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En este artículo se presentan la labores de la Iglesia Católica durante las epidemias de cólera de 1833 y 1849-1850 en las parroquias que se encontraban en el partido de Aguascalientes. Se describen los auxilios sacramentales, la labor hospitalaria, la creación de camposantos provisionales y las misas rezos y procesiones que organizó el clero para socorrer y aliviar a los feligreses durante las crisis sanitarias.

This article entitled State Taxes in Guanajuato briefly and precisely develops the taxes that are contributed in said state to comply in a timely manner, each tax includes the necessary elements to be understood and applied by the reader to their current tax situation such as who are the people who must comply with said tax, what will be applied and what percentage or rate should be applied to determine the amount to pay, in such a way as to help a healthy tax culture in our State and Country.

Electronic invoicing in Mexico is considered under a tax verification scheme, derived by all sales and purchases made, either in a regular period or irregular period, by an economic authority, considering the egresses and also the income. In turn they can be used by buyers and also by sellers, offering the market a good or a service, expressing as a receipt to the authorities, whether federal, state or municipal, also used in internal and external audits. The electronic invoice is a document that verifies the making of a business transaction of a natural person or moral person to a natural or moral person depending on the assumption, and can be digitally or in printed form. This project is carried out in order to have a document that validates the inputs and outputs of goods, for this it is necessary to develop an Accounting-Administrative process, which processes the information and serves for the business management of the entity Granjero Feliz S de R.L de C.V., this process has an alternative that adapts to the rotation of said company which is the Marketing and transformation of pork cuts. The project is developed with the company information, which it has provided, for an accounting period. In this way, the referrals will be properly controlled. It is also important to mention that it can be easy for the authorities to give indications, under the grounds of laws where it obliges users, to use, develop or apply. Those provisions must also be analysed the situation raised which is addressed to the first sector, in this case it is applied to the primary sector, specifically to the primary sector, farmers. The purpose of this research is both to guide and structure the information of a farmer who, for different reasons, is unaware of federal and government provisions to be able to invoice. For the farmer it is very difficult, to understand and understand the tax provisions that challenge him, from the process of developing for obtaining the electronic signature, to the elaboration, issuance and cancellation of the invoice. This research aims to guide and support primary sector individuals, seeing it as an area of opportunity for their better understanding. Also to support you so that you know the administrative facilities from which you have benefit. Considering some of the objectives of this investigation, it is to manage the reality of the farmer's accounting, in accordance with tax procedures and provisions, giving a general diagnosis to the farmer, to contribute to decision-making in the electronic invoicing process. Considering the degree of knowledge of a farmer, he departed from there to provide support and to be able to apply a billing process, and knew the degree involved in this process, considering the obligations to which he is exposed, as part of this regime, of course that many farmers, do not know that they are obliged to invoice for sales made by the sale is a seed considering also in the mistake for the sale of livestock. In particular, the farmer's theme will be touched, through the billing process, thus giving a specific interpretation and analysis to each of the subject. The farmer's location is in a municipality belonging to Valle de Santiago, Gto. Mexico.

The economic situation in our country, the emergence of new companies and the disappearance of others, makes many taxpayers resort to unconventional strategies, in order to avoid compliance with tax obligations as established in the regulations, to improve their finances , This, many of the times they do it by resorting to some figures inherent to evasion practices, those that imitate and others that give tax effects, the authority colloquially calls them EFOS and EDOS, Companies that Invoice Simulated Operations and Companies that Deduct Simulated Operations . The taxpayer who resorts to the use of this evasion practice and who is identified by the competent authority, will have to abide by the procedure established in article 69-B of the Federal Tax Code. The work shows the analysis of this procedure, and the relationship that it has with an adequate Tax Culture, through the implementation of an adequate Fiscal Citizenship.

