1. Does positron emission tomography/computed tomography change management in colorectal cancer?
- Author
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Adrian Balasingam, Rachel Falconer, Saxon Connor, and Tim Eglinton
- Subjects
medicine.medical_specialty ,Colorectal cancer ,030218 nuclear medicine & medical imaging ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Carcinoembryonic antigen ,Randomized controlled trial ,law ,medicine ,Recurrent Colorectal Cancer ,Positron Emission Tomography-Computed Tomography ,Lung ,medicine.diagnostic_test ,biology ,business.industry ,Retrospective cohort study ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,Positron emission tomography ,030220 oncology & carcinogenesis ,biology.protein ,Surgery ,Radiology ,business - Abstract
BACKGROUND Positron emission tomography/computed tomography (PET/CT) is used pre-operatively in patients with metastatic or recurrent colorectal cancer to identify those who have potentially curative disease. However, a recent randomized trial questioned the added benefit of PET/CT over conventional imaging in patients with liver metastases. The aim of this study was to determine the proportion of patients with colorectal cancer in whom PET/CT altered surgical management, in a single tertiary centre. METHODS This was a retrospective study of all patients with colorectal cancer who had a PET/CT for colorectal cancer, funded by the Canterbury District Health Board between 2010 and 2014. RESULTS Some 111 PET/CT scans were performed on 105 patients. A total of 38% of PET/CT were for patients with known or suspected liver metastases, 23% for suspected local recurrence and 18% for known or suspected lung metastases. Five scans were for post-operative patients with a rising carcinoembryonic antigen and no attributable source on conventional imaging. PET/CT identified additional extrahepatic sites of disease in 19 of 111 (17%) scans in patients deemed to have potentially operable disease. Overall, PET/CT altered surgical management following six of 42 (14%) scans for patients with liver metastases, four of 20 (20%) scans for patients with lung metastases and six of 26 (23%) scans for patients with local recurrence. CONCLUSION PET/CT remains a useful adjunct to conventional imaging in the pre-operative workup of patients with colorectal cancer.
- Published
- 2016
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