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Your search keyword '"Adroub, Sabir A."' showing total 23 results
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23 results on '"Adroub, Sabir A."'

1. PRC2-EZH1 contributes to circadian gene expression by orchestrating chromatin states and RNA polymerase II complex stability

Author

Liu, Peng, Nadeef, Seba, Serag, Maged F, Paytuví-Gallart, Andreu, Abadi, Maram, Della Valle, Francesco, Radío, Santiago, Roda, Xènia, Dilmé Capó, Jaïr, Adroub, Sabir, Hosny El Said, Nadine, Fallatah, Bodor, Celii, Mirko, Messa, Gian Marco, Wang, Mengge, Li, Mo, Tognini, Paola, Aguilar-Arnal, Lorena, Habuchi, Satoshi, Masri, Selma, Sassone-Corsi, Paolo, and Orlando, Valerio

Published
2024
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3. Outcome of Transplant Recipients Infected with Omicron BA.1 and BA.2: A Single-Center Retrospective Study in Saudi Arabia

Author

Alshukairi, Abeer N., Aldabbagh, Yasser, Adroub, Sabir A., Mourier, Tobias, Abumelha, Khalid Y., Albishi, Ghadeer E., Alraddadi, Basem M., Al Hroub, Mohammad K., El-Saed, Aiman, Ibrahim, Suzan M. Nagash, Al Musawa, Mohammed, Almasari, Ahlam, Habahab, Wael T., Alhamlan, Fatimah S., Al-Omari, Awad, Pain, Arnab, and Dada, Ashraf

Published
2023
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7. Transdifferentiation of Mouse Embryonic Fibroblasts into Dopaminergic Neurons Reactivates LINE-1 Repetitive Elements

Author

Della Valle, Francesco, Thimma, Manjula P, Caiazzo, Massimiliano, Pulcrano, Salvatore, Celii, Mirko, Adroub, Sabir A, Liu, Peng, Alanis-Lobato, Gregorio, Broccoli, Vania, Orlando, Valerio, Della Valle, Francesco, Thimma, Manjula P, Caiazzo, Massimiliano, Pulcrano, Salvatore, Celii, Mirko, Adroub, Sabir A, Liu, Peng, Alanis-Lobato, Gregorio, Broccoli, Vania, and Orlando, Valerio

Published
2020

8. Transdifferentiation of Mouse Embryonic Fibroblasts into Dopaminergic Neurons Reactivates LINE-1 Repetitive Elements

Author

Afd Pharmaceutics, Pharmaceutics, Della Valle, Francesco, Thimma, Manjula P, Caiazzo, Massimiliano, Pulcrano, Salvatore, Celii, Mirko, Adroub, Sabir A, Liu, Peng, Alanis-Lobato, Gregorio, Broccoli, Vania, Orlando, Valerio, Afd Pharmaceutics, Pharmaceutics, Della Valle, Francesco, Thimma, Manjula P, Caiazzo, Massimiliano, Pulcrano, Salvatore, Celii, Mirko, Adroub, Sabir A, Liu, Peng, Alanis-Lobato, Gregorio, Broccoli, Vania, and Orlando, Valerio

Published
2020

12. Nuclear AGO1 Regulates Gene Expression by Affecting Chromatin Architecture in Human Cells

Author

Shuaib, Muhammad, primary, Parsi, Krishna Mohan, additional, Thimma, Manjula, additional, Adroub, Sabir Abdu, additional, Kawaji, Hideya, additional, Seridi, Loqmane, additional, Ghosheh, Yanal, additional, Fort, Alexandre, additional, Fallatah, Bodor, additional, Ravasi, Timothy, additional, Carninci, Piero, additional, and Orlando, Valerio, additional

Published
2019
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13. AGO1 in association with NEAT1 lncRNA contributes to nuclear and 3D chromatin architecture in human cells: Supplemental Data

Author

Shuaib, Muhammad, Parsi, Krishna Mohan, Kawaji, Hideya, Thimma, Manjula, Adroub, Sabir Abdu, Fort, Alexandre, Ghosheh, Yanal, Yamazaki, Tomohiro, Mannen, Taro, Seridi, Loqmane, Fallatah, Bodor, Albawardi, Waad, Ravasi, Timothy, Carninci, Piero, Hirose, Tetsuro, and Orlando, Valerio

Subjects
fungi
Abstract

Aside from their roles in the cytoplasm, RNA-interference components have been reported to localize also in the nucleus of human cells. In particular, AGO1 associates with active chromatin and appears to influence global gene expression. However, the mechanistic aspects remain elusive. Here, we identify AGO1 as a paraspeckle component that in combination with the NEAT1 lncRNA maintains 3D genome architecture. We demonstrate that AGO1 interacts with NEAT1 lncRNA and its depletion affects NEAT1 expression and the formation of paraspeckles. By Hi-C analysis in AGO1 knockdown cells, we observed global changes in chromatin organization, including TADs configuration, and A/B compartment mixing. Consistently, distinct groups of genes located within the differential interacting loci showed altered expression upon AGO1 depletion. NEAT1 knockout cells displayed similar changes in TADs and higher-order A/B compartmentalization. We propose that AGO1 in association with NEAT1 lncRNA can act as a scaffold that bridges chromatin and nuclear bodies to regulate genome organization and gene expression in human cells.

