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4. Cost Effectiveness of Rectal Culture-based Antibiotic Prophylaxis in Transrectal Prostate Biopsy: The Results from a Randomized, Nonblinded, Multicenter Trial

Author

Tops, Sofie C.M., Kolwijck, Eva, Koldewijn, Evert L., Somford, Diederik M., Delaere, Filip J.M., van Leeuwen, Menno A., Breeuwsma, Anthonius J., de Vocht, Thijn F., Broos, Hans J.H.P., Schipper, Rob A., Steffens, Martijn G., Wegdam-Blans, Marjolijn C.A., de Brauwer, Els, van den Bijllaardt, Wouter, Leenders, Alexander C.A.P., Sedelaar, J.P. Michiel, Wertheim, Heiman F.L., and Adang, Eddy

Published
2023
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5. Early Eculizumab Withdrawal in Patients With Atypical Hemolytic Uremic Syndrome in Native Kidneys Is Safe and Cost-Effective: Results of the CUREiHUS Study

Author

Bouwmeester, Romy N., Duineveld, Caroline, Wijnsma, Kioa L., Bemelman, Frederike J., van der Heijden, Joost W., van Wijk, Joanna A.E., Bouts, Antonia H.M., van de Wetering, Jacqueline, Dorresteijn, Eiske, Berger, Stefan P., Gracchi, Valentina, van Zuilen, Arjan D., Keijzer-Veen, Mandy G., de Vries, Aiko P.J., van Rooij, Roos W.G., Engels, Flore A.P.T., Altena, Wim, de Wildt, Renée, van Kempen, Evy, Adang, Eddy M., ter Avest, Mendy, ter Heine, Rob, Volokhina, Elena B., van den Heuvel, Lambertus P.W.J., Wetzels, Jack F.M., and van de Kar, Nicole C.A.J.

Published
2023
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6. Implementing a Personalized Physical Therapy Approach (Coach2Move) Is Effective in Increasing Physical Activity and Improving Functional Mobility in Older Adults: A Cluster-Randomized, Stepped Wedge Trial

Author

Heij, Ward, Sweerts, Lieke, Staal, J. Bart, Teerenstra, Steven, Adang, Eddy, van der Wees, Philip J., Nijhuis-van der Sanden, Maria W.G., and Hoogeboom, Thomas J.

Subjects
Testing, Care and treatment, Methods, Precision medicine -- Methods, Physical therapy -- Methods -- Testing, Elderly -- Care and treatment, Aged -- Care and treatment, Therapeutics, Physiological -- Methods -- Testing, Physical therapy for the aged -- Methods -- Testing
Abstract

Introduction Physical activity is beneficial to improve quality of life and to counter adverse effects of frailty and comorbidities in older adults. (1) However, adoption and maintenance of an active [...], Objective. The purpose of this study was to assess whether the superior cost-effectiveness of a personalized physical therapy approach (Coach2Move)--which was demonstrated in a previous trial compared with usual care physical therapy (UCP)--can be replicated in daily clinical practice. Methods. A multicenter, cluster-randomized, stepped wedge trial with 4 clusters consisting of 4 physical therapist practices in the Netherlands was used to compare a personalized physical therapy approach to elicit physical activity (Coach2Move) versus care as usual. Multilevel analyses for effectiveness were conducted for the amount of physical activity (Longitudinal Aging Study Amsterdam Physical Activity Questionnaire) and functional mobility (Timed "Up & Go" Test) at 3, 6 (primary outcome), and 12 months' follow-up. Secondary outcomes were level of frailty (Evaluative Frailty Index for Physical Activity), perceived effect (Global Perceived Effect and Patient-Specific Complaints Questionnaires), quality of life (Euro Quality of Life-5 Dimensions-5 Levels [EQ-5D-5L]), and health care expenditures. Results. The 292 community-dwelling older adults with mobility problems visiting physical therapists were included in either the Coach2Move (n = 112; mean [SD] age = 82 [5] years; 60% female) or UCP (n = 180; mean [SD] age = 81 (6) years; 62% female) section of the trial. At baseline, Coach2Move participants were less physically active compared with UCP participants (mean difference = -198; 95% CI = -90 to -306 active minutes). At 6 months, between-group mean differences [95% CI] favored Coach2Move participants on physical activity levels (297 [83 to 512] active minutes), functional mobility (-14.2 [-21 to -8]) seconds), and frailty levels (-5[-8 to -1] points). At 12 months, the physical activity levels of Coach2Move participants further increased, and frailty levels and secondary outcomes remained stable, whereas outcomes of UCP participants decreased. After the Coach2Move implementation strategy, physical therapists utilized significantly fewer treatment sessions compared with before the implementation (15 vs 22). Anticipated cost savings were not observed. Conclusion. This study replicated the results of an earlier trial and shows that Coach2Move leads to better mid- and long-term outcomes (physical activity, functional mobility, level of frailty) in fewer therapy sessions compared with UCF' Based on these and earlier findings, the implementation of Coach2Move in physical therapist practice is recommended. Impact. This article describes the implementation of the Coach2Move approach, a treatment strategy that has proven to be cost-effective in a previously conducted randomized controlled trial. Implementation of Coach2Move in a real-life setting allowed an evaluation of the effects in a clinically relevant population. Coach2Move has been shown to increase physical activity, improve functional mobility, and reduce frailty more effectively compared with UCP therapy and therefore has application for physical therapists working with older adults in daily clinical practice. Lay summary. Coach2Move is a new physical therapy approach for older adults. Implementation of Coach2Move in daily clinical practice can help people better outcomes over a longer period of time against similar costs compared with regular physical therapy. Keywords: Aged, Decision Making: Clinical, Evidence-Based Practice, Patient-Centered Care, Physical Therapists, Primary Health Care

