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2. Evaluation of the interest to combine a CD4 Th1-inducer cancer vaccine derived from telomerase and atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma: a randomized non-comparative phase II study (TERTIO – PRODIGE 82)

Author

Vienot, Angélique, Jacquin, Marion, Rebucci-Peixoto, Magali, Pureur, Dimitri, Ghiringhelli, François, Assenat, Eric, Hammel, Pascal, Rosmorduc, Olivier, Stouvenot, Morgane, Allaire, Manon, Bouattour, Mohamed, Regnault, Hélène, Fratte, Serge, Raymond, Eric, Soularue, Emilie, Husson-Wetzel, Stéphanie, Di Martino, Vincent, Muller, Allison, Clairet, Anne-Laure, Fagnoni-Legat, Christine, Adotevi, Olivier, Meurisse, Aurélia, Vernerey, Dewi, and Borg, Christophe

Published
2023
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3. First-line durvalumab and tremelimumab with chemotherapy in RAS-mutated metastatic colorectal cancer: a phase 1b/2 trial

Author

Thibaudin, Marion, Fumet, Jean-David, Chibaudel, Benoist, Bennouna, Jaafar, Borg, Christophe, Martin-Babau, Jerome, Cohen, Romain, Fonck, Marianne, Taieb, Julien, Limagne, Emeric, Blanc, Julie, Ballot, Elise, Hampe, Léa, Bon, Marjorie, Daumoine, Susy, Peroz, Morgane, Mananet, Hugo, Derangère, Valentin, Boidot, Romain, Michaud, Henri-Alexandre, Laheurte, Caroline, Adotevi, Olivier, Bertaut, Aurélie, Truntzer, Caroline, and Ghiringhelli, François

Published
2023
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8. Feasibility of health-related quality of life (HRQoL) assessment for cancer patients using electronic patient-reported outcome (ePRO) in daily clinical practice

Author

Mouillet, Guillaume, Falcoz, Antoine, Fritzsch, Joëlle, Almotlak, Hamadi, Jacoulet, Pascale, Pivot, Xavier, Villanueva, Cristian, Mansi, Laura, Kim, Stefano, Curtit, Elsa, Meneveau, Nathalie, Adotevi, Olivier, Jary, Marine, Eberst, Guillaume, Vienot, Angelique, Calcagno, Fabien, Pozet, Astrid, Djoumakh, Oumelkheir, Borg, Christophe, Westeel, Virginie, Anota, Amélie, and Paget-Bailly, Sophie

Published
2021
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9. Transcriptomic and genomic heterogeneity in blastic plasmacytoid dendritic cell neoplasms: from ontogeny to oncogenesis

Author

Renosi, Florian, Roggy, Anne, Giguelay, Ambre, Soret, Lou, Viailly, Pierre-Julien, Cheok, Meyling, Biichle, Sabeha, Angelot-Delettre, Fanny, Asnafi, Vahid, Macintyre, Elizabeth, Geffroy, Sandrine, Callanan, Mary, Petrella, Tony, Deconinck, Eric, Daguindau, Etienne, Harrivel, Véronique, Bouyer, Sabrina, Salaun, Véronique, Saussoy, Pascale, Feuillard, Jean, Fuseau, Pascal, Saas, Philippe, Adotévi, Olivier, Jardin, Fabrice, Ferrand, Christophe, Preudhomme, Claude, Colinge, Jacques, Roumier, Christophe, and Garnache-Ottou, Francine

Published
2021
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11. How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients?

