, Fabrizio, Davoli, M., Fini, M., Gini, R., Lapi, F., Onder, Graziano, Sorge, C., Tari, M., Vetrano, D. L., Liperoti R. (ORCID:0000-0003-3740-1687), Bernabei R. (ORCID:0000-0002-9197-004X), Cipriani F., and Onder G. (ORCID:0000-0003-3400-4491)
- Abstract
Background: Little is known about the comparative risk of death with atypical or conventional antipsychotics (APs) among persons with cardiovascular or cerebrovascular disease (CCD). Research design and methods: A cohort study was conducted using five Italian claims databases. New atypical AP users with CCD aged ≥65 (reference) were matched to new conventional AP users. Mortality per 100 person-years (PYs) and hazard ratios (HR), estimated using Cox models, were reported. Incidence and risk of death were estimated for persons having drug–drug interactions. Outcome occurrence was evaluated 180 days after AP initiation. Results: Overall 24,711 and 27,051 elderly new conventional and atypical AP users were identified. The mortality rate was 51.3 and 38.5 deaths per 100 PYs for conventional and atypical AP users. Mortality risk was 1.33 (95%CI: 1.27–1.39) for conventional APs. There was no increased mortality risk with single drug–drug interactions (DDIs) vs. no DDI. AP users with ≥1 DDI had a 29% higher mortality risk compared to no DDI in the first 90 days of treatment (HR: 1.29 (95% CI: 1.00–1.67)). Conclusions: Conventional APs had a higher risk of death than atypical APs among elderly persons with CCD. Having ≥1 DDI was associated with an increased risk of death.
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- 2019
40. Parallel Session 7 – Hospital Management: Influence of hospital procedure volume on in-hospital mortality following surgery for esophageal and pancreatic cancer
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Cavalieri, L. dʼOro, Agabiti, N., Merlo, E., Bramo, C., Cabrini, A., Galeazzi, A., Perri, G., and Bisanti, L.
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- 2003
41. Passive smoking and lung function in α1-antitrypsin heterozygote schoolchildren
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Corbo, G M, Forastiere, F, Agabiti, N, Dell’Orco, V, Pistelli, R, Massi, G, Perucci, C A, and Valente, S
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- 2003
42. Effect of gas cooking on lung function in adolescents: modifying role of sex and immunoglobulin E
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Corbo, G M, Forastiere, F, Agabiti, N, DellʼOrco, V, Pistelli, R, Aebischer, M L, Valente, S, and Perucci, C A
- Published
- 2001
43. Cohort profile: the Italian Network of Longitudinal Metropolitan Studies (IN-LiMeS), a multicentre cohort for socioeconomic inequalities in health monitoring
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Caranci, N, Di Girolamo, C, Giorgi Rossi, P, Spadea, T, Pacelli, B, Broccoli, S, Ballotari, P, Costa, G, Zengarini, N, Agabiti, N, Bargagli, Am, Cacciani, L, Canova, C, Cestari, L, Biggeri, A, Grisotto, L, Terni, G, Costanzo, G, Mirisola, C, Petrelli, A, IN-LiMeS, Group, Caranci, Nicola, Di Girolamo, Chiara, Giorgi Rossi, Paolo, Spadea, Teresa, Pacelli, Barbara, Broccoli, Serena, Ballotari, Paola, Costa, Giuseppe, Zengarini, Nicolá, Agabiti, Nera, Bargagli, Anna Maria, Cacciani, Laura, Canova, Cristina, Cestari, Laura, Biggeri, Annibale, Grisotto, Laura, Terni, Gianna, Costanzo, Gianfranco, Mirisola, Concetta, and Petrelli, Alessio
- Subjects
