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2. Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease.

Author

Young, William J, Haessler, Jeffrey, Benjamins, Jan-Walter, Repetto, Linda, Yao, Jie, Isaacs, Aaron, Harper, Andrew R, Ramirez, Julia, Garnier, Sophie, van Duijvenboden, Stefan, Baldassari, Antoine R, Concas, Maria Pina, Duong, ThuyVy, Foco, Luisa, Isaksen, Jonas L, Mei, Hao, Noordam, Raymond, Nursyifa, Casia, Richmond, Anne, Santolalla, Meddly L, Sitlani, Colleen M, Soroush, Negin, Thériault, Sébastien, Trompet, Stella, Aeschbacher, Stefanie, Ahmadizar, Fariba, Alonso, Alvaro, Brody, Jennifer A, Campbell, Archie, Correa, Adolfo, Darbar, Dawood, De Luca, Antonio, Deleuze, Jean-François, Ellervik, Christina, Fuchsberger, Christian, Goel, Anuj, Grace, Christopher, Guo, Xiuqing, Hansen, Torben, Heckbert, Susan R, Jackson, Rebecca D, Kors, Jan A, Lima-Costa, Maria Fernanda, Linneberg, Allan, Macfarlane, Peter W, Morrison, Alanna C, Navarro, Pau, Porteous, David J, Pramstaller, Peter P, Reiner, Alexander P, Risch, Lorenz, Schotten, Ulrich, Shen, Xia, Sinagra, Gianfranco, Soliman, Elsayed Z, Stoll, Monika, Tarazona-Santos, Eduardo, Tinker, Andrew, Trajanoska, Katerina, Villard, Eric, Warren, Helen R, Whitsel, Eric A, Wiggins, Kerri L, Arking, Dan E, Avery, Christy L, Conen, David, Girotto, Giorgia, Grarup, Niels, Hayward, Caroline, Jukema, J Wouter, Mook-Kanamori, Dennis O, Olesen, Morten Salling, Padmanabhan, Sandosh, Psaty, Bruce M, Pattaro, Cristian, Ribeiro, Antonio Luiz P, Rotter, Jerome I, Stricker, Bruno H, van der Harst, Pim, van Duijn, Cornelia M, Verweij, Niek, Wilson, James G, Orini, Michele, Charron, Philippe, Watkins, Hugh, Kooperberg, Charles, Lin, Henry J, Wilson, James F, Kanters, Jørgen K, Sotoodehnia, Nona, Mifsud, Borbala, Lambiase, Pier D, Tereshchenko, Larisa G, and Munroe, Patricia B

Subjects
Humans, Cardiovascular Diseases, Electrocardiography, Risk Factors, Arrhythmias, Cardiac, Atrioventricular Block, Genome-Wide Association Study, Biomarkers, Human Genome, Cardiovascular, Genetics, Heart Disease
Abstract

The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.

Published
2023

4. Heart rate variability and stroke or systemic embolism in patients with atrial fibrillation

Author

Aeschbacher, Stefanie, Bhend, Katalin, Blum, Steffen, Bonati, Leo H., Carmine, Désirée, Conen, David, Eken, Ceylan, Fischer, Urs, Girroy, Corinne, Hennings, Elisa, Krisai, Philipp, Kühne, Michael, Mäder, Nina, Meyer-Zürn, Christine, Meyre, Pascal B., Monsch, Andreas U., Mosher, Luke, Müller, Christian, Osswald, Stefan, Paladini, Rebecca E., Peter, Raffaele, Schweigler, Adrian, Sticherling, Christian, Szucs, Thomas, Völlmin, Gian, Aujesky, Drahomir, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Netzer, Seraina, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Loewe, Axel, Moutzouri, Elisavet, Schneider, Claudio, Flückiger, Tanja, Groen, Cindy, Ehrsam, Lukas, Hellrigl, Sven, Nuoffer, Alexandra, Rakovic, Damiana, Schwab, Nathalie, Wenger, Rylana, Zarrabi Saffari, Tu Hanh, Rodondi, Nicolas, Reichlin, Tobias, Beynon, Christopher, Dillier, Roger, Deubelbeiss, Michèle, Eberli, Franz, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Murugiah, Samira, Nadler, Jacqueline, Obst, Thayze, Roth, Jasmin, Schlomowitsch, Fiona, Schneider, Xiaoye, Studerus, Katrin, Tynan, Noreen, Weishaupt, Dominik, Müller, Andreas, Friedli, Corinne, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Grau, Alexandra, Villinger, Jonas, Laube, Eva, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Montrasio, Giulia, Leuenberger, Stefanie, Rutz, Franziska, Beer, Jürg-Hans, Auricchio, Angelo, Anesini, Adriana, Camporini, Cristina, Caputo, Maria Luce, Peronaci, Rebecca, Regoli, Francois, Ronchi, Martina, Conte, Giulio, Brenner, Roman, Altmann, David, Fink, Karin, Gemperle, Michaela, Ammann, Peter, Firmann, Mathieu, Foucras, Sandrine, Rime, Martine, Hayoz, Daniel, Berte, Benjamin, Bühler, Kathrin, Justi, Virgina, Kellner-Weldon, Frauke, Koch, Melanie, Mehmann, Brigitta, Meier, Sonja, Roth, Myriam, Ruckli-Kaeppeli, Andrea, Russi, Ian, Schmidt, Kai, Young, Mabelle, Kobza, Richard, Rigamonti, Elia, Cereda, Carlo, Cianfoni, Alessandro, De Perna, Maria Luisa, Frangi-Kultalahti, Jane, Mayer Melchiorre, Patrizia Assunta, Pin, Anica, Terrot, Tatiana, Vicari, Luisa, Moschovitis, Giorgio, Ehret, Georg, Gallet, Hervé, Guillermet, Elise, Lazeyras, Francois, Lovblad, Karl-Olof, Perret, Patrick, Tavel, Philippe, Teres, Cheryl, Shah, Dipen, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Schläpfer, Jürg, Porretta, Alessandra Pia, Grêt, Andrea, Novak, Jan, Vitelli, Sandra, Stephan, Frank-Peter, Gallino, Augusto, Di Valentino, Marcello, Aebersold, Helena, Foster, Fabienne, Schwenkglenks, Matthias, Düring, Marco, Sinnecker, Tim, Altermatt, Anna, Amann, Michael, Huber, Petra, Hürbin, Manuel, Ruberte, Esther, Thöni, Alain, Würfel, Jens, Zuber, Vanessa, Coslovsky (Head), Michael, Neuschwander, Pia, Simon, Patrick, Wunderlin, Olivia, Schmid, Ramun, Baumann, Christian, Hämmerle, Peter, Schlageter, Vincent, Coslovsky, Michael, Coduri, Federica, Blum, Manuel R., Stauber, Annina, Beer, Jürg, and Zuern, Christine S.

Published
2024
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5. Real-World Cost-Effectiveness of Pulmonary Vein Isolation for Atrial Fibrillation: A Target Trial Approach

Author

Serra-Burriel, Miquel, Aebersold, Helena, Foster-Witassek, Fabienne, Coslovsky, Michael, Rodondi, Nicolas, Blum, Manuel R., Sticherling, Christian, Moschovitis, Giorgio, Beer, Jürg H., Reichlin, Tobias, Krisai, Philipp, Aeschbacher, Stefanie, Paladini, Rebecca E., Kühne, Michael, Osswald, Stefan, Conen, David, Felder, Stefan, and Schwenkglenks, Matthias

Published
2023
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6. Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.

