1. Stress ulcer prophylaxis versus placebo—a blinded randomized control trial to evaluate the safety of two strategies in critically ill infants with congenital heart disease (SUPPRESS-CHD)
- Author
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Kimberly I. Mills, Ben D. Albert, Lori J. Bechard, Christopher P. Duggan, Aditya Kaza, Seth Rakoff-Nahoum, Hera Vlamakis, Lynn A. Sleeper, Jane W. Newburger, Gregory P. Priebe, and Nilesh M. Mehta
- Subjects
Pediatric critical care ,Pediatric cardiac critical care ,Pediatric intensive care ,H2 blocker ,Congenital heart disease ,Gastrointestinal hemorrhage ,Medicine (General) ,R5-920 - Abstract
Abstract Background Critically ill infants with congenital heart disease (CHD) are often prescribed stress ulcer prophylaxis (SUP) to prevent upper gastrointestinal bleeding, despite the low incidence of stress ulcers and limited data on the safety and efficacy of SUP in infants. Recently, SUP has been associated with an increased incidence of hospital-acquired infections, community-acquired pneumonia, and necrotizing enterocolitis. The objective of this pilot study is to investigate the feasibility of performing a randomized controlled trial to assess the safety and efficacy of withholding SUP in infants with congenital heart disease admitted to the cardiac intensive care unit. Methods A single center, prospective, double-blinded, randomized placebo-controlled pilot feasibility trial will be performed in infants with CHD admitted to the cardiac intensive care unit and anticipated to require respiratory support for > 24 h. Patients will be randomized to receive a histamine-2 receptor antagonist (H2RA) or placebo until they are discontinued from respiratory support. Randomization will be performed within 2 strata defined by admission type (medical or surgical) and age (neonate, age
- Published
- 2020
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