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1. Navigating the evolving landscape of atopic dermatitis: Challenges and future opportunities: The 4th Davos declaration.

Author

Traidl‐Hoffmann, Claudia, Afghani, Jamie, Akdis, Cezmi A., Akdis, Mübecel, Aydin, Handan, Bärenfaller, Katja, Behrendt, Heidrun, Bieber, Thomas, Bigliardi, Paul, Bigliardi‐Qi, Mei, Bonefeld, Charlotte Menné, Bösch, Stefanie, Brüggen, Marie Charlotte, Diemert, Sebastian, Duchna, Hans‐Werner, Fähndrich, Martina, Fehr, Danielle, Fellmann, Marc, Frei, Remo, and Garvey, Lena H.

Subjects
*PATIENT advocacy, *ATOPIC dermatitis, *TARGETED advertising, *DISEASE management, *STAKEHOLDER analysis
Abstract

The 4th Davos Declaration was developed during the Global Allergy Forum in Davos which aimed to elevate the care of patients with atopic dermatitis (AD) by uniting experts and stakeholders. The forum addressed the high prevalence of AD, with a strategic focus on advancing research, treatment, and management to meet the evolving challenges in the field. This multidisciplinary forum brought together top leaders from research, clinical practice, policy, and patient advocacy to discuss the critical aspects of AD, including neuroimmunology, environmental factors, comorbidities, and breakthroughs in prevention, diagnosis, and treatment. The discussions were geared towards fostering a collaborative approach to integrate these advancements into practical, patient‐centric care. The forum underlined the mounting burden of AD, attributing it to significant environmental and lifestyle changes. It acknowledged the progress in understanding AD and in developing targeted therapies but recognized a gap in translating these innovations into clinical practice. Emphasis was placed on the need for enhanced awareness, education, and stakeholder engagement to address this gap effectively and to consider environmental and lifestyle factors in a comprehensive disease management strategy. The 4th Davos Declaration marks a significant milestone in the journey to improve care for people with AD. By promoting a holistic approach that combines research, education, and clinical application, the Forum sets a roadmap for stakeholders to collaborate to improve patient outcomes in AD, reflecting a commitment to adapt and respond to the dynamic challenges of AD in a changing world. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Navigating the evolving landscape of atopic dermatitis:Challenges and future opportunities: The 4th Davos declaration

Author

Traidl-Hoffmann, Claudia, Afghani, Jamie, Akdis, Cezmi, Akdis, Mubecel, Aydin, Handan, Barenfaller, Katja, Behrendt, Heidrun, Bieber, Thomas, Bigliardi, Paul, Bigliardi-Qi, Mei, Bonefeld, Charlotte Menne, Bosch, Stefanie, Bruggen, Marie Charlotte, Diemert, Sebastian, Duchna, Hans-Werner, Fahndrich, Martina, Fehr, Danielle, Fellmann, Marc, Frei, Remo, Garvey, Lena H., Gharbo, Raschid, Goekkaya, Mehmet, Grando, Karin, Guillet, Carole, Guler, Erman, Gutermuth, Jan, Herrmann, Nadine, Hijnen, Dirk Jan, Huelpuesch, Claudia, Irvine, Alan D., Jensen-Jarolim, Erika, Kong, Heidi H., Koren, Hillel, Lang, Claudia C. V., Lauener, Roger, Maintz, Laura, Mantel, Pierre-Yves, Maverakis, Emanuel, Mohrenschlager, Matthias, Mueller, Svenja, Nadeau, Kari, Neumann, Avidan U., O'Mahony, Liam, Rabenja, Fahafahantsoa Rapelanoro, Renz, Harald, Rhyner, Claudio, Rietschel, Ernst, Ring, Johannes, Roduit, Caroline, Sasaki, Mari, Schenk, Mirjam, Schroeder, Jens, Simon, Dagmar, Simon, Hans-Uwe, Sokolowska, Milena, Staender, Sonja, Steinhoff, Martin, Piccirillo, Doris Straub, Taieb, Alain, Takaoka, Roberto, Tapparo, Martin, Teixeira, Henrique, Thyssen, Jacob Pontoppidan, Traidl, Stephan, Uhlmann, Miriam, van de Veen, Willem, van Hage, Marianne, Virchow, Christian, Wollenberg, Andreas, Yasutaka, Mitamura, Zink, Alexander, Schmid-Grendelmeier, Peter, Traidl-Hoffmann, Claudia, Afghani, Jamie, Akdis, Cezmi, Akdis, Mubecel, Aydin, Handan, Barenfaller, Katja, Behrendt, Heidrun, Bieber, Thomas, Bigliardi, Paul, Bigliardi-Qi, Mei, Bonefeld, Charlotte Menne, Bosch, Stefanie, Bruggen, Marie Charlotte, Diemert, Sebastian, Duchna, Hans-Werner, Fahndrich, Martina, Fehr, Danielle, Fellmann, Marc, Frei, Remo, Garvey, Lena H., Gharbo, Raschid, Goekkaya, Mehmet, Grando, Karin, Guillet, Carole, Guler, Erman, Gutermuth, Jan, Herrmann, Nadine, Hijnen, Dirk Jan, Huelpuesch, Claudia, Irvine, Alan D., Jensen-Jarolim, Erika, Kong, Heidi H., Koren, Hillel, Lang, Claudia C. V., Lauener, Roger, Maintz, Laura, Mantel, Pierre-Yves, Maverakis, Emanuel, Mohrenschlager, Matthias, Mueller, Svenja, Nadeau, Kari, Neumann, Avidan U., O'Mahony, Liam, Rabenja, Fahafahantsoa Rapelanoro, Renz, Harald, Rhyner, Claudio, Rietschel, Ernst, Ring, Johannes, Roduit, Caroline, Sasaki, Mari, Schenk, Mirjam, Schroeder, Jens, Simon, Dagmar, Simon, Hans-Uwe, Sokolowska, Milena, Staender, Sonja, Steinhoff, Martin, Piccirillo, Doris Straub, Taieb, Alain, Takaoka, Roberto, Tapparo, Martin, Teixeira, Henrique, Thyssen, Jacob Pontoppidan, Traidl, Stephan, Uhlmann, Miriam, van de Veen, Willem, van Hage, Marianne, Virchow, Christian, Wollenberg, Andreas, Yasutaka, Mitamura, Zink, Alexander, and Schmid-Grendelmeier, Peter

Abstract

The 4th Davos Declaration was developed during the Global Allergy Forum in Davos which aimed to elevate the care of patients with atopic dermatitis (AD) by uniting experts and stakeholders. The forum addressed the high prevalence of AD, with a strategic focus on advancing research, treatment, and management to meet the evolving challenges in the field. This multidisciplinary forum brought together top leaders from research, clinical practice, policy, and patient advocacy to discuss the critical aspects of AD, including neuroimmunology, environmental factors, comorbidities, and breakthroughs in prevention, diagnosis, and treatment. The discussions were geared towards fostering a collaborative approach to integrate these advancements into practical, patient-centric care. The forum underlined the mounting burden of AD, attributing it to significant environmental and lifestyle changes. It acknowledged the progress in understanding AD and in developing targeted therapies but recognized a gap in translating these innovations into clinical practice. Emphasis was placed on the need for enhanced awareness, education, and stakeholder engagement to address this gap effectively and to consider environmental and lifestyle factors in a comprehensive disease management strategy. The 4th Davos Declaration marks a significant milestone in the journey to improve care for people with AD. By promoting a holistic approach that combines research, education, and clinical application, the Forum sets a roadmap for stakeholders to collaborate to improve patient outcomes in AD, reflecting a commitment to adapt and respond to the dynamic challenges of AD in a changing world.

Published
2024

3. Systematic review of the association between short‐chain fatty acids and allergic diseases.

Author

Sasaki, Mari, Suaini, Noor H. A., Afghani, Jamie, Heye, Kristina N., O'Mahony, Liam, Venter, Carina, Lauener, Roger, Frei, Remo, and Roduit, Caroline

Subjects
WHEEZE, SHORT-chain fatty acids, ALLERGIES, FOOD allergy, ATOPIC dermatitis, CHILD development
Abstract

We performed a systematic review to investigate the current evidence on the association between allergic diseases and short chain fatty acids (SCFAs), which are microbially produced and suggested as one mechanism on how gut microbiome affects the risk of allergic diseases. Medline, Embase and Web of Science were searched from data inception until September 2022. We identified 37 papers, of which 17 investigated prenatal or early childhood SCFAs and the development of allergic diseases in childhood, and 20 assessed SCFAs in patients with pre‐existing allergic diseases. Study design, study populations, outcome definition, analysis method and reporting of the results varied between papers. Overall, there was some evidence showing that the three main SCFAs (acetate, propionate and butyrate) in the first few years of life had a protective effect against allergic diseases, especially for atopic dermatitis, wheeze or asthma and IgE‐mediated food allergy in childhood. The association between each SCFA and allergic disease appeared to be different by disease and the age of assessment. Further research that can determine the potentially timing specific effect of each SCFA will be useful to investigate how SCFAs can be used in treatment or in prevention against allergic diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Transcription factor NF-κB in a basal metazoan, the sponge, has conserved and unique sequences, activities, and regulation

Author

Williams, Leah M., Inge, Melissa M., Mansfield, Katelyn M., Rasmussen, Anna, Afghani, Jamie, Agrba, Mikhail, Albert, Colleen, Andersson, Cecilia, Babaei, Milad, Babaei, Mohammad, Bagdasaryants, Abigail, Bonilla, Arianna, Browne, Amanda, Carpenter, Sheldon, Chen, Tiffany, Christie, Blake, Cyr, Andrew, Dam, Katie, Dulock, Nicholas, Erdene, Galbadrakh, Esau, Lindsie, Esonwune, Stephanie, Hanchate, Anvita, Huang, Xinli, Jennings, Timothy, Kasabwala, Aarti, Kehoe, Leanne, Kobayashi, Ryan, Lee, Migi, LeVan, Andre, Liu, Yuekun, Murphy, Emily, Nambiar, Avanti, Olive, Meagan, Patel, Devansh, Pavesi, Flaminio, Petty, Christopher A., Samofalova, Yelena, Sanchez, Selma, Stejskal, Camilla, Tang, Yinian, Yapo, Alia, Cleary, John P., Jr., Yunes, Sarah A., Siggers, Trevor, and Gilmore, Thomas D.