Accounting is such an ancient activity or discipline that some authors consider it to be art, science or discipline, which teaches the rules and procedures for classifying and recording operations carried out by economic authorities, who are constituted as natural persons or moral persons with commercial, industrial, scientific, religious, government, basic information that serves as a livelihood to develop financial and useful information to the economic body in the taking of of their economic decisions in regular and irregular periods. Whereas some of the objectives of presents her research consists in quantifying the financial reality of the company, according to the rules, procedures and fiscal provisions, through the application of various financial reasons, giving a diagnosis generally to the economic entity, to contribute to decision-making on resource optimization. The present project was carried out with the aim of measuring the economic and financial reality in which most of the companies located in the region are located, it is an important derived issue, where many companies only the objective is to invest, but is not reanalyzed , a financial accounting diagnostic to verify profitability and whether it is appropriate to continue investing, or otherwise make a small modification, and find the right investment point in the business. In particular, the company "Cadena de tiendas Cristyfer" will be discussed through the application of financial reasons, thus giving a specific interpretation and analysis to each of these. Located in the community of San Ignacio de Mogotes, municipality of Valle de Santiago, Gto. México.

Every profession has a function of responsibility to society, which implies dedication, compliance and permanent updating, credibility and, above all, appropriating their ideals, making them part of their being, with certain ideas, ethical compliance, values and practices that characterize him as a professional. Exercising the profession of Public Accountant implies a sense of social responsibility, of acting with integrity of values and ethics, if one takes into account that society demands such compliance, in addition to a behavior of honesty and certainty. In Mexico, the Public Accountant has different areas of specialization in which professionals can find work cavity today. The main objective of this article is to analyze and identify the functions of a future professional in Public Accounting as well as the work areas to be carried out.The background, essential characteristics, challenges and fields of action of the profession in Mexico are included, thus contributing to the election of career for university futures.

espanolEn este articulo se presenta como fue utilizado el programa Atlas.ti en una investigacion historica en particular. Aunque es cada vez mas frecuente el uso de diferentes CAQDAS entre los historiadores, el objetivo de este documento es presentar Atlas.ti como una herramienta que puede ayudar en el manejo y analisis de un corpus voluminoso de informacion. Se presenta el caso del analisis de los monumentos funerarios construidos entre 1875 y 1930 en el estado de Aguascalientes. EnglishThis article presents how the ATLAS.ti software was used in historical research. Although the use of different CAQDAS among historians is increasingly common, the objective of this document is to present ATLAS.ti as a tool that can help with the management and analysis of a bulky corpus of information. The case of the iconological analysis of the funerary monuments built between 1875 and 1930 in the state of Aguascalientes is presented.

Raspberry production represents an alternative for farmers in the temperate zones of Mexico. Due to the environmental impact caused by conventional agriculture, there is currently greater demand for organic food in the national and international market. To achieve this need, new fertilization techniques based on organic amendments are being tested. In the present study, yields and quality were evaluated over a 3-year period (2015, 2016 and 2017) as well as the phytochemical compounds of the production in 2017, with management of organic versus conventional fertilization of raspberry crop in open field in Cuauhtémoc, Chihuahua, Mexico. During the three years of study, the conventional fertilization system obtained higher yields, compared to the organic one, with values of 2,698 and 2,351 g per linear meter in 2015, 2,423 and 1,301 g per linear meter in 2016 and the data for 2017 were 3,077 and 2,550 g per linear meter, respectively. Regarding quality, the results showed no statistical differences between the two systems of production about colour, firmness, total soluble solids, titratable acidity and pH of the fruit. Differently the composition of phytochemicals, phenols, flavonoids, total anthocyanins and antioxidant capacity was better under the organic management. In conclusion, the conventional system showed higher yields, the quality of the fruits was not different between the two systems, while the levels of phytochemicals were higher with the organic farming. Therefore, it is important to continue the research in order to improve soil fertility and achieve higher yields under the organic management.