Published
2022
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8. Potentially Inappropriate Treatments at the End of Life in Nursing Home Residents: Findings From the PACE Cross-Sectional Study in Six European Countries

Author

Gatsolaeva, Yuliana, Miranda, Rose, Pivodic, Lara, Tanghe, Marc, van Hout, Hein, Van Den Noortgate, Nele, Froggatt, Katherine, Pasman, H. Roeline W., Baranska, Ilona, Oosterveld-Vlug, Mariska, Wichmann, Anne B., Engels, Yvonne, Vernooij-Dassen, Myrra, Hockley, Jo, Leppäaho, Suvi, Pautex, Sophie, Bassal, Catherine, Mammarella, Federica, Mercuri, Martina, Rossi, Paola, Segat, Ivan, Stodolska, Agata, Adang, Eddy, Kylänen, Marika, Andreasen, Paula, Kuitunen-Kaija, Outi, Moore, Danni Collingridge, Pac, Agnieszka, Kijowska, Violetta, Ten Koppel, Maud, van der Steen, Jenny T., de Paula, Emilie Morgan, Honinx, Elisabeth, Van den Block, Lieve, Piers, Ruth, Van Kuijk, Sander M.J., Onwuteaka-Philipsen, Bregje D., Payne, Sheila A., Szczerbińska, Katarzyna, Gambassi, Giovanni G., Finne-Soveri, Harriet, Deliens, Luc, and Smets, Tinne

Published
2021
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12. Perception of the Quality of Communication With Physicians Among Relatives of Dying Residents of Long-term Care Facilities in 6 European Countries: PACE Cross-Sectional Study

Author

Adang, Eddy, Andreasen, Paula, Moore, Danni Collingridge, van Hout, Hein, ten Koppel, Maud, Mammarella, Federica, Mercuri, Martina, Onwuteaka-Philipsen, Bregje D., Pivodic, Lara, Rossi, Paola, Sowerby, Eleanor, Stodolska, Agata, Wichmann, Anne, van der Steen, Jenny T., Vernooij-Dassen, Myrra, the European Association for Palliative Care Onlus, European Forum for Primary Care, Age Platform Europe, Alzheimer Europe, Barańska, Ilona, Kijowska, Violetta, Engels, Yvonne, Finne-Soveri, Harriet, Froggatt, Katherine, Gambassi, Giovanni, Hammar, Teija, Oosterveld-Vlug, Mariska, Payne, Sheila, Van Den Noortgate, Nele, Smets, Tinne, Deliens, Luc, Van den Block, Lieve, and Szczerbińska, Katarzyna

Published
2020
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14. Evaluation of a shared decision-making strategy with online decision aids in surgical and orthopaedic practice: study protocol for the E-valuAID, a multicentre study with a stepped-wedge design

Author

Thunnissen, Floris M., Schreurs, Bernhard W., Latenstein, Carmen S. S., Meinders, Marjan J., Adang, Eddy M., Elwyn, Glyn, Boersma, Doeke, Bosmans, Bas, Bosscha, Koop, Ginsel, Bastiaan L., Hazebroek, Eric J., Nieuwenhuis, Jeroen J., Staarink, Maarten, Verhallen, Dries, Wagener, Marc L., Atsma, Femke, and de Reuver, Philip R.

