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15 results on '"Adepiti, Awodayo O."'

9. Influence of MAMAdecoction, an Herbal Antimalarial, on the Pharmacokinetics of Amodiaquine in Mice

Author

Adepiti, Awodayo O., Adeagbo, Babatunde A., Adehin, Ayorinde, Bolaji, Oluseye O., and Elujoba, Anthony A.

Abstract

Background and Objective: MAMAdecoction (MD) is an antimalarial product prepared from the leaves of Mangifera indicaL. (Anacardiaceae), Alstonia booneiDe Wild (Apocynaceae), Morinda lucidaBenth (Rubiaceae) and Azadirachta indicaA. Juss (Meliaceae). A previous report showed that MD enhanced the efficacy of amodiaquine (AQ) in malaria-infected mice, thus suggesting a herb–drug interaction. The present study hence evaluated the effect of MD on the disposition of AQ in mice with a view to investigating a possible pharmacokinetic interaction. Methods: In a 3-period study design, three groups of mice (n= 72) were administered oral doses of AQ (10 mg/kg/day) alone, concurrently with MD (120 mg/kg/day), and in the 3rd period, mice were given AQ after a 3-day pre-treatment with MD. Blood samples were collected between 0 and 96 h for quantification of AQ and its major metabolite, desethylamodiaquine, by a validated high-performance liquid chromatography method. Results: Maximum concentrations of AQ increased by 12% with the concurrent dosing of MD and by 85% in the group of mice pre-treated with MD. The exposure and half-life of desethylamodiaquine increased by approximately 11% and 21%, respectively, with concurrent administration. Corresponding increases of approximately 20% and 33% of desethylamodiaquine were also observed in mice pre-treated with MD. Conclusion: MD influenced the pharmacokinetics of AQ and desethylamodiaquine, its major metabolite. The increase in the half-life and systemic exposure of AQ following its co-administration with MD may provide a basis for the enhanced pharmacological effect of the combination in an earlier study in Plasmodium-infected mice.

Published
2020
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14. Antimalarial Properties of Morinda lucida and Alstonia boonei on Sulphadoxine-Pyrimethamine and Curcuma longa on Quinine in Mice.

Author

Agbedahunsi, Joseph M., Adepiti, Awodayo O., Adedini, Adeteju A., Akinsomisoye, Adetola, and Adepitan, Olusegun

Subjects
*ANIMAL experimentation, *ANTIMALARIALS, *DOSE-effect relationship in pharmacology, *MEDICINAL plants, *MICE, *QUININE, *PLANT extracts, *PHARMACODYNAMICS
Abstract

The article focuses on a research related to antimalarial properties of Morinda lucida and Alstonia boonei species on Sulphadoxine-Pyrimethamine and Curcuma longa on quinine. Topics discussed include effectiveness of quinine from Cinchona succirubra (Rubiaceae) and artemisinin from Artemisia annua towards treatment of malaria; use of Curcuma longa as a constituent in preparations for fever and malaria; and low bioavailability and rapid metabolism in rodents and humans exhibited by curcumin.

Published
2016
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15. Plasmepsin II inhibitory potential of phytochemicals isolated from African antimalarial plants: a computational approach.

Author

Faloye KO, Tripathi MK, Fakola EG, Adepiti AO, Adesida SA, Oyeleke IO, Adebayo PA, Aregbesola AE, Famuyiwa SO, and Akinyele OF

Abstract

Plamepsin II has been identified as a therapeutic target in the Plasmodium falciparum's life cycle and may lead to a drastic reduction in deaths caused by malaria worldwide. Africa flora is rich in medicinal qualities and possesses both simple and complex bioactive phytochemicals. This study utilized computational approaches like molecular docking, molecular dynamics simulation, quantum chemical calculations and ADMET to evaluate the plasmepsin II inhibitory properties of phytochemicals isolated from African antimalarial plants. Molecular docking was carried out to estimate the binding affinity of 229 phytochemicals whereby ekeberin A, dichamanetin, 10-hydroxyusambaresine, chamuvaritin and diuvaretin were selected. Further, RMSD and RMSF plots from the 100 ns simulation results showed that the screened phytochemicals were stable in the enzyme's binding pocket. The quantum chemical calculation revealed that all the phytochemicals are strong electrophiles, while ekeberin A was identified as the most stable and dichamanetin as the most reactive. Also, ADMET studies established the drug candidacy of the phytochemicals. Thus, these phytochemicals could act as good antimalarial agents after extensive in vitro and in vivo studies.Communicated by Ramaswamy H. Sarma.

Published
2023
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