Author

Garnache-Ottou, Francine, Vidal, Chrystelle, Biichlé, Sabeha, Renosi, Florian, Poret, Eve, Pagadoy, Maïder, Desmarets, Maxime, Roggy, Anne, Seilles, Estelle, Soret, Lou, Schillinger, Françoise, Puyraimond, Sandrine, Petrella, Tony, Preudhomme, Claude, Roumier, Christophe, MacIntyre, Elisabeth A., Harrivel, Véronique, Desbrosses, Yohan, Gruson, Bérengère, Geneviève, Franck, Thepot, Sylvain, Drebit, Yuriy, Leguay, Thibaut, Gros, François-Xavier, Lechevalier, Nicolas, Saussoy, Pascale, Salaun, Véronique, Cornet, Edouard, Benseddik, Zehaira, Veyrat-Masson, Richard, Wagner-Ballon, Orianne, Salanoubat, Célia, Maynadié, Marc, Guy, Julien, Caillot, Denis, Jacob, Marie-Christine, Cahn, Jean-Yves, Gressin, Rémy, Rose, Johann, Quesnel, Bruno, Guerin, Estelle, Trimoreau, Franck, Feuillard, Jean, Gourin, Marie-Pierre, Plesa, Adriana, Baseggio, Lucile, Arnoux, Isabelle, Vey, Norbert, Blaise, Didier, Lacroix, Romaric, Arnoulet, Christine, Benet, Blandine, Dorvaux, Véronique, Bret, Caroline, Drenou, Bernard, Debliquis, Agathe, Latger-Cannard, Véronique, Bonmati, Caroline, Bene, Marie-Christine, Peterlin, Pierre, Ticchioni, Michel, Rohrlich, Pierre-Simon, Arnaud, Anne, Wickenhauser, Stefan, Bardet, Valérie, Brechignac, Sabine, Papoular, Benjamin, Raggueneau, Victoria, Vargaftig, Jacques, Letestu, Rémi, Lusina, Daniel, Braun, Thorsten, Foissaud, Vincent, Tamburini, Jérôme, Bennani, Hind, Freynet, Nicolas, Cordonnier, Catherine, Le Garff-Tavernier, Magali, Jacques, Nathalie, Maloum, Karim, Roos-Weil, Damien, Bouscary, Didier, Asnafi, Vahid, Lhermitte, Ludovic, Suarez, Felipe, Lengline, Etienne, Féger, Frédéric, Battipaglia, Giorgia, Mohty, Mohamad, Bouyer, Sabrina, Ghoual, Ouda, Dindinaud, Elodie, Basle, Caroline, Puyade, Mathieu, Lafon, Carinne, Fest, Thierry, Roussel, Mikael, Cahu, Xavier, Bera, Elsa, Daliphard, Sylvie, Jardin, Fabrice, Campos, Lydia, Solly, Françoise, Guyotat, Denis, Galoisy, Anne-Cécile, Eischen, Alice, Mayeur-Rousse, Caroline, Guffroy, Blandine, Recher, Christian, Loosveld, Marie, Garnier, Alice, Barlogis, Vincent, Rosenthal, Maria Alessandra, Brun, Sophie, Contentin, Nathalie, Maury, Sébastien, Callanan, Mary, Lefebvre, Christine, Maillard, Natacha, Okamba, Patricia, Ferrand, Christophe, Adotevi, Olivier, Saas, Philippe, Angelot-Delettre, Fanny, Binda, Delphine, and Deconinck, Eric

Published
2019
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12. Weak immunogenicity of SARS-CoV-2 vaccine in patients with hematologic malignancies

Author

Malard, Florent, Gaugler, Béatrice, Gozlan, Joel, Bouquet, Lucie, Fofana, Djeneba, Siblany, Lama, Eshagh, Deborah, Adotevi, Olivier, Laheurte, Caroline, Ricard, Laure, Dulery, Rémy, Stocker, Nicolas, van de Wyngaert, Zoe, Genthon, Alexis, Banet, Anne, Memoli, Mara, Ikhlef, Souhila, Sestilli, Simona, Vekhof, Anne, Brissot, Eolia, Marjanovic, Zora, Chantran, Yannick, Cuervo, Nancy, Ballot, Eric, Morand-Joubert, Laurence, and Mohty, Mohamad

Published
2021
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13. L29-3 CAR CD123 : exemple d’un CAR-T académique

Author

Fredon, Maxime, primary, Bole Richard, Elodie, additional, Frederic Mantion, Charles, additional, Biichle, Sabeha, additional, Bonnefoy, Francis, additional, Godet, Yann, additional, Adotevi, Olivier, additional, Delettre, Fanny, additional, Galaine, Jeanne, additional, and Garnache Ottou, Francine, additional