Published
2021
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17. Agreement of Nursing Home Staff With Palliative Care Principles: A PACE Cross-sectional Study Among Nurses and Care Assistants in Five European Countries

Author

Gatsolaeva, Yuliana, Miranda, Rose, Pivodic, Lara, Tanghe, Marc, van Hout, Hein, Van Den Noortgate, Nele, Froggatt, Katherine, Onwuteaka-Philipsen, Bregje, Szczerbińska, Katarzyna, Oosterveld-Vlug, Mariska, Wichmann, Anne B., Engels, Yvonne, Vernooij-Dassen, Myrra, Hockley, Jo, Leppäaho, Suvi, Pautex, Sophie, Bassal, Catherine, Mammarella, Federica, Mercuri, Martina, Rossi, Paola, Segat, Ivan, Stodolska, Agata, Adang, Eddy, Andreasen, Paula, Kuitunen-Kaija, Outi, Moore, Danni Collingridge, Pac, Agnieszka, Kijowska, Violetta, Koppel, Maud ten, van der Steen, Jenny T., Morgan de Paula, Emilie, Honinx, Elisabeth, Smets, Tinne, Piers, Ruth, Deliens, Luc, Payne, Sheila, Kylänen, Marika, Barańska, Ilona, Pasman, H. Roeline W., Gambassi, Giovanni, and Van den Block, Lieve

Published
2019
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18. Prophylactic antibiotics reduce hospitalisations and cost in locally advanced head and neck cancer patients treated with chemoradiotherapy: A randomised phase 2 study

Author

Ham, Janneke C., Driessen, Chantal M., Hendriks, Mathijs P., Fiets, Edward, Kreike, Bas, Hoeben, Ann, Slingerland, Marije, van Opstal, Claudia C., Kullberg, Bart Jan, Jonker, Marianne A., Adang, Eddy M., Kaanders, Johannes H., van der Graaf, Winette T., and van Herpen, Carla M.

Published
2019
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19. Pre-hospital rule-out of non-ST-segment elevation acute coronary syndrome by a single troponin: final one-year outcomes of the ARTICA randomised trial

Author

Aarts, Goaris W A, primary, Camaro, Cyril, additional, Adang, Eddy M M, additional, Rodwell, Laura, additional, van Hout, Roger, additional, Brok, Gijs, additional, Hoare, Anouk, additional, de Pooter, Frank, additional, de Wit, Walter, additional, Cramer, Gilbert E, additional, van Kimmenade, Roland R J, additional, Ouwendijk, Eva, additional, Rutten, Martijn H, additional, Zegers, Erwin, additional, van Geuns, Robert-Jan M, additional, Gomes, Marc E R, additional, Damman, Peter, additional, and van Royen, Niels, additional

Published
2024
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22. Differences in risk and costs between prehospital identified low-risk men and women with chest pain

Author

Aarts, Goaris W A, primary, Camaro, Cyril, additional, Rodwell, Laura, additional, Adang, Eddy M M, additional, van Hout, Roger, additional, Brok, Gijs, additional, Hoare, Anouk, additional, de Pooter, Frank P C, additional, de Wit, Walter, additional, Cramer, Gilbert E, additional, van Kimmenade, Roland R J, additional, Ouwendijk, Eva, additional, Rutten, Martijn, additional, Zegers, Erwin, additional, van Geuns, Robert-Jan M, additional, Gomes, Marc E R, additional, Damman, Peter, additional, and van Royen, Niels, additional

Published
2023
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24. Do independent treatment centers offer more value than general hospitals? The case of cataract care

Author

Kruse, Florien M., Groenewoud, Stef, Atsma, Femke, van der Galien, Onno P., Adang, Eddy M.M., and Jeurissen, Patrick P.T.