Author

Ntalla, Ioanna, Weng, Lu-Chen, Cartwright, James H, Hall, Amelia Weber, Sveinbjornsson, Gardar, Tucker, Nathan R, Choi, Seung Hoan, Chaffin, Mark D, Roselli, Carolina, Barnes, Michael R, Mifsud, Borbala, Warren, Helen R, Hayward, Caroline, Marten, Jonathan, Cranley, James J, Concas, Maria Pina, Gasparini, Paolo, Boutin, Thibaud, Kolcic, Ivana, Polasek, Ozren, Rudan, Igor, Araujo, Nathalia M, Lima-Costa, Maria Fernanda, Ribeiro, Antonio Luiz P, Souza, Renan P, Tarazona-Santos, Eduardo, Giedraitis, Vilmantas, Ingelsson, Erik, Mahajan, Anubha, Morris, Andrew P, Del Greco M, Fabiola, Foco, Luisa, Gögele, Martin, Hicks, Andrew A, Cook, James P, Lind, Lars, Lindgren, Cecilia M, Sundström, Johan, Nelson, Christopher P, Riaz, Muhammad B, Samani, Nilesh J, Sinagra, Gianfranco, Ulivi, Sheila, Kähönen, Mika, Mishra, Pashupati P, Mononen, Nina, Nikus, Kjell, Caulfield, Mark J, Dominiczak, Anna, Padmanabhan, Sandosh, Montasser, May E, O'Connell, Jeff R, Ryan, Kathleen, Shuldiner, Alan R, Aeschbacher, Stefanie, Conen, David, Risch, Lorenz, Thériault, Sébastien, Hutri-Kähönen, Nina, Lehtimäki, Terho, Lyytikäinen, Leo-Pekka, Raitakari, Olli T, Barnes, Catriona LK, Campbell, Harry, Joshi, Peter K, Wilson, James F, Isaacs, Aaron, Kors, Jan A, van Duijn, Cornelia M, Huang, Paul L, Gudnason, Vilmundur, Harris, Tamara B, Launer, Lenore J, Smith, Albert V, Bottinger, Erwin P, Loos, Ruth JF, Nadkarni, Girish N, Preuss, Michael H, Correa, Adolfo, Mei, Hao, Wilson, James, Meitinger, Thomas, Müller-Nurasyid, Martina, Peters, Annette, Waldenberger, Melanie, Mangino, Massimo, Spector, Timothy D, Rienstra, Michiel, van de Vegte, Yordi J, van der Harst, Pim, Verweij, Niek, Kääb, Stefan, Schramm, Katharina, Sinner, Moritz F, Strauch, Konstantin, Cutler, Michael J, Fatkin, Diane, London, Barry, Olesen, Morten, and Roden, Dan M

Subjects
Humans, Cardiovascular Diseases, Genetic Predisposition to Disease, Electrocardiography, Gene Expression, Multifactorial Inheritance, Quantitative Trait Loci, Female, Male, Arrhythmias, Cardiac, Genetic Variation, Genome-Wide Association Study, Genetic Loci, Endophenotypes, Arrhythmias, Cardiac
Abstract

The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key regulation processes for atrioventricular conduction. Additionally, 8 loci not previously reported harbor genes underlying inherited arrhythmic syndromes and/or cardiomyopathies suggesting a role for these genes in cardiovascular pathology in the general population. We show that polygenic predisposition to PR interval duration is an endophenotype for cardiovascular disease, including distal conduction disease, AF, and atrioventricular pre-excitation. These findings advance our understanding of the polygenic basis of cardiac conduction, and the genetic relationship between PR interval duration and cardiovascular disease.

Published
2020

8. Association of pulmonary vein isolation and major cardiovascular events in patients with atrial fibrillation

Author

Girod, Marc, Coslovsky, Michael, Aeschbacher, Stefanie, Sticherling, Christian, Reichlin, Tobias, Roten, Laurent, Rodondi, Nicolas, Ammann, Peter, Auricchio, Angelo, Moschovitis, Giorgio, Kobza, Richard, Badertscher, Patrick, Knecht, Sven, Krisai, Philipp, Marugg, Andrea, Aebersold, Helena, Hennings, Elisa, Serra-Burriel, Miquel, Schwenkglenks, Matthias, Zuern, Christine S., Bonati, Leo H, Conen, David, Osswald, Stefan, and Kühne, Michael

Published
2022
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9. Biomarker, Imaging, and Clinical Factors Associated With Overt and Covert Stroke in Patients With Atrial Fibrillation

Author

De Marchis, Gian Marco, Krisai, Philipp, Werlen, Laura, Sinnecker, Tim, Aeschbacher, Stefanie, Dittrich, Tolga D., Polymeris, Alexandros A., Coslovksy, Michael, Blum, Manuel R., Rodondi, Nicolas, Reichlin, Tobias, Moschovitis, Giorgio, Wuerfel, Jens, Lyrer, Philippe A., Fischer, Urs, Conen, David, Kastner, Peter, Ziegler, André, Osswald, Stefan, Kühne, Michael, and Bonati, Leo H.

Published
2023
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11. New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Author

Evangelou, Evangelos, Gao, He, Chu, Congying, Ntritsos, Georgios, Blakeley, Paul, Butts, Andrew R, Pazoki, Raha, Suzuki, Hideaki, Koskeridis, Fotios, Yiorkas, Andrianos M, Karaman, Ibrahim, Elliott, Joshua, Luo, Qiang, Aeschbacher, Stefanie, Bartz, Traci M, Baumeister, Sebastian E, Braund, Peter S, Brown, Michael R, Brody, Jennifer A, Clarke, Toni-Kim, Dimou, Niki, Faul, Jessica D, Homuth, Georg, Jackson, Anne U, Kentistou, Katherine A, Joshi, Peter K, Lemaitre, Rozenn N, Lind, Penelope A, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Milaneschi, Yuri, Nelson, Christopher P, Nolte, Ilja M, Perälä, Mia-Maria, Polasek, Ozren, Porteous, David, Ratliff, Scott M, Smith, Jennifer A, Stančáková, Alena, Teumer, Alexander, Tuominen, Samuli, Thériault, Sébastien, Vangipurapu, Jagadish, Whitfield, John B, Wood, Alexis, Yao, Jie, Yu, Bing, Zhao, Wei, Arking, Dan E, Auvinen, Juha, Liu, Chunyu, Männikkö, Minna, Risch, Lorenz, Rotter, Jerome I, Snieder, Harold, Veijola, Juha, Blakemore, Alexandra I, Boehnke, Michael, Campbell, Harry, Conen, David, Eriksson, Johan G, Grabe, Hans J, Guo, Xiuqing, van der Harst, Pim, Hartman, Catharina A, Hayward, Caroline, Heath, Andrew C, Jarvelin, Marjo-Riitta, Kähönen, Mika, Kardia, Sharon LR, Kühne, Michael, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lehtimäki, Terho, McIntosh, Andrew M, Mohlke, Karen L, Morrison, Alanna C, Martin, Nicholas G, Oldehinkel, Albertine J, Penninx, Brenda WJH, Psaty, Bruce M, Raitakari, Olli T, Rudan, Igor, Samani, Nilesh J, Scott, Laura J, Spector, Tim D, Verweij, Niek, Weir, David R, Wilson, James F, Levy, Daniel, Tzoulaki, Ioanna, Bell, Jimmy D, Matthews, Paul M, Rothenfluh, Adrian, Desrivières, Sylvane, Schumann, Gunter, and Elliott, Paul

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Epidemiology, Health Sciences, Psychology, Pharmacology and Pharmaceutical Sciences, Biotechnology, Substance Misuse, Brain Disorders, Mental Health, Neurosciences, Serious Mental Illness, Alcoholism, Alcohol Use and Health, Schizophrenia, Genetics, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Cardiovascular, Mental health, Stroke, Cancer, Oral and gastrointestinal, Good Health and Well Being, Adult, Aged, Alcohol Drinking, Alcoholism, Brain, Female, Genes, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Magnetic Resonance Imaging, Male, Mental Disorders, Middle Aged, Neuroimaging, Polymorphism, Single Nucleotide, Quantitative Trait Loci, White People, Biomedical and clinical sciences, Health sciences
Abstract

Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d-1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.