Introduccion: La dinamica del uso de suelo y cambios de la cubierta vegetal es crucial para la gestion de los recursos naturales. Objetivo: Analizar el cambio de uso de suelo en la microcuenca Zoquiapan, entre 1989 y 2009, y estimar la tendencia de cambio para el ano 2020. Materiales y metodos: Se obtuvieron dos imagenes de satelite (21 de marzo del 2009 y 7 de marzo de 1989), correspondientes al sensor Landsat, y se procesaron en el software IDRISI©. Las clases estudiadas fueron bosque, pastizal y uso agricola. Se aplico el comando Markov-Markovian transition estimator , para estimar el vector estacionario de la cadena entre los anos de estudio y conocer las tendencias futuras de cobertura vegetal. Resultados y discusion: Entre 1989 y 2009, la superficie agricola y de pastizales se redujo 1.86 y 88.63 ha, respectivamente; la superficie forestal incremento 90.5 ha. Para el ano 2020, la microcuenca Zoquiapan tiene baja probabilidad de cambio. Las probabilidades de permanencia son de 94 % para uso forestal, 88 % para el pastizal y 91 % para la actividad agricola. Conclusion: La microcuenca Zoquiapan no ha tenido algun cambio significativo de uso de suelo. Las zonas cubiertas por bosques presentan baja probabilidad de cambio, siempre y cuando continuen los esfuerzos de conservacion hasta ahora realizados.

A combined analysis of geochemical and production data of 39 wells of the Los Azufres (Mexico) geothermal field (227.4 MWe) over time was developed to investigate the exploitation-related processes for 2003-2011. In the south zone, important effects of reinjection were observed through Cl increases in some wells (up to 8000 mg/kg) while in wells with significant boiling, Cl has decreased. In most of the north zone wells, the variations in gas data indicated boiling and condensation of a highly gas-depleted brine, which seems to consist of reinjection fluids. It is suggested that this process maintains the production in the zone relatively stable. The main reservoir exploitation-related processes found were: 1) production of reinjection returns; for this, it was possible to distinguish a) wells that produce liquid and steam from injection, and b) wells that produce steam from injection and sometimes condensed steam from injection; 2) boiling: two types of boiling were identified: a) boiling with steam gain, and b) boiling with steam loss. The results indicated that an effective reservoir recharge occurs since very moderate production declining rates were found.

Neurocysticercosis is a widely prevalent disease in the tropics that causes seizures and a variety into of neurological symptoms in most of the world. Experimental models are limited and do not allow assessment of the degree of inflammation around brain cysts. The vital dye Evans Blue (EB) was injected to 11 pigs naturally infected with Taenia solium cysts to visually identify the extent of disruption of the blood-brain barrier. A total of 369 cysts were recovered from the 11 brains and classified according to the staining of their capsules as blue or unstained. The proportion of cysts with blue capsules was significantly higher in brains from pigs that had received anthelmintic treatment 48 and 120 h before the EB infusion, indicating a greater compromise of the blood-brain barrier due to treatment. The model could be useful for understanding the pathology of treatment-induced inflammation in neurocysticercosis.

In a 210d experiment, the potential of biofloc technology (BFT) was evaluated for Farfantepenaeus duorarum. Water quality parameters, microorganisms profile and proximate analysis of biofloc were also assessed. BFT did not improve the growth performance in F. duorarum when compared to conventional clear-water water exchange system (final weight and survival of 13.3 g and 63.2 %; and 13.9 g and 81.4 %, respectively). Microorganism assessment suggested a higher presence of filamentous cyanobacteria followed by protozoa, nematodes and copepods. Proximate analysis of biofloc showed crude protein and crude lipid means levels of 25 and 0.6 %, respectively, and these values varied during the experiment. F. duorarum seemed to be susceptible to high stocking density and high levels of suspended solids (>15 mL L−1).

The effects of two microencapsulated feeds were evaluated on development, growth, survival, proteolytic activity, and biochemical composition of white shrimp, Litopenaeus vannamei, larvae. The treatments were: (1) basal microcapsules (BM), (2) microcapsules containing krill hydrolysate (BMK), and (3) live food control (LFC: Artemia franciscana nauplii) with all treatments receiving algae (Chaetoceros ceratosporum and Tetraselmis chuii). No significant differences were found in development index and survival among larvae. Growth rate was significantly higher in larvae fed LFC (15 +/- 0.06%/d) as compared with those offered the BM diet (7.5 +/- 0.5%/d) with the BMK (11 +/- 0.04%/d) treatment producing intermediate results. The activity of total proteases and chymotrypsin decreased significantly after Mysis I (MI) in larvae fed LFC or BMK. Protein content of larvae increased significantly toward PL1. The acylglycerides content in MIII fed on LFC (2.3 +/- 0.2%/dw) was higher than that MI fed BM (1 +/- 0.01%/dw). No difference was observed in the cholesterol (CH) content of the larvae. The acylglycerides/protein and cholesterol/protein ratios showed a decreasing pattern between MI and PL1, indicating that these two ratios were related to ontogenetic shifts. These results demonstrate improvements in microparticulate diets when krill hydrolysates are included in the formulation.

