1. Adenylate Cyclase Toxin Tinkering With Monocyte-Macrophage Differentiation.
- Author
-
Ahmad JN and Sebo P
- Subjects
- Adenylate Cyclase Toxin pharmacology, Animals, Antigen Presentation drug effects, Cell Dedifferentiation drug effects, Cell Differentiation, Cyclic AMP physiology, Host-Pathogen Interactions immunology, Humans, Immunity, Innate drug effects, Immunity, Mucosal drug effects, Macrophages, Alveolar cytology, Mice, Models, Biological, Monocytes cytology, Phagocytosis, Respiratory System drug effects, Respiratory System immunology, Respiratory System microbiology, Second Messenger Systems drug effects, Second Messenger Systems physiology, Adenylate Cyclase Toxin physiology, Bordetella pertussis physiology, Macrophages, Alveolar drug effects, Monocytes drug effects
- Abstract
Circulating inflammatory monocytes are attracted to infected mucosa and differentiate into macrophage or dendritic cells endowed with enhanced bactericidal and antigen presenting capacities. In this brief Perspective we discuss the newly emerging insight into how the cAMP signaling capacity of Bordetella pertussis adenylate cyclase toxin manipulates the differentiation of monocytes and trigger dedifferentiation of the alveolar macrophages to facilitate bacterial colonization of human airways., (Copyright © 2020 Ahmad and Sebo.)
- Published
- 2020
- Full Text
- View/download PDF