Published
2023
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17. Supplementary Data from Plasma CD27, a Surrogate of the Intratumoral CD27–CD70 Interaction, Correlates with Immunotherapy Resistance in Renal Cell Carcinoma

Author

Benhamouda, Nadine, primary, Sam, Ikuan, primary, Epaillard, Nicolas, primary, Gey, Alain, primary, Phan, Letuan, primary, Pham, Hang Phuong, primary, Gruel, Nadège, primary, Saldmann, Antonin, primary, Pineau, Joséphine, primary, Hasan, Milena, primary, Quiniou, Valentin, primary, Nevoret, Camille, primary, Verkarre, Virginie, primary, Libri, Valentina, primary, Mella, Sebastien, primary, Granier, Clémence, primary, Broudin, Chloe, primary, Ravel, Patrice, primary, De Guillebon, Eléonore, primary, Mauge, Laetitia, primary, Helley, Dominique, primary, Jabla, Bernd, primary, Chaput, Nathalie, primary, Albiges, Laurence, primary, Katsahian, Sandrine, primary, Adam, Julien, primary, Mejean, Arnaud, primary, Adotevi, Olivier, primary, Vano, Yann A., primary, Oudard, Stéphane, primary, and Tartour, Eric, primary

Published
2023
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18. Supplementary Figure from Plasma CD27, a Surrogate of the Intratumoral CD27–CD70 Interaction, Correlates with Immunotherapy Resistance in Renal Cell Carcinoma

Author

Benhamouda, Nadine, primary, Sam, Ikuan, primary, Epaillard, Nicolas, primary, Gey, Alain, primary, Phan, Letuan, primary, Pham, Hang Phuong, primary, Gruel, Nadège, primary, Saldmann, Antonin, primary, Pineau, Joséphine, primary, Hasan, Milena, primary, Quiniou, Valentin, primary, Nevoret, Camille, primary, Verkarre, Virginie, primary, Libri, Valentina, primary, Mella, Sebastien, primary, Granier, Clémence, primary, Broudin, Chloe, primary, Ravel, Patrice, primary, De Guillebon, Eléonore, primary, Mauge, Laetitia, primary, Helley, Dominique, primary, Jabla, Bernd, primary, Chaput, Nathalie, primary, Albiges, Laurence, primary, Katsahian, Sandrine, primary, Adam, Julien, primary, Mejean, Arnaud, primary, Adotevi, Olivier, primary, Vano, Yann A., primary, Oudard, Stéphane, primary, and Tartour, Eric, primary

Published
2023
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19. Data from CML Hematopoietic Stem Cells Expressing IL1RAP Can Be Targeted by Chimeric Antigen Receptor–Engineered T Cells

Author

Warda, Walid, primary, Larosa, Fabrice, primary, Neto Da Rocha, Mathieu, primary, Trad, Rim, primary, Deconinck, Eric, primary, Fajloun, Ziad, primary, Faure, Cyril, primary, Caillot, Denis, primary, Moldovan, Marius, primary, Valmary-Degano, Severine, primary, Biichle, Sabeha, primary, Daguindau, Etienne, primary, Garnache-Ottou, Francine, primary, Tabruyn, Sebastien, primary, Adotevi, Olivier, primary, Deschamps, Marina, primary, and Ferrand, Christophe, primary

Published
2023
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20. Supplementary Table 1 from A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors

Author

Teixeira, Luis, primary, Medioni, Jacques, primary, Garibal, Julie, primary, Adotevi, Olivier, primary, Doucet, Ludovic, primary, Durey, Marie-Agnès Dragon, primary, Ghrieb, Zineb, primary, Kiladjian, Jean-Jacques, primary, Brizard, Mara, primary, Laheurte, Caroline, primary, Wehbe, Maria, primary, Pliquet, Elodie, primary, Escande, Marie, primary, Defrance, Rémy, primary, Culine, Stephane, primary, Oudard, Stephane, primary, Wain-Hobson, Simon, primary, Doppler, Valérie, primary, Huet, Thierry, primary, and Langlade-Demoyen, Pierre, primary

Published
2023
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21. Supplementary Figure 2 from A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors

Author

Teixeira, Luis, primary, Medioni, Jacques, primary, Garibal, Julie, primary, Adotevi, Olivier, primary, Doucet, Ludovic, primary, Durey, Marie-Agnès Dragon, primary, Ghrieb, Zineb, primary, Kiladjian, Jean-Jacques, primary, Brizard, Mara, primary, Laheurte, Caroline, primary, Wehbe, Maria, primary, Pliquet, Elodie, primary, Escande, Marie, primary, Defrance, Rémy, primary, Culine, Stephane, primary, Oudard, Stephane, primary, Wain-Hobson, Simon, primary, Doppler, Valérie, primary, Huet, Thierry, primary, and Langlade-Demoyen, Pierre, primary

Published
2023
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22. Supplementary Data from CML Hematopoietic Stem Cells Expressing IL1RAP Can Be Targeted by Chimeric Antigen Receptor–Engineered T Cells

Author

Warda, Walid, primary, Larosa, Fabrice, primary, Neto Da Rocha, Mathieu, primary, Trad, Rim, primary, Deconinck, Eric, primary, Fajloun, Ziad, primary, Faure, Cyril, primary, Caillot, Denis, primary, Moldovan, Marius, primary, Valmary-Degano, Severine, primary, Biichle, Sabeha, primary, Daguindau, Etienne, primary, Garnache-Ottou, Francine, primary, Tabruyn, Sebastien, primary, Adotevi, Olivier, primary, Deschamps, Marina, primary, and Ferrand, Christophe, primary

Published
2023
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23. Supplementary Figure 1 from A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors

Author

Teixeira, Luis, primary, Medioni, Jacques, primary, Garibal, Julie, primary, Adotevi, Olivier, primary, Doucet, Ludovic, primary, Durey, Marie-Agnès Dragon, primary, Ghrieb, Zineb, primary, Kiladjian, Jean-Jacques, primary, Brizard, Mara, primary, Laheurte, Caroline, primary, Wehbe, Maria, primary, Pliquet, Elodie, primary, Escande, Marie, primary, Defrance, Rémy, primary, Culine, Stephane, primary, Oudard, Stephane, primary, Wain-Hobson, Simon, primary, Doppler, Valérie, primary, Huet, Thierry, primary, and Langlade-Demoyen, Pierre, primary

Published
2023
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24. Supplementary Table 5 from A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors

Author

Teixeira, Luis, primary, Medioni, Jacques, primary, Garibal, Julie, primary, Adotevi, Olivier, primary, Doucet, Ludovic, primary, Durey, Marie-Agnès Dragon, primary, Ghrieb, Zineb, primary, Kiladjian, Jean-Jacques, primary, Brizard, Mara, primary, Laheurte, Caroline, primary, Wehbe, Maria, primary, Pliquet, Elodie, primary, Escande, Marie, primary, Defrance, Rémy, primary, Culine, Stephane, primary, Oudard, Stephane, primary, Wain-Hobson, Simon, primary, Doppler, Valérie, primary, Huet, Thierry, primary, and Langlade-Demoyen, Pierre, primary

Published
2023
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25. Supplementary Data. Figure Legends S1-S12 & Tables S1-S4 from CML Hematopoietic Stem Cells Expressing IL1RAP Can Be Targeted by Chimeric Antigen Receptor–Engineered T Cells

Author

Warda, Walid, primary, Larosa, Fabrice, primary, Neto Da Rocha, Mathieu, primary, Trad, Rim, primary, Deconinck, Eric, primary, Fajloun, Ziad, primary, Faure, Cyril, primary, Caillot, Denis, primary, Moldovan, Marius, primary, Valmary-Degano, Severine, primary, Biichle, Sabeha, primary, Daguindau, Etienne, primary, Garnache-Ottou, Francine, primary, Tabruyn, Sebastien, primary, Adotevi, Olivier, primary, Deschamps, Marina, primary, and Ferrand, Christophe, primary

Published
2023
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26. Supplementary Table 4 from A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors

Author

Teixeira, Luis, primary, Medioni, Jacques, primary, Garibal, Julie, primary, Adotevi, Olivier, primary, Doucet, Ludovic, primary, Durey, Marie-Agnès Dragon, primary, Ghrieb, Zineb, primary, Kiladjian, Jean-Jacques, primary, Brizard, Mara, primary, Laheurte, Caroline, primary, Wehbe, Maria, primary, Pliquet, Elodie, primary, Escande, Marie, primary, Defrance, Rémy, primary, Culine, Stephane, primary, Oudard, Stephane, primary, Wain-Hobson, Simon, primary, Doppler, Valérie, primary, Huet, Thierry, primary, and Langlade-Demoyen, Pierre, primary

Published
2023
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27. Supplementary Table 2 from A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors

Author

Teixeira, Luis, primary, Medioni, Jacques, primary, Garibal, Julie, primary, Adotevi, Olivier, primary, Doucet, Ludovic, primary, Durey, Marie-Agnès Dragon, primary, Ghrieb, Zineb, primary, Kiladjian, Jean-Jacques, primary, Brizard, Mara, primary, Laheurte, Caroline, primary, Wehbe, Maria, primary, Pliquet, Elodie, primary, Escande, Marie, primary, Defrance, Rémy, primary, Culine, Stephane, primary, Oudard, Stephane, primary, Wain-Hobson, Simon, primary, Doppler, Valérie, primary, Huet, Thierry, primary, and Langlade-Demoyen, Pierre, primary

Published
2023
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28. Supplementary Figure 3 from A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors

Author

Teixeira, Luis, primary, Medioni, Jacques, primary, Garibal, Julie, primary, Adotevi, Olivier, primary, Doucet, Ludovic, primary, Durey, Marie-Agnès Dragon, primary, Ghrieb, Zineb, primary, Kiladjian, Jean-Jacques, primary, Brizard, Mara, primary, Laheurte, Caroline, primary, Wehbe, Maria, primary, Pliquet, Elodie, primary, Escande, Marie, primary, Defrance, Rémy, primary, Culine, Stephane, primary, Oudard, Stephane, primary, Wain-Hobson, Simon, primary, Doppler, Valérie, primary, Huet, Thierry, primary, and Langlade-Demoyen, Pierre, primary

Published
2023
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29. Supplementary Table 3 from A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors

Author

Teixeira, Luis, primary, Medioni, Jacques, primary, Garibal, Julie, primary, Adotevi, Olivier, primary, Doucet, Ludovic, primary, Durey, Marie-Agnès Dragon, primary, Ghrieb, Zineb, primary, Kiladjian, Jean-Jacques, primary, Brizard, Mara, primary, Laheurte, Caroline, primary, Wehbe, Maria, primary, Pliquet, Elodie, primary, Escande, Marie, primary, Defrance, Rémy, primary, Culine, Stephane, primary, Oudard, Stephane, primary, Wain-Hobson, Simon, primary, Doppler, Valérie, primary, Huet, Thierry, primary, and Langlade-Demoyen, Pierre, primary

Published
2023
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30. Supplementary Methods, Table 1 from Prognostic Value of Angiopoietin-2 for Death Risk Stratification in Patients with Metastatic Colorectal Carcinoma

Author

Jary, Marine, primary, Vernerey, Dewi, primary, Lecomte, Thierry, primary, Dobi, Erion, primary, Ghiringhelli, François, primary, Monnien, Franck, primary, Godet, Yann, primary, Kim, Stefano, primary, Bouché, Olivier, primary, Fratte, Serge, primary, Gonçalves, Anthony, primary, Leger, Julie, primary, Queiroz, Lise, primary, Adotevi, Olivier, primary, Bonnetain, Franck, primary, and Borg, Christophe, primary

Published
2023
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31. Data not shown from A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors

Author

Teixeira, Luis, primary, Medioni, Jacques, primary, Garibal, Julie, primary, Adotevi, Olivier, primary, Doucet, Ludovic, primary, Durey, Marie-Agnès Dragon, primary, Ghrieb, Zineb, primary, Kiladjian, Jean-Jacques, primary, Brizard, Mara, primary, Laheurte, Caroline, primary, Wehbe, Maria, primary, Pliquet, Elodie, primary, Escande, Marie, primary, Defrance, Rémy, primary, Culine, Stephane, primary, Oudard, Stephane, primary, Wain-Hobson, Simon, primary, Doppler, Valérie, primary, Huet, Thierry, primary, and Langlade-Demoyen, Pierre, primary

