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6. The effects of polyunsaturated fatty acid (PUFA) administration on the microbiome-gut-brain axis in adolescents with anorexia nervosa (the MiGBAN study): study protocol for a longitudinal, double-blind, randomized, placebo-controlled trial

Author

Keller, Lara, Dempfle, Astrid, Dahmen, Brigitte, Schreiber, Samira, Adan, Roger A. H., Andreani, Nadia Andrea, Danner, Unna N., Eisert, Albrecht, Fetissov, Sergueï, Fischmeister, Florian Ph. S., Karwautz, Andreas, Konrad, Kerstin, Kooij, Karlijn L., Trinh, Stefanie, van der Vijgh, Benny, van Elburg, Annemarie A., Zeiler, Michael, Baines, John, Seitz, Jochen, and Herpertz-Dahlmann, Beate

Published
2022
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8. Fecal microbiota transplantation of patients with anorexia nervosa did not alter flexible behavior in rats.

Author

Kooij, Karlijn L., Andreani, Nadia Andrea, van der Gun, Luna L., Keller, Lara, Trinh, Stefanie, van der Vijgh, Benny, Luijendijk, Mieneke, Dempfle, Astrid, Herpertz‐Dahlmann, Beate, Seitz, Jochen, van Elburg, Annemarie, Danner, Unna N., Baines, John, and Adan, Roger A. H.

Subjects
ANOREXIA nervosa treatment, ANXIETY treatment, ANTIBIOTICS, FECAL microbiota transplantation, BIOLOGICAL models, RESEARCH funding, GUT microbiome, ANIMALS, ANXIETY, BEHAVIOR, DESCRIPTIVE statistics, RATS, REWARD (Psychology), ANIMAL behavior, BRAIN stem, LEARNING strategies, DOPAMINE, COMPARATIVE studies, PHENOTYPES, DISEASE progression, COGNITION
Abstract

Objective: Patients with anorexia nervosa (AN) are often anxious, display inflexible behavior and disrupted reward processing. Emerging evidence suggests that gut dysbiosis in patients contributes to the disease phenotype and progression. Methods: In a preclinical study, we explored whether AN‐derived microbiota impacts cognitive flexibility, anxiety, and dopamine signaling using fecal microbiota transplantation (FMT) in tyrosine hydroxylase‐cre rats. We performed probabilistic reversal learning task (PRLT) at the baseline, after antibiotic treatment, and following FMT from patients with AN and controls. We assessed flexible behavior, task engagement, and ventral tegmental area (VTA) dopamine signaling during and in the absence of reward. Furthermore, anxiety‐like behavior was evaluated with open field (OF) and elevated plus maze (EPM) tests. Results: Neither antibiotic‐induced dysbiosis nor AN FMT led to significant alterations in the number of reversals or lever press strategies after reinforced or nonreinforced lever presses (win and lose‐stay) in the PRLT. However, the number of initiated trials decreased after antibiotic treatment while remaining unchanged after FMT. No significant differences were observed in VTA dopamine activity, anxiety measures in the OF and EPM tests. Microbiome analysis revealed limited overlap between the microbiota of the donors and recipients. Discussion: No evidence was found that the microbiota of patients compared to controls, nor a depleted microbiome impacts cognitive flexibility. Nonetheless, antibiotic‐induced dysbiosis resulted in reduced task engagement during the PRLT. The relatively low efficiency of the FMT is a limitation of our study and highlights the need for improved protocols to draw robust conclusions in future studies. Public Significance: While our study did not reveal direct impacts of AN‐associated gut microbiota on cognitive flexibility or anxiety behaviors in our preclinical model, we observed a decrease in task engagement after antibiotic‐induced dysbiosis, underscoring that the presence of a gut microbiome matters. Our findings underscore the need for further refinement in FMT protocols to better elucidate the complex interplay between gut microbiota and behaviors characteristic of anorexia nervosa. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Reduced GABA transmission onto ventral tegmental area dopamine neurons underlies vulnerability for hyperactivity in a mouse model of Anorexia Nervosa

Author

Ducrocq, Fabien, primary, Brouwer, Eileen, additional, Kooij, Karlijn L., additional, Wolterink-Donselaar, Inge G., additional, Drost, Lisa, additional, Hak, Jaimie, additional, Veendijk, Melissa, additional, Luijendijk, Mieneke C. M., additional, Meye, Frank J., additional, and Adan, Roger A. H., additional

Published
2024
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15. Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Author

Watson, Hunna J., Yilmaz, Zeynep, Thornton, Laura M., Hübel, Christopher, Coleman, Jonathan R. I., Gaspar, Héléna A., Bryois, Julien, Hinney, Anke, Leppä, Virpi M., Mattheisen, Manuel, Medland, Sarah E., Ripke, Stephan, Yao, Shuyang, Giusti-Rodríguez, Paola, Anorexia Nervosa Genetics Initiative, Hanscombe, Ken B., Purves, Kirstin L., Eating Disorders Working Group of the Psychiatric Genomics Consortium, Adan, Roger A. H., Alfredsson, Lars, Ando, Tetsuya, Andreassen, Ole A., Baker, Jessica H., Berrettini, Wade H., Boehm, Ilka, Boni, Claudette, Perica, Vesna Boraska, Buehren, Katharina, Burghardt, Roland, Cassina, Matteo, Cichon, Sven, Clementi, Maurizio, Cone, Roger D., Courtet, Philippe, Crow, Scott, Crowley, James J., Danner, Unna N., Davis, Oliver S. P., de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, DeSocio, Janiece E., Dick, Danielle M., Dikeos, Dimitris, