Search

Despite considerable studies, thrombocytopenia is still affecting millions of people with an increasing rate of morbidity and mortality around the globe. Therefore, we aimed to identify pharmacologically active polyphenolic compounds such as quercetin, apigenin and kaempferol in Psidium guajava for the management of thrombocytopenia using network pharmacology and in-silico molecular docking. The results of ADME/Tox screening revealed that all the polyphenolic compounds possess the drug-likeness activity and were found safe. Moreover, network pharmacology revealed that polyphenolic compounds of Psidium guajava may combat diabetes by acting on key targets, such as MAPK, TP53 and TNF-α which were strongly involved in oxidative stress, inflammatory responses and blood-related parameters involved in thrombocytopenia. Further, a mechanistic approach through molecular docking also supports the strong binding sites of quercetin, apigenin and kaempferol. Conclusively, in-silico ADME, molecular docking and network pharmacology study revealed that identified compounds are safe and pharmacologically effective. These identified compounds could be a great source for the development of new anti-thrombocytopenic drugs in the future.

Curcumin is a fat-soluble natural substance obtained from Curcuma longa and finds its applications in treatment of numerous disorders and diseases. Apart from its vast pharmacological profile, it is also used as a flavoring agent in the Asian subcontinent. This has drawn attention of the scientists to use it as an important scaffold to prepare its synthetic derivatives in order to improve the efficacy as well as potency of drug molecules and also reducing their toxicity effects. Here we tried to give some deeper insights of curcumin with a focus on its biological activities and various synthetic derivatives with a view to get potential lead molecules for future drug discovery and expansion of its medicinal profile.