Published
2019

12. Genome-wide analyses identify SCN5A as a susceptibility locus for premature atrial contraction frequency

Author

Thériault, Sébastien, Imboden, Medea, Biggs, Mary L., Austin, Thomas R., Aeschbacher, Stefanie, Schaffner, Emmanuel, Brody, Jennifer A., Bartz, Traci M., Risch, Martin, Grossmann, Kirsten, Lin, Henry J., Soliman, Elsayed Z., Post, Wendy S., Risch, Lorenz, Krieger, Jose E., Pereira, Alexandre C., Heckbert, Susan R., Sotoodehnia, Nona, Probst-Hensch, Nicole M., and Conen, David

Published
2022
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14. Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

Author

Young, William J., Lahrouchi, Najim, Isaacs, Aaron, Duong, ThuyVy, Foco, Luisa, Ahmed, Farah, Brody, Jennifer A., Salman, Reem, Noordam, Raymond, Benjamins, Jan-Walter, Haessler, Jeffrey, Lyytikäinen, Leo-Pekka, Repetto, Linda, Concas, Maria Pina, van den Berg, Marten E., Weiss, Stefan, Baldassari, Antoine R., Bartz, Traci M., Cook, James P., Evans, Daniel S., Freudling, Rebecca, Hines, Oliver, Isaksen, Jonas L., Lin, Honghuang, Mei, Hao, Moscati, Arden, Müller-Nurasyid, Martina, Nursyifa, Casia, Qian, Yong, Richmond, Anne, Roselli, Carolina, Ryan, Kathleen A., Tarazona-Santos, Eduardo, Thériault, Sébastien, van Duijvenboden, Stefan, Warren, Helen R., Yao, Jie, Raza, Dania, Aeschbacher, Stefanie, Ahlberg, Gustav, Alonso, Alvaro, Andreasen, Laura, Bis, Joshua C., Boerwinkle, Eric, Campbell, Archie, Catamo, Eulalia, Cocca, Massimiliano, Cutler, Michael J., Darbar, Dawood, De Grandi, Alessandro, De Luca, Antonio, Ding, Jun, Ellervik, Christina, Ellinor, Patrick T., Felix, Stephan B., Froguel, Philippe, Fuchsberger, Christian, Gögele, Martin, Graff, Claus, Graff, Mariaelisa, Guo, Xiuqing, Hansen, Torben, Heckbert, Susan R., Huang, Paul L., Huikuri, Heikki V., Hutri-Kähönen, Nina, Ikram, M. Arfan, Jackson, Rebecca D., Junttila, Juhani, Kavousi, Maryam, Kors, Jan A., Leal, Thiago P., Lemaitre, Rozenn N., Lin, Henry J., Lind, Lars, Linneberg, Allan, Liu, Simin, MacFarlane, Peter W., Mangino, Massimo, Meitinger, Thomas, Mezzavilla, Massimo, Mishra, Pashupati P., Mitchell, Rebecca N., Mononen, Nina, Montasser, May E., Morrison, Alanna C., Nauck, Matthias, Nauffal, Victor, Navarro, Pau, Nikus, Kjell, Pare, Guillaume, Patton, Kristen K., Pelliccione, Giulia, Pittman, Alan, Porteous, David J., Pramstaller, Peter P., Preuss, Michael H., Raitakari, Olli T., Reiner, Alexander P., Ribeiro, Antonio Luiz P., Rice, Kenneth M., Risch, Lorenz, Schlessinger, David, Schotten, Ulrich, Schurmann, Claudia, Shen, Xia, Shoemaker, M. Benjamin, Sinagra, Gianfranco, Sinner, Moritz F., Soliman, Elsayed Z., Stoll, Monika, Strauch, Konstantin, Tarasov, Kirill, Taylor, Kent D., Tinker, Andrew, Trompet, Stella, Uitterlinden, André, Völker, Uwe, Völzke, Henry, Waldenberger, Melanie, Weng, Lu-Chen, Whitsel, Eric A., Wilson, James G., Avery, Christy L., Conen, David, Correa, Adolfo, Cucca, Francesco, Dörr, Marcus, Gharib, Sina A., Girotto, Giorgia, Grarup, Niels, Hayward, Caroline, Jamshidi, Yalda, Järvelin, Marjo-Riitta, Jukema, J. Wouter, Kääb, Stefan, Kähönen, Mika, Kanters, Jørgen K., Kooperberg, Charles, Lehtimäki, Terho, Lima-Costa, Maria Fernanda, Liu, Yongmei, Loos, Ruth J. F., Lubitz, Steven A., Mook-Kanamori, Dennis O., Morris, Andrew P., O’Connell, Jeffrey R., Olesen, Morten Salling, Orini, Michele, Padmanabhan, Sandosh, Pattaro, Cristian, Peters, Annette, Psaty, Bruce M., Rotter, Jerome I., Stricker, Bruno, van der Harst, Pim, van Duijn, Cornelia M., Verweij, Niek, Wilson, James F., Arking, Dan E., Ramirez, Julia, Lambiase, Pier D., Sotoodehnia, Nona, Mifsud, Borbala, Newton-Cheh, Christopher, and Munroe, Patricia B.

Published
2022
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15. Long-term risk of adverse outcomes according to atrial fibrillation type

Author

Blum, Steffen, Aeschbacher, Stefanie, Coslovsky, Michael, Meyre, Pascal B., Reddiess, Philipp, Ammann, Peter, Erne, Paul, Moschovitis, Giorgio, Di Valentino, Marcello, Shah, Dipen, Schläpfer, Jürg, Müller, Rahel, Beer, Jürg H., Kobza, Richard, Bonati, Leo H., Moutzouri, Elisavet, Rodondi, Nicolas, Meyer-Zürn, Christine, Kühne, Michael, Sticherling, Christian, Osswald, Stefan, and Conen, David

Published
2022
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17. Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study

Author

Aeschbacher, Stefanie, Barakovic, Muhamed, Buser, Andreas, Chan, Andrew, Disanto, Giulio, D'Souza, Marcus, Du Pasquier, Renaud, Findling, Oliver, Galbusera, Riccardo, Hrusovsky, Kevin, Khalil, Michael, Lorscheider, Johannes, Mathias, Amandine, Orleth, Annette, Radue, Ernst-Wilhelm, Rahmanzadeh, Reza, Sinnecker, Tim, Subramaniam, Suvitha, Vehoff, Jochen, Wellmann, Sven, Wuerfel, Jens, Zecca, Chiara, Benkert, Pascal, Meier, Stephanie, Schaedelin, Sabine, Manouchehrinia, Ali, Yaldizli, Özgür, Maceski, Aleksandra, Oechtering, Johanna, Achtnichts, Lutz, Conen, David, Derfuss, Tobias, Lalive, Patrice H, Mueller, Christian, Müller, Stefanie, Naegelin, Yvonne, Oksenberg, Jorge R, Pot, Caroline, Salmen, Anke, Willemse, Eline, Kockum, Ingrid, Blennow, Kaj, Zetterberg, Henrik, Gobbi, Claudio, Kappos, Ludwig, Wiendl, Heinz, Berger, Klaus, Sormani, Maria Pia, Granziera, Cristina, Piehl, Fredrik, Leppert, David, and Kuhle, Jens

Published
2022
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18. Blood pressure, brain lesions and cognitive decline in patients with atrial fibrillation.

Author

Carmine, Désirée, Aeschbacher, Stefanie, Coslovsky, Michael, Hennings, Elisa, Paladini, Rebecca E., Peter, Raffaele, Burger, Melanie, Reichlin, Tobias, Rodondi, Nicolas, Müller, Andreas S., Ammann, Peter, Conte, Giulio, Auricchio, Angelo, Moschovitis, Giorgio, Bardoczi, Julia B., Stauber, Annina, De Perna, Maria Luisa, Zuern, Christine S., Sinnecker, Tim, and Badertscher, Patrick

Published
2024
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19. Heart rate variability and stroke or systemic embolism in patients with atrial fibrillation.

Author

Hämmerle, Peter, Aeschbacher, Stefanie, Schlageter, Vincent, Coslovsky, Michael, Hennings, Elisa, Krisai, Philipp, Coduri, Federica, Blum, Manuel R., Rodondi, Nicolas, Reichlin, Tobias, Müller, Andreas, Stauber, Annina, Moschovitis, Giorgio, Rigamonti, Elia, Beer, Jürg, Ammann, Peter, Bonati, Leo H., Conen, David, Osswald, Stefan, and Kühne, Michael

Abstract

Stroke remains one of the most serious complications in atrial fibrillation (AF) patients and has been linked to disturbances of the autonomic nervous system. The purpose of this study was to test the hypothesis that impaired cardiac autonomic function might be associated with an enhanced stroke risk in AF patients. A total of 1922 AF patients who were in either sinus rhythm (SR group; n = 1121) or AF (AF group; n = 801) on a 5-minute resting electrocardiographic (ECG) recording were enrolled in the study. Heart rate variability triangular index (HRVI), standard deviation of normal-to-normal intervals, root mean square root of successive differences of normal-to-normal intervals, mean heart rate, 5-minute total power, and power in the high-frequency, low-frequency, and very-low-frequency ranges were calculated. Cox regression models were constructed to examine the association of heart rate variability (HRV) parameters with the composite endpoint of stroke or systemic embolism. Mean age was 71 ± 8 years in the SR group and 75 ± 8 years in the AF group. Thirty-seven patients in the SR group (3.4%) and 60 patients in the AF group (8.0%) experienced a stroke or systemic embolism during follow-up of 5 years. In patients with SR, HRVI <15 was the strongest HRV parameter to be associated with stroke or systemic embolism (hazard ratio 3.04; 95% confidence interval 1.3–7.0; P =.009) after adjustment for multiple confounders. In the AF group, no HRV parameter was found to be associated with the composite endpoint. HRVI measured during SR on a single 5-minute ECG recording is independently associated with stroke or systemic embolism in AF patients. HRV analysis in SR may help to improve risk stratification in AF patients. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Multi-ethnic genome-wide association study for atrial fibrillation