Male ,Urban Population ,Social Determinants of Health ,Epidemiology ,Health Status ,Immigration ,0302 clinical medicine ,Medicine ,Health Status Indicators ,030212 general & internal medicine ,Longitudinal Studies ,Child ,media_common ,education.field_of_study ,immigrants ,General Medicine ,Census ,Middle Aged ,Italy ,Child, Preschool ,Cohort ,Female ,Record linkage ,Cohort study ,Adult ,Adolescent ,media_common.quotation_subject ,Population ,Emigrants and Immigrants ,030209 endocrinology & metabolism ,immigrant ,inequalities ,mortality ,03 medical and health sciences ,Young Adult ,statistica medica ,inequalitie ,Humans ,Mortality ,education ,Socioeconomic status ,Aged ,Cohort Profile ,business.industry ,Infant, Newborn ,Urban Health ,Infant ,Health Status Disparities ,Metropolitan area ,Socioeconomic Factors ,business ,Demography - Abstract
Purpose The Italian Network of Longitudinal Metropolitan Studies (IN-LiMeS) is a system of integrated data on health outcomes, demographic and socioeconomic information, and represents a powerful tool to study health inequalities. Participants IN-LiMeS is a multicentre and multipurpose pool of metropolitan population cohorts enrolled in nine Italian cities: Turin, Venice, Reggio Emilia, Modena, Bologna, Florence, Leghorn, Prato and Rome. Data come from record linkage of municipal population registries, the 2001 population census, mortality registers and hospital discharge archives. Depending on the source of enrolment, cohorts can be closed or open. The census-based closed cohort design includes subjects resident in any of the nine cities at the 2001 census day; 4 466 655 individuals were enrolled in 2001 in the nine closed cohorts. The open cohort design includes subjects resident in 2001 or subsequently registered by birth or immigration until the latest available follow-up (currently 31 December 2013). The open cohort design is available for Turin, Venice, Reggio Emilia, Modena, Bologna, Prato and Rome. Detailed socioeconomic data are available for subjects enrolled in the census-based cohorts; information on demographic characteristics, education and citizenship is available from population registries. Findings to date The first IN-LiMeS application was the study of differentials in mortality between immigrants and Italians. Either using a closed cohort design (nine cities) or an open one (Turin and Reggio Emilia), individuals from high migration pressure countries generally showed a lower mortality risk. However, a certain heterogeneity between the nine cities was noted, especially among men, and an excess mortality risk was reported for some macroareas of origin and specific causes of death. Future plans We are currently working on the linkage of the 2011 population census data, the expansion of geographical coverage and the implementation of the open design in all the participating cohorts.
- Published
- 2018
44. Sex differences in factors associated with heart failure and diastolic left ventricular dysfunction: a cross-sectional population-based study.
- Author
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Cesaroni, Giulia, Mureddu, Gian Francesco, Agabiti, Nera, Mayer, Flavia, Stafoggia, Massimo, Forastiere, Francesco, Latini, Roberto, Masson, Serge, Davoli, Marina, Boccanelli, Alessandro, on behalf of the PREDICTOR Study Group, Boccanelli, A., Cacciatore, G., Mureddu, G. F., Rizzello, V., Agabiti, N., Cesaroni, G., Forastiere, F., Perucci, C. A., and Davoli, M.
