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3 results on '"Adriano J. Pereira"'

1. Mitochondrial function of immune cells in septic shock: A prospective observational cohort study.

Author

Tobias M Merz, Adriano J Pereira, Roger Schürch, Joerg C Schefold, Stephan M Jakob, Jukka Takala, and Siamak Djafarzadeh

Subjects
Medicine, Science
Abstract

Reduced cellular ATP synthesis due to impaired mitochondrial function of immune cells may be a factor influencing the immune response in septic shock. We investigate changes in mitochondrial function and bioenergetics of human monocytes and lymphocyte subsets.Thirty patients with septic shock were studied at ICU admission, after 24 and 48 hours, and after resolution of shock. Enzymatic activities of citrate synthase and mitochondrial complexes I, IV, and ATP synthase and ATP content of monocytes, T-cells and B-cells and pro-inflammatory (IL-1β and IL-6) and anti-inflammatory (IL-10) cytokine plasma concentrations were compared to samples from 20 healthy volunteers.Large variations in mitochondrial enzymatic activities of immune cells of septic patients were detected. In monocytes, maximum levels of citrate synthase activity in sepsis were significantly lower when compared to controls (p = 0.021). Maximum relative enzymatic activity (ratio relative to citrate synthase activity) of complex I (p

Published
2017
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2. IMPACTO-MR: a Brazilian nationwide platform study to assess infections and multidrug resistance in intensive care units

Author

Bruno M. Tomazini, Antonio Paulo Nassar Júnior, Thiago Costa Lisboa, Luciano César Pontes de Azevedo, Viviane Cordeiro Veiga, Daniela Ghidetti Mangas Catarino, Debora Vacaro Fogazzi, Beatriz Arns, Filipe Teixeira Piastrelli, Camila Dietrich, Karina Leal Negrelli, Isabella de Andrade Jesuíno, Luiz Fernando Lima Reis, Renata Rodrigues de Mattos, Carla Cristina Gomes Pinheiro, Mariane Nascimento Luz, Clayse Carla da Silva Spadoni, Elisângela Emilene Moro, Flávia Regina Bueno, Camila Santana Justo Cintra Sampaio, Débora Patrício Silva, Franca Pellison Baldassare, Ana Cecilia Alcantara Silva, Thabata Veiga, Leticia Barbante, Marianne Lambauer, Viviane Bezerra Campos, Elton Santos, Renato Hideo Nakawaga Santos, Ligia Nasi Laranjeiras, Nanci Valeis, Eliana Santucci, Tamiris Abait Miranda, Ana Cristina Lagoeiro do Patrocínio, Andréa de Carvalho, Eduvirgens Maria Couto de Sousa, Ancelmo Honorato Ferraz de Sousa, Daniel Tavares Malheiro, Isabella Lott Bezerra, Mirian Batista Rodrigues, Julliana Chicuta Malicia, Sabrina Souza da Silva, Bruna dos Passos Gimenes, Guilhermo Prates Sesin, Alexandre Prehn Zavascki, Daniel Sganzerla, Gregory Saraiva Medeiros, Rosa da Rosa Minho dos Santos, Fernanda Kelly Romeiro Silva, Maysa Yukari Cheno, Carolinne Ferreira Abrahão, Haliton Alves de Oliveira Junior, Leonardo Lima Rocha, Pedro Aniceto Nunes Neto, Valéria Chagas Pereira, Luis Eduardo Miranda Paciência, Elaine Silva Bueno, Eliana Bernadete Caser, Larissa Zuqui Ribeiro, Caio Cesar Ferreira Fernandes, Juliana Mazzei Garcia, Vanildes de Fátima Fernandes Silva, Alisson Junior dos Santos, Flávia Ribeiro Machado, Maria Aparecida de Souza, Bianca Ramos Ferronato, Hugo Corrêa de Andrade Urbano, Danielle Conceição Aparecida Moreira, Vicente Cés de Souza-Dantas, Diego Meireles Duarte, Juliana Coelho, Rodrigo Cruvinel Figueiredo, Fernanda Foreque, Thiago Gomes Romano, Daniel Cubos, Vladimir Miguel Spirale, Roberta Schiavon Nogueira, Israel Silva Maia, Cassio Luis Zandonai, Wilson José Lovato, Rodrigo Barbosa Cerantola, Tatiana Gozzi Pancev Toledo, Pablo Oscar Tomba, Joyce Ramos de Almeida, Luciana Coelho Sanches, Leticia Pierini, Mariana Cunha, Michelle Tereza Sousa, Bruna Azevedo, Felipe Dal-Pizzol, Danusa de Castro Damasio, Marina Peres Bainy, Dagoberta Alves Vieira Beduhn, Joana D’Arc Vila Nova Jatobá, Maria Tereza Farias de Moura, Leila Rezegue de Moraes Rego, Adria Vanessa da Silva, Luana Pontes Oliveira, Eliene Sá Sodré Filho, Silvana Soares dos Santos, Itallo de Lima Neves, Vanessa Cristina de Aquino Leão, João Lucidio Lobato Paes, Marielle Cristina Mendes Silva, Cláudio Dornas de Oliveira, Raquel Caldeira Brant Santiago, Jorge Luiz da Rocha Paranhos, Iany Grinezia da Silva Wiermann, Durval Ferreira Fonseca Pedroso, Priscilla Yoshiko Sawada, Rejane Martins Prestes, Glícia Cardoso Nascimento, Cintia Magalhães Carvalho Grion, Claudia Maria Dantas de Maio Carrilho, Roberta Lacerda Almeida de Miranda Dantas, Eliane Pereira Silva, Antônio Carlos da Silva, Sheila Mara Bezerra de Oliveira, Nicole Alberti Golin, Rogerio Tregnago, Valéria Paes Lima, Kamilla Grasielle Nunes da Silva, Emerson Boschi, Viviane Buffon, André Sant’Ana Machado, Leticia Capeletti, Rafael Botelho Foernges, Andréia Schubert de Carvalho, Lúcio Couto de Oliveira Junior, Daniela Cunha de Oliveira, Everton Macêdo Silva, Julival Ribeiro, Francielle Constantino Pereira, Fernanda Borges Salgado, Caroline Deutschendorf, Cristofer Farias da Silva, Andre Luiz Nunes Gobatto, Carolaine Bomfim de Oliveira, Marianna Deway Andrade Dracoulakis, Natália Oliveira Santos Alvaia, Roberta Machado de Souza, Larissa Liz Cardoso de Araújo, Rodrigo Morel Vieira de Melo, Luiz Carlos Santana Passos, Claudia Fernanda de Lacerda Vidal, Fernanda Lopes de Albuquerque Rodrigues, Pedro Kurtz, Cássia Righy Shinotsuka, Maria Brandão Tavares, Igor das Virgens Santana, Luciana Macedo da Silva Gavinho, Alaís Brito Nascimento, Adriano J. Pereira, and Alexandre Biasi Cavalcanti