Author

Roselli, Carolina, Chaffin, Mark D, Weng, Lu-Chen, Aeschbacher, Stefanie, Ahlberg, Gustav, Albert, Christine M, Almgren, Peter, Alonso, Alvaro, Anderson, Christopher D, Aragam, Krishna G, Arking, Dan E, Barnard, John, Bartz, Traci M, Benjamin, Emelia J, Bihlmeyer, Nathan A, Bis, Joshua C, Bloom, Heather L, Boerwinkle, Eric, Bottinger, Erwin B, Brody, Jennifer A, Calkins, Hugh, Campbell, Archie, Cappola, Thomas P, Carlquist, John, Chasman, Daniel I, Chen, Lin Y, Chen, Yii-Der Ida, Choi, Eue-Keun, Choi, Seung Hoan, Christophersen, Ingrid E, Chung, Mina K, Cole, John W, Conen, David, Cook, James, Crijns, Harry J, Cutler, Michael J, Damrauer, Scott M, Daniels, Brian R, Darbar, Dawood, Delgado, Graciela, Denny, Joshua C, Dichgans, Martin, Dörr, Marcus, Dudink, Elton A, Dudley, Samuel C, Esa, Nada, Esko, Tonu, Eskola, Markku, Fatkin, Diane, Felix, Stephan B, Ford, Ian, Franco, Oscar H, Geelhoed, Bastiaan, Grewal, Raji P, Gudnason, Vilmundur, Guo, Xiuqing, Gupta, Namrata, Gustafsson, Stefan, Gutmann, Rebecca, Hamsten, Anders, Harris, Tamara B, Hayward, Caroline, Heckbert, Susan R, Hernesniemi, Jussi, Hocking, Lynne J, Hofman, Albert, Horimoto, Andrea RVR, Huang, Jie, Huang, Paul L, Huffman, Jennifer, Ingelsson, Erik, Ipek, Esra Gucuk, Ito, Kaoru, Jimenez-Conde, Jordi, Johnson, Renee, Jukema, J Wouter, Kääb, Stefan, Kähönen, Mika, Kamatani, Yoichiro, Kane, John P, Kastrati, Adnan, Kathiresan, Sekar, Katschnig-Winter, Petra, Kavousi, Maryam, Kessler, Thorsten, Kietselaer, Bas L, Kirchhof, Paulus, Kleber, Marcus E, Knight, Stacey, Krieger, Jose E, Kubo, Michiaki, Launer, Lenore J, Laurikka, Jari, Lehtimäki, Terho, Leineweber, Kirsten, Lemaitre, Rozenn N, Li, Man, Lim, Hong Euy, Lin, Henry J, and Lin, Honghuang

Subjects
Biological Sciences, Genetics, Heart Disease, Cardiovascular, Human Genome, Biotechnology, 2.1 Biological and endogenous factors, Aetiology, Atrial Fibrillation, Case-Control Studies, Ethnicity, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Quantitative Trait Loci, Transcriptome, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Atrial fibrillation (AF) affects more than 33 million individuals worldwide1 and has a complex heritability2. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.

Published
2018

23. Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation

Author

Aeschbacher, Stefanie, Auberson, Chloé, Blum, Steffen, Bonati, Leo, Ceylan, Selinda, Conen, David, Doerpfeld, Simone, Eken, Ceylan, Girod, Marc, Hämmerle, Peter, Krisai, Philipp, Kühne, Michael, Meyer-Zürn, Christine, Meyre, Pascal, Monsch, Andreas U., Müller, Christian, Osswald, Stefan, Springer, Anne, Sticherling, Christian, Szucs, Thomas, Voellmin, Gian, Zwimpfer, Leon, Aujesky, Drahomir, Fischer, Urs, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Loewe, Axel, Moutzouri, Elisavet, Schneider, Claudio, Flückiger, Tanja, Groen, Cindy, Ehrsam, Lukas, Hellrigl, Sven, Nuoffer, Alexandra, Rakovic, Damiana, Schwab, Nathalie, Wenger, Rylana, Rodondi, Nicolas, Beynon, Christopher, Dillier, Roger, Deubelbeiss, Michèle, Eberli, Franz, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Nadler, Jacqueline, Obst, Thayze, Roth, Jasmin, Schlomowitsch, Fiona, Schneider, Xiaoye, Studerus, Katrin, Tynan, Noreen, Weishaupt, Dominik, Müller, Andreas, Fontana, Simone, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Grau, Alexandra, Villinger, Jonas, Laube, Eva, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Montrasio, Giulia, Leuenberger, Stefanie, Rutz, Franziska, Beer, Jürg-Hans, Auricchio, Angelo, Anesini, Adriana, Camporini, Cristina, Conte, Giulio, Caputo, Maria Luce, Regoli, Francois, Moccetti, Tiziano, Brenner, Roman, Altmann, David, Gemperle, Michaela, Ammann, Peter, Firmann, Mathieu, Foucras, Sandrine, Rime, Martine, Hayoz, Daniel, Berte, Benjamin, Justi, Virgina, Kellner-Weldon, Frauke, Mehmann, Brigitta, Meier, Sonja, Roth, Myriam, Ruckli-Kaeppeli, Andrea, Russi, Ian, Schmidt, Kai, Young, Mabelle, Zbinden, Melanie, Kobza, Richard, Frangi-Kultalahti, Jane, Pin, Anica, Vicari, Luisa, Moschovitis, Giorgio, Ehret, Georg, Gallet, Hervé, Guillermet, Elise, Lazeyras, Francois, Lovblad, Karl-Olof, Perret, Patrick, Tavel, Philippe, Teres, Cheryl, Shah, Dipen, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Schläpfer, Jürg, Grêt, Andrea, Novak, Jan, Vitelli, Sandra, Stephan, Frank-Peter, Gallino, Augusto, Di Valentino, Marcello, Witassek, Fabienne, Schwenkglenks, Matthias, Würfel, Jens, Altermatt, Anna, Amann, Michael, Huber, Petra, Ruberte, Esther, Sinnecker, Tim, Zuber, Vanessa, Coslovsky, Michael, Benkert, Pascal, Dutilh, Gilles, Markovic, Milica, Simon, Patrick, Schmid, Ramun, Beer, Jürg H., Bonati, Leo H., Blum, Manuel R., Kastner, Peter, and Baguley, Fiona

Published
2021
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24. Novel bleeding risk score for patients with atrial fibrillation on oral anticoagulants, including direct oral anticoagulants

Author

Adam, Luise, Feller, Martin, Syrogiannouli, Lamprini, Del‐Giovane, Cinzia, Donzé, Jacques, Baumgartner, Christine, Segna, Daniel, Floriani, Carmen, Roten, Laurent, Fischer, Urs, Aeschbacher, Stefanie, Moschovitis, Giorgio, Schläpfer, Jürg, Shah, Dipen, Amman, Peter, Kobza, Richard, Schwenkglenks, Matthias, Kühne, Michael, Bonati, Leo H., Beer, Jürg, Osswald, Stefan, Conen, David, Aujesky, Drahomir, and Rodondi, Nicolas

Published
2021
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25. Sex-specific differences in physiological parameters related to SARS-CoV-2 infections among a national cohort (COVI-GAPP study)