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CARDIOVASCULAR diseases risk factors ,HEART failure risk factors ,SEX differences in the heart ,LIFESTYLES & health ,DISEASE prevalence ,ATRIAL fibrillation ,DISEASES in older people ,LEFT ventricular dysfunction - Abstract
Background: Although sex differences in cardiovascular diseases are recognised, including differences in incidence, clinical presentation, response to treatments, and outcomes, most of the practice guidelines are not sex-specific. Heart failure (HF) is a major public health challenge, with high health care expenditures, high prevalence, and poor clinical outcomes. The objective was to analyse the sex-specific association of socio-demographics, life-style factors and health characteristics with the prevalence of HF and diastolic left ventricular dysfunction (DLVD) in a cross-sectional population-based study.Methods: A random sample of 2001 65-84 year-olds underwent physical examination, laboratory measurements, including N-terminal pro-B-type natriuretic peptide (NT-proBNP), electrocardiography, and echocardiography. We selected the subjects with no missing values in covariates and echocardiographic parameters and performed a complete case analysis. Sex-specific multivariable logistic regression models were used to identify the factors associated with the prevalence of the diseases, multinomial logistic regression was used to investigate the factors associated to asymptomatic and symptomatic LVD, and spline curves to display the relationship between the conditions and both age and NT-proBNP.Results: In 857 men included, there were 66 cases of HF and 408 cases of DLVD (77% not reporting symptoms). In 819 women, there were 51 cases of HF and 382 of DLVD (79% not reporting symptoms). In men, the factors associated with prevalence of HF were age, ischemic heart disease (IHD), and suffering from three or more comorbid conditions. In women, the factors associated with HF were age, lifestyles (smoking and alcohol), BMI, hypertension, and atrial fibrillation. Age and diabetes were associated to asymptomatic DLVD in both genders. NT-proBNP levels were more strongly associated with HF in men than in women.Conclusions: There were sex differences in the factors associated with HF. The results suggest that prevention policies should consider the sex-specific impact on cardiac function of modifiable cardiovascular risk factors. [ABSTRACT FROM AUTHOR]- Published
- 2021
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45. Lung function in children and adolescents with occasional exposure to environmental tobacco smoke.
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Corbo, G M, Agabiti, N, Forastiere, F, DellʼOrco, V, Pistelli, R, Kriebel, D, Pacifici, R, Zuccaro, P, Ciappi, G, and Perucci, C A
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- 1996
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46. NSAIDs utilization for musculoskeletal indications in elderly patients with cerebro/cardiovascular disease
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Roberto, G, Bartolini, C, Rea, F, Onder, G, Vitale, C, Trifirò, G, Kirchmayer, U, Chinellato, A, Lucenteforte, E, Corrao, G, Mugelli, A, Lapi, F, Gini, R, On Behalf Of The Italian Group For Appropriate Drug Prescription In The Elderly (I-Grade): Agabiti, N, Bernabei, R, Bettiol, A, Bonassi, S, Caputi, A, Cascini, S, Davoli, M, Fini, M, Giorgianni, F, Lombardi, N, Sorge, C, Tari, M, Vannacci, A, Vetrano, D, Caputi, AP, Vetrano, DL, Roberto, G, Bartolini, C, Rea, F, Onder, G, Vitale, C, Trifirò, G, Kirchmayer, U, Chinellato, A, Lucenteforte, E, Corrao, G, Mugelli, A, Lapi, F, Gini, R, On Behalf Of The Italian Group For Appropriate Drug Prescription In The Elderly (I-Grade): Agabiti, N, Bernabei, R, Bettiol, A, Bonassi, S, Caputi, A, Cascini, S, Davoli, M, Fini, M, Giorgianni, F, Lombardi, N, Sorge, C, Tari, M, Vannacci, A, Vetrano, D, Caputi, AP, and Vetrano, DL
- Abstract
Objectives: To describe NSAID utilization for musculoskeletal conditions in a large cohort of Italian elderly with cerebro/cardiovascular disease, a population in which NSAIDs should be generally avoided due to the prothrombotic potential. Methods: Administrative data from five Italian geographic areas were analyzed. Patients aged ≥ 65 with a cerebro/cardiovascular event recorded between 2008 and 2011 (cohort entry) were selected. Prescription NSAIDs reimbursed for musculoskeletal conditions and dispensed during 1 year follow-up were retrieved to describe (i) prevalence of use, (ii) average amount of defined daily doses of NSAIDs claimed by users per day of follow-up, and (iii) distribution of the received daily dose (RDD) among patients with ≥ 2 dispensings. Among new users, i.e., patients without NSAID dispensings during 2 years before cohort entry, the first dispensed NSAID molecule was observed. Results: Overall, 511,989 patients were selected. Across the five geographic areas, prevalence of use ranged from 48 to 21% and average consumption ranged between 30 and 67 DDD/1000 users/day. Around 10% of patients in the overall cohort had a RDD > 1. Nimesulide (9.6%) and diclofenac (7.5%) had the highest prevalence of use. The most consumed NSAIDs were nimesulide and coxibs with 10.6 and 7.5 DDD/1000 users/day, respectively. Among new users recruited in 2011, 30% had diclofenac or a coxibs as the first prescription. Conclusions: NSAID use was common in the study cohort, particularly in central-southern areas. In contrast with current recommendations, coxibs and diclofenac were among the most prescribed active principles, even in new users. Interventions to promote appropriateness of use are warranted.
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- 2018
47. Functional impairment and risk of mortality in patients on chronic hemodialysis: results of the Lazio Dialysis Registry
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Bossola, Maurizio, Marino, C., Di Napoli, A., Agabiti, N., Tazza, Luigi, Davoli, M., Bossola M. (ORCID:0000-0003-1627-0235), Tazza L. (ORCID:0000-0002-6461-0137), Bossola, Maurizio, Marino, C., Di Napoli, A., Agabiti, N., Tazza, Luigi, Davoli, M., Bossola M. (ORCID:0000-0003-1627-0235), and Tazza L. (ORCID:0000-0002-6461-0137)
- Abstract
Background: Functional impairment is associated with adverse outcomes in older people, as well as in patients on chronic hemodialysis. The aim of this study was to evaluate if functional impairment represents a risk factor for reduced survival in patients on chronic hemodialysis. Methods: All incident chronic hemodialysis patients of Lazio, a large region of central Italy, registered in the Dialysis and Transplant Lazio Region Registry (DTLRR) in the period 2008–2013 were considered eligible. Inclusion criteria were: age > 18 years, resident in Lazio, still doing dialysis after 90 days from incidence date, doing hemodialysis or hemodiafiltration treatment for > 9 h/week. Patients were stratified into three classes of functional activity: total autonomy, autonomy in some activities, and not self-sufficient. Functional activity was assessed for each patient by the referring physician for the DTLRR from the ~ 90 hemodialysis units of the Lazio region. Each patient was followed from date of first dialysis treatment to the end of the study (31/12/2015) or death or renal transplant, whichever occurred first. Cox proportional hazard models were performed to obtain mortality hazard ratios (HR), 95% confidence intervals (CI), for each class of functional activity adjusting for sex, age, country of birth, city of residence, body mass index (BMI), type of nephropathy, vascular access, previous nephrology counselling, weekly hours of hemodialysis, serum albumin, hemoglobin, and presence of comorbidities (e.g. vascular diseases, coronary disease, and diabetes). Results: A total of 3356 patients were studied. In the whole follow-up period, 1622 deaths occurred (48%). Functional impairment was associated with the risk of mortality: compared to ‘total autonomy’, the HR for ‘autonomy in some activities’ was 1.30 [95% CI: 1.14–1.49] and for ‘not self-sufficient’ 1.71 [1.47–1.99] (p for trend < 0.05). The number of evitable deaths attributable to reduced functional
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- 2018
48. Passive smoking as a determinant of bronchial responsiveness in children.
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Forastiere, F, Agabiti, N, Corbo, G M, Pistelli, R, DellʼOrco, V, Ciappi, G, and Perucci, C A
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- 1994
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49. Repeatability of the ISAAC video questionnaire and its accuracy against a clinical diagnosis of asthma
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FUSO, L., DE ROSA, M., CORBO, G.M., VALENTE, S., FORASTIERE, F., AGABITI, N., and PISTELLI, R.
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- 2000
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50. Polypharmacy in the elderly: A population based cross-sectional study in Lazio, Italy
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Kirchmayer, U., Mayer, F., Basso, M., De Cristofaro, R., Mores, N., Cappai, G., Agabiti, N., Fusco, D., Davoli, M., and Gambassi, G.
- Published
- 2016
- Full Text
- View/download PDF
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