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This study investigates factors contributing to the injury severity of truck-involved work zones crashes in South Carolina (SC). The outcome of interest is injury or property damage only crashes, and the explanatory factors examined include the occupant, vehicle, collision, roadway, temporal, and environmental characteristics. Two mixed (random parameter) logit models are developed, one for non-interstates with speed limits less than 60 miles per hour (mph) and one for interstates with speed limits greater than or equal to 60 mph, using South Carolina statewide truck-involved work zone crash data from 2014 to 2020. Results of log-likelihood ratio tests indicate that separate speed models are warranted. The factors that were found to contribute to injury at the 90% confidence level in both models (interstate and non-interstate) are (1) dark lighting conditions, (2) female (at-fault) drivers, and (3) driving too fast for roadway conditions. Significant factors that apply only to non-interstates are SC or US primary roadways, activity area of the work zone, at-fault drivers under 35, sideswipe collision, presence of workers in the work zone, and collision with fixed objects. Significant factors that apply only to interstates are three or more vehicles, rear-end collision, location before the first work zone sign, and weekdays.