Author

UMC Utrecht Holding, Global Health, Planetary Health & Exposoom, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Grossmann, Kirsten, Risch, Martin, Markovic, Andjela, Aeschbacher, Stefanie, Weideli, Ornella C., Velez, Laura, Kovac, Marc, Pereira, Fiona, Wohlwend, Nadia, Risch, Corina, Hillmann, Dorothea, Lung, Thomas, Renz, Harald, Twerenbold, Raphael, Rothenbühler, Martina, Leibovitz, Daniel, Kovacevic, Vladimir, Klaver, Paul, Brakenhoff, Timo B., Franks, Billy, Mitratza, Marianna, Downward, George S., Dowling, Ariel, Montes, Santiago, Veen, Duco, Grobbee, Diederick E., Cronin, Maureen, Conen, David, Goodale, Brianna M., Risch, Lorenz, behalf of the COVID-19 remote early detection (COVID-RED) consortium, UMC Utrecht Holding, Global Health, Planetary Health & Exposoom, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Grossmann, Kirsten, Risch, Martin, Markovic, Andjela, Aeschbacher, Stefanie, Weideli, Ornella C., Velez, Laura, Kovac, Marc, Pereira, Fiona, Wohlwend, Nadia, Risch, Corina, Hillmann, Dorothea, Lung, Thomas, Renz, Harald, Twerenbold, Raphael, Rothenbühler, Martina, Leibovitz, Daniel, Kovacevic, Vladimir, Klaver, Paul, Brakenhoff, Timo B., Franks, Billy, Mitratza, Marianna, Downward, George S., Dowling, Ariel, Montes, Santiago, Veen, Duco, Grobbee, Diederick E., Cronin, Maureen, Conen, David, Goodale, Brianna M., Risch, Lorenz, and behalf of the COVID-19 remote early detection (COVID-RED) consortium

Published
2024

27. Patients on vitamin K treatment: is switching to direct-acting oral anticoagulation cost-effective? A target trial on a prospective cohort.

Author

Aebersold, Helena, Foster-Witassek, Fabienne, Aeschbacher, Stefanie, Beer, Juerg H., Blozik, Eva, Blum, Manuel, Bonati, Leo, Conte, Giulio, Coslovsky, Michael, De Perna, Maria Luisa, Di Valentino, Marcello, Felder, Stefan, Huber, Carola A., Moschovitis, Giorgio, Mueller, Andreas, Paladini, Rebecca E., Reichlin, Tobias, Rodondi, Nicolas, Stauber, Annina, and Sticherling, Christian

Published
2024
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29. Omega-3 Fatty Acids and Markers of Thrombosis in Patients with Atrial Fibrillation

Author

Reiner, Martin F., primary, Bertschi, Daniela A., additional, Werlen, Laura, additional, Wiencierz, Andrea, additional, Aeschbacher, Stefanie, additional, Lee, Pratintip, additional, Rodondi, Nicolas, additional, Moutzouri, Elisavet, additional, Bonati, Leo, additional, Reichlin, Tobias, additional, Moschovitis, Giorgio, additional, Rutishauser, Jonas, additional, Kühne, Michael, additional, Osswald, Stefan, additional, Conen, David, additional, and Beer, Jürg H., additional

Published
2024
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33. Relationships of Overt and Silent Brain Lesions With Cognitive Function in Patients With Atrial Fibrillation

Author

Berger, Sebastian, Bernasconi, Raffaele, Fröhlich, Lorin, Göldi, Tobias, Gugganig, Rebecca, Kofler, Thomas, Krisai, Philipp, Mongiat, Michel, Pudenz, Christiane, Repilado, Javier Ruperti, Schweizer, Aleksandra, Springer, Anne, Stempfel, Samuel, Szucs, Thomas, van der Stouwe, Jan, Voellmin, Gian, Zwimpfer, Leon, Aujesky, Drahomir, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Schneider, Claudio, Loewe, Axel, Flückiger, Tanja, Groen, Cindy, Schwab, Nathalie, Beynon, Christopher, Dillier, Roger, Eberli, Franz, Fontana, Simone, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Nadler, Jacqueline, Obst, Thayze, Schneider, Xiaoye, Studerus, Katrin, Weishaupt, Dominik, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Bello, Corina, Isberg, Henriette, Grau, Alexandra, Villinger, Jonas, Papaux, Mary-Monica, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Anesini, Adriana, Camporini, Cristina, Conte, Giulio, Caputo, Maria Luce, Regoli, Francois, Moccetti, Tiziano, Brenner, Roman, Altmann, David, Forrer, Manuela, Gemperle, Michaela, Firmann, Mathieu, Foucras, Sandrine, Berte, Benjamin, Kaeppeli, Andrea, Mehmann, Brigitta, Pfeiffer, Markus, Russi, Ian, Schmidt, Kai, Weberndoerfer, Vanessa, Young, Mabelle, Zbinden, Melanie, Vicari, Luisa, Frangi, Jane, Terrot, Tatiana, Gallet, Hervé, Guillermet, Elise, Lazeyras, Francois, Lovblad, Karl-Olof, Perret, Patrick, Teres, Cheryl, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Arenja, Nisha, Grêt, Andrea, Vitelli, Sandra, Gallino, Augusto, Schoenenberger-Berzins, Renate, Witassek, Fabienne, Radue, Ernst-Wilhelm, Benkert, Pascal, Fabbro, Thomas, Simon, Patrick, Schmid, Ramun, Conen, David, Rodondi, Nicolas, Müller, Andreas, Beer, Juerg H., Ammann, Peter, Moschovitis, Giorgio, Auricchio, Angelo, Hayoz, Daniel, Kobza, Richard, Shah, Dipen, Novak, Jan, Schläpfer, Jürg, Di Valentino, Marcello, Aeschbacher, Stefanie, Blum, Steffen, Meyre, Pascal, Sticherling, Christian, Bonati, Leo H., Ehret, Georg, Moutzouri, Elisavet, Fischer, Urs, Monsch, Andreas U., Stippich, Christoph, Wuerfel, Jens, Sinnecker, Tim, Coslovsky, Michael, Schwenkglenks, Matthias, Kühne, Michael, and Osswald, Stefan

Published
2019
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34. Alcohol consumption and risk of cardiovascular outcomes and bleeding in patients with established atrial fibrillation

Author

Reddiess, Philipp, Aeschbacher, Stefanie, Meyre, Pascal, Coslovsky, Michael, Kuhne, Michael, Rodondi, Nicolas, Baretella, Oliver, Beer, Jurg H., Kobza, Richard, Moschovitis, Giorgio, Valentino, Marcello Di, Muller, Cyrill, Steiner, Fabienne, Bonati, Leo H., Sticherling, Christian, Osswald, Stefan, and Conen, David

Subjects
Stroke (Disease) -- Risk factors, Drinking of alcoholic beverages -- Health aspects, Embolism -- Risk factors, Cardiovascular research, Atrial fibrillation -- Complications and side effects, Health
Abstract

BACKGROUND: Little is known about the association between alcohol consumption and risk of cardiovascular events in patients with established atrial fibrillation (AF). The main aim of the current study was to investigate the associations of regular alcohol intake with incident stroke or systemic embolism in patients with established AF. METHODS: To assess the association between alcohol consumption and cardiovascular events in patients with established AF, we combined data from 2 comparable prospective cohort studies that followed 3852 patients with AF for a median of 3.0 years. Patients were grouped into 4 categories of daily alcohol intake (none, > 0 to < 1, 1 to < 2 and [greater than or equal to] 2 drinks/d). The primary outcome was a composite of stroke and systemic embolism. Secondary outcomes were all-cause mortality, myocardial infarction, hospital admission for acute heart failure, and a composite of major and clinically relevant nonmajor bleeding. Associations were assessed using time-updated, multivariable-adjusted Cox proportional hazards models. RESULTS: Mean age ([+ or -] standard deviation) was 71 [+ or -] 10 years (28% were women and 84% were on oral anticoagulants). We observed 136 confirmed strokes or systemic emboli. Compared with nondrinkers, adjusted hazard ratios for the primary outcome event were 0.87, 95% confidence interval (CI) 0.55-1.37 for > 0 to < 1 drinks/d; 0.70, 95% CI 0.39-1.25 for 1 to < 2 drinks/d; and 0.96, 95% CI 0.56-1.67 for [greater than or equal to] 2 drinks/d (p for linear [quadratic] trend 0.71 [0.22]). There was no significant association between alcohol consumption and bleeding, but there was a nonlinear association with heart failure (p for quadratic trend 0.01) and myocardial infarction (p for quadratic trend 0.007). INTERPRETATION: In patients with AF, we did not find a significant association between low to moderate alcohol intake and risk of stroke or other cardiovascular events. Our findings do not support special recommendations for patients with established AF with regard to alcohol consumption. Trial registration: ClinicalTrials.gov, no. NCT02105844, An association between excessive alcohol intake and atrial arrhythmias was described about 40 years ago as 'holiday heart syndrome.' (1) Since then, several studies have shown that even low amounts [...]

