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We report a case of a 62-year-old woman, HIV positive, with a 3-week history of jaundice and elevated cholestatic enzymes. Imaging studies displayed intrahepatic biliary dilatation and a central liver lesion. Pathology described lesions of active cholangitis, lymphoplasmacytic infiltration and fibrosis, suggesting a hepatic inflammatory pseudotumour (IPT) IgG4 related. IgG4-related lymphoplasmacytic form of IPT belongs to IgG4-related diseases. We discuss the importance to include IgG4-related hepatic IPT as part of the differential diagnosis of any liver lesion, highlighting potential imaging clues that may help in establishing the correct diagnosis.

Esta pesquisa tem por objetivo verificar a aplicabilidade da relação CustoVolume-Lucro (CVL) na produção de tilápias em tanques-redes de águas públicas. Trata-se de uma pesquisa qualitativa, descritiva, a qual se baseia em dados primários como fonte e os achados foram analisados por meio do Microsof Office Excel®. O período analisado compreende os meses de janeiro de 2017 a maio de 2018, referente a dois ciclos de criação e comercialização. Os principais achados da pesquisa tratam sobre a relação CVL possuir aplicabilidade na produção de tilápias, fornecendo informações úteis a tomada de decisão, especialmente no que diz respeito ao ponto de equilíbrio, a margem de contribuição, margem de segurança e Grau de Alavancagem Operacional (GAO). Em relação ao objeto desta pesquisa, a CVL revelou que o filé de tilápia e o peixe vivo, apesar de representarem quase 90% das receitas, não são os principais formadores unitários do lucro, o qual é representado pelo peixe eviscerado (47,13%). Esta pesquisa contribui com o incentivo de pesquisas relacionadas com a gestão financeira na piscicultura, produzindo informações que podem auxiliar a elaboração do planejamento estratégico e ao melhoramento da gestão do negócio.

This work developed a reflection on the city of Beirut, in the region of the container terminal and the Karantina neighborhood. One of the biggest challenges of the project was to understand the potential of the infrastructure as a tool to consolidate the urban fabric of the city, namely how to articulate the neighborhood, the terminal and the river. Another challenge of the project was the articulation of spaces between artificial or natural barriers. Regarding the Karantina neighborhood there was the potential to design and urbanize this area as if this intervention is not only localized, but as a general strategy to dynamize already consolidated spaces in the city, as Lteif said “In a way, Karantina is a microcosm of Lebanon”. After the exposure of the military events that tore Lebanon apart, the Syrian refugees from the war in Syria, the city divided in two based, the lack of public spaces, the lack of fresh green areas, and the potential for connection between the port, the river the neighborhood and the city instead of a disadvantage would be used in one strategy, a great symbiosis where everyone can live in community. We can check out how the boundaries would help reconnect people and their cultures in Beirut. It was as a basis for the urban redesign of the neighborhood, the river waterfront, as of the container terminal, that I intended to suppress the needs of the place after damage caused by the explosion of the silos in the port. Este trabalho desenvolveu-se uma reflexão sobre a cidade de Beirut, na região do terminal de contentores e no Bairro da Karantina. Um dos maiores desafios do projeto foi entender a potencialidade da infraestrutura como ferramenta consolidadora do tecido urbano da cidade, nomeadamente como articular o Bairro o terminal e rio. Outro desafio do projeto foram a articulação de espaços entre barreiras artificiais ou naturais. Relativamente ao bairro da Karantina havia o potencial de projetar e urbanizar esta área como se esta intervenção não seja apenas localizada, mas como uma estratégia geral para dinamizar espaços já consolidados na cidade, como disse Lteif “De certa forma, a Karantina é um microcosmo do Líbano”. Após a exposição dos eventos militares que dilaceraram o Líbano, a vinda de mais de um milhão de refugiados Sírios oriundos da guerra na Síria, a guerra civil, a cidade dividida em dois com base a religião praticada, a falta de espaços públicos, a inexistência de zonas verdes frescas, e o potencial de ligação entre o porto, o rio o bairro e a cidade em vez de uma desvantagem, seriam utilizados numa única estratégia, uma grande simbiose onde todos podem viver em comunidade. Podemos conferir como os limites iriam ajudar a conectar novamente as pessoas e as suas culturas em Beirut. Foi como base no redesenho urbano do bairro, da foz e marginal do rio, como do terminal de contentores, que pretendo suprimir as necessidades do local após os vastos danos originados pela explosão dos silos do porto.