Neurocysticercosis (NCC), an infection of the brain by Taenia solium (Ts) cysts, is the most common cause of adult-onset epilepsy in developing countries. Serological testing consists primarily of varying methods to detect antibodies in body fluids and more recently antigen (Ag) detection assays to identify individuals or animals with viable parasites. Antigen assays currently in use employ monoclonal antibodies (mAbs) raised against T. saginata, which have known cross reactivity to animal cestodes but are highly specific in human samples. We produced, characterized and tested 21 mAbs raised against T. solium whole cyst antigens, vesicular fluid or excretory secretory products. Reactivity of the TsmAbs against specific cyst structures was determined using immunofluorescence and immunohistochemistry on histological sections of Ts muscle cysts. Four TsmAbs reacted to vesicular space alone, 9 to the neck and cyst wall, one to the neck and vesicular space and 7 to the neck, cyst wall and vesicular space. An in-house ELISA assay to detect circulating Ts antigen, using the TsmAbs as capture antibodies and a rabbit polyclonal anti-Ts whole cyst antibody as a detector antibody demonstrated that eight of the 21 TsmAbs detected antigens in known NCC-positive human sera and three of these also in urine samples. Reactivity was expressed as normalized ratios of optical densities (OD positive control/OD negative control). Three TsmAbs had ratios >10 and five between 2 and 10. The TsmAbs have potential utility for the diagnosis and post-treatment monitoring of patients with viable NCC infections.

Cell signaling pathways are the mechanisms by which cells transduce external stimuli, which control the transcription of genes, to regulate diverse biological effects. In cancer, distinct signaling pathways, such as the Wnt/β-catenin pathway, have been implicated in the deregulation of critical molecular processes that affect cell proliferation and differentiation. For example, changes in β-catenin localization have been identified in Human Papillomavirus (HPV)-related cancers as the lesion progresses. Specifically, β-catenin relocates from the membrane/cytoplasm to the nucleus, suggesting that this transcription regulator participates in cervical carcinogenesis. The E6 and E7 oncoproteins are responsible for the transforming activity of HPV, and some studies have implicated these viral oncoproteins in the regulation of the Wnt/β-catenin pathway. Nevertheless, new interactions of HPV oncoproteins with cellular proteins are emerging, and the study of the biological effects of such interactions will help to understand HPV-related carcinogenesis. Viruses 2015, 7 4735 This review addresses the accumulated evidence of the involvement of the HPV E6 and E7 oncoproteins in the activation of the Wnt/β-catenin pathway.

Litopenaeus vannamei were reared in close cycle over seven generations and tested for their capacity to digest starch and to metabolise glucose at different stages of the moulting cycle. After acclimation with 42.3% of carbohydrates (HCBH) or 2.3% carbohydrates (LCBH) diets and at high salinity (40 g kg(-1)) or low salinity (15 g kg(-1)), shrimp were sampled and hepatopancreas (HP) were stored. Total soluble protein in HP was affected by the interaction between salinity and moult stages (p0.05). Specific activity of alpha-amylase ranged from 44 to 241 U mg protein(-1) and a significant interaction between salinity and moult stages was observed (p0.05), resulting in highest values at stage C for low salinity (mean value 196.4 U mg protein(-1)), and at D0 in high salinity (mean value 175.7 U mg protein(-1)). Specific activity of alpha-glucosidase ranged between 0.09 and 0.63 U mg protein(-1), an interaction between dietary CBH and salinity was observed for the alpha-glucosidase (p0.05) and highest mean value was found in low salinity-LCBH diet treatment (0.329 U mg protein(-1)). Hexokinase specific activity (range 9-113 mU mg protein(-1)) showed no significant differences when measured at 5 mM glucose (p0.05). Total hexokinase specific activity (range 17-215 mU mg protein(-1)) showed a significant interaction between dietary CBH and salinity (p0.05) with highest value (mean value 78.5 mU mg protein(-1)) found in HCBH-high salinity treatment, whereas in the other treatments the activity was not significantly different (mean value 35.93 mU mg protein(-1)). A synergistic effect of dietary CBH, salinity and moult stages over hexokinase IV-like specific activity was also observed (p0.05). As result of this interaction, the highest value (135.5+/-81 mU mg protein(-1)) was observed in HCBH, high salinity at D0 moult stage. Digestive enzymes activity is enhanced in the presence of high starch diet (HCBH) and hexokinase can be induced at certain moulting stages under the influence of blood glucose level. Perspectives are opened to add more carbohydrates in a growing diet, exemplifying the potential approach for less-polluting feed.

