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10. Maternal lipid levels in early pregnancy as a predictor of childhood lipid levels:a prospective cohort study

Author

Adank, Maria C., Johansen, Anja K., Benschop, Laura, Van Streun, Sophia P., Smak Gregoor, Anna M., Øyri, Linn K.L., Mulder, Monique T., Steegers, Eric A.P., Holven, Kirsten B., Roeters van Lennep, Jeanine E., Adank, Maria C., Johansen, Anja K., Benschop, Laura, Van Streun, Sophia P., Smak Gregoor, Anna M., Øyri, Linn K.L., Mulder, Monique T., Steegers, Eric A.P., Holven, Kirsten B., and Roeters van Lennep, Jeanine E.

Abstract

Background: Maternal lipid levels in early pregnancy are associated with maternal health and foetal growth. It is however unclear if maternal lipids in early pregnancy can be used to predict childhood lipid levels. The aim of this study is to assess the association between maternal and offspring childhood lipid levels, and to investigate the influence of maternal BMI and diet on these associations. Methods: This study included 2692 women participating in the Generation R study, an ongoing population-based prospective cohort study from early life onwards. Women with an expected delivery date between 2002 and 2006 living in Rotterdam, the Netherlands were included. Total cholesterol, triglycerides and high-density lipoprotein cholesterol (HDL-c) were measured in early pregnancy (median 13.2 weeks [90% range 10.6; 17.1]). Low-density lipoprotein cholesterol (LDL-c), remnant cholesterol and non-HDL-c were calculated. Corresponding lipid measurements were determined in 2692 children at the age of 6 (median 6.0 years [90% range 5.7; 7.5]) and 1673 children 10 years (median 9.7 years [90% range 9.5; 10.3]). Multivariate linear regression analysis was used to examine the association between maternal lipid levels in early pregnancy and the corresponding childhood lipid measurements at the ages of 6 and 10 years while adjusting for confounders. Results: Maternal lipid levels in early pregnancy are positively associated with corresponding childhood lipid levels 6 and 10 years after pregnancy, independent of maternal body mass index and diet. Conclusions: Maternal lipid levels in early pregnancy may provide an insight to the lipid profile of children years later. Gestational lipid levels may therefore be used as an early predictor of children’s long-term health. Monitoring of these gestational lipid levels may give a window-of-opportunity to start early interventions to decrease offspring’s lipid levels and possibly diminish their cardiovascular risk later in life. Future st

Published
2022

11. Additional file 1 of Maternal lipid levels in early pregnancy as a predictor of childhood lipid levels: a prospective cohort study

Author

Adank, Maria C., Johansen, Anja K., Benschop, Laura, Van Streun, Sophia P., Smak Gregoor, Anna M., Øyri, Linn K. L., Mulder, Monique T., Steegers, Eric A. P., Holven, Kirsten B., and Roeters van Lennep, Jeanine E.

Abstract

Additional file 1: Table S1. E-value of the association of maternal lipid profile in early pregnancy with their corresponding offspring lipid level at the age of 6 and 10 years. Table S2. Lipid profile in boys and girls 6 (n = 2692) and 10 years after pregnancy (n = 1673). Table S3. Association of maternal lipid profile in early pregnancy with their corresponding offspring lipid level at the age of 6 and 10 years in women without a placental syndrome in their index pregnancy. Table S4. Association of cut-off values of the maternal lipid profile in early pregnancy with their corresponding offspring lipid level at the age of 6 and 10 years.

Published
2022
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15. Additional file 1 of Gestational lipid profile as an early marker of metabolic syndrome in later life: a population-based prospective cohort study

Author

Adank, Maria C., Benschop, Laura, Streun, Sophia P. Van, Gregoor, Anna M. Smak, Mulder, Monique T., Steegers, Eric A. P., Schalekamp-Timmermans, Sarah, and Lennep, Jeanine E. Roeters Van

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

Additional file 1: Table S1. Association of maternal lipid profile in early pregnancy with their corresponding lipid levels six years later (n = 3510). Table S2. Baseline characteristics of women with and without available lipid measurements six years after pregnancy.

Published
2020
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16. Additional file 1 of Maternal lipid profile in early pregnancy is associated with foetal growth and the risk of a child born large-for-gestational age: a population-based prospective cohort study

Author

Adank, Maria C., Benschop, Laura, Alet W. Kors, Peterbroers, Kelly R., Gregoor, Anna M. Smak, Mulder, Monique T., Schalekamp-Timmermans, Sarah, Lennep, Jeanine E. Roeters Van, and Steegers, Eric A. P.

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

Additional file 1: Figure S1. Directed acyclic graph (DAG) of exposure, outcome and possible covariates. Table S1. Association of maternal lipid profile in early pregnancy with birth outcomes, excluding women with a hypertensive disorder of pregnancy. Table S2a. Maternal lipid profile in early pregnancy of the total population (n = 5702) and a subgroup of nulliparous, non-smoking women with a pre-pregnancy BMI

Published
2020
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