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Prostate cancer (PCa) is a severe type of cancer and causes major deaths among men due to its poor diagnostic system. The images obtained from patients with carcinoma consist of complex and necessary features that cannot be extracted readily by traditional diagnostic techniques. This research employed deep learning long short-term memory $(LSTM)$ and Residual Net $(ResNet-101)$ , independent of hand-crafted features, and is fine-tuned. The results were compared with hand-crafted features such as texture, morphology, and gray level co-occurrence matrix $(GLCM)$ using non-deep learning classifiers such as support vector machine $(SVM)$ Gaussian Kernel, k-nearest neighbor-Cosine $(KNN-Cosine)$ , kernel naive Bayes, decision tree $(DT)$ and RUSBoost tree. This study reduces the features of carcinoma images, employed machine learning and deep learning approaches. For validation of training and testing data, a jack-knife ten-fold cross-validation method was used. The performance was measured using a confusion matrix such as sensitivity, specificity, positive predictive value $(PPV)$ , negative predictive value $(NPV)$ , accuracy $(AC)$ , Mathews Correlation Coefficient ( $MCC$ ), and area under the curve $(AUC)$ . The most remarkable performance was obtained using non-deep learning methods with $GLCM$ features using KNN-Cosine with sensitivity (98.00%), specificity (99.25%), PPV (98.99%), NPV (99.11%), accuracy (99.07%), and AUC (0.998). The LSTM deep learning method yields performance with sensitivity (98.33%), specificity (100%), PPV (100%), NPV (99.26%), accuracy (99.48%), MCC (0.9879) and AUC (0.9999), where using Deep learning method $ResNet-101$ , we obtained (100%) Accuracy and AUC (1) for Kernel Naive Bayes, SVM Gaussian and RUSBoost Tree. The results show that $ResNet-101$ deep learning outperformed than non-deep learning methods and $LSTM$ . Thus, the deep learning method $ResNet-101$ could be used as a better predictor for the detection of prostate cancer.

The incidence of congestive heart failure (CHF) is approximately 10 per 1000 for Americans over the age of 65 years. The dynamics of CHF are highly complex, nonlinear, and temporal dynamics. Based ...

BACKGROUND Brain neural activity is measured using electroencephalography (EEG) recording from the scalp. The EEG motor/imagery tasks help disabled people to communicate with the external environment. OBJECTIVE In this paper, robust multiscale sample entropy (MSE) and wavelet entropy measures are employed using topographic maps' analysis and tabulated form to quantify the dynamics of EEG motor movements tasks with actual and imagery opening and closing of fist or feet movements. METHODS To distinguish these conditions, we used the topographic maps which visually show the significance level of the brain regions and probes for dominant activities. The paired t-test and Posthoc Tukey test are used to find the significance levels. RESULTS The topographic maps results obtained using MSE reveal that maximum electrodes show the significance in frontpolar, frontal, and few frontal and parietal brain regions at temporal scales 3, 4, 6 and 7. Moreover, it was also observed that the distribution of significance is from frontoparietal brain regions. Using wavelet entropy, the significant results are obtained at frontpolar, frontal, and few electrodes in right hemisphere. The highest significance is obtained at frontpolar electrodes followed by frontal and few central and parietal electrodes.

Prostate Cancer in men has become one of the most diagnosed cancer and also one of the leading causes of death in United States of America. Radiologists cannot detect prostate cancer properly because of complexity in masses. In recent past, many prostate cancer detection techniques were developed but these could not diagnose cancer efficiently. In this research work, robust deep learning convolutional neural network (CNN) is employed, using transfer learning approach. Results are compared with various machine learning strategies (Decision Tree, SVM different kernels, Bayes). Cancer MRI database are used to train GoogleNet model and to train Machine Learning classifiers, various features such as Morphological, Entropy based, Texture, SIFT (Scale Invariant Feature Transform), and Elliptic Fourier Descriptors are extracted. For the purpose of performance evaluation, various performance measures such as specificity, sensitivity, Positive predictive value, negative predictive value, false positive rate and receive operating curve are calculated. The maximum performance was found with CNN model (GoogleNet), using Transfer learning approach. We have obtained reasonably good results with various Machine Learning Classifiers such as Decision Tree, Support Vector Machine RBF kernel and Bayes, however outstanding results were obtained by using deep learning technique.