Subjects
United States. Medicare Payment Advisory Commission, Quality management, Health aspects, Hospitals -- United Kingdom -- Netherlands -- Health aspects, Health care costs -- Health aspects, Patient satisfaction -- Health aspects, Patient care -- Health aspects, Medical care quality -- Health aspects, Cataracts -- Health aspects, Health insurance industry -- Health aspects, Surgery, Insurance industry, Medical economics, Medical consultants
Abstract

1 | INTRODUCTION Provoked by the increasing pressure to sustain rising health care costs, policy makers are seeking for more efficient ways to organize health care delivery. To pursue the [...], Objective: To identify differences between independent treatment centers (ITCs) and general hospitals (GHs) regarding costs, quality of care, and efficiency. Data Sources: Anonymous claims data (2013-2015) were used. We also obtained quality indicators from a semipublic platform. Study Design: This study uses a comparative multilevel analysis, controlling for case mix, to evaluate the performance of ITCs and GHs for patients diagnosed with cataract. Data Collection: Reimbursement claims were extracted from existing claims databases of the largest Dutch health insurer. Quality indicators were obtained by external agencies through a mixed-mode survey. Principal Findings: There are no stark differences in complexity of cases for cataract care. ITCs seem to perform surgeries more frequently per care pathway, but conduct a lower number of health care activities per surgical claim. Total average costs are lower in ITCs compared with GHs, but when adjusted for case mix, the differences in costs are lower. The findings with the adjusted quality differences suggest that ITCs outperform GHs on patient satisfaction, but patients' outcomes are similar. Conclusion: This finding supports the postulation--based on the focus factory theory--that ITCs can provide more value for cataract care than GHs. KEYWORDS efficiency, health care costs, independent treatment centers, quality of care, value

Published
2019
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26. Factors Associated with Perception of the Quality of Physicians' End-of-life Communication in Long-Term Care Facilities: PACE Cross-Sectional Study

Author

Adang, Eddy, Andreasen, Paula, Collingridge Moore, Danni, van Hout, Hein, ten Koppel, Maud, Mammarella, Federica, Mercuri, Martina, Onwuteaka-Philipsen, Bregje D., Pivodic, Lara, Rossi, Paola, Sowerby, Eleanor, Stodolska, Agata, Wichmann, Anne, van der Steen, Jenny T., Vernooij-Dassen, Myrra, the European Association for Palliative Care Onlus, European Forum for Primary Care, Age Platform Europe, Alzheimer Europe, Barańska, Ilona, Kijowska, Violetta, Engels, Yvonne, Finne-Soveri, Harriet, Froggatt, Katherine, Gambassi, Giovanni, Hammar, Teija, Oosterveld-Vlug, Mariska, Payne, Sheila, Van Den Noortgate, Nele, Smets, Tinne, Deliens, Luc, Van den Block, Lieve, and Szczerbińska, Katarzyna

Published
2020
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28. Evaluation of two vaginal, uterus sparing operations for pelvic organ prolapse: modified Manchester operation (MM) and sacrospinous hysteropexy (SSH), a study protocol for a multicentre randomized non-inferiority trial (the SAM study)

Author

Schulten, Sascha F. M., Enklaar, Rosa A., Kluivers, Kirsten B., van Leijsen, Sanne A. L., Jansen-van der Weide, Marijke C., Adang, Eddy M. M., van Bavel, Jeroen, van Dongen, Heleen, Gerritse, Maaike B. E., van Gestel, Iris, Malmberg, G. G. Alec, Mouw, Ronald J. C., van Rumpt-van de Geest, Deliana A., Spaans, Wilbert A., van der Steen, Annemarie, Stekelenburg, Jelle, Tiersma, E. Stella M., Verkleij-Hagoort, Anneke C., Vollebregt, Astrid, Wingen, Chantal B. M., Weemhoff, Mirjam, and van Eijndhoven, Hugo W. F.

Published
2019
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29. Early Eculizumab Withdrawal in Patients With Atypical Hemolytic Uremic Syndrome in Native Kidneys Is Safe and Cost-Effective:Results of the CUREiHUS Study

Author

Bouwmeester, Romy N., Duineveld, Caroline, Wijnsma, Kioa L., Bemelman, Frederike J., van der Heijden, Joost W., van Wijk, Joanna A.E., Bouts, Antonia H.M., van de Wetering, Jacqueline, Dorresteijn, Eiske, Berger, Stefan P., Gracchi, Valentina, van Zuilen, Arjan D., Keijzer-Veen, Mandy G., de Vries, Aiko P.J., van Rooij, Roos W.G., Engels, Flore A.P.T., Altena, Wim, de Wildt, Renée, van Kempen, Evy, Adang, Eddy M., ter Avest, Mendy, ter Heine, Rob, Volokhina, Elena B., van den Heuvel, Lambertus P.W.J., Wetzels, Jack F.M., van de Kar, Nicole C.A.J., Bouwmeester, Romy N., Duineveld, Caroline, Wijnsma, Kioa L., Bemelman, Frederike J., van der Heijden, Joost W., van Wijk, Joanna A.E., Bouts, Antonia H.M., van de Wetering, Jacqueline, Dorresteijn, Eiske, Berger, Stefan P., Gracchi, Valentina, van Zuilen, Arjan D., Keijzer-Veen, Mandy G., de Vries, Aiko P.J., van Rooij, Roos W.G., Engels, Flore A.P.T., Altena, Wim, de Wildt, Renée, van Kempen, Evy, Adang, Eddy M., ter Avest, Mendy, ter Heine, Rob, Volokhina, Elena B., van den Heuvel, Lambertus P.W.J., Wetzels, Jack F.M., and van de Kar, Nicole C.A.J.

Abstract

Introduction: The introduction of eculizumab has improved the outcome in patients with atypical hemolytic uremic syndrome (aHUS). The optimal treatment strategy is debated. Here, we report the results of the CUREiHUS study, a 4-year prospective, observational study monitoring unbiased eculizumab discontinuation in Dutch patients with aHUS after 3 months of therapy. Methods: All pediatric and adult patients with aHUS in native kidneys and a first-time eculizumab treatment were evaluated. In addition, an extensive cost-consequence analysis was conducted. Results: A total of 21 patients were included in the study from January 2016 to October 2020. In 17 patients (81%), a complement genetic variant or antibodies against factor H were identified. All patients showed full recovery of hematological thrombotic microangiopathy (TMA) parameters after the start of eculizumab. A renal response was noted in 18 patients. After a median treatment duration of 13.6 weeks (range 2.1–43.9), eculizumab was withdrawn in all patients. During follow-up (80.7 weeks [0.0–236.9]), relapses occurred in 4 patients. Median time to first relapse was 19.5 (14.3–53.6) weeks. Eculizumab was reinitiated within 24 hours in all relapsing patients. At last follow-up, there were no chronic sequelae, i.e., no clinically relevant increase in serum creatinine (sCr), proteinuria, and/or hypertension in relapsing patients. The low sample size and event rate did not allow to determine predictors of relapse. However, relapses only occurred in patients with a likely pathogenic variant. The cost-effectiveness analysis revealed that the total medical expenses of our population were only 30% of the fictive expenses that would have been made when patients received eculizumab every fortnight. Conclusion: It is safe and cost-effective to discontinue eculizumab after 3 months of therapy in patients with aHUS in native kidneys. Larger data registries are needed to determine factors associated with suboptimal kidney

Published
2023

30. The most efficient and effective BRCA1/2 testing strategy in epithelial ovarian cancer: Tumor-First or Germline-First?

Author

Genetica Klinische Genetica, Cancer, Witjes, Vera M, Ligtenberg, Marjolijn J L, Vos, Janet R, Braspenning, Jozé C C, Ausems, Margreet G E M, Mourits, Marian J E, de Hullu, Joanne A, Adang, Eddy M M, Hoogerbrugge, Nicoline, Genetica Klinische Genetica, Cancer, Witjes, Vera M, Ligtenberg, Marjolijn J L, Vos, Janet R, Braspenning, Jozé C C, Ausems, Margreet G E M, Mourits, Marian J E, de Hullu, Joanne A, Adang, Eddy M M, and Hoogerbrugge, Nicoline

Published
2023

31. Early Eculizumab Withdrawal in Patients With Atypical Hemolytic Uremic Syndrome in Native Kidneys Is Safe and Cost-Effective: Results of the CUREiHUS Study