Cysticidal treatment of neurocysticercosis, an infection of humans and pig brains with Taenia solium, results in an early inflammatory response directed to cysts causing seizures and focal neurological manifestations. Treatment-induced pericystic inflammation and its association with blood brain barrier (BBB) dysfunction, as determined by Evans blue (EB) extravasation, was studied in infected untreated and anthelmintic-treated pigs. We compared the magnitude and extent of the pericystic inflammation, presence of EB-stained capsules, the level of damage to the parasite, expression of genes for proinflammatory and regulatory cytokines, chemokines, and tissue remodeling by quantitative PCR assays between treated and untreated infected pigs and between EB-stained (blue) and non stained (clear) cysts. Inflammatory scores were higher in pericystic tissues from EB-stained cysts compared to clear cysts from untreated pigs and also from anthelmintic-treated pigs 48 hr and 120 hr after treatment. The degree of inflammation correlated with the severity of cyst wall damage and both increased significantly at 120 hours. Expression levels of the proinflammatory genes for IL-6, IFN-γ, TNF-α were higher in EB-stained cysts compared to clear cysts and unaffected brain tissues, and were generally highest at 120 hr. Additionally, expression of some markers of immunoregulatory activity (IL-10, IL-2Rα) were decreased in EB-stained capsules. An increase in other markers for regulatory T cells (CTLA4, FoxP3) was found, as well as significant increases in expression of two metalloproteases, MMP1 and MMP2 at 48 hr and 120 hr post-treatment. We conclude that the increase in severity of the inflammation caused by treatment is accompanied by both a proinflammatory and a complex regulatory response, largely limited to pericystic tissues with compromised vascular integrity. Because treatment induced inflammation occurs in porcine NCC similar to that in human cases, this model can be used to investigate mechanisms involved in host damaging inflammatory responses and agents or modalities that may control damaging post treatment inflammation., Author Summary Neurocysticercosis is caused by infection of the brain with the larval (cyst) stage of the tape worm Taenia solium in humans and pigs. Antiparasitic drug treatment is compromised by worsening of neurological symptoms during therapy due to reactive inflammation triggered by the dying parasite. The immune mechanisms that cause this inflammation are poorly understood. In this study, we investigated the nature of inflammation after treatment in pigs naturally infected with T. solium cysts. Evans blue dye injected into infected pigs marks areas in the brain where the normally impermeable capillaries have become more permeable, allowing damaging cells and molecules to leak out into the brain. By microscopy and measurement of gene expression for inflammation-inducing immune mediators, we show that inflammation in the brain tissues around cysts is more severe with increased vessel leakage. Furthermore, the levels of these mediators increased after antiparasitic drug treatment. A significant implication of these findings is that it may be possible to inhibit the inflammation around parasites using drugs or biologics that inhibit these inflammatory pathways and, thereby, reduce local brain damage during treatment. These observations may also be applicable to other inflammatory conditions that affect the brain.

