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326 results on '"Adani, Gian Luigi"'

3. Association between indocyanine green clearance test and ischemic type biliary lesions within one year after orthotopic liver transplantation

Author

Cherchi, Vittorio, Vetrugno, Luigi, Zanini, Victor, Pravisani, Riccardo, Ventin, Marco, Lorenzin, Dario, Adani, Gian Luigi, Clocchiatti, Lucrezia, Boscolo, Erica, Vit, Alessandro, Sponza, Massimo, D’Alì, Lorenzo, Di Loreto, Carla, Bove, Tiziana, Terrosu, Giovanni, Risaliti, Andrea, and Baccarani, Umberto

Published
2021
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7. Kidney Retransplantation after Graft Failure: Variables Influencing Long-Term Survival

Author

Adani, Gian Luigi, Adani, G L ( Gian Luigi ), Ehrsam, Jonas, Rössler, Fabian; https://orcid.org/0000-0002-2968-347X, Horisberger, Karoline, Hübel, Kerstin, Nilsson, Jakob, de Rougemont, Olivier, Adani, Gian Luigi, Adani, G L ( Gian Luigi ), Ehrsam, Jonas, Rössler, Fabian; https://orcid.org/0000-0002-2968-347X, Horisberger, Karoline, Hübel, Kerstin, Nilsson, Jakob, and de Rougemont, Olivier

Abstract

Background: There is an increasing demand for kidney retransplantation. Most studies report inferior outcomes compared to primary transplantation, consequently feeding an ethical dilemma in the context of chronic organ shortage. Objective: To assess variables influencing long-term graft survival after kidney retransplantation. Material and Methods. All patients transplanted at our center between 2000 and 2016 were analyzed retrospectively. Survival was estimated with the Kaplan-Meier method, and risk factors were identified using multiple Cox regression. Results: We performed 1,376 primary kidney transplantations and 222 retransplantations. The rate of retransplantation was 67.8% after the first graft loss, with a comparable 10-year graft survival compared to primary transplantation (67% vs. 64%, p=0.104) but an inferior graft survival thereafter (log-rank p=0.026). Independent risk factors for graft survival in retransplantation were age ≥ 50 years, time on dialysis ≥1 year, previous graft survival <2 years, ≥1 mild comorbidity in the Charlson-Deyo index, active smoking, and life-threatening complications (Clavien-Dindo grade IV) at first transplantation. Conclusion: Graft survival is comparable for first and second kidney transplantation within the first 10 years. Risk factors for poor outcomes after retransplantation are previous graft survival, dialysis time after graft failure, recipient age, comorbidities, and smoking. Patients with transplant failure should have access to retransplantation as early as possible.

Published
2022

18. Postoperative Trends and Prognostic Values of Inflammatory and Nutritional Biomarkers after Liver Transplantation for Hepatocellular Carcinoma

Author

Pravisani, Riccardo, primary, Mocchegiani, Federico, additional, Isola, Miriam, additional, Lorenzin, Dario, additional, Adani, Gian Luigi, additional, Cherchi, Vittorio, additional, De Martino, Maria, additional, Risaliti, Andrea, additional, Lai, Quirino, additional, Vivarelli, Marco, additional, and Baccarani, Umberto, additional

Published
2021
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19. Hypothermic machine perfusion can safely prolong cold ischemia time in deceased donor kidney transplantation. A retrospective analysis on postoperative morbidity and graft function

Author

Adani, Gian Luigi, primary, Pravisani, Riccardo, additional, Tulissi, Patrizia, additional, Isola, Miriam, additional, Calini, Giacomo, additional, Terrosu, Giovanni, additional, Boscutti, Giuliano, additional, Avital, Itzhak, additional, Ekser, Burcin, additional, and Baccarani, Umberto, additional

Published
2021
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37. Controlling Nutritional Status score does not predict patients' overall survival or hepatocellular carcinoma recurrence after deceased donor liver transplantation

Author

Pravisani, Riccardo, primary, Mocchegiani, Federico, additional, Isola, Miriam, additional, Lorenzin, Dario, additional, Adani, Gian Luigi, additional, Cherchi, Vittorio, additional, Righi, Elda, additional, Terrosu, Giovanni, additional, Vivarelli, Marco, additional, Risaliti, Andrea, additional, and Baccarani, Umberto, additional

Published
2020
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38. Effects of Delayed Hypothermic Machine Perfusion on Kidney Grafts with a Preliminary Period of Static Cold Storage and a Total Cold Ischemia Time of Over 24 Hours

Author

Adani, Gian Luigi, primary, Pravisani, Riccardo, additional, Crestale, Sara, additional, Baccarani, Umberto, additional, Scott, Cathryn A., additional, D’Alì, Lorenzo, additional, DeMaglio, Giovanna, additional, Tulissi, Patrizia, additional, Vallone, Clotilde, additional, Isola, Miriam, additional, Righi, Elda, additional, Pizzolito, Stefano, additional, Di Loreto, Carla, additional, and Risaliti, Andrea, additional

Published
2020
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49. PO221% oxygenated hypothermic machine perfusion in kidney transplantation: Any clinical benefit?

Author

Pravisani, Riccardo, Baccarani, Umberto, Molinari, Elena, Cherchi, Vittorio, Bacchetti, Stefano, Terrosu, Giovanni, Avital, Itzhak, Ekser, Burcin, and Adani, Gian Luigi

Abstract

Background: In deceased donor kidney transplantation (KT), the use of hypothermic machine perfusion (HMP) has been acquiring the status of best practice in the pre-transplant management of kidney grafts. Two types of HMP are currently available, oxygenated HMP and non-oxygenated HMP. However, data on the real clinical impact of oxygenation on KT outcome are still heterogeneous.Methods: Retrospective study on a cohort of 103 patients transplanted with a single kidney graft that was managed either with end-ischemic oxygenated (O2group, Waves Machine, n= 51, 49.5%) or non-oxygenated HMP (no-O2group, Life Port Kidney Transporter Machine, n= 52, 50.5%), during the period January 2016–December 2020. Oxygenation was performed at pO221%.Results: The median cold ischemia time was 29 h:40 min [IQR 26 h:55 min–31 h:10 min] and the prevalence of grafts from extended criteria donors (ECD) was 46.7%, with a median kidney donor profile index (KDPI) of 72 [41–94]. The study groups were homogeneous in terms of recipient characteristics, ischemia times and donor characteristics. O2and no-O2groups showed comparable outcomes in terms of delayed graft function (O2vs no-O2, 21.5% vs 25%, p= 0.58), vascular (0.2% vs 0.2%, p> 0.99) and urologic (13.7% vs 11.5%, p= 0.77) complications, and episodes of graft rejection (11.7% vs 7.7%, p= 0.52). At 1 year follow up, even creatinine serum levels were comparable between the groups (1.27 mg/dL [1.09 and 1.67] vs 1.4 mg/dL [1.9–1.78], p= 0.319), with similar post-transplant trend (p= 0.870). No significant benefit was either observed in ECD or KDPI > 60 subgroups, respectively.Conclusions: Oxygenation at pO221% during HMP seems not to significantly enhance the KT outcomes in terms of postoperative complications or graft function.

Published
2022
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