Author

MS Nefrologie, Circulatory Health, Nefrologie patientenzorg, Child Health, Bouwmeester, Romy N., Duineveld, Caroline, Wijnsma, Kioa L., Bemelman, Frederike J., van der Heijden, Joost W., van Wijk, Joanna A.E., Bouts, Antonia H.M., van de Wetering, Jacqueline, Dorresteijn, Eiske, Berger, Stefan P., Gracchi, Valentina, van Zuilen, Arjan D., Keijzer-Veen, Mandy G., de Vries, Aiko P.J., van Rooij, Roos W.G., Engels, Flore A.P.T., Altena, Wim, de Wildt, Renée, van Kempen, Evy, Adang, Eddy M., ter Avest, Mendy, ter Heine, Rob, Volokhina, Elena B., van den Heuvel, Lambertus P.W.J., Wetzels, Jack F.M., van de Kar, Nicole C.A.J., MS Nefrologie, Circulatory Health, Nefrologie patientenzorg, Child Health, Bouwmeester, Romy N., Duineveld, Caroline, Wijnsma, Kioa L., Bemelman, Frederike J., van der Heijden, Joost W., van Wijk, Joanna A.E., Bouts, Antonia H.M., van de Wetering, Jacqueline, Dorresteijn, Eiske, Berger, Stefan P., Gracchi, Valentina, van Zuilen, Arjan D., Keijzer-Veen, Mandy G., de Vries, Aiko P.J., van Rooij, Roos W.G., Engels, Flore A.P.T., Altena, Wim, de Wildt, Renée, van Kempen, Evy, Adang, Eddy M., ter Avest, Mendy, ter Heine, Rob, Volokhina, Elena B., van den Heuvel, Lambertus P.W.J., Wetzels, Jack F.M., and van de Kar, Nicole C.A.J.

Published
2023

34. Rule-out of non-ST-segment elevation acute coronary syndrome by a single, pre-hospital troponin measurement: a randomized trial

Author

Camaro, Cyril, primary, Aarts, Goaris W A, additional, Adang, Eddy M M, additional, van Hout, Roger, additional, Brok, Gijs, additional, Hoare, Anouk, additional, Rodwell, Laura, additional, de Pooter, Frank, additional, de Wit, Walter, additional, Cramer, Gilbert E, additional, van Kimmenade, Roland R J, additional, Damman, Peter, additional, Ouwendijk, Eva, additional, Rutten, Martijn, additional, Zegers, Erwin, additional, van Geuns, Robert-Jan M, additional, Gomes, Marc E R, additional, and van Royen, Niels, additional

Published
2023
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35. REMBRANDT trial:The effectiveness of adding Braun anastomosis to standard Child reconstruction to reduce delayed gastric emptying after pancreatoduodenectomy: a multicenter randomized-controlled trial

Author

Hopstaken, Jana, primary, Endo, Chikako, additional, de Vries, Marjan, additional, Atsma, Femke, additional, Adang, Eddy, additional, van der Wees, Philip, additional, van Santvoort, Hjalmar, additional, Den Dulk, Marcel, additional, Koerkamp, Bas Groot, additional, Mieog, Sven, additional, Besselink, Marc, additional, Stommel, Martijn, additional, and van Laarhoven, Kees, additional

Published
2023
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36. Evaluation and optimisation of the colorectal cancer screening programme

Author

Cornel, MC, Dekkers, O.M., Adang, Eddy M., Broeders, Mireille J M, Das, Enny, Drewes, Yvonne M., Elders, PJM, Krom, Andre, van Langen, I.M., Linn, Sabine C., Ploem, M.C., van Tol-Geerdink, Julia J., Twisk, JWR, van der Berg, JD, and Aitken, Clare A.

Abstract

The colorectal cancer screening programme was introduced gradually from 2014. Since 2019, all people aged 55 to 75 have been invited to participate once every two years. In 2021, more than 1.6 million people took part in the screening programme, and colorectal cancer was detected in 2,700 participants, with an early stage of colorectal cancer being detected in 17,000 participants. At this stage, the screening programme has been running for too short a time to be able to scientifically demonstrate that it leads to less mortality from colorectal cancer; however, there are clear indications in that direction. Under the current circumstances, the benefits (prevention of colorectal cancer and associated mortality) outweigh the risks of the screening programme (screening test that detects no abnormalities but is taxing and causes concern, and cases of cancer that are missed). The Council therefore recommends that no modifications be made to the regular programme at this time.The Council does, however, recommend conducting a regional pilot population screening programme with one-off screening of people around 50 years of age. This will allow a review of to what extent such a programme would provide health benefits and whether the benefits would outweigh the risks. Based on the results, a decision can be made as to whether the age limit of the programme should be lowered. One promising development that may improve the screening programme in the long term is customised screening. As such, the Council recommends that this be reviewed. In addition, the Council recommends continuing investment in increasing participation rates.

Published
2022

37. Advies Evaluatie en optimalisatie van het bevolkingsonderzoek darmkanker

Author

Cornel, MC, Dekkers, O.M., Adang, Eddy M., Broeders, Mireille J M, Das, Enny, Drewes, Yvonne M., Elders, PJM, Krom, Andre, van Langen, I.M., Linn, Sabine C., Ploem, M.C., van Tol-Geerdink, Julia J., Twisk, JWR, van der Berg, JD, Aitken, Clare A., Human genetics, APH - Personalized Medicine, APH - Quality of Care, Amsterdam Reproduction & Development (AR&D), General practice, APH - Health Behaviors & Chronic Diseases, APH - Methodology, Epidemiology and Data Science, and ACS - Diabetes & metabolism

Abstract

The colorectal cancer screening programme was introduced gradually from 2014. Since 2019, all people aged 55 to 75 have been invited to participate once every two years. In 2021, more than 1.6 million people took part in the screening programme, and colorectal cancer was detected in 2,700 participants, with an early stage of colorectal cancer being detected in 17,000 participants. At this stage, the screening programme has been running for too short a time to be able to scientifically demonstrate that it leads to less mortality from colorectal cancer; however, there are clear indications in that direction. Under the current circumstances, the benefits (prevention of colorectal cancer and associated mortality) outweigh the risks of the screening programme (screening test that detects no abnormalities but is taxing and causes concern, and cases of cancer that are missed). The Council therefore recommends that no modifications be made to the regular programme at this time. The Council does, however, recommend conducting a regional pilot population screening programme with one-off screening of people around 50 years of age. This will allow a review of to what extent such a programme would provide health benefits and whether the benefits would outweigh the risks. Based on the results, a decision can be made as to whether the age limit of the programme should be lowered. One promising development that may improve the screening programme in the long term is customised screening. As such, the Council recommends that this be reviewed. In addition, the Council recommends continuing investment in increasing participation rates.

Published
2022

38. Early treatment versus expectative management of patent ductus arteriosus in preterm infants: a multicentre, randomised, non-inferiority trial in Europe (BeNeDuctus trial)

Author

Hundscheid, Tim, Onland, Wes, van Overmeire, Bart, Dijk, Peter, van Kaam, Anton H. L. C., Dijkman, Koen P., Kooi, Elisabeth M. W., Villamor, Eduardo, Kroon, André A., Visser, Remco, Vijlbrief, Daniel C., de Tollenaer, Susanne M., Cools, Filip, van Laere, David, Johansson, Anne-Britt, Hocq, Catheline, Zecic, Alexandra, Adang, Eddy, Donders, Rogier, de Vries, Willem, van Heijst, Arno F. J., and de Boode, Willem P.

Published
2018
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40. Implementing a Personalized Physical Therapy Approach (Coach2Move) Is Effective in Increasing Physical Activity and Improving Functional Mobility in Older Adults: A Cluster-Randomized, Stepped Wedge Trial

Author

Heij, Ward, primary, Sweerts, Lieke, additional, Staal, J Bart, additional, Teerenstra, Steven, additional, Adang, Eddy, additional, van der Wees, Philip J, additional, Nijhuis-van der Sanden, Maria W G, additional, and Hoogeboom, Thomas J, additional

Published
2022
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41. MiCare study, an evaluation of structured, multidisciplinary and personalised post-ICU care on physical and psychological functioning, and quality of life of former ICU patients: a study protocol of a stepped-wedge cluster randomised controlled trial

Author

van Sleeuwen, Dries, primary, van de Laar, Floris A, additional, Simons, Koen, additional, van Bommel, Daniëlle, additional, Burgers-Bonthuis, Dominique, additional, Koeter, Julia, additional, Bisschops, Laurens L A, additional, Vloet, Lilian, additional, Brackel, Marianne, additional, Teerenstra, Steven, additional, Adang, Eddy, additional, van der Hoeven, Johannes G, additional, Zegers, Marieke, additional, and van den Boogaard, Mark, additional

Published
2022
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