Albendazole is an anthelmintic drug widely used in the treatment of neurocysticercosis (NCC), an infection of the brain with Taenia solium cysts. However, drug levels of its active metabolite, albendazole sulfoxide (ABZSO), are erratic, likely resulting in decreased efficacy and suboptimal cure rates in NCC. Racemic albendazole sulfoxide is composed of ABZSO (+)-( R )- and (−)-( S ) enantiomers that have been shown to differ in pharmacokinetics and activity against other helminths. The antiparasitic activities of racemic ABZSO and its (+)-( R )- and (−)-( S ) enantiomers against T. solium cysts were evaluated in vitro . Parasites were collected from naturally infected pigs, cultured, and exposed to the racemic mixture or to each enantiomer (range, 10 to 500 ng/ml) or to praziquantel as a reference drug. The activity of each compound against cysts was assayed by measuring the ability to evaginate and inhibition of alkaline phosphatase (AP) and parasite antigen release. (+)-( R )-ABZSO was significantly more active than (−)-( S )-ABZSO in suppressing the release of AP and antigen into the supernatant in a dose- and time-dependent manner, indicating that most of the activity of ABZSO resides in the (+)-( R ) enantiomer. Use of this enantiomer alone may lead to increased efficacy and/or less toxicity compared to albendazole.

Neurocysticercosis resulting from Taenia solium infections is a major cause of adult-acquired seizures worldwide. Disease is caused by larval cysts, and treatment consists of the anthelmintic drugs albendazole or praziquantel. There are no standard methods to assess drug activity to T. solium cysts in vitro . Morphological, functional, and biochemical changes that might reflect damaging (inhibiting, cytotoxic) drug effects were analyzed after exposure of cysts to albendazole sulfoxide (ABZ-SO), the major active metabolite of the drug in vivo , praziquantel (PZQ), or combinations of both. PZQ exposure led to a decrease in cyst size and inhibition of evagination, whereas ABZ-SO exposure resulted in minimal changes. Alkaline phosphatase (AP) is normally secreted by cysts, and both drugs inhibited AP secretion at concentrations of 5 and 50 ng/ml for PZQ and ABZ-SO, respectively. Some combinations of both drugs resulted in additive and/or synergistic activities. Parasite-specific antigen, detected in the cerebrospinal fluid and blood of infected patients, is also normally secreted by T. solium cysts. Antigen secretion was similarly inhibited by ABZ-SO and PZQ and a combination of both drugs, suggesting that inhibition of secretion is a common downstream consequence of the activities of both drugs. These studies establish quantitative methods to measure in vitro anthelmintic activity and suggest combination therapy with ABZ-SO and PZQ may have clinical benefit.

The effect of hesperetin, naringenin and its glycoside form on the Sindbis neurovirulent strain (NSV) replication in vitro was studied. All flavanones tested were not cytotoxic on Baby Hamster cells 21 clone 15 (BHK-21). Antiviral effect was evaluated by a colorimetric assay using MTT (3-(4,5 dimethylthiazol-2-yl)-2,5-dipheyl-tetrazolium bromide) and by plaque reduction assay. Hesperetin and naringenin had inhibitory activity on NSV infection. The 50% inhibitory doses (ID(50%)) of both compounds were 20.5 and 14.9 microg/ml respectively, as established by plaque assay. However their glycosides, hesperidin and naringin did not have inhibitory activity. Implying that the presence of rutinose moiety of flavanones blocks the antiviral effect. Oxygenation on the 3' positions at the B rings on the hesperetin skeleton decrease the anti viral activity at 25 microg/ml.

Neste artigo analiso a noção do alimentar dos camponeses do centro poblado El Tambo que se organizam para vigiar continuamente a lagoa Mamacocha que está localizada na região do Conga, onde será instalado um projeto de mineração a céu aberto com o mesmo nome. A partir de pesquisa de abordagem etnográfica entre 2013 e 2014, observei que a relacionalidade dos camponeses com a lagoa Mamacocha é ativada pela realidade da experiência vivida com a água, mas que é coproduzida com histórias orais e com encontros com ambientalistas. O alimentar é a palavra que emerge nos meus diálogos com os camponeses onde se torna visível uma cadeia complexa de eventos que leva a uma firme oposição contra o projeto de mineração Conga. Ao mesmo tempo, um novo e dinâmico território se torna visível onde Mamacocha tem um papel fundamental e é por isso que os camponeses estendem o seu papel para com a comunidade como Guardiões das Lagoas.