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1. Cognitive Acceleration in Mathematics Education: Further Evidence of Impact

Author

Seleznyov, Sarah, Adhami, M., Black, A., Hodgen, J., and Twiss, S.

Abstract

The Cognitive Acceleration (or Let's Think) approach to mathematics teaching is a Piagetian programme drawing on Vygotsky's research, developed at King's College London over 30 years ago, along with its associated professional development (PD) programme. This project sought to replicate the original studies conducted 10-15 years earlier and before much national curriculum change, through a professional development project with 41 teachers of children aged 6-12 from London in 2014. Results of pre- and post-test of mathematics attainment are reported for 232 students. Despite a shorter duration, data shows increased teacher efficacy, improved teaching and a mean gain equivalent to 2.6 months learning for benefitting students, which broadly mirrors cognitive effects of original trials with twice the duration. This evidence corroborates the impact demonstrated in several original CA research papers, and additionally details specific impact on teacher confidence and classroom practice.

Published
2022
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2. Plain language summary: treatment of paroxysmal nocturnal hemoglobinuria with pegcetacoplan for 48 weeks (PEGASUS study)

Author

de Latour, RP, Szer, J, Weitz, I, Röth, A, Höchsmann, B, Panse, J, Usuki, K, Griffin, M, Kiladjian, JJ, Castro, CD, Nishimori, H, Al-Adhami, M, Deschatelets, P, Francois, C, Risitano, A, Hillmen, P, de Latour, RP, Szer, J, Weitz, I, Röth, A, Höchsmann, B, Panse, J, Usuki, K, Griffin, M, Kiladjian, JJ, Castro, CD, Nishimori, H, Al-Adhami, M, Deschatelets, P, Francois, C, Risitano, A, and Hillmen, P

Published
2024

6. P828: NORMALIZATION OF HEMATOLOGIC AND HEALTH-RELATED QUALITY OF LIFE MARKERS IN PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA TREATED WITH PEGCETACOPLAN AND BASELINE HEMOGLOBIN AT OR ABOVE 10 G/DL

Author

Panse, J., primary, Daguindau, N., additional, Okuyama, S., additional, Peffault de Latour, R., additional, Schafhausen, P., additional, Straetmans, N., additional, Al-Adhami, M., additional, Ajayi, T., additional, Persson, E., additional, Yeh, M., additional, and Wong, R., additional

Published
2022
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11. Hypotension in Posterior Retroperitoneoscopic Versus Transperitoneal Laparoscopic Adrenalectomy.

Author

Chen F., Adhami M., Tan M., Grodski S., Serpell J., Orr A., Stark A., Lee J.C., Chen F., Adhami M., Tan M., Grodski S., Serpell J., Orr A., Stark A., and Lee J.C.

Abstract

Introduction: Despite preoperative optimization, hemodynamic instability can be a major challenge during adrenalectomy. Even brief episodes of intraoperative hypotension can be associated with ischemia-reperfusion injury. This study aimed to compare intraoperative hemodynamic parameters between posterior retroperitoneoscopic adrenalectomy (PRA) and transperitoneal laparoscopic adrenalectomy (TPA). Method(s): This is a retrospective study of patients undergoing PRA and TPA without conversion or concomitant intraabdominal pathology from 2008 to 2019. The primary outcome was intraoperative hypotension defined by mean arterial pressure <60 mm Hg or the need for >=1 intravenous vasopressors at least 30 min after anesthetic induction. Result(s): Overall, 108 patients met the inclusion criteria; 33 (30.6%) had pheochromocytoma, 26 (24.1%) had aldosterone excess, 8 (7.4%) had corticosteroid excess, and 41 (38.0%) had nonfunctioning adrenal tumors. Of these, 68 (63.0%) underwent PRA and 40 (37.0%) underwent TPA. Age, sex, body mass index, preinduction blood pressure, number of preoperative antihypertensives, and histopathological diagnosis were similar in the two groups. Tumor size was greater in the TPA group. The presence of pheochromocytoma was an independent risk factor for hypotension. Multivariate analysis revealed that PRA was associated with a higher risk of experiencing a mean arterial pressure <60 mm Hg (odds ratio 4.44, 95% confidence interval 1.27-15.54, P = 0.02) and the need for >=1 intravenous vasopressors (odds ratio 9.97, 95% confidence interval 3.34-29.78, P < 0.001) compared with TPA. Conclusion(s): Although PRA offers several advantages over TPA, it carries a greater risk of intraoperative hypotension. A prospective trial is required to validate these findings. Nevertheless, institution of risk reduction strategies is encouraged to be considered for individuals undergoing PRA.Copyright © 2022 Elsevier Inc.

