1. In vitro and in silico studies of antibacterial activities of secofriedelane derivatives from Senna alata (L) Roxb.
- Author
-
Chimi, Simplice F., Ewonkem, Monique B., Tiakouang, Eunice N., Moto, Jean O., Adjieufack, Abel I., Deussom, Pascaline M., Mbock, Michel A., Wansi, Duplex J., and Toze, Alfred F. A.
- Subjects
DNA topoisomerase II ,MOLECULAR docking ,METHYL groups ,ANTIBACTERIAL agents ,CHEMICAL structure - Abstract
In this study, six compounds were obtained from a methanolic extract of air-dried leaves of Senna alata and one of them, a triterpenoid (secofriedelane) named as 7-(2-carboxyethyl)-3, 4b, 6a, 8, 10a, 12a-hexamethyl-8-vinyloctadecahydrochrysene-3-carboxylic acid (5) was isolated for the first time from this plant. Then, its chemical structure was detailed and characterised by FT-IR,
1 H and13 C- NMR and ESI-MS. Besides, two chemical-modified derivatives of secofriedelane (5a, 5b) were synthesised by methylation and allylation reactions, respectively, and their in vitro antibacterial activities were also evaluated. The results revealed that all the triterpenes showed, against gram-positive and -negative bacterial strains, good and moderate antibacterial activities with bactericidal effects that were enhanced by the methyl groups and altered with the allyl ones. Moreover, the molecular docking results of 5, 5a and 5b in the DNA gyrase (2XCT) active site showed that triterpene 5 has a good score very close to reference (ciprofloxacin). [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF