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La osteonecrosis de los maxilares es un serio efecto adverso asociado a medicamentos antirresortivos especialmente en pacientes con osteoporosis y neoplasias malignas. En este manuscrito, presentamos un caso clínico de una mujer caucásica de 56 años, con antecedentes de osteoporosis, medicada con bisfosfonatos, que cursó con osteonecrosis del maxilar inferior en relación con un implante dental. El tratamiento se basó fundamentalmente en la administración de terapia antibiótica, enjuagues bucales antibacterianos y en el tratamiento periodontal. El objetivo de ésta presentación fue comunicar un caso de osteonecrosis de la mandíbula alrededor de un implante dental relacionado con el uso de ácido ibandrónico tratado con éxito mediante un tratamiento conservador que incluía la aplicación local de minociclina.

Objective: There is limited evidence suggesting a link between posttraumatic stress disorder (PTSD) and Attention-Deficit/Hyperactivity Disorder (ADHD). This study examined the association between PTSD and ADHD using retrospective and current clinical evaluations. Method: Twenty-five male veterans with PTSD and 22 male veterans with panic disorder were evaluated for ADHD. The data was analyzed using chi-square and student's t-tests. Results: Thirty-six percent of participants with PTSD and 9% of participants with panic disorder met criteria for childhood ADHD. Twenty-eight percent of participants with PTSD and 5% of participants with panic disorder met criteria for current ADHD. Conclusions: There appears to be a significant association of PTSD with ADHD. ADHD or common predisposing factors may increase the vulnerability for developing PTSD. (Contains 2 tables.)

The ability of a mother to produce a nutritionally complete neonatal food source has provided a powerful evolutionary advantage to mammals. Milk production by mammary epithelial cells is adaptive, its release is exquisitely timed, and its own glandular stagnation with the permanent cessation of suckling triggers the cell death and tissue remodeling that enables female mammals to nurse successive progeny. Chemical and mechanical signals both play a role in this process. However, despite this duality of input, much remains unknown about the nature and function of mechanical forces in this organ. Here, we characterize the force landscape in the functionally mature gland and the capacity of luminal and basal cells to experience and exert force. We explore molecular instruments for force-sensing, in particular channel-mediated mechanotransduction, revealing increased expression of Piezo1 in mammary tissue in lactation and confirming functional expression in luminal cells. We also reveal, however, that lactation and involution proceed normally in mice with luminal-specific Piezo1 deletion. These findings support a multifaceted system of chemical and mechanical sensing in the mammary gland, and a protective redundancy that ensures continued lactational competence and offspring survival. [ABSTRACT FROM AUTHOR]