Published
2021
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35. Sex-specific differences in physiological parameters related to SARS-CoV-2 infections among a national cohort (COVI-GAPP study).

Author

Grossmann, Kirsten, Risch, Martin, Markovic, Andjela, Aeschbacher, Stefanie, Weideli, Ornella C., Velez, Laura, Kovac, Marc, Pereira, Fiona, Wohlwend, Nadia, Risch, Corina, Hillmann, Dorothea, Lung, Thomas, Renz, Harald, Twerenbold, Raphael, Rothenbühler, Martina, Leibovitz, Daniel, Kovacevic, Vladimir, Klaver, Paul, Brakenhoff, Timo B., and Franks, Billy

Subjects
HEART beat, COVID-19 pandemic, COVID-19, MACHINE learning, SEX (Biology), SARS-CoV-2
Abstract

Considering sex as a biological variable in modern digital health solutions, we investigated sex-specific differences in the trajectory of four physiological parameters across a COVID-19 infection. A wearable medical device measured breathing rate, heart rate, heart rate variability, and wrist skin temperature in 1163 participants (mean age = 44.1 years, standard deviation [SD] = 5.6; 667 [57%] females). Participants reported daily symptoms and confounders in a complementary app. A machine learning algorithm retrospectively ingested daily biophysical parameters to detect COVID-19 infections. COVID-19 serology samples were collected from all participants at baseline and follow-up. We analysed potential sex-specific differences in physiology and antibody titres using multilevel modelling and t-tests. Over 1.5 million hours of physiological data were recorded. During the symptomatic period of infection, men demonstrated larger increases in skin temperature, breathing rate, and heart rate as well as larger decreases in heart rate variability than women. The COVID-19 infection detection algorithm performed similarly well for men and women. Our study belongs to the first research to provide evidence for differential physiological responses to COVID-19 between females and males, highlighting the potential of wearable technology to inform future precision medicine approaches. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Estimating the cost impact of atrial fibrillation using a prospective cohort study and population-based controls

Author

Aebersold, Helena, primary, Foster-Witassek, Fabienne, additional, Serra-Burriel, Miquel, additional, Brüngger, Beat, additional, Aeschbacher, Stefanie, additional, Beer, Jürg-Hans, additional, Blozik, Eva, additional, Blum, Manuel, additional, Bonati, Leo, additional, Conen, David, additional, Conte, Giulio, additional, Felder, Stefan, additional, Huber, Carola, additional, Kuehne, Michael, additional, Moschovitis, Giorgio, additional, Mueller, Andreas, additional, Paladini, Rebecca E, additional, Reichlin, Tobias, additional, Rodondi, Nicolas, additional, Springer, Anne, additional, Stauber, Annina, additional, Sticherling, Christian, additional, Szucs, Thomas, additional, Osswald, Stefan, additional, and Schwenkglenks, Matthias, additional

Published
2023
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40. Physical activity and brain health in patients with atrial fibrillation

Author

SWISS-AF Investigators, Herber, Elena, Aeschbacher, Stefanie, Coslovsky, Michael, Schwendinger, Fabian, Hennings, Elisa, Gasser, Andreas, Di Valentino, Marcello, Rigamonti, Elia, Reichlin, Tobias, Rodondi, Nicolas, Netzer, Seraina, Beer, Juerg H, Stauber, Annina, Mueller, Andreas, Ammann, Peter, Sinnecker, Tim, Düring, Marco, Wuerfel, Jens, Conen, David, Kühne, Michael, Osswald, Stefan, Bonati, Leo H, and Clinical sciences

Subjects
neurocognitive function, Neurology, cerebral microbleeds, total brain volume, White matter disease, Neuroscience(all), Atrial Fibrillation, Physical Activity, Neurology (clinical), cerebral infarction, Cardiology and Cardiovascular Medicine, cognitive disorders and dementia
Abstract

Background and purpose: Vascular brain lesions, such as ischemic infarcts, are common among patients with atrial fibrillation (AF) and are associated with impaired cognitive function. The role of physical activity (PA) in the prevalence of brain lesions and cognition in AF has not been investigated. Methods: Patients from the multicenter Swiss-AF cohort study were included in this cross-sectional analysis. We assessed regular exercise (RE; at least once weekly) and minutes of weekly PA using a validated questionnaire. We studied associations with ischemic infarcts, white matter hyperintensities, cerebral microbleeds, and brain volume on brain magnetic resonance imaging and with global cognition measured with a cognitive construct (CoCo) score. Results: Among 1490 participants (mean age = 72 ± 9 years), 730 (49%) engaged in RE. In adjusted regression analyses, RE was associated with a lower prevalence of ischemic infarcts (odds ratio [OR] = 0.78, 95% confidence interval [CI] = 0.63–0.98, p = 0.03) and of moderate to severe white matter hyperintensities (OR = 0.78, 95% CI = 0.62–0.99, p = 0.04), higher brain volume (β-coefficient = 10.73, 95% CI = 2.37–19.09, p = 0.01), and higher CoCo score (β-coefficient = 0.08, 95% CI = 0.03–0.12, p < 0.001). Increasing weekly PA was associated with higher brain volume (β-coefficient = 1.40, 95% CI = 0.65–2.15, p < 0.001). Conclusions: In AF patients, RE was associated with a lower prevalence of ischemic infarcts and of moderate to severe white matter disease, with larger brain volume, and with better cognitive performance. Prospective studies are needed to investigate whether these associations are causal. Until then, our findings suggest that patients with AF should be encouraged to remain physically active.

Published
2022

41. Blood Pressure and Brain Lesions in Patients With Atrial Fibrillation

Author

Aeschbacher, Stefanie, Blum, Steffen, Meyre, Pascal B., Coslovsky, Michael, Vischer, Annina S., Sinnecker, Tim, Rodondi, Nicolas, Beer, Jürg H., Moschovitis, Giorgio, Moutzouri, Elisavet, Hunkeler, Christof, Burkard, Thilo, Eken, Ceylan, Roten, Laurent, Zuern, Christine S., Sticherling, Christian, Wuerfel, Jens, Bonati, Leo H., Conen, David, Osswald, Stefan, and Kühne, Michael

Published
2021
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42. Association of chocolate consumption with neurological and cardiovascular outcomes in atrial fibrillation: data from two Swiss atrial fibrillation cohort studies (Swiss-AF and BEAT-AF)

Author

Stauber, Annina, primary, Müller, Andreas, additional, Rommers, Nikki, additional, Aeschbacher, Stefanie, additional, Rodondi, Nicolas, additional, Bonati, Leo H., additional, Beer, Juerg H., additional, Jeger, Raban V., additional, Kurz, David J., additional, Liedtke, Claudia, additional, Ammann, Peter, additional, Di Valentino, Marcello, additional, Chocano, Patricia, additional, Kobza, Richard, additional, Kühne, Michael, additional, Conen, David, additional, Osswald, Stefan, additional, and Bernheim, Alain M., additional

Published
2023
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43. Concentrations of Serum Brain Injury Biomarkers Following SARS-CoV-2 Infection in Individuals with and without Long-COVID—Results from the Prospective Population-Based COVI-GAPP Study

Author

Telser, Julia, primary, Grossmann, Kirsten, additional, Weideli, Ornella C., additional, Hillmann, Dorothea, additional, Aeschbacher, Stefanie, additional, Wohlwend, Niklas, additional, Velez, Laura, additional, Kuhle, Jens, additional, Maleska, Aleksandra, additional, Benkert, Pascal, additional, Risch, Corina, additional, Conen, David, additional, Risch, Martin, additional, and Risch, Lorenz, additional

Published
2023
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46. Patient clusters and cost trajectories in the Swiss Atrial Fibrillation cohort

Author

Aebersold, Helena, Serra-Burriel, Miquel, Foster-Wittassek, Fabienne, Moschovitis, Giorgio, Aeschbacher, Stefanie, Auricchio, Angelo, Beer, Jürg Hans, Blozik, Eva, Bonati, Leo H, Conen, David, Felder, Stefan, Huber, Carola A, Kuehne, Michael, Mueller, Andreas, Oberle, Jolanda, Paladini, Rebecca E, Reichlin, Tobias, Rodondi, Nicolas, Springer, Anne, Stauber, Annina, Sticherling, Christian, Szucs, Thomas D, Osswald, Stefan, Schwenkglenks, Matthias, University of Zurich, and Aebersold, Helena

Subjects
360 Soziale Probleme, Sozialdienste, 610 Medicine & health, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), 610 Medizin und Gesundheit, Cardiology and Cardiovascular Medicine, 2705 Cardiology and Cardiovascular Medicine
Abstract

ObjectiveEvidence on long-term costs of atrial fibrillation (AF) and associated factors is scarce. As part of the Swiss-AF prospective cohort study, we aimed to characterise AF costs and their development over time, and to assess specific patient clusters and their cost trajectories.MethodsSwiss-AF enrolled 2415 patients with variable duration of AF between 2014 and 2017. Patient clusters were identified using hierarchical cluster analysis of baseline characteristics. Ongoing yearly follow-ups include health insurance clinical and claims data. An algorithm was developed to adjudicate costs to AF and related complications.ResultsA subpopulation of 1024 Swiss-AF patients with available claims data was followed up for a median (IQR) of 3.24 (1.09) years. Average yearly AF-adjudicated costs amounted to SFr5679 (€5163), remaining stable across the observation period. AF-adjudicated costs consisted mainly of inpatient and outpatient AF treatment costs (SFr4078; €3707), followed by costs of bleeding (SFr696; €633) and heart failure (SFr494; €449). Hierarchical analysis identified three patient clusters: cardiovascular (CV; N=253 with claims), isolated-symptomatic (IS; N=586) and severely morbid without cardiovascular disease (SM; N=185). The CV cluster and SM cluster depicted similarly high costs across all cost outcomes; IS patients accrued the lowest costs.ConclusionOur results highlight three well-defined patient clusters with specific costs that could be used for stratification in both clinical and economic studies. Patient characteristics associated with adjudicated costs as well as cost trajectories may enable an early understanding of the magnitude of upcoming AF-related healthcare costs.

Published
2022

47. Association of statin use and lipid levels with cerebral microbleeds and intracranial hemorrhage in patients with atrial fibrillation: A prospective cohort study.

Author

Moutzouri, Elisavet, Glutz, Matthias, Abolhassani, Nazanin, Feller, Martin, Adam, Luise, Gencer, Baris, Del Giovane, Cinzia, Bétrisey, Sylvain, Paladini, Rebecca E, Hennings, Elisa, Aeschbacher, Stefanie, Beer, Jürg H, Moschovitis, Giorgio, Seiffge, David, De Marchis, Gian Marco, Coslovsky, Michael, Reichlin, Tobias, Conte, Giulio, Sinnecker, Tim, and Schwenkglenks, Matthias

Subjects
INTRACRANIAL hemorrhage, STATINS (Cardiovascular agents), ATRIAL fibrillation, TRANSIENT ischemic attack, CORONARY disease
Abstract

Background: An increased risk of intracranial hemorrhage (ICH) associated with statins has been reported, but data on the relationship between statin use and cerebral microbleeds (CMBs) in patients with atrial fibrillation (AF), a population at high bleeding and cardiovascular risk, are lacking. Aims: To explore the association between statin use and blood lipid levels with the prevalence and progression of CMBs in patients with AF with a particular focus on anticoagulated patients. Methods: Data of Swiss-AF, a prospective cohort of patients with established AF, were analyzed. Statin use was assessed during baseline and throughout follow-up. Lipid values were measured at baseline. CMBs were assessed using magnetic resonance imagining (MRI) at baseline and at 2 years follow-up. Imaging data were centrally assessed by blinded investigators. Associations of statin use and low-density lipoprotein (LDL) levels with CMB prevalence at baseline or CMB progression (at least one additional or new CMB on follow-up MRI at 2 years compared with baseline) were assessed using logistic regression models; the association with ICH was assessed using flexible parametric survival models. Models were adjusted for hypertension, smoking, body mass index, diabetes, stroke/transient ischemic attack, coronary heart disease, antiplatelet use, anticoagulant use, and education. Results: Of the 1693 patients with CMB data at baseline MRI (mean ± SD age 72.5 ± 8.4 years, 27.6% women, 90.1% on oral anticoagulants), 802 patients (47.4%) were statin users. The multivariable adjusted odds ratio (adjOR) for CMBs prevalence at baseline for statin users was 1.10 (95% CI = 0.83–1.45). AdjOR for 1 unit increase in LDL levels was 0.95 (95% CI = 0.82–1.10). At 2 years, 1188 patients had follow-up MRI. CMBs progression was observed in 44 (8.0%) statin users and 47 (7.4%) non-statin users. Of these patients, 64 (70.3%) developed a single new CMB, 14 (15.4%) developed 2 CMBs, and 13 developed more than 3 CMBs. The multivariable adjOR for statin users was 1.09 (95% CI = 0.66–1.80). There was no association between LDL levels and CMB progression (adjOR 1.02, 95% CI = 0.79–1.32). At follow-up 14 (1.2%) statin users had ICH versus 16 (1.3%) non-users. The age and sex adjusted hazard ratio (adjHR) was 0.75 (95% CI = 0.36–1.55). The results remained robust in sensitivity analyses excluding participants without anticoagulants. Conclusions: In this prospective cohort of patients with AF, a population at increased hemorrhagic risk due to anticoagulation, the use of statins was not associated with an increased risk of CMBs. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Genetic Susceptibility for Atrial Fibrillation in Patients Undergoing Atrial Fibrillation Ablation

Author

Shoemaker, M. Benjamin, Husser, Daniela, Roselli, Carolina, Al Jazairi, Meelad, Chrispin, Jonathan, Kühne, Michael, Neumann, Benjamin, Knight, Stacey, Sun, Han, Mohanty, Sanghamitra, Shaffer, Christian, Thériault, Sébastien, Rinke, Lauren Lee, Siland, Joylene E., Crawford, Diane M., Ueberham, Laura, Zardkoohi, Omeed, Büttner, Petra, Geelhoed, Bastiaan, Blum, Steffen, Aeschbacher, Stefanie, Smith, Jonathan D., Van Wagoner, David R., Freudling, Rebecca, Müller-Nurasyid, Martina, Montgomery, Jay, Yoneda, Zachary, Wells, Quinn, Issa, Tariq, Weeke, Peter, Jacobs, Victoria, Van Gelder, Isabelle C., Hindricks, Gerhard, Barnard, John, Calkins, Hugh, Darbar, Dawood, Michaud, Greg, Kääb, Stefan, Ellinor, Patrick, Natale, Andrea, Chung, Mina, Nazarian, Saman, Cutler, Michael J., Sinner, Moritz F., Conen, David, Rienstra, Michiel, Bollmann, Andreas, Roden, Dan M., and Lubitz, Steven

Published
2020
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49. Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