BackgroundThe large volume and suboptimal image quality of portable chest X-rays (CXRs) as a result of the COVID-19 pandemic could post significant challenges for radiologists and frontline physicians. Deep-learning artificial intelligent (AI) methods have the potential to help improve diagnostic efficiency and accuracy for reading portable CXRs.PurposeThe study aimed at developing an AI imaging analysis tool to classify COVID-19 lung infection based on portable CXRs.Materials and methodsPublic datasets of COVID-19 (N = 130), bacterial pneumonia (N = 145), non-COVID-19 viral pneumonia (N = 145), and normal (N = 138) CXRs were analyzed. Texture and morphological features were extracted. Five supervised machine-learning AI algorithms were used to classify COVID-19 from other conditions. Two-class and multi-class classification were performed. Statistical analysis was done using unpaired two-tailedttests with unequal variance between groups. Performance of classification models used the receiver-operating characteristic (ROC) curve analysis.ResultsFor the two-class classification, the accuracy, sensitivity and specificity were, respectively, 100%, 100%, and 100% for COVID-19 vs normal; 96.34%, 95.35% and 97.44% for COVID-19 vs bacterial pneumonia; and 97.56%, 97.44% and 97.67% for COVID-19 vs non-COVID-19 viral pneumonia. For the multi-class classification, the combined accuracy and AUC were 79.52% and 0.87, respectively.ConclusionAI classification of texture and morphological features of portable CXRs accurately distinguishes COVID-19 lung infection in patients in multi-class datasets. Deep-learning methods have the potential to improve diagnostic efficiency and accuracy for portable CXRs.

Smart devices are effective in helping people with impairments, overcome their disabilities, and improve their living standards. Braille is a popular method used for communication by visually impaired people. Touch screen smart devices can be used to take Braille input and instantaneously convert it into a natural language. Most of these schemes require location-specific input that is difficult for visually impaired users. In this study, a position-free accessible touchscreen-based Braille input algorithm is designed and implemented for visually impaired people. It aims to place the least burden on the user, who is only required to tap those dots that are needed for a specific character. The user has input English Braille Grade 1 data (a–z) using a newly designed application. A total dataset comprised of 1258 images was collected. The classification was performed using deep learning techniques, out of which 70%–30% was used for training and validation purposes. The proposed method was thoroughly evaluated on a dataset collected from visually impaired people using Deep Learning (DL) techniques. The results obtained from deep learning techniques are compared with classical machine learning techniques like Naïve Bayes (NB), Decision Trees (DT), SVM, and KNN. We divided the multi-class into two categories, i.e., Category-A (a–m) and Category-B (n–z). The performance was evaluated using Sensitivity, Specificity, Positive Predicted Value (PPV), Negative Predicted Value (NPV), False Positive Rate (FPV), Total Accuracy (TA), and Area under the Curve (AUC). GoogLeNet Model, followed by the Sequential model, SVM, DT, KNN, and NB achieved the highest performance. The results prove that the proposed Braille input method for touch screen devices is more effective and that the deep learning method can predict the user's input with high accuracy.

Cardiac arrhythmias are disturbances in the rhythm of the heart manifested by irregularity or by abnormally fast rates (‘tachycardia’) or abnormally slow rates (‘bradycardias’). In the past researc...

Lung Cancer is one of the leading causes of cancer-related deaths worldwide with minimal survival rate due to poor diagnostic system at the advanced cancer stage. In the past, researchers developed various tools in image processing to detect the Lung cancer of types as non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) which are based on few features extracting methods. In this research, we extracted multimodal features such as texture, morphological, entropy based, scale invariant Fourier transform (SIFT), Ellipse Fourier Descriptors (EFDs) by considering multiple aspects and shapes morphologies. We then applied robust machine learning classification methods such as Naive Bayes, Decision Tree and Support Vector Machine (SVM) with its kernels such as Gaussian, Radial Base Function (RBF) and Polynomial. Jack-knife 10-fold cross validation was applied for training/ validation of data. The performance was evaluated in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), total accuracy (TA), false positive rate (FPR) and area under the receiving curve (AUC). The highest detection accuracy was obtained with (TA=100%) with entropy, SIFT and texture features using Naive Bayes, texture features using SVM Polynomial. Moreover, the highest separation was obtained using entropy, morphological, SIFT and texture features with (AUC=1.00) using Naive Bayes classifier and texture features using Decision tree and SVM polynomial kernel.

DNA repair protein counteracting oxidative promoter lesions may modulate gene expression. Oxidative DNA bases modified by reactive oxygen species (ROS), primarily as 7, 8-dihydro-8-oxo-2′-deoxyguanosine (8-oxoG), which is repaired by 8-oxoguanine DNA glycosylase1 (OGG1) during base excision repair (BER) pathway. Because cellular response to oxidative challenge is accompanied by DNA damage repair, we tested whether the repair by OGG1 is compatible with transcription factor binding and gene expression. We performed electrophoretic mobility shift assay (EMSA) using wild-type sequence deriving from Cxcl2 gene promoter and the same sequence bearing a single synthetic 8-oxoG at defined 5′ or 3′ guanine in runs of guanines to mimic oxidative effects. We showed that DNA occupancy of NF-κB present in nuclear extracts from tumour necrosis factor alpha (TNFα) exposed cells is OGG1 and 8-oxoG position dependent, importantly, OGG1 counteracting 8-oxoG outside consensus motif had a profound influence on purified NF-κB binding to DNA. Furthermore, OGG1 is essential for NF-κB dependent gene expression, prior to 8-oxoG excised from DNA. These observations imply that pre-excision step(s) during OGG1 initiated BER evoked by ROS facilitates NF-κB DNA occupancy and gene expression.