1. Genetic, reproductive and oxidative damage in mice triggered by co-exposure of nanoparticles: From a hypothetical scenario to a real concern
- Author
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Milene Dalmina, Adekunle Akanji Bakare, Adny Henrique Silva, Frederico Pittella, Okunola A. Alabi, Leônidas João de Mello Junior, Fabíola Branco Filippin-Monteiro, Tânia Beatriz Creczynski-Pasa, Gabriela Regina Rosa Souza, and Louise Rubia Probst Purnhagen
- Subjects
Male ,Environmental Engineering ,010504 meteorology & atmospheric sciences ,010501 environmental sciences ,Pharmacology ,medicine.disease_cause ,Ferric Compounds ,01 natural sciences ,Mice ,Bone Marrow ,In vivo ,Solid lipid nanoparticle ,medicine ,Animals ,Nanotechnology ,Environmental Chemistry ,Waste Management and Disposal ,0105 earth and related environmental sciences ,Micronucleus Tests ,Sperm Count ,Chemistry ,Lipids ,Spermatozoa ,Pollution ,Sperm ,body regions ,Oxidative Stress ,medicine.anatomical_structure ,Toxicity ,Micronucleus test ,Nanoparticles ,Bone marrow ,Reproductive toxicity ,Genotoxicity ,DNA Damage - Abstract
Humans are potentially exposed to multiple nanoparticles kinds through nanotechnology-based consumer products. There is insufficient data on the in vivo toxicity of nanotechnology products, as well as no data on the possible toxicity, including genotoxicity and reproductive toxicity of co-exposure to different kind of nanoparticles. In this work, solid lipid nanoparticles (SLNs) and superparamagnetic iron oxide nanoparticles (SPIONs) were selected for evaluation of a hypothetical condition of in vivo co-exposure. Genotoxicity of SPIONs and SLNs was performed separately and in 1:1 mixture in mice. Bone marrow micronucleus assay, sperm morphology test, and sperm count were carried out. Also, the serum ALT and AST activities; and hematological parameters of the treated mice were analyzed. The results showed a significant increase (p
- Published
- 2019
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