Published
2022

12. Multiple Target Tracking in Wireless Sensor Networks Based on Sensor Grouping and Hybrid Iterative-Heuristic Optimization.

Author

Adhami, M. H. and Ghazizadeh, R.

Subjects
WIRELESS sensor networks, MULTIPLE target tracking, PARTICLE swarm optimization, MAXIMUM likelihood detection, SEARCH algorithms
Abstract

A novel hybrid method for tracking multiple indistinguishable maneuvering targets using a wireless sensor network is introduced in this paper. The problem of tracking the location of targets is formulated as a Maximum Likelihood Estimation. We propose a hybrid optimization method, which consists of an iterative and a heuristic search method, for finding the location of targets simultaneously. The Levenberg-Marquardt (LM) algorithm is used for iterative search, while the Particle Swarm Optimization (PSO) is used for the heuristic search. We use the maximum sensors separating distance-grouping algorithm (G-MSSD), which was introduced in our previous work, to generate initial guesses for search algorithms. The estimates of both methods are compared and the best one is selected as the final estimation. We demonstrate the accuracy and performance of our new tracking method via simulations and compare our results with the Gauss-Newton (GN) method. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Numerical Modeling Based on Implicit Differential Quadrature Method for Two-Dimensional Groundwater Flow Problems.

Author

Adhami, M., Kaya, B., Gharehbaghi, A., and Çakır, H. Utku

Subjects
NUMERICAL analysis, STANDARD deviations, AQUIFERS, HYDROGEOLOGY, FLUID flow
Abstract

Predicting the behavior of fluid flow through the porous media is significantly important, especially in arid and semi-arid regions. In the present research, a novel numerical model based on the Implicit Differential Quadrature Method (IDQM) was developed to simulate the two-dimensional groundwater flow problems with the nonlinear Boussinesq equation. The data of the grid points were calculated from Chebyshev–Gauss–Lobatto formula. To evaluate the accuracy and the efficiency of the suggested model, three commonly reported in the literature groundwater problems were employed: (i) a problem related to the Boussinesq equation with an analytical solution, (ii) a hypothetical case of groundwater flow problem in a confined aquifer, and (iii) an aquifer pumping test. In addition, the results of the above-mentioned model were compared with the numerical predictions of the explicit and implicit schemes of the finite difference method (EFDM and IFDM). The findings demonstrated high accuracy, efficiency, and superiority of the numerical results of the IDQM. According to the results, the lowest values of root mean square error (RMSE) in the first, second, and third test cases with a range of (2.83E-23-5.65E-12), (0.072-0.065), and (0.230-0.100) were observed using IDQM. The values of dimensionless differences (DD) were also assigned the lowest values in this method in all tests. Briefly, the IDQM using less number of nodes provided more accurate results than EFDM and IFDM and as a result, is applicable to a wide range of problems in numerous fields of science and engineering. [ABSTRACT FROM AUTHOR]

Published
2022
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16. Forty-eight week efficacy and safety of pegcetacoplan in adult patients with paroxysmal nocturnal hemoglobinuria and suboptimal response to prior eculizumab treatment

Author

Röth, Alexander, Peffault de Latour, R., Szer, J., Weitz, I., Höchsmann, B., Panse, J., Usuki, K., Griffin, M., Kiladijan, J.-J., De Castro, C. M., Nishimori, H., Tan, L., Al-Adhami, M., Deschatelets, P., Francois, C., Grossi, F., Risitano, A., and Hillmen, P.

Subjects
Medizin, ComputingMethodologies_GENERAL
Abstract

Poster-Abstract

Published
2021

17. Less extensive surgery for low-risk papillary thyroid cancers post 2015 American Thyroid Association guidelines in an Australian tertiary centre.

Author

Adhami M., Bhatt C.R., Grodski S., Serpell J., Lee J.C., Adhami M., Bhatt C.R., Grodski S., Serpell J., and Lee J.C.

Abstract

Introduction: The 2015 American Thyroid Association guidelines (ATA15) consider hemithyroidectomy (HT) a viable treatment option for low-risk papillary thyroid cancers (PTCs) between 1 and 4 cm. We aimed to examine the impact of ATA15 in a high-volume Australian endocrine surgery unit. Method(s): A retrospective study of all patients undergoing thyroidectomy from January 2010 to December 2019. Inclusion criteria: PTC histopathology, Bethesda V-VI, size 1-4 cm, and absence of clinical evidence of lymph node or distant metastases pre-operatively. Primary outcome was rate of HT before and after ATA15. Result(s): Of 5408 thyroidectomy patients, 339 (6.3%) met the inclusion criteria - 186 (54.9%) pre-ATA15 (2010-2015) and 153 (45.1%) post-ATA15 (2016-2019). The patient groups were similar; there were no significant differences between groups in age, sex, tumour size, proportion with Bethesda VI cytology, compressive symptoms, or thyrotoxicosis. Post-ATA15, there was a significant increase in HT rate from 5.4% to 19.6% (P = 0.0001). However, there was no corresponding increase in completion thyroidectomy (CT) rate (50.0% versus 27.6%, P = 0.2). The proportion managed with prophylactic central neck dissection (pCND) fell from 80.5% to 10.8% (P < 0.0001). Pre-ATA15, the only factor significantly associated with HT was Bethesda V. In contrast, post-ATA15, HT was more likely in patients with younger age, smaller tumours, and Bethesda V. Conclusion(s): After the release of 2015 ATA guidelines, we observed a significant increase in HT rate and a significant decrease in pCND rate for low-risk PTCs in our specialised thyroid cancer unit. This reflects a growing clinician uptake of a more conservative approach as recommended by ATA15.Copyright © 2021 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology

Published
2021

18. Anti-Thyroid Antibodies and TSH as Potential Markers of Thyroid Carcinoma and Aggressive Behavior in Patients with Indeterminate Fine-Needle Aspiration Cytology.

Author

Grodski S., Rao A., Bhatt C.R., Serpell J.W., Lee J.C., Adhami M., Michail P., Grodski S., Rao A., Bhatt C.R., Serpell J.W., Lee J.C., Adhami M., and Michail P.

Abstract

BACKGROUND: Indeterminate fine-needle aspiration cytology (FNAC) imposes challenges in the management of thyroid nodules. This study aimed to examine whether preoperative anti-thyroid antibodies (Abs) and TSH are indicators of thyroid malignancy and aggressive behavior in patients with indeterminate FNAC. METHOD(S): This was a retrospective study of thyroidectomy patients from 2008 to 2016. We analyzed Abs and TSH levels, FNAC, and histopathology. Serum antibody levels were categorized as 'Undetectable', 'In-range' if detectable but within normal range, and 'Elevated' if above upper limit of normal. 'Detectable' levels referred to 'In-range' and 'Elevated' combined. RESULT(S): There were 531 patients included. Of 402 patients with preoperative FNAC, 104 (25.9%) had indeterminate cytology (Bethesda III-V). Of these, 39 (37.5%) were malignant and 65 (62.5%) benign on histopathology. In the setting of indeterminate FNAC, an increased risk of malignancy was associated with 'Elevated' thyroglobulin antibodies (TgAb) (OR 7.25, 95% CI 1.13-77.15, P=0.01) and 'Elevated' thyroid peroxidase antibodies (TPOAb) (OR 6.79, 95% CI 1.23-45.88, P=0.008). Similarly, while still 'In-range', TSH>=1 mIU/L was associated with an increased risk of malignancy (OR 3.23, 95% CI 1.14-9.33, P=0.01). In all patients with malignancy, the mean tumor size was 8 mm larger in those with TSH>=1 mIU/L (P=0.03); furthermore, in PTC patients, 'Detectable' TgAb conferred a 4xrisk of lymph node metastasis (95% CI 1.03-13.77, P=0.02). CONCLUSION(S): In this cohort, in indeterminate FNAC patients, Abs and TSH were associated with an increased risk of malignancy. Additionally, TgAb and TSH were potential markers of aggressive biology. As such, they may be diagnostic and prognostic adjuncts.

Published
2020

23. A comprehensive approach to the study of the housing sector in Iraq with special reference to needs, standards, inputs, density and costs as factors in the analysis of housing problems in Baghdad

Author

al-Adhami, M. B.