[EN] Balance disorders can have substantial adverse implications on the performance of daily activities and lead to an increased risk of falls, which often have severe negative consequences for older adults. Quantitative assessment through computerized force plate-based posturography enables objective assessment of postural control but could not successfully represent specific abilities required during daily activities. The use of virtual reality (VR) could improve the representative design of functional activities and increase the ecological validity of posturographic tests, which would enhance the transferability of results to the real world. In this work, we investigate the feasibility of a simulated bus ride experienced in a surround-screen VR system to assess balance with increased ecological validity. Participants were first evaluated with a posturography test and then with the VR-based bus ride test, while the reactions of their centre of pressure were registered. Lastly, participants provided self-reported measures of the elicited sense of presence during the test. A total of 16 healthy young adults completed the study. Results showed that the simulation could elicit significant medial-lateral excursions of the centre of pressure in response to variations in the optical flow. Furthermore, these responses' amplitude negatively correlated with the participants' posturography excursions when fixating a target. Although the sense of presence was moderate, likely due to the passive nature of the test, the results support the feasibility of our proposed paradigm, based in the context of a meaningful daily living activity, in assessing balance control components, This work was supported by the Fundacao para a Ciencia e Tecnologia through the AHA project (CMUPERI/HCI/0046/2013), and NOVA-LINCS (UID/CEC/04516/2019), by the INTERREG program through the MACBIOIDI project (MAC/1.1.b/098), by project VALORA, Grant 201701-10 of the Fundacio la Marato de la TV3 (Barcelona, Spain) and the European Union through the Operational Program of the European Regional Development Fund (ERDF) of the Valencian Community 2014-2020 (IDIFEDER/2018/029)

Os KPI são indicadores crucias para o desenvolvimento dos processos de tomada de decisão por parte das empresas, e cada vez mais é necessário que as empresas apostem nestes softwares se querem sobreviver neste mercado em constante mudança. Outro fator que leva para que as empresas comecem a apostar na análise destas métricas é o constante crescimento das redes sociais e um papel mais ativo por parte do consumidor. No desenvolvimento do estudo de caso que foi elaborado na marca Flamingo S.A, uma fábrica de peças ourivesarias, tendo também venda para o mercado Business como consumidor final. Dentro da empresa foram desenvolvidos relatórios com base nas métricas,do impacto das marcas nas redes sociais como Facebook e Instagram, bem como a sua relevância tanto numa perpetiva de impacto no alcance das publicações efetuadas como a sua interceção com os utilizadores. KPIs are crucial indicators for the development of decision-making processes by companies, and it is increasingly necessary for companies to bet on this kind of software, if they want to survive in this constantly changing market. Another factor that leads companies to start investing in the analysis of these metrics is the constant growth of social networks and a more active role on the part of the consumer. In the development of the case study that was carried out in the Flamingo S.A brand, a jewelry factory, also selling to the Business market as a final consumer. Within the company, reports were developed based on the metrics of the impact of brands on social networks such as Facebook and Instagram, which will be among themselves as well as their relevance in the impact both in the reach of the publications made as well as their interception with users.