Author

Young, William J., Haessler, Jeffrey, Benjamins, Jan Walter, Repetto, Linda, Yao, Jie, Isaacs, Aaron, Harper, Andrew R., Ramirez, Julia, Garnier, Sophie, van Duijvenboden, Stefan, Baldassari, Antoine R., Concas, Maria Pina, Duong, Thuy Vy, Foco, Luisa, Isaksen, Jonas L., Mei, Hao, Noordam, Raymond, Nursyifa, Casia, Richmond, Anne, Santolalla, Meddly L., Sitlani, Colleen M., Soroush, Negin, Thériault, Sébastien, Trompet, Stella, Aeschbacher, Stefanie, Ahmadizar, Fariba, Alonso, Alvaro, Brody, Jennifer A., Campbell, Archie, Correa, Adolfo, Darbar, Dawood, De Luca, Antonio, Deleuze, Jean François, Ellervik, Christina, Fuchsberger, Christian, Goel, Anuj, Grace, Christopher, Guo, Xiuqing, Hansen, Torben, Heckbert, Susan R., Jackson, Rebecca D., Kors, Jan A., Lima-Costa, Maria Fernanda, Linneberg, Allan, Macfarlane, Peter W., Morrison, Alanna C., Navarro, Pau, Porteous, David J., Pramstaller, Peter P., Reiner, Alexander P., Risch, Lorenz, Schotten, Ulrich, Shen, Xia, Sinagra, Gianfranco, Soliman, Elsayed Z., Stoll, Monika, Tarazona-Santos, Eduardo, Tinker, Andrew, Trajanoska, Katerina, Villard, Eric, Warren, Helen R., Whitsel, Eric A., Wiggins, Kerri L., Arking, Dan E., Avery, Christy L., Conen, David, Girotto, Giorgia, Grarup, Niels, Hayward, Caroline, Jukema, J. Wouter, Mook-Kanamori, Dennis O., Olesen, Morten Salling, Padmanabhan, Sandosh, Psaty, Bruce M., Pattaro, Cristian, Ribeiro, Antonio Luiz P., Rotter, Jerome I., Stricker, Bruno H., van der Harst, Pim, van Duijn, Cornelia M., Verweij, Niek, Wilson, James G., Orini, Michele, Charron, Philippe, Watkins, Hugh, Kooperberg, Charles, Lin, Henry J., Wilson, James F., Kanters, Jørgen K., Sotoodehnia, Nona, Mifsud, Borbala, Lambiase, Pier D., Tereshchenko, Larisa G., Munroe, Patricia B., Young, William J., Haessler, Jeffrey, Benjamins, Jan Walter, Repetto, Linda, Yao, Jie, Isaacs, Aaron, Harper, Andrew R., Ramirez, Julia, Garnier, Sophie, van Duijvenboden, Stefan, Baldassari, Antoine R., Concas, Maria Pina, Duong, Thuy Vy, Foco, Luisa, Isaksen, Jonas L., Mei, Hao, Noordam, Raymond, Nursyifa, Casia, Richmond, Anne, Santolalla, Meddly L., Sitlani, Colleen M., Soroush, Negin, Thériault, Sébastien, Trompet, Stella, Aeschbacher, Stefanie, Ahmadizar, Fariba, Alonso, Alvaro, Brody, Jennifer A., Campbell, Archie, Correa, Adolfo, Darbar, Dawood, De Luca, Antonio, Deleuze, Jean François, Ellervik, Christina, Fuchsberger, Christian, Goel, Anuj, Grace, Christopher, Guo, Xiuqing, Hansen, Torben, Heckbert, Susan R., Jackson, Rebecca D., Kors, Jan A., Lima-Costa, Maria Fernanda, Linneberg, Allan, Macfarlane, Peter W., Morrison, Alanna C., Navarro, Pau, Porteous, David J., Pramstaller, Peter P., Reiner, Alexander P., Risch, Lorenz, Schotten, Ulrich, Shen, Xia, Sinagra, Gianfranco, Soliman, Elsayed Z., Stoll, Monika, Tarazona-Santos, Eduardo, Tinker, Andrew, Trajanoska, Katerina, Villard, Eric, Warren, Helen R., Whitsel, Eric A., Wiggins, Kerri L., Arking, Dan E., Avery, Christy L., Conen, David, Girotto, Giorgia, Grarup, Niels, Hayward, Caroline, Jukema, J. Wouter, Mook-Kanamori, Dennis O., Olesen, Morten Salling, Padmanabhan, Sandosh, Psaty, Bruce M., Pattaro, Cristian, Ribeiro, Antonio Luiz P., Rotter, Jerome I., Stricker, Bruno H., van der Harst, Pim, van Duijn, Cornelia M., Verweij, Niek, Wilson, James G., Orini, Michele, Charron, Philippe, Watkins, Hugh, Kooperberg, Charles, Lin, Henry J., Wilson, James F., Kanters, Jørgen K., Sotoodehnia, Nona, Mifsud, Borbala, Lambiase, Pier D., Tereshchenko, Larisa G., and Munroe, Patricia B.

Abstract

The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.

Published
2023

50. Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

Author

RWE/Causal inference, Child Health, Gezonde Vaten, Circulatory Health, Young, William J, Haessler, Jeffrey, Benjamins, Jan-Walter, Repetto, Linda, Yao, Jie, Isaacs, Aaron, Harper, Andrew R, Ramirez, Julia, Garnier, Sophie, van Duijvenboden, Stefan, Baldassari, Antoine R, Concas, Maria Pina, Duong, ThuyVy, Foco, Luisa, Isaksen, Jonas L, Mei, Hao, Noordam, Raymond, Nursyifa, Casia, Richmond, Anne, Santolalla, Meddly L, Sitlani, Colleen M, Soroush, Negin, Thériault, Sébastien, Trompet, Stella, Aeschbacher, Stefanie, Ahmadizar, Fariba, Alonso, Alvaro, Brody, Jennifer A, Campbell, Archie, Correa, Adolfo, Darbar, Dawood, De Luca, Antonio, Deleuze, Jean-François, Ellervik, Christina, Fuchsberger, Christian, Goel, Anuj, Grace, Christopher, Guo, Xiuqing, Hansen, Torben, Heckbert, Susan R, Jackson, Rebecca D, Kors, Jan A, Lima-Costa, Maria Fernanda, Linneberg, Allan, Macfarlane, Peter W, Morrison, Alanna C, Navarro, Pau, Porteous, David J, Pramstaller, Peter P, Reiner, Alexander P, Risch, Lorenz, Schotten, Ulrich, Shen, Xia, Sinagra, Gianfranco, Soliman, Elsayed Z, Stoll, Monika, Tarazona-Santos, Eduardo, Tinker, Andrew, Trajanoska, Katerina, Villard, Eric, Warren, Helen R, Whitsel, Eric A, Wiggins, Kerri L, Arking, Dan E, Avery, Christy L, Conen, David, Girotto, Giorgia, Grarup, Niels, Hayward, Caroline, Jukema, J Wouter, Mook-Kanamori, Dennis O, Olesen, Morten Salling, Padmanabhan, Sandosh, Psaty, Bruce M, Pattaro, Cristian, Ribeiro, Antonio Luiz P, Rotter, Jerome I, Stricker, Bruno H, van der Harst, Pim, van Duijn, Cornelia M, Verweij, Niek, Wilson, James G, Orini, Michele, Charron, Philippe, Watkins, Hugh, Kooperberg, Charles, Lin, Henry J, Wilson, James F, Kanters, Jørgen K, Sotoodehnia, Nona, Mifsud, Borbala, Lambiase, Pier D, Tereshchenko, Larisa G, Munroe, Patricia B, RWE/Causal inference, Child Health, Gezonde Vaten, Circulatory Health, Young, William J, Haessler, Jeffrey, Benjamins, Jan-Walter, Repetto, Linda, Yao, Jie, Isaacs, Aaron, Harper, Andrew R, Ramirez, Julia, Garnier, Sophie, van Duijvenboden, Stefan, Baldassari, Antoine R, Concas, Maria Pina, Duong, ThuyVy, Foco, Luisa, Isaksen, Jonas L, Mei, Hao, Noordam, Raymond, Nursyifa, Casia, Richmond, Anne, Santolalla, Meddly L, Sitlani, Colleen M, Soroush, Negin, Thériault, Sébastien, Trompet, Stella, Aeschbacher, Stefanie, Ahmadizar, Fariba, Alonso, Alvaro, Brody, Jennifer A, Campbell, Archie, Correa, Adolfo, Darbar, Dawood, De Luca, Antonio, Deleuze, Jean-François, Ellervik, Christina, Fuchsberger, Christian, Goel, Anuj, Grace, Christopher, Guo, Xiuqing, Hansen, Torben, Heckbert, Susan R, Jackson, Rebecca D, Kors, Jan A, Lima-Costa, Maria Fernanda, Linneberg, Allan, Macfarlane, Peter W, Morrison, Alanna C, Navarro, Pau, Porteous, David J, Pramstaller, Peter P, Reiner, Alexander P, Risch, Lorenz, Schotten, Ulrich, Shen, Xia, Sinagra, Gianfranco, Soliman, Elsayed Z, Stoll, Monika, Tarazona-Santos, Eduardo, Tinker, Andrew, Trajanoska, Katerina, Villard, Eric, Warren, Helen R, Whitsel, Eric A, Wiggins, Kerri L, Arking, Dan E, Avery, Christy L, Conen, David, Girotto, Giorgia, Grarup, Niels, Hayward, Caroline, Jukema, J Wouter, Mook-Kanamori, Dennis O, Olesen, Morten Salling, Padmanabhan, Sandosh, Psaty, Bruce M, Pattaro, Cristian, Ribeiro, Antonio Luiz P, Rotter, Jerome I, Stricker, Bruno H, van der Harst, Pim, van Duijn, Cornelia M, Verweij, Niek, Wilson, James G, Orini, Michele, Charron, Philippe, Watkins, Hugh, Kooperberg, Charles, Lin, Henry J, Wilson, James F, Kanters, Jørgen K, Sotoodehnia, Nona, Mifsud, Borbala, Lambiase, Pier D, Tereshchenko, Larisa G, and Munroe, Patricia B

Published
2023

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