Subjects
363.5, HD Industries. Land use. Labor
Abstract

Iraq has a stock of buildings, particularly dwellings, many of which are neither physically fit nor capable of meeting the economic and social needs of today. Many people, particularly in the cities, live in overcrowded and insanitary conditions. Many dwellings are badly located and mixed with derelict land. Population is expected to grow and even without any rise in standards, this would greatly increase the need for building and works of all kinds. At the macro level the main cause of the housing problem must be attributed to the process of migration and urbanization, which have contributed to the creation of slums and squatter settlements. At the policy level, the existing machinery of planning is scarcely adequate. Housing has conventionally received only scant attention in national development plans and this central neglect is mirrored by a similar failure at the municipal level. At the micro level, with which this study has primarily been concerned, it must be emphasised that housing is not simply an economic commodity but has deep social and political as well as environmental implications. The increasing gap between incomes and housing costs has to be contained and this can only be done by operating on a number of fronts simultaneously. The purpose of this study is to examine the housing sector in Iraq with special reference to the city of Baghdad-from the point of view that housing is not only a shelter which provides protection from the elements but a synthesis in which social, economic, physical and political forces interact. The study also develops an argument that housing density is not simply another planning index to be used with others in the formulation of town plans but a crucial variable which once fixed will have far reaching effects not only to the inhabitants of the housing areas but also to the social, economic and physical environment of the urban structure as a whole. The study adopts two related approaches. The first approach is a general survey of the causes and effects of housing problems and the interrelationships of housing aspects. Then, having identified particular topics of concern, the study examines some of these, such as housing needs, standards, housing inputs, i. e. land, finance building materials, labour and the construction industry, housing densities and costs relationships, in some detail. The study stresses the need to establish principles and processes of comprehensive analysis stems from the importance of housing as a community problem area, since housing is a major land use and its form reflects and influences, in a critical way, the pattern of urban experience and activity. Throughout, the aim has not been to produce a model or concrete figures so much as to analyse present trends and suggest some likely future developments in the hope that, with modification and. improvement, this study could act as a basis for further detailed study of the housing sector and assist in the formulation of long - term housing programme.

Published
1975

25. EMBRACA: Efficacy and safety in comparing talazoparib (TALA) with physician's choice of therapy (PCT) in patients (pts) with advanced breast cancer (aBC) and a germline BRCA mutation (gBRCAm); BRCA1/BRCA2 subgroup analysis

Author

Gonçalves, A., primary, Eiermann, W., additional, Rugo, H.S., additional, Ettl, J., additional, Hurvitz, S.A., additional, Yerushalmi, R., additional, Martín, M., additional, Al-Adhami, M., additional, Tudor, I.C., additional, Blum, J.L., additional, Hannah, A.L., additional, and Litton, J.K., additional

Published
2018
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26. A phase III, randomized, double-blind, placebo (PBO)-controlled study of enzalutamide (ENZA) in men with nonmetastatic (M0) castration-resistant prostate cancer (CRPC): Results of PROSPER by age and region

Author

Fizazi, K., primary, Hussain, M., additional, Saad, F., additional, Shore, N., additional, De Giorgi, U., additional, Efstathiou, E., additional, Ferreira, U., additional, Ivashchenko, P., additional, Madziarska, K., additional, Al-Adhami, M., additional, Modelska, K., additional, Phung, D., additional, Steinberg, J., additional, and Sternberg, C.N., additional

Published
2018
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31. Use of immunohistochemical evaluation of DNA repair proteins to demonstrate cisplatin response prediction in resected NSCLC squamous cell carcinoma.

Author

Pierceall, W. E., primary, Sprott, K. M., additional, Brambilla, E., additional, Pirker, R., additional, Popper, H. H., additional, Wang, X., additional, Chen, Y., additional, Quan, S., additional, Filipits, M., additional, Alaparthi, L., additional, Kutok, J., additional, Weaver, D. T., additional, Al-Adhami, M., additional, Andre, F., additional, Le Chevalier, T., additional, Ward, B. E., additional, and Soria, J., additional

Published
2011
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40. Updated activity and safety results of a phase II randomized discontinuation trial (RDT) of AV-951, a potent and selective VEGFR1, 2, and 3 kinase inhibitor, in patients with renal cell carcinoma (RCC)

Author

Bhargava, P., primary, Esteves, B., additional, Nosov, D. A., additional, Lipatov, O. N., additional, Lyulko, A. A., additional, Anischenko, A. A., additional, Chacko, R. T., additional, Lee, P., additional, Al-Adhami, M., additional, and Ryan, J., additional

Published
2009
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41. [649] CPG 10101 (ACTILON) IN COMBINATION WITH PEGYLATED INTERFERON AND/OR RIBAVIRIN IN CHRONIC HCV GENOTYPE 1 INFECTED PATIENTS WITH PRIOR RELAPSED RESPONSE: WEEK 48 DATA

Author

Shiftman, M.L., primary, Ghalib, R., additional, Lawitz, E., additional, Freilich, B., additional, Gordon, S.C., additional, Kwo, P.Y., additional, Riley, T.R., additional, Schiff, E., additional, Flamm, S., additional, Jacobson, I.M., additional, Zein, N.N., additional, Reuben, A., additional, Swaim, M., additional, Bright, D., additional, Al-Adhami, M., additional, Lekstrom-Himes, J., additional, Massari, F.E., additional, and McHutchison, J.G., additional