Dissertação de mestrado integrado em Engenharia Informática, A aplicação de técnicas orientadas a objectos e de aprendizagem automática sobre imagens de satélite tem sido alvo de interesse nos últimos anos. O aumento da qualidade e quantidade de imagens, disponibilizadas por programas de observação da Terra como por exemplo o Programa Cope rnicus, levou à geração de uma grande quantidade de dados. De entre as várias aplicações destes dados destaca-se a criação de mapas do coberto do solo. Com a presente dissertação pretendia-se criar modelos de aprendizagem automática capazes de segmentar e classificar com precisão imagens de satélite, gerando automaticamente um mapa do coberto do território Português. Durante a dissertação foram realizadas várias experiências com as bandas espetrais do satélite Sentinel-2, com índices espetrais e com diversos conjuntos de classes do coberto. Foram testadas três arquiteturas nos modelos de aprendizagem automática treinados, que adotam duas técnicas diferentes para classificação das imagens. Numa das técnicas a classificação é orientada ao objeto, e neste caso a arquitetura adotada nos modelos foi uma rede neuronal artificial U-Net. Na outra técnica, a classificação é orientada ao pixel e os modelos de aprendizagem automática testados foram a floresta aleatória e a máquina de vetores de suporte. A acurácia global dos resultados obtidos variou entre 82.32% e 94.75%, dependendo fortemente do número de classes em que se classifica o coberto. O resultado de 94.75% foi obtido quando se classifica o coberto em apenas 5 dasses. Contudo conseguiu-se uma acurácia bem interessante de 92.37%, no modelo treinado para classificar 8 classes., The application of object-oriented and machine learning techniques on satellite imagery has been the subject of interest in recent years. The increase in quality and quantity of images, made available by Earth observation programs, such as the Copernicus program, led to the generation of a large amounts of data. Among the various applications of these data is the creation of land cover maps. This dissertation aimed to create machine learning models capable of accurately segment and classify satellite images, automatically generating a land cover map of the Portuguese territory. During the dissertation several experiments were carried out with the spectral bands of the Sentinel-2 satellite, with vegetation indices, and with several sets of land cover classes. Three architectures were tested in the trained machine learning models, which adopt two different techniques for image classification. One of the classification techniques follows an object-oriented approach, and in this case the architecture adopted in our models was a U-Net artificial neural network. The other classification technique is pixel-oriented, and the machine learning models tested were random forest and support vector machine. The overall accuracy of the results obtained ranged from 82.32% to 94.75%, depending strongly on the number of classes into which the land cover was classified. The result of 94.75% was obtained when classifying the cover into only 5 classes. However, a very interesting accuracy of 92.37% was achieved by the model trained to classify 8 classes.

Made available in DSpace on 2022-04-29T08:38:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01 Rationale: The FDA-approved Dimethyl Fumarate (DMF) as an oral drug for Multiple Sclerosis (MS) treatment based on its immunomodulatory activities. However, it also caused severe adverse effects mainly related to the gastrointestinal system. Objective: Investigated the potential effects of solid lipid nanoparticles (SLNs) containing DMF, administered by inhalation on the clinical signs, central nervous system (CNS) inflammatory response, and lung function changes in mice with experimental autoimmune encephalomyelitis (EAE). Materials and methods: EAE was induced using MOG35-55 peptide in female C57BL/6J mice and the mice were treated via inhalation with DMF-encapsulated SLN (CTRL/SLN/DMF and EAE/SLN/DMF), empty SLN (CTRL/SLN and EAE/SLN), or saline solution (CTRL/saline and EAE/saline), every 72 h during 21 days. Results: After 21 days post-induction, EAE mice treated with DMF-loaded SLN, when compared with EAE/saline and EAE/SLN, showed decreased clinical score and weight loss, reduction in brain and spinal cord injury and inflammation, also related to the increased influx of Foxp3+ cells into the spinal cord and lung tissues. Moreover, our data revealed that EAE mice showed signs of respiratory disease, marked by increased vascular permeability, leukocyte influx, production of TNF-α and IL-17, perivascular and peribronchial inflammation, with pulmonary mechanical dysfunction associated with loss of respiratory volumes and elasticity, which DMF-encapsulated reverted in SLN nebulization. Conclusion: Our study suggests that inhalation of DMF-encapsulated SLN is an effective therapeutic protocol that reduces not only the CNS inflammatory process and disability progression, characteristic of EAE disease, but also protects mice from lung inflammation and pulmonary dysfunction. Neuroscience Group Department of Physiology and Biophysics Institute of Biological Sciences Federal University of Minas Gerais (UFMG), MG Nanoneurobiophysics Research Group Department of Physics Chemistry and Mathematics Federal University of Sao Carlos (UFSCAR), Sao Paulo State of Sao Paulo University (UNESP) Drugs and Medicines Department School of Pharmaceutical Sciences, Sao Paulo Laboratory of Pulmonary Immunology and Mechanics Department of Physiology and Biophysics Institute of Biological Sciences Federal University of Minas Gerais (UFMG), MG Laboratory of Immunology and Genomics of Parasites Department of Parasitology Institute of Biological Sciences Federal University of Minas Gerais (UFMG), MG Center for Technology and Research in Magneto-Resonance (CTPMAG) Federal University of Minas Gerais (UFMG), MG Department of Pathology Institute of Biological Sciences Federal University of Minas Gerais (UFMG), MG Laboratory of Functional Genetics Department of Genetics Ecology and Evolution Institute of Biological Sciences Federal University of Minas Gerais (UFMG), MG Department of Pharmacology Institute of Biological Sciences Federal University of Goias (UFG), GO State of Sao Paulo University (UNESP) Drugs and Medicines Department School of Pharmaceutical Sciences, Sao Paulo

