1. CSF neuroinflammatory biomarkers in bipolar disorder are associated with cognitive impairment
- Author
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Erik Pålsson, Joel Jakobsson, Sindre Rolstad, Carl Johan Ekman, Mikael Landén, Henrik Zetterberg, Anniella Isgren, Kaj Blennow, Maria Bjerke, Carl M. Sellgren, and Clinical sciences
- Subjects
Oncology ,Adult ,Male ,medicine.medical_specialty ,Bipolar Disorder ,Cognition Disorders/cerebrospinal fluid ,Neuropsychological Tests ,Executive Function ,Cerebrospinal fluid ,Cognition ,Adipokines ,Internal medicine ,Lectins ,medicine ,Humans ,Pharmacology (medical) ,Biomarkers/cerebrospinal fluid ,Executive Function/physiology ,Effects of sleep deprivation on cognitive performance ,Bipolar disorder ,Chitinase-3-Like Protein 1 ,Biological Psychiatry ,Neuroinflammation ,Cognition/physiology ,Pharmacology ,Medicine(all) ,Neuropsychology ,medicine.disease ,Executive functions ,Lectins/cerebrospinal fluid ,Psychiatry and Mental health ,Neurology ,Adipokines/cerebrospinal fluid ,Bipolar Disorder/cerebrospinal fluid ,Biomarker (medicine) ,Female ,Neurology (clinical) ,linear models ,Psychology ,Cognition Disorders ,Neuroscience ,Biomarkers - Abstract
Persistent cognitive impairment in the euthymic state of bipolar disorder is increasingly recognized. Mounting evidence also suggests an association between neuroinflammation and cognitive dysfunction. The purpose of this study was to test if cerebrospinal fluid (CSF) markers of neuroinflammation could account for cognitive impairment in bipolar disorder. Hierarchical linear regression models were applied to account for performance in five cognitive domains using CSF neuroinflammatory biomarkers as predictors in patients with bipolar disorder type I and II (N=78). The associations between these biomarkers and cognition were further tested in healthy age- and sex-matched controls (N=86). In patients with bipolar disorder, the CSF biomarkers accounted for a significant proportion of the variance in executive functions (42.8%, p=
- Published
- 2015