Published
2019
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14. Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator

Author

Abdallah, Abdallah M., primary, Weerdenburg, Eveline M., additional, Guan, Qingtian, additional, Ummels, Roy, additional, Borggreve, Stephanie, additional, Adroub, Sabir A., additional, Malas, Tareq B., additional, Naeem, Raeece, additional, Zhang, Huoming, additional, Otto, Thomas D., additional, Bitter, Wilbert, additional, and Pain, Arnab, additional

Published
2019
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15. AGO1 in association with NEAT1 lncRNA contributes to nuclear and 3D chromatin architecture in human cells

Author

Shuaib, Muhammad, primary, Parsi, Krishna Mohan, additional, Kawaji, Hideya, additional, Thimma, Manjula, additional, Adroub, Sabir Abdu, additional, Fort, Alexandre, additional, Ghosheh, Yanal, additional, Yamazaki, Tomohiro, additional, Mannen, Taro, additional, Seridi, Loqmane, additional, Fallatah, Bodor, additional, Albawardi, Waad, additional, Ravasi, Timothy, additional, Carninci, Piero, additional, Hirose, Tetsuro, additional, and Orlando, Valerio, additional

Published
2019
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16. Progenitor strain introduction of Mycobacterium bovis at the wildlife-livestock interface can lead to clonal expansion of the disease in a single ecosystem

Author

Dippenaar, Anzaan, primary, Parsons, Sven David Charles, additional, Miller, Michele Ann, additional, Hlokwe, Tiny, additional, Gey van Pittius, Nicolaas Claudius, additional, Adroub, Sabir Abdu, additional, Abdallah, Abdallah Musa, additional, Pain, Arnab, additional, Warren, Robin Mark, additional, Michel, Anita Luise, additional, and van Helden, Paul David, additional

Published
2017
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17. Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations

Author

Abdallah, Abdallah M., primary, Hill-Cawthorne, Grant A., additional, Otto, Thomas D., additional, Coll, Francesc, additional, Guerra-Assunção, José Afonso, additional, Gao, Ge, additional, Naeem, Raeece, additional, Ansari, Hifzur, additional, Malas, Tareq B., additional, Adroub, Sabir A., additional, Verboom, Theo, additional, Ummels, Roy, additional, Zhang, Huoming, additional, Panigrahi, Aswini Kumar, additional, McNerney, Ruth, additional, Brosch, Roland, additional, Clark, Taane G., additional, Behr, Marcel A., additional, Bitter, Wilbert, additional, and Pain, Arnab, additional

Published
2015
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18. Genome-Wide Transposon Mutagenesis Indicates that Mycobacterium marinum Customizes Its Virulence Mechanisms for Survival and Replication in Different Hosts

Author

Weerdenburg, Eveline M., primary, Abdallah, Abdallah M., additional, Rangkuti, Farania, additional, Abd El Ghany, Moataz, additional, Otto, Thomas D., additional, Adroub, Sabir A., additional, Molenaar, Douwe, additional, Ummels, Roy, additional, ter Veen, Kars, additional, van Stempvoort, Gunny, additional, van der Sar, Astrid M., additional, Ali, Shahjahan, additional, Langridge, Gemma C., additional, Thomson, Nicholas R., additional, Pain, Arnab, additional, and Bitter, Wilbert, additional

Published
2015
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20. Complete Genome Sequence of Mycobacterium vaccae Type Strain ATCC 25954

Author

Ho, Yung S., primary, Adroub, Sabir A., additional, Abadi, Maram, additional, Al Alwan, Bader, additional, Alkhateeb, Reham, additional, Gao, Ge, additional, Ragab, Alaa, additional, Ali, Shahjahan, additional, van Soolingen, Dick, additional, Bitter, Wilbert, additional, Pain, Arnab, additional, and Abdallah, Abdallah M., additional

Published
2012
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23. Genome-Wide Transposon Mutagenesis Indicates that Mycobacterium marinumCustomizes Its Virulence Mechanisms for Survival and Replication in Different Hosts

Author

Weerdenburg, Eveline M., Abdallah, Abdallah M., Rangkuti, Farania, Abd El Ghany, Moataz, Otto, Thomas D., Adroub, Sabir A., Molenaar, Douwe, Ummels, Roy, ter Veen, Kars, van Stempvoort, Gunny, van der Sar, Astrid M., Ali, Shahjahan, Langridge, Gemma C., Thomson, Nicholas R., Pain, Arnab, and Bitter, Wilbert

Abstract

ABSTRACTThe interaction of environmental bacteria with unicellular eukaryotes is generally considered a major driving force for the evolution of intracellular pathogens, allowing them to survive and replicate in phagocytic cells of vertebrate hosts. To test this hypothesis on a genome-wide level, we determined for the intracellular pathogen Mycobacterium marinumwhether it uses conserved strategies to exploit host cells from both protozoan and vertebrate origin. Using transposon-directed insertion site sequencing (TraDIS), we determined differences in genetic requirements for survival and replication in phagocytic cells of organisms from different kingdoms. In line with the general hypothesis, we identified a number of general virulence mechanisms, including the type VII protein secretion system ESX-1, biosynthesis of polyketide lipids, and utilization of sterols. However, we were also able to show that M. marinumcontains an even larger set of host-specific virulence determinants, including proteins involved in the modification of surface glycolipids and, surprisingly, the auxiliary proteins of the ESX-1 system. Several of these factors were in fact counterproductive in other hosts. Therefore, M. marinumcontains different sets of virulence factors that are tailored for specific hosts. Our data imply that although amoebae could function as a training ground for intracellular pathogens, they do not fully prepare pathogens for crossing species barriers.

Published
2015
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