Objective: To know the experiences, practices and challenges for the development of the School Health Program through Primary Health Care. Methodology: An integrative literature review study was conducted, the secondary databases used were the Virtual Health Library, Latin American and Caribbean Literature on Health Sciences (LILACS) and the Scientific Electronic Library Online (Scielo). The articles were searched with the descriptors School Health Services, Family Health Strategy and Primary Health Care. Results: Twenty-eight articles were found in the Virtual Health Library database, 63 in Scielo and 17 in LILACS, with the aid of inclusion and exclusion criteria, the final sample consisted of 17 articles. The School Health Program is a unique opportunity to approach the health and education sectors, being a strategy to promote students' health, with numerous benefits. Final considerations: The actions developed in schools are punctual and unsystematic, only as responses to specific demands, which limits the scope of the actions of the School Health Program. Objetivo: Conocer las experiencias, prácticas y desafíos para el desarrollo del Programa de Salud Escolar a través de la Atención Primaria de Salud. Metodología: Se realizó un estudio de revisión de la literatura integrativa, las bases de datos secundarias utilizadas fueron la Biblioteca Virtual de Salud, la Literatura Latinoamericana y del Caribe sobre Ciencias de la Salud (LILACS) y la Biblioteca Electrónica Científica en Línea (Scielo). Los artículos fueron buscados con los descriptores Servicios de Salud Escolar, Estrategia de Salud Familiar y Atención Primaria de Salud. Resultados: Veintiocho artículos fueron encontrados en la base de datos de la Biblioteca Virtual en Salud, 63 en Scielo y 17 en LILACS, con la ayuda de criterios de inclusión y exclusión, la muestra final consistió en 17 artículos. El Programa de Salud Escolar es una oportunidad única para acercarse a los sectores de la salud y la educación, siendo una estrategia para promover la salud de los estudiantes, con numerosos beneficios. Finalización del estudio: Las acciones desarrolladas en las escuelas son puntuales y poco subsistemas, sólo como respuestas a demandas específicas, lo que limita el alcance de las acciones del Programa de Salud Escolar. Objetivo: Conhecer as experiências, práticas e desafios para o desenvolvimento do Programa Saúde na Escola pela Atenção Básica à Saúde. Metodologia: Conduziu-se um estudo de revisão integrativa de literatura, as bases de dados secundários utilizadas foram a Biblioteca Virtual em Saúde, Literatura Latino - Americana e do Caribe em Ciências da Saúde (LILACS) e a Scientific Electronic Library Online (Scielo). A busca dos artigos foi realizada por meio dos descritores Serviços de Saúde Escolar, Estratégia Saúde da Família e Atenção Básica à Saúde. Resultados: Foram encontrados 28 artigos na base de dados Biblioteca Virtual em Saúde, 63 na Scielo e 17 na LILACS, com auxílio dos critérios de inclusão e exclusão a amostra final foi composta por 17 artigos. O Programa Saúde na Escola é uma oportunidade ímpar de aproximação dos setores saúde e educação, sendo uma estratégia de promoção à saúde dos estudantes, com inúmeros benefícios. Study completion: As ações desenvolvidas nas escolas são pontuais e assistemáticas, apenas como respostas a demandas específicas, o que limita o alcance das ações do Programa Saúde na Escola.

