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Ovarian cancer is characterized by the establishment of tolerance, the recurrence of disease, as well as a poor prognosis. Gene signatures in ovarian cancer cells enable cancer medicine research, therapy, prevention, & management problematic. Notwithstanding advances in tumor puncture surgery, novel combinations regimens, and abdominal radiation, which can provide outstanding reaction times, the bulk of gynecological tumor patients suffer from side effects & relapse. As a consequence, more therapy alternatives for individuals with ovarian cancer must always be studied to minimize side effects and improve progression-free and total response rates. The development of cancer medications is presently undergoing a renaissance in the quest for descriptive and prognostic ovarian cancer biomarkers. Nevertheless, abnormalities in the BRCA2 or BRCA1 genes, a variety of hereditary predispositions, unexplained onset and progression, molecular tumor diversity, and illness staging can all compromise the responsiveness and accuracy of such indicators. As a result, current ovarian cancer treatments must be supplemented with broad-spectrum & customized targeted therapeutic approaches. The objective of this review is to highlight recent contributions to the knowledge of the interrelations between selected ovarian tumor markers, various perception signs, and biochemical and molecular signaling processes, as well as one’s interpretation of much more targeted and effective treatment interventions.

The 18th World Lake Conference, entitled “Governance, Resilience, and Sustainability of Lakes for a Better Society” was held virtually from November 9th to 11th, 2022 at the University of Guanajuato, Mexico. This forum was designed with the primary objective of providing a space where scientists, professionals, students, managers, and practitioners could propose, share, and learn about studies, strategies, and actions which enhance the management of lakes around the world. Different activities were contemplated and scheduled in the organization of this forum, such as conferences, special sessions, technical sessions, and workshops where 194 distinguished investigators and participants shared the results of their research and the knowledge they have gained over the years.

The last Indian parliamentary election held in 2014, proved to be the finest example of India’s age-old commitment towards the pinnacle of democratic norms. India had set a niche by conducting the largest democratic franchise in history. First time ever since the 1984, Bharatiya Janata Party (BJP) achieved the majority in the Lok Sabha without clubbing with coalition partners. It also got the absolute mandate to rule India’s federal government by ending the Congress monopoly. Interestingly, the Prime Ministerial candidate Narendra Modi in his campaigns criticized Congress-led United Progressive Alliance II (UPA II) for its impotency towards establishing friendly and cooperative relations with India’s neighbors. He also gave assurance that if his party (BJP) got the mandate, his leadership would adopt appropriate measures to resuscitate convivial ties with neighbors. Since forming the government, Prime Minister Modi has been persistently trying to pursue those promises by proceeding towards friendly ties with India’s neighbors. In the light of above discussion, this paper seeks to critically analyze the progress in Indo-Nepal relations under BJP government led by Prime Minister Narendra Modi.

Prostate carcinoma is typical cancer. It is the second most common cancer globally. The estimated new cases in 2020 was 191 930 and estimated deaths was 33 330. Age, family history, & genetic factors are major factors that drive prostate cancer. Although, for treating metastatic disease, the major therapies available are radiation,bisphosphonate, and palliative chemotherapy. But the major drawback is therapy is disease-driven and later becomes metastatic and requires treatment. The ability to revolutionize cancer treatment by major targeting vehicles via the exploration of nanoemulsion suggests a potential for cancer treatment. The unique property of a biphasic liquid dosage form called nanoemulsion to reach leaky tumor vasculature is due to its nano-meter oil-droplet size of 20–200 nm. Recent reporting on nanoemulsions disclose their embracing and lay alternative for re-purposing herbal and synthetic drugs and their combination especially for targeting prostate cancer formulating an obtainable nanomedicine. So, this article emphasizes the use of nanoemulsions incorporating therapeutic agents for successful and targeted delivery for prostate cancer.

Chandra et al. (2018) have conducted seismic hazard and probability assessment of the Kashmir valley by following multifaceted research methodologies that have mainly used the earthquake data from the United States Geological Survey, which ranges from 1902–2017. These data are supplemented by the lithological, geomorphological, geotechnical, hydrogeological and socio-economic datasets. However, the results are conflicting, contradictory, and questionable, because the authors have used scientifically invalid research methods. Therefore, the comment aims to highlight the major concerns with a motivation to offer solutions that could help the authors to refine the science on the earthquake hazards in the region.

Our recent mapping of the Dras fault zone in the NW Himalaya has answered one of the most anticipated searches in recent times where strike-slip faulting was expected from the geodetic studies. Therefore, the discovery of the fault is a leap towards the understanding of the causes of active faulting in the region, and how the plate tectonic convergence between India and Eurasia is compensated in the interior portions of the Himalayan collision zone, and what does that imply about the overall convergence budget and the associated earthquake hazards. The present work is an extended version of our previous studies on the mapping of the Dras fault zone, and we show details that were either not available or briefly touched. We have used the 30 m shuttle radar topography to map the tectonic geomorphological features that includes the fault scarps, deflected drainage, triangular facets, ridge crests, faulted Quaternary landforms and so on. The results show that oblique strike-slip faulting is active in the suture zone, which suggests that the active crustal deformation is actively compensated in the interior portions of the orogen, and it is not just restricted to the frontal portions. The Dras fault is a major fault that we have interpreted either as a south dipping oblique backthrust or an oblique north dipping normal fault. The fieldwork was conducted in Leh, but it did not reveal any evidence for active faulting, and the fieldwork in the Dras region was not possible because of the politically sensitive nature of border regions where fieldwork is always an uphill task.

Herbal medicines therapy is appreciated by many research works because herbal drugs have relatively high therapeutic window, lower side effects and more cost effective. Guggulipid is an ethyl acetate extract of resin known as guggul from the tree Commiphora wightii / mukul (Arn.) Bhandari. Chemical analysis revealed that the compounds responsible for the major activities of gum guggul are the isomers E- and Z-guggulsterone. Guggul has been used for thousands of years in the treatment of arthritis, inflammation, obesity, cardiac protection, anti-ulcer, anti-epileptic and disorders of lipid metabolism. This review is an assortment of available information reported on its chemical, pharmacological and toxicological properties in various research studies. The available therapeutic properties of guggulipid make it suitable natural product for the treatment of various disorders like inflammation, pain, wounds, liver disorder and Acne etc. Graphical Abstract Graphical Abstract.

Dementia is a neurodegenerative condition that is considered a major factor contributing to cognitive decline that reduces independent function. Pathophysiological pathways are not well defined for neurodegenerative diseases such as dementia; however, published evidence has shown the role of numerous inflammatory processes in the brain contributing toward their pathology. Microglia of the central nervous system (CNS) are the principal components of the brain’s immune defence system and can detect harmful or external pathogens. When stimulated, the cells trigger neuroinflammatory responses by releasing proinflammatory chemokines, cytokines, reactive oxygen species, and nitrogen species in order to preserve the cell’s microenvironment. These proinflammatory markers include cytokines such as IL-1, IL-6, and TNFα chemokines such as CCR3 and CCL2 and CCR5. Microglial cells may produce a prolonged inflammatory response that, in some circumstances, is indicated in the promotion of neurodegenerative diseases. The present review is focused on the involvement of microglial cell activation throughout neurodegenerative conditions and the link between neuroinflammatory processes and dementia.

