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1. Synthesis, characterization, antioxidant potential, and cytotoxicity screening of new Cu(II) complexes with 4-(arylchalcogenyl)-1H-pyrazoles ligands

Author

Adriana C. Pinheiro, Franciele F. Busatto, Bruna T. Schaefer, Paula P. Tomasini, Ianka J. Nunes, Tamara Dos S. Machado, Roberta Cargnelutti, Thalita F.B. de Aquino, Kethlin De Q. Ferreira, Angela M. Casaril, Raquel G. Jacob, Lucielli Savegnago, Daniela Hartwig, and Jenifer Saffi

Subjects
Inorganic Chemistry, Selenium, Coordination Complexes, Humans, Pyrazoles, Ligands, Biochemistry, Antioxidants, Copper, Sulfur
Abstract

Two new Cu(II) complexes based on 4-(arylchalcogenyl)-1H-pyrazoles monodentate bis(ligand) containing selenium or sulfur groups (2a and 2b) have been synthesized and characterized by IR spectroscopy, high-resolution mass spectrometry (HRMS), and by X-ray crystallography. In the effort to propose new applications for the biomedical area, we evaluated the antioxidant activity and cytotoxicity of the newly synthesized complexes. The antioxidant activity of the Cu(II) complexes (2a - 2b) were assessed through their ability to inhibit the formation of reactive species (RS) induced by sodium azide and to scavenge the synthetic radicals 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS

Published
2022
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