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1. Analysis of the Factors Associated With ED in Type 2 Diabetics at the University Hospital of Libreville

Author

Steevy Ndang Ngou Milama, MD, Adrien Mougougou, MD, Smith Giscard Olagui, MD, Dimitri Mbethe, MD, Daniella Nsame, MD, Herman Gael Boundama, MD, and Brice Edgard Ngoungou, MSs, PhD

Subjects
Erectile dysfunction, Type 2 diabetes mellitus, Associated factors, Medicine
Abstract

Introduction: Erectile dysfunction (ED) is very common in diabetic males, especially type 2 diabetes mellitus (T2DM). Many factors and complications of diabetes such as macro- and micro-angiopathy are associated with risks leading to ED in male patients. Aim: Analysis of factors associated with ED in T2DM. The purpose of this study is to shed light on potential associations between ED, type 2 diabetes, and some risks factors. Material and methods: This was a prospective analytic study of T2DM over 18. The study population consisted of diabetic patients seen at the endocrinology and urology departments of the University Hospital during the study period. Evaluation of ED was made by IIEF 5 score. Outcomes: A total of 333 patients were selected for the study. The mean age was 56.6 ± 9.8 and the prevalence of ED was 82.6% (n = 275). Results: In univariate analysis, several associated factors were identified such as micro-angiopathic type complications including diabetic retinopathy (OR 4.88 [2.31–10.33], P < .001), diabetic nephropathy (OR 12.67 [1.71–93.66], P = .002) and macro-angiopathic type including arterial hypertension (OR 3.12 [1.69–5.75], P < .001). In multivariate analysis, duration of diabetes, micro and macroangiopathic complications, and hyperuricemia were independent risk factors for the occurrence of ED (P < .05). Clinical Implications: The presence of certain complications of diabetes such as micro or macro angiopathy or hyperuricemia should lead to a search for a ED. The presence of these associated factors identified in type 2 diabetic patients should systematically prompt an ED diagnosis which is often moderate or severe. That diagnosis would help design a protocol for the management and improvement of the life quality of these patients. Strengths and Limitations: The strength of this work is that it was conducted in the biggest hospital in the country which gives us a good idea of the trend of this ailment in the country. But the limitation of the study is that it only included patients who visited the hospital. This is monocentric hospital study was also transversal which does allow to establish a causal link. Conclusion: ED has a significant prevalence in T2DM. Several associated factors identified in uni and multivariate analyses, including duration of diabetes, micro and macro angiopathic complications, and hyperuricemia, increase ED risk. Therefore, it is essential to investigate the existence of these factors to improve the management of ED, which may allow the patient to regain a better overall health status.SNN Milama, A Mougougou, S G Olagui, et al. Analysis of the Factors Associated With ED in Type 2 Diabetics at the University Hospital of Libreville. Sex Med 2022;10:100564.

Published
2022
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5. Prostatic Burkitt Lymphoma, a Rare Secondary Location

Author

Smith Giscard Olagui, Steevy Ndang Ngou Milama, Jean Massande Mouyendi, and Adrien Mougougou

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Cancer, Physical examination, Stage ii, medicine.disease, Gastroenterology, Lymphoma, Malignant lymphoma, medicine.anatomical_structure, immune system diseases, Prostate, hemic and lymphatic diseases, Internal medicine, medicine, Etiology, business, Complication
Abstract

Introduction: Non-Hodgkin’s malignant lymphoma is found primarily in African children. Prostate localization is a rare entity. We report the case of a secondary prostatic localization of Burkitt lymphoma in a 14-year-old child. Observation: the 14-year-old child NNJ was followed at the Libreville Cancer Institute (ICL) for Burkitt maxillo-facial stage II bilateral Murphy lymphoma. The clinical examination noted an alteration of the general state, total hematuria, a voluminous prostatic mass filling the rectal ampoule. The paraclinical assessment noted renal insufficiency, a prostatic mass on ultrasound. Anatomo-pathological examination of the prostatic biopsy diagnosed Burkitt type non-Hodgkin’s malignant lymphoma. He died a week later. Conclusion: Primary or secondary prostatic lymphoma is rare. Obstructive renal insufficiency is an additional complication that darkens its prognosis by delaying etiological treatment based on polychemotherapy.