Worldwide health and therapeutic practices seek to amalgamate alternative medications with evidence-based medicine for an improved understanding of metabolic progression and its influences on the human body. Actinidia deliciosa, also known as “Kiwi fruit”, is a dioecious plant that is native to China and distributed widely across the Asian continent. Commercial planting of kiwifruit was started in the early 20th century when it reached New Zealand from China. In recent times, Kiwi fruit has gained a major demand due to its high content of vitamin C. Kiwi fruit also contains dietary fiber, iron, carotenoids and is a rich source of antioxidants. These may aid in lowering blood pressure, improve wound healing, blood glucose control and improve bowel health. Vitamin C, choline, lutein, and zeaxanthin are antioxidants that assist in the removal of free radicals from the body and may prevent the body from various diseases and inflammations. Herein, we state the health benefits found in diverse compounds from Actinidia deliciosa, highlighting the source, morphology, chemical constituent, cultivation, production, traditional uses, nutritional value, health benefits, toxicity studies, clinical trials, and pharmacological activities while highlighting side effects associated with kiwifruit. This review provides a bird’s eye insight mainly on the morphological, phytochemical, and pharmacological activity, which could be beneficial in making use of technological and scientific advances. This plant can be used as a current medical adjuvant for its potential. The complete plant must be broadly investigated for further future perspective.

The article has been withdrawn at the request of the editor of the journal CNS & Neurological Disorders - Drug Targets due to incoherent content. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php Bentham Science Disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

Landslides are downslope movements of rock and soil materials under the influence of gravity, and often these are triggered by various causes, and the factors that govern the landslide occurrence in Brunei Darussalam, Borneo, have not been investigated in any detail, although landslide hazards are the second most damaging hazards in the country. The equatorial tropical monsoon conditions contribute to the cause of landslides in the sultanate, and our mapping of landslide sites in the Brunei-Muara region has revealed a number of key factors that initiate and influence the formation and nucleation of landslides. And these are mainly related to extent of urbanisation, amount and intensity of rainfall, loss of vegetation cover, slope and geological factors. These factors may or may not work together for a particular landslide event, but the occurrence of landslides has been linked to these factors. Gravitational active faults were also mapped at three landslide sites and related to creep. Google, and 30 m shuttle radar topography satellite images, followed by detailed fieldwork with the aid of unmanned aerial vehicle tool, were employed to map the topographic, structural, bedrock, and landslide details and to differentiate the types of landslides. The landslide and rainfall data were obtained from the National Disaster Management Centre and Geotechnical and Geological Section of the Public Works Department and used in combination with the bedrock and slope maps. Our work should be used by local administrative departments to plan any future anthropogenic activity in the region.

There have been many studies carried out in the past decades attempting to develop strategies for a safe injection of CO2 into storage sites without leakage and contamination of valuable resources. Leakage from these storage sites through capillary seals is one of the long-standing issues, which require a comprehensive assessment prior to CO2 injection. However, surface wettability, which is one of the major parameters controlling the capillary pressure of seals, is a poorly understood parameter, changing as a function of temperature, pressure, surface roughness, etc. The aim of this paper is to provide a deeper insight into the surface wettability of minerals in rocks, especially sandstone and shales, under subsurface conditions for a better assessment of the structural integrity in CO2 storage sites. The results obtained from a series of contact angle measurements under different pressure and temperature conditions indicated that quartz- and feldspar-dominated sandstones are strongly water wet, while kaolinite-dominated shales have a weakly water to intermediate wet system. It is also apparent that the interfacial tension is a function of the pressure and temperature conditions. It appears that the size of pore throats in rocks is the major contributor to capillary threshold pressure and it must be determined very accurately. It is recommended that surface wettability and interfacial tension under reservoir conditions are determined a priori to ensure that the seal integrity analysis is as concise as possible.

Detailed structural analysis of an onshore field was carried out to study the geometry and interactions of the interpreted normal faults. The faults have E-W strike and are dipping towards the south. Majority of the faults are coherently linked with only a few displaying isolated growth model. Throw generally increases with increasing depth. The distribution of the throw on the fault planes shows different geometries ranging from symmetrical with steep gradients at the fault tips and displacement maxima at the center to asymmetrical with steep gradient at one tip. Faults interacted by way of splay and systematically formed relay ramp structures. At depth, splay display isolated fault profile rather than a maxima at the intersections suggesting an unusual interaction at intersection between major fault and splay with low displacement at intersection.

Alpinia galanga plant which is associated with family Zingiberaceae is mainly scattered in tropical areas and widely known for ethno medicine. Against fungi and bacteria rhizome extract have a maximum inhibitory effect. Alpinia galanga plant is used in medicine and in food preparation. Rhizome extract of Alpinia galanga have high phenolic and flavonoid contents when compared to leaf extract. Because of elevated phenolic and flavonoid content in rhizome extract of Alpinia galanga there is noticeable antimicrobial as well as radical scavenging potential. It is a well-known official drug thought out the country as integrated contribution of nature. It is commonly used for the management of eczema, coryza, bronchitis, otitis interna, gastritis, ulcers, morbilli and cholera, pityriasis versicolor, to clear the mouth, emaciation. The different parts of the plant have various effects like antifungal, antiprotozoal, antiplatelet, antiviral, antidiabetic, immunomodulatory, antibacterial, anti-oxidant effects, hypolipidemic and many others. The essential oil of A. galanga identified 1, 8-cineol as a bioactive agent having antifeeding activity. An aqueous acetone extract of fruit of Alpinia galanga shows inhibitory effect on melanogenesis (formation of melanin). By using different methods, active constituent namely, 1'-acetochavicol acetate in hexane extract of Alpinia galanga rhizome was investigated for their corrosion inhibition properties. The current review add significant information about its, pharmacological activities, medicinal properties and phytochemical investigations as a traditional drug to cure for a number of diseases. Every fraction of the plant has valuable properties that can deliver humanity. The complete plant will be broadly investigated for further future prospective.

The active tectonics of the Kashmir basin is an interesting research problem because it involves a region that is located away from the Himalayan frontal portions where most of the tectonic activity is absorbed on the Main Frontal Thrust system. Therefore, any study on the active tectonics of the region would increase our understanding on how interior faults form, activate or reactive. However, several problematic and controversial research articles have been published over the years on the active tectonics of the Kashmir basin. These have questioned the quality of research, which has been raised by Shah in several of his commentary papers. The work presented below is a discussion on the recently published article by Bhat et a. (2020) where the authors argue to have identified a new active fault in Aripal basin, Kashmir, by using the geomorphic indices, morphometric parameters, and detailed fieldwork. However, the fault does not exist, and the field details are conflicting and controversial. Therefore, I suggest that the paper should be removed and authors should be allowed to correct the problems that I have raised below, and resubmit when they are ready with the data.

The coronavirus disease 2019 (COVID-19) pandemic has highlighted the need to have virtual field libraries accessible to users, which is possible if the field data are collected, archived, and processed to retain the actual field configurations. Therefore, we demonstrate the veracity of geological mapping with the help of Unmanned Air Vehicle (UAV) coupled with the traditional field site visits in Brunei Darussalam, SE Asia. We have selected two geological field sites that expose faulted Miocene sedimentary rocks. We visited these sites with geology undergraduates to teach them the field components of the courses on Field Mapping and Structural Geology at the Universiti Brunei Darussalam. A field assignment was given to students, which had to be submitted at the end of the fieldwork. The same exercise was repeated in the classroom with the UAV aided field data as virtual field exercises. The geological outcrop details were captured at kilometer and millimeter (mm) scales with both the static and dynamic mode of operations. The drone-based imagery was used to generate the 3D point clouds that used 67 oriented photographs to recreate the outcrop details. We discovered that both the traditional and drone based field data are highly useful to capture kilometer to mm scale details. Our results also revealed that students were very engaged during the virtual field exercises, and completed the field assignment with care, which was largely missing during the onsite field exercises. We think this is partly because of the relaxed state of the mind to grasp details while in a classroom environment where the hot sunny and humid weather of tropical Brunei was avoidable. The virtual field exercises have opened a new arena of field geology where the use of technology enhances the usability and accessibility of field based courses that are often disrupted because of various reasons. However, the traditional field visits should not be completely replaced by the virtual field.