Subjects
General Medicine, Critical Care and Intensive Care Medicine
Published
2022
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3. Hyperbaric oxygen therapy for choroidal neovascularization: a pilot study

Author

Fernando K, Malerbi, Eduardo A, Novais, Emmerson Badaró, Pedro Paulo de O, Bonomo, Adriano J, Pereira, Claudio L, Lottenberg, and André, Maia

Subjects
Aged, 80 and over, Male, Vascular Endothelial Growth Factor A, Analysis of Variance, Hyperbaric Oxygenation, Visual Acuity, Angiogenesis Inhibitors, Pilot Projects, Middle Aged, Antibodies, Monoclonal, Humanized, Combined Modality Therapy, Choroidal Neovascularization, Bevacizumab, Macular Degeneration, Intravitreal Injections, Humans, Female, Aged
Abstract

Choroidal neovascularization (CNV) is one of the leading causes of blindness worldwide and affects patients with wet age-related macular degeneration (AMD). Its natural course may lead to impaired central vision and macular fibrosis. Even VEGF blockade, currently the best available treatments for CNV, may fail to improve vision. Hyperbaric oxygen (HBO2) therapy may be an alternative or ancillary treatment for CNV.AMD patients with active CNV underwent 10 daily sessions of HBO2 at 2 atmospheres absolute (atm abs) for 120 minutes each session. After the end of the sessions, patients with clinical or tomographical signs of CNV activity underwent standard anti-VEGF treatment.Seven patients (average age 73) underwent 10 daily 120-minute sessions of HBO2 at 2 atm abs. After the sessions, five patients underwent intravitreal injection of bevacizumab. Average follow-up was 150 days. Average CNV area at baseline was 14.42 mm2; average CNV greatest linear diameter at baseline was 4.56 mm. Statistical analysis of variance (ANOVA) was performed for central retinal thickness and volume mean percentage changes post-treatment. At the end of follow up, five patients showed anatomical improvement, one patient maintained anatomical aspect and one patient showed anatomical worsening.HBO2 may be a safe and tolerable treatment option for patients with active CNV, potentially delaying its progression, as monotherapy or in combination with intravitreal bevacizumab.

Published
2015

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