Published
2023
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32. Supplementary data (Figures S1 to S12) from CML Hematopoietic Stem Cells Expressing IL1RAP Can Be Targeted by Chimeric Antigen Receptor–Engineered T Cells

Author

Warda, Walid, primary, Larosa, Fabrice, primary, Neto Da Rocha, Mathieu, primary, Trad, Rim, primary, Deconinck, Eric, primary, Fajloun, Ziad, primary, Faure, Cyril, primary, Caillot, Denis, primary, Moldovan, Marius, primary, Valmary-Degano, Severine, primary, Biichle, Sabeha, primary, Daguindau, Etienne, primary, Garnache-Ottou, Francine, primary, Tabruyn, Sebastien, primary, Adotevi, Olivier, primary, Deschamps, Marina, primary, and Ferrand, Christophe, primary

Published
2023
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34. TREM1+regulatory myeloid cells expand in steatohepatitis-HCC and associate with poor prognosis and therapeutic resistance to immune checkpoint blockade

Author

Giraud, Julie, primary, Chalopin, Domitille, additional, Ramel, Eloïse, additional, Boyer, Thomas, additional, Zouine, Atika, additional, Derieppe, Marie-Alix, additional, Larmonier, Nicolas, additional, Adotevi, Olivier, additional, Bail, Brigitte Le, additional, Blanc, Jean-Frédéric, additional, Chiche, Laurence, additional, Nikolski, Macha, additional, and Saleh, Maya, additional

Published
2022
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35. Plasma CD27, a Surrogate of the Intratumoral CD27–CD70 Interaction, Correlates with Immunotherapy Resistance in Renal Cell Carcinoma

Author

Benhamouda, Nadine, primary, Sam, Ikuan, additional, Epaillard, Nicolas, additional, Gey, Alain, additional, Phan, Letuan, additional, Pham, Hang Phuong, additional, Gruel, Nadège, additional, Saldmann, Antonin, additional, Pineau, Joséphine, additional, Hasan, Milena, additional, Quiniou, Valentin, additional, Nevoret, Camille, additional, Verkarre, Virginie, additional, Libri, Valentina, additional, Mella, Sebastien, additional, Granier, Clémence, additional, Broudin, Chloe, additional, Ravel, Patrice, additional, De Guillebon, Eléonore, additional, Mauge, Laetitia, additional, Helley, Dominique, additional, Jabla, Bernd, additional, Chaput, Nathalie, additional, Albiges, Laurence, additional, Katsahian, Sandrine, additional, Adam, Julien, additional, Mejean, Arnaud, additional, Adotevi, Olivier, additional, Vano, Yann A., additional, Oudard, Stéphane, additional, and Tartour, Eric, additional

Published
2022
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39. Interplay between plasmacytoid dendritic cells and tumor-specific T cells in peripheral blood influences long-term survival in non-small cell lung carcinoma

Author

Laheurte, Caroline, primary, Seffar, Evan, additional, Gravelin, Eléonore, additional, Lecuelle, Julie, additional, Renaudin, Adeline, additional, Boullerot, Laura, additional, Malfroy, Marine, additional, Marguier, Amélie, additional, Lecoester, Benoit, additional, Gaugler, Béatrice, additional, Saas, Philippe, additional, Truntzer, Caroline, additional, Ghiringhelli, Francois, additional, and Adotevi, Olivier, additional

Published
2022
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40. TIE-2 Signaling Activation by Angiopoietin 2 On Myeloid-Derived Suppressor Cells Promotes Melanoma-Specific T-cell Inhibition

Author

Marguier, Amélie, primary, Laheurte, Caroline, additional, Lecoester, Benoît, additional, Malfroy, Marine, additional, Boullerot, Laura, additional, Renaudin, Adeline, additional, Seffar, Evan, additional, Kumar, Abhishek, additional, Nardin, Charlée, additional, Aubin, François, additional, and Adotevi, Olivier, additional