O presente trabalho teve por objetivo explorar as mudanças que traçam os contornos do pacote anticrime e, de modo específico, a figura do juiz das garantias. Assim, tem-se como objetivo principal a análise da neutralidade e parcialidade dos magistrados que atuam na fase pré-processual e processual do processo penal e se o envolvimento com este trabalho pode acabar os influenciando. Para realizar o estudo foram utilizados os métodos de revisão bibliográfica e o hipotético-dedutivo. Como resultado da pesquisa, entendemos que o aprimoramento do processo penal é essencial para a realização da justiça em nosso país, mediante a garantia dos direitos dos investigados e o combate da parcialidade.

While exergames have been used with older adults in an attempt to promote higher physical activity (PA) levels, and its subsequent health benefits, there is a lack of research that objectively quantifies the PA levels that custom-made exergames can produce throughout an extended training program. In this paper, we describe a 3-month intervention study that aimed to measure the participants PA levels during exergames’ sessions and their effectiveness in eliciting the recommended activity levels. Over the course of the study, two groups of older adults participated in either a conventional multidimensional fitness training program of two sessions of exercise per week (n = 16) or in an equivalent combined program (n = 15), of one conventional and one exergame session per week. Both the objective PA levels (through accelerometry) and subjective effort (perceived exertion) were collected in each session. Results revealed that while participants spent more time in moderate-to-vigorous PA during exergaming than during conventional sessions, they also spent less energy, thus working out at lower intensities but for a more sustained amount of time. The self-reported exertion was consistently higher for the sessions of the combined exercise program. We showed that a set of custom-made exergames can be successfully used by trainers to set up personalized training sessions and can be used in combination with regular exercise for sustained long-term training, exposing differences between the two training regimes in terms of efficiency, elicited PA, and perceived effort.

Background Zika virus (ZIKV) infection during pregnancy may cause major congenital defects, including microcephaly, ocular, articular and muscle abnormalities, which are collectively defined as Congenital Zika Syndrome. Here, we performed an in-depth characterization of the effects of congenital ZIKV infection (CZI) in immunocompetent mice. Methods Pregnant dams were inoculated with ZIKV on embryonic day 5.5 in the presence or absence of a sub-neutralizing dose of a pan-flavivirus monoclonal antibody (4G2) to evaluate the potential role of antibody-dependent enhancement phenomenon (ADE) during short and long outcomes of CZI. Findings ZIKV infection induced maternal immune activation (MIA), which was associated with occurrence of foetal abnormalities and death. Therapeutic administration of AH-D antiviral peptide during the early stages of pregnancy prevented ZIKV replication and death of offspring. In the post-natal period, CZI was associated with a decrease in whole brain volume, ophthalmologic abnormalities, changes in testicular morphology, and disruption in bone microarchitecture. Some alterations were enhanced in the presence of 4G2 antibody. Interpretation Our results reveal that early maternal ZIKV infection causes several birth defects in immunocompetent mice, which can be potentiated by ADE phenomenon and are associated with MIA. Additionally, antiviral treatment with AH-D peptide may be beneficial during early maternal ZIKV infection. Fund This work was supported by the Brazilian National Science Council (CNPq, Brazil), Minas Gerais Foundation for Science (FAPEMIG), Funding Authority for Studies and Projects (FINEP), Coordination of Superior Level Staff Improvement (CAPES), National Research Foundation of Singapore and Centre for Precision Biology at Nanyang Technological University.