Published
2020
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5. Navigating the Evolving Landscape of Atopic Dermatitis: Challenges and Future Opportunities: the 4 th Davos Declaration

Author

Traidl-Hoffmann, Claudia, primary, Afghani, Jamie, additional, Akdis, Cezmi, additional, Akdis, Mubeccel, additional, Handan, Aydin, additional, Baerenfaller, Katja, additional, Behrendt, Heidrun, additional, Bieber, Thomas, additional, Bigliardi, Paul L., additional, Bigliardi-Qi, Mei, additional, Bonefeld, Charlotte, additional, Bösch, Stefanie, additional, Brüggen, Marie-Charlotte, additional, Diemert, Sebastian, additional, Duchna, Hans-Werner, additional, Fähndrich, Martina, additional, Fehr, Danielle, additional, Fellmann, Marc, additional, Frei, Remo, additional, Garvey, Lene, additional, Gharbo, Raschid, additional, Gökkaya, Mehmet, additional, Grando, Karin, additional, Guillet, Carole, additional, Güler, Erman, additional, Gutermuth, Jan, additional, Herrmann, Nadine, additional, Hijnen, DirkJan, additional, Hülpüsch, Claudia, additional, Irvine, Alan, additional, Jensen-Jarolim, Erika, additional, Kong, Heidi H, additional, Koren, Hillel, additional, Lang, Claudia, additional, Lauener, Roger, additional, Maintz, Laura, additional, Mantel, Pierre-Yves, additional, maverakis, Emanual, additional, Moehrenschlager, Matthias, additional, Müller, Svenja, additional, Nadeau, Kari, additional, Neumann, Avidan U., additional, O'Mahony, Liam, additional, Rabenja, Fahafahantsoa Rapelanoro, additional, Renz, Harald, additional, Rhyner, Claudio, additional, Rietschel, Ernst, additional, Ring, Johannes, additional, Roduit, Caroline, additional, Sasaki, Mari, additional, Schenk, Mirjam, additional, Schroder, Jens, additional, Simon, Dagmar, additional, Simon, Hans-Uwe, additional, Sokolowska, Milena, additional, stander, sonja, additional, Steinhoff, Martin, additional, Piccirillo, Doris Straub, additional, Taïeb, Alain, additional, Takaoka, Roberto, additional, Tapparo, Martin, additional, Teixeira, Henrique, additional, Thyssen, Jacob, additional, Traidl, Stephan, additional, Uhlmann, Miriam, additional, Veen, Willem van de, additional, Hage, Marianne van, additional, Virchow, Christian, additional, Wollenberg, Andreas, additional, mitamura, yasutaka, additional, Zink, Alexander, additional, and Schmid-Grendelmeier, Peter, additional

Published
2024
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8. Transcription factor NF-κB in a basal metazoan, the sponge, has conserved and unique sequences, activities, and regulation

Author

Williams, Leah M., primary, Inge, Melissa M., additional, Mansfield, Katelyn M., additional, Rasmussen, Anna, additional, Afghani, Jamie, additional, Agrba, Mikhail, additional, Albert, Colleen, additional, Andersson, Cecilia, additional, Babaei, Milad, additional, Babaei, Mohammad, additional, Bagdasaryants, Abigail, additional, Bonilla, Arianna, additional, Browne, Amanda, additional, Carpenter, Sheldon, additional, Chen, Tiffany, additional, Christie, Blake, additional, Cyr, Andrew, additional, Dam, Katie, additional, Dulock, Nicholas, additional, Erdene, Galbadrakh, additional, Esau, Lindsie, additional, Esonwune, Stephanie, additional, Hanchate, Anvita, additional, Huang, Xinli, additional, Jennings, Timothy, additional, Kasabwala, Aarti, additional, Kehoe, Leanne, additional, Kobayashi, Ryan, additional, Lee, Migi, additional, LeVan, Andre, additional, Liu, Yuekun, additional, Murphy, Emily, additional, Nambiar, Avanti, additional, Olive, Meagan, additional, Patel, Devansh, additional, Pavesi, Flaminio, additional, Petty, Christopher A., additional, Samofalova, Yelena, additional, Sanchez, Selma, additional, Stejskal, Camilla, additional, Tang, Yinian, additional, Yapo, Alia, additional, Cleary, John P., additional, Yunes, Sarah A., additional, Siggers, Trevor, additional, and Gilmore, Thomas D., additional

Published
2019
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