Published
2021
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6. Co-infection paludisme et COVID-19 chez les patients admis au service d’infectiologie COVID du Centre Hospitalier Universitaire de Libreville

Author

Marielle Igala, Elsa Ayo Bivigou, Ulrich Davy Kombila, Stéphanie Ntsame Ngoua, Jean Felix Ngomas, Adrien Mougougou, Arsène Ifoudji Makao, Charlene Manomba, Irène Augustine Mistoul, Gabrielle Atsame Ebang, Anita Akiko Mbourou, Metogho Essandone, Liliane Flore Pemba, Annick Flore Mfoumou, Fifi Claire Ada Loembe, Léonard Kouegnigan Rerambiah, Jean Bruno Boguikouma, and Marielle Carine Bouyou Akotet

Subjects
Co-infection, paludisme, COVID-19
Abstract

Le travail visait à rapporter les cas de co-infection paludisme - COVID-19, après la recherche systématique de plasmodium chez les patients pris en charge dans les services d´infectiologie COVID (SiCOV) du Centre Hospitalier Universitaire de Libreville (CHUL). Il s´est agi d´une étude prospective, observationnelle menée d´Avril à Juillet 2020 dans les SiCov du CHUL. Les patients des deux sexes, âgés de plus de 18 ans avec un test PCR positif pour le SARS Cov 2 dont le résultat de la goutte épaisse était disponible, ont été inclus. Pour chaque patient les données démographiques (âge, sexe, poids, taille), les antécédents et les examens clinique et biologique étaient reportées dans le fichier excel. Sur un total de 253 patients qui répondaient aux critères d´inclusions, 8 faisaient un accès palustre associé à une PCR à SARS-COV 2 positive. Il s´agissait de 3 femmes et de 5 hommes d´un âge moyen de 36,9 ans (25-53 ans). Le mode de contamination était inconnu pour 7/8. Tous les patients étaient fébriles, 6/8 avaient des céphalées et 5/8 présentaient une gêne respiratoire. Moins de la moitié des patients avaient des manifestations oto-rhino-laryngées (anosmie, ageusie) ou digestives (diarrhée). Le seul patient qui présentait une forme sévère est décédé au 5ejour de l´hospitalisation. Les similitudes cliniques entre le paludisme et la COVID-19 peuvent prêter à confusion en zone d´endémie palustre. La co-infection paludisme- COVID-19 n´a pas donné lieu à des formes cliniques graves.

Published
2022

7. Complete Blood Count Parameters, C-Reactive Protein and the Severity of Coronavirus Disease

Author

Marielle, Igala, Elsa Ayo, Bivigou, Ulrich D, Kombila, Jean F, Ngomas, Adrien, Mougougou, Arsene Ifoudji, Makao, Charleine, Manomba, Irene A, Mistoul, Stephanie Ntsame, Ngoua, Gabrielle Atsame, Ebang, Anita Akiko, Mbourou, Metogho, Liliane F, Mpemba, Annick F, Mfoumou, Fifi C Loembe, Ada, Leonard Kouegnigan, Rerambiah, Jean B, Boguikouma, and Marielle Bouyou, Akotet

Subjects
Male, ARDS, medicine.medical_specialty, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Intensive care, Internal medicine, medicine, Humans, Prospective Studies, Leukocytosis, Receptors, Immunologic, Prospective cohort study, Coronavirus, medicine.diagnostic_test, biology, SARS-CoV-2, business.industry, C-reactive protein, Patient Acuity, COVID-19, Complete blood count, Middle Aged, medicine.disease, Neutrophilia, Blood Cell Count, C-Reactive Protein, biology.protein, RNA, Viral, medicine.symptom, business
Abstract

Coronavirus disease, which initially appeared in Wuhan, China during the month of December 2019, very quickly spread and became a worldwide pandemic. The African continent was not spared. The poor health system and low socioeconomic status in some regions has raised concern on the risk of an epidemic disaster due to the rapid transmission of the virus. This study therefore aims to determine the relationship between the modifications of complete blood count parameters, CRP, and the severity and outcome of SARS-CoV2 infection in the first patients hospitalized at the Centre Hospitalier Universitaire de Libreville (Libreville University Hospital Center) in Gabon.This is a prospective study led from April to July 2020 in the COVID infectious department (SICov) of the Centre Hospitalier Universitaire de Libreville (CHUL).In total, 184 patients participated in the study. The median age was 47 (37 - 54) years. Male subjects predominated. The median number of leucocytes was 5.6 (4.4 - 7.45) x 109/L. It was significantly higher in patients with acute respiratory distress syndrome (ARDS) and in intensive care units (ICU) compared to pauci-symptomatic cases (p0.01). Factors associated with death were leukocytosis (crude OR 37.1 (8.3 - 98.4) p0.01), neutrophilia (OR 20.1 (4.6 - 89.0) p0.01), NRL ≥ 9 (OR 13.5 (2.7 - 67.4); p0.01) and CRP100 mg/L (OR 17.8 (2.0 - 154.0) p = 0.02).The hematological profile of patients with COVID-19 varies according to the severity of the disease. Leukocytosis, neutrophilia, a NLR above 6 and a CRP higher than 100 mg/L were associated with the severity of the infection and death in Gabonese patients.

Published
2021
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