Published
2007
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42. O.105 Early clinical results with CPG 10101, a new investigational antiviral TRL9 agonist being developed for treatment of subjects chronically infected with hepatitis C virus

Author

McHutchison, J.G., primary, Bacon, B.R., additional, Gordon, S.C., additional, Lawitz, E., additional, Shiffman, M., additional, Afdhal, N.H., additional, Jacobson, I.M., additional, Muir, A., additional, Ghalib, R., additional, Kwo, P., additional, Freilich, B., additional, Davis, H.L., additional, Vicari, A., additional, Efler, S., additional, Al-Adhami, M., additional, Morris, M.L., additional, Masciari, F., additional, and Himes, J.L., additional

Published
2006
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49. Haemopoietic centres in the developing angelfish, Pterophyllum scalare (cuvier and valenciennes).

Author

Al-Adhami, M. and Kunz, Yvette

Abstract

The first haemopoietic centres in the embryo of Pterophyllum scalare are found in the blood islands of the yolk sac. These results are in contrast to the classical theory of blood formation in teleosts, which maintains that the first blood formation occurs intraembryonically, in the so-called intermediate cell mass of Oellacher. In Pterophyllum, the intermediate cell mass forms only the axial blood vessels. Haemopoiesis in the post-embryo is carried out by the pronephros. This organ remains haemopoietic to the adult stage. In the adult, the pronephric tubules are degenerated; the organ is filled with haemopoietic tissue and also contains strands of adrenal tissue. The adult kidney (mesonephros) is also haemopoietic, though to a much lesser degree than the pronephros. The blood islands in the yolk sac form only stem cells (haemocytoblasts) and proerythroblasts. Released into the circulation, they differentiate and mature into round, disc-like erythrocytes (erythrocytes-E). Erythropoiesis in the pronephros produces elliptical erythrocytes (erythrocytes-ImA). Thus for the latter part of the postembryonic phase, until complete absorption of the yolk, there is a mixed erythrocyte population in circulation. During metamorphosis into the laterally-compressed adult, the adult type of erythrocyte (erythrocyte-A) makes its first appearance. Leucocytes and thrombocytes appear much later in development than the red blood cells. They are formed in the pronephros and are seen in circulation only after the yolk has been absorbed. [ABSTRACT FROM AUTHOR]

Published
1976
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50. CPG 7909, an Immunostimulatory TLR9 Agonist Oligodeoxynucleotide, as Adjuvant to Engerix-B®HBV Vaccine in Healthy Adults: A Double-Blind Phase I/II Study

Author

COOPER, C.L., DAVIS, H.L., MORRIS, M.L., EFLER, S.M., ADHAMI, M., KRIEG, A.M., CAMERON, D.W., and HEATHCOTE, J.

Abstract

Oligodeoxynucleotides containing immunostimulatory CpG motifs (CpG ODN) act as potent Th1-like immune enhancers with many antigens in animal models. We have extended these observations to the first clinical evaluation of the safety, tolerability and immunogenicity of CPG 7909 when added to a commercial HBV vaccine. In a randomized, double-blind phase I dose escalation study, healthy volunteers aged 18–35 years were vaccinated at 0, 4 and 24 weeks by intramuscular injection with Engerix-B®(GlaxoSmithKline). The regular adult dose of 20 μg recombinant hepatitis B surface antigen (HBsAg) adsorbed to alum was administered mixed with saline (control) or with CPG 7909 at one of three doses (0.125, 0.5 or 1.0 mg). HBsAg-specific antibody responses (anti-HBs) appeared significantly sooner and were significantly higher at all timepoints up to and including 24 weeks in CPG 7909 recipients compared to control subjects (p⩽0.001). Strikingly, most CpG 7909-vaccinated subjects developed protective levels of anti-HBs IgG within just two weeks of the priming vaccine dose. A trend towards higher rates of positive cytotoxic T cell lymphocyte responses was noted in the two higher dose groups of CPG 7909 compared to controls. The most frequently reported adverse events were injection site reactions, flu-like symptoms and headache. While these were more frequent in CPG 7909 groups than in the control group (p<0.0001), most were reported to be of mild to moderate intensity regardless of group. In summary, CPG 7909 as an adjuvant to Engerix-B was well-tolerated and enhanced vaccine immunogenicity. CPG 7909 may allow the development of a two-dose prophylactic HBV vaccine.

Published
2004
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