Published
2022
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41. A Phase II Study Evaluating the Interest to Combine UCPVax, a Telomerase CD4 TH1-Inducer Cancer Vaccine, and Atezolizumab for the Treatment of HPV Positive Cancers: VolATIL Study

Author

Rebucci-Peixoto, Magali, primary, Vienot, Angélique, additional, Adotevi, Olivier, additional, Jacquin, Marion, additional, Ghiringhelli, Francois, additional, de la Fouchardière, Christelle, additional, You, Benoit, additional, Maurina, Tristan, additional, Kalbacher, Elsa, additional, Bazan, Fernando, additional, Meynard, Guillaume, additional, Clairet, Anne-Laure, additional, Fagnoni-Legat, Christine, additional, Spehner, Laurie, additional, Bouard, Adeline, additional, Vernerey, Dewi, additional, Meurisse, Aurélia, additional, Kim, Stefano, additional, Borg, Christophe, additional, and Mansi, Laura, additional

Published
2022
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42. Umbilical Cord Blood as a Source of Less Differentiated T Cells to Produce CD123 CAR-T Cells

Author

Caël, Blandine, primary, Galaine, Jeanne, additional, Bardey, Isabelle, additional, Marton, Chrystel, additional, Fredon, Maxime, additional, Biichle, Sabeha, additional, Poussard, Margaux, additional, Godet, Yann, additional, Angelot-Delettre, Fanny, additional, Barisien, Christophe, additional, Bésiers, Christophe, additional, Adotevi, Olivier, additional, Pouthier, Fabienne, additional, Garnache-Ottou, Francine, additional, and Bôle-Richard, Elodie, additional

Published
2022
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43. High-throughput preclinical screening of CD123 scFv to design 3rd generation of CAR T-cell in the treatment of BPDCN patient

Author

Fredon, Maxime, primary, Poussard, Margaux, additional, Biichle, Sabeha, additional, Bonnefoy, Francis, additional, Seffar, Evan, additional, Bôle-Richard, Elodie, additional, Renosi, Florian, additional, Boidot, Romain, additional, Anna, François, additional, Loustau, Maria, additional, Caumartin, Julien, additional, Saas, Philippe, additional, Deconinck, Eric, additional, Daguindeau, Etienne, additional, Roussel, Xavier, additional, Adotevi, Olivier, additional, Angelot-Delettre, Fanny, additional, Galaine, Jeanne, additional, and Garnache-Ottou, Francne, additional

Published
2022
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44. c‐Maf enforces cytokine production and promotes memory‐like responses in mouse and human type 2 innate lymphoid cells

Author

Trabanelli, Sara, primary, Ercolano, Giuseppe, additional, Wyss, Tania, additional, Gomez‐Cadena, Alejandra, additional, Falquet, Maryline, additional, Cropp, Daniela, additional, Imbratta, Claire, additional, Leblond, Marine M, additional, Salvestrini, Valentina, additional, Curti, Antonio, additional, Adotevi, Olivier, additional, Jandus, Camilla, additional, and Verdeil, Grégory, additional

Published
2022
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45. Human Monocyte-Derived Suppressor Cell Supernatant Induces Immunoregulatory Effects and Mitigates xenoGvHD

Author

Gérard, Claire, primary, Thébault, Marine, additional, Lamarthée, Baptiste, additional, Genet, Coraline, additional, Cattin, Florine, additional, Brazdova, Andréa, additional, Janikashvili, Nona, additional, Cladière, Claudie, additional, Ciudad, Marion, additional, Ouandji, Séthi, additional, Ghesquière, Thibault, additional, Greigert, Hélène, additional, Tinel, Claire, additional, Adotevi, Olivier, additional, Saas, Philippe, additional, Samson, Maxime, additional, Audia, Sylvain, additional, and Bonnotte, Bernard, additional

Published
2022
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46. A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens

Author

Pere, Helene, Montier, Yves, Bayry, Jagadeesh, Quintin-Colonna, Francoise, Merillon, Nathalie, Dransart, Estelle, Badoual, Cecile, Gey, Alain, Ravel, Patrice, Marcheteau, Elie, Batteux, Frederic, Sandoval, Federico, Adotevi, Olivier, Chiu, Christopher, Garcia, Sylvie, Tanchot, Corinne, Lone, Yu-Chun, Ferreira, Luis Carlos, Nelson, Brad H., Hanahan, Douglas, Fridman, Wolf Herman, Johannes, Ludger, and Tartour, Eric

Published
2011
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49. Chemoradiation triggers antitumor Th1 and tissue resident memory-polarized immune responses to improve immune checkpoint inhibitors therapy

Author

Lauret Marie Joseph, Elodie, Kirilovsky, Amos, Lecoester, Benoît, El Sissy, Carine, Boullerot, Laura, Rangan, Laurie, Marguier, Amélie, Tochet, Florent, Dosset, Magalie, Boustani, Jihane, Ravel, Patrice, Boidot, Romain, Spehner, Laurie, Haicheur-Adjouri, Nacilla, Marliot, Florence, Pallandre, Jean-René, Bonnefoy, Francis, Scripcariu, Viorel, Van den Eynde, Marc, Cornillot, Emmanuel, Mirjolet, Céline, Pages, Franck, Adotevi, Olivier, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de gastro-entérologie, and UCL - (SLuc) Unité d'oncologie médicale

Subjects
Cancer Research, Immunology, Mice, Tumor Microenvironment, Immunology and Allergy, Animals, Humans, Immune Checkpoint Inhibitors, radiotherapy, RC254-282, Pharmacology, combination, Immunity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Basic Tumor Immunology, adaptive immunity, Chemoradiotherapy, Th1 Cells, drug therapy, Disease Models, Animal, Oncology, Molecular Medicine, Female, Immunotherapy
Abstract

BACKGROUND: Multiple synergistic combination approaches with cancer drugs are developed to overcome primary resistance to immunotherapy; however, the mechanistic rationale to combine chemoradiotherapy (CRT) with immune checkpoint inhibitors remains elusive. METHODS: This study described the immunological landscape of tumor microenvironment (TME) exposed to CRT. Tumor samples from patients with rectal cancer (n=43) treated with neoadjuvant CRT or radiotherapy were analyzed by nanostring and immunohistochemistry. Studies in mice were performed using three syngeneic tumors (TC1, CT26 and MC38). Tumor-bearing mice were treated either with platinum-based CRT, radiotherapy or chemotherapy. Anti-CTLA-4 and/or anti-Programmed Cell Death Receptor-1 (PD-1) therapy was used in combination with CRT. The therapy-exposed TME was screened by RNA sequencing and flow cytometry and tumor-infiltrating T lymphocyte functionality was evaluated by interferon (IFN)-γ ELIspot and intracellular cytokine staining. RESULTS: Front-to-front comparison analysis revealed the synergistic effect of CRT to establish a highly inflamed and Th1-polarized immune signature in the TME of patients and mice. In both settings, CRT-exposed TMEs were highly enriched in newly-infiltrated tumor-specific CD8+ T cells as well as tissue resident memory CD103+CD8+ T cells. In mice, CD8 T cells were involved in the antitumor response mediated by CRT and were primed by CRT-activated CD103+ dendritic cells. In the three tumor models, we showed that concurrent combination of CRT with a dual CTLA-4 and PD-1 blockade was required to achieve an optimal antitumor effect and to establish a broad and long-lasting protective antitumor T cell immunity. CONCLUSIONS: Our results highlight the ability of CRT to stimulate strong antitumor T-cell-mediated immunity and tissue resident memory T activation in TME, to foster immune checkpoint inhibitors action. These findings have implications in clinic for the design clinical trials combining chemoradiation with immunotherapy.

Published
2021

50. 346 Translational program of the phase II MEDITREME trial: identification of prognostic factors for response to durvalumab and tremelimumab in combination with FOLFOX in metastatic colorectal cancer

Author

Thibaudin, Marion, primary, Ballot, Elise, additional, Limagne, Emeric, additional, Laheurte, Caroline, additional, Fumet, Jean-David, additional, Truntzer, Caroline, additional, Adotevi, Olivier, additional, and Ghiringhelli, François, additional

Published
2021
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