[EN] Two of the most popular mediums for virtual reality are head-mounted displays and surround-screen projection systems, such as CAVE Automatic Virtual Environments. In recent years, HMDs suffered a significant reduction in cost and have become widespread consumer products. In contrast, CAVEs are still expensive and remain accessible to a limited number of researchers. This study aims to evaluate both objective and subjective characteristics of a CAVE-like monoscopic low-cost virtual reality surround-screen projection system compared to advanced setups and HMDs. For objective results, we measured the head position estimation accuracy and precision of a low-cost active infrared (IR) based tracking system, used in the proposed low-cost CAVE, relatively to an infrared marker-based tracking system, used in a laboratory-grade CAVE system. For subjective characteristics, we investigated the sense of presence and cybersickness elicited in users during a visual search task outside personal space, beyond arms reach, where the importance of stereo vision is diminished. Thirty participants rated their sense of presence and cybersickness after performing the VR search task with our CAVE-like system and a modern HMD. The tracking showed an accuracy error of 1.66 cm and .4 mm of precision jitter. The system was reported to elicit presence but at a lower level than the HMD, while causing significant lower cybersickness. Our results were compared to a previous study performed with a laboratory-grade CAVE and support that a VR system implemented with low-cost devices could be a viable alternative to laboratory-grade CAVEs for visual search tasks outside the users personal space., This work was supported by the Fundação para a Ciência e Tecnologia through the AHA project (CMUPERI/HCI/0046/2013), by the INTERREG program through the MACBIOIDI project (MAC/1.1.b/098), LARSyS (UIDB/50009/2020), NOVA-LINCS (UID/CEC/04516/2019), by Fundació la Marató de la TV3 (201701-10), and the European Union through the Operational Program of the European Regional Development Fund (ERDF) of the Valencian Community 2014-2020 (IDIFEDER/2018/029)

The Northwest Atlantic Shelf provides ecological and economic benefits along the heavily populated North American coastline and beyond. In 2009-2010, abrupt warming prompted an ecosystem shift with consequences for fisheries, yet the cause of this event is unclear. Here we use satellite altimetry and in situ measurements to show that, in 2008, the Gulf Stream migrated closer to the Tail of the Grand Banks, a shift that has persisted ever since. This change reduced the westward connectivity of the Labrador Current that otherwise supplies cold, fresh, oxygen-rich waters to the shelf. Within one year after the appearance of anomalously warm and saline water at the Tail of Grand Banks, subsurface warming progressed south-westwards. Historical observations suggest a similar sequence of events may have occurred in the 1970s. Therefore, monitoring water properties at the Tail of Grand Banks may offer predictability for shelf properties and ecosystem perturbations with substantial lead time. A northward shift of the Gulf Stream in 2008 interrupted the Labrador Current and may have contributed to abrupt warming and an ecosystem shift in the Northwest Atlantic Shelf a year later, suggest satellite altimetry and direct subsurface measurements.

In recent years, increasing evidence of the positive impact of Virtual Reality (VR) on neurofeedback training has emerged. The immersive properties of VR training scenarios have been shown to facilitate neurofeedback learning while leading to cognitive enhancements such as increased working memory performance. However, in the design of an immersive VR environment, there are several covariates that can influence the level of immersion. To date, the specific factors which contribute to the improvement of neurofeedback performance have not yet been clarified. This research aims to investigate the effects of vividness in a Cave automatic virtual environment (CAVE-VR) on neurofeedback training outcome, and to assess the effect on working memory performance. To achieve this, we recruited 21 participants, exposed to neurofeedback training inside a CAVE-VR environment. Participants were divided into three experimental groups, each of which received feedback in a different neurofeedback training scenario with increasing level of vividness (i.e., low, medium, high) while also assessing the effect of neurofeedback on working memory performance. Current findings show that highly vivid feedback in CAVE-VR results in increased neurofeedback performance. In addition, highly vivid training scenarios had a positive effect on user’s motivation, concentration, and reduced boredom. Finally, current results corroborate the efficacy of the neurofeedback enhancement protocol in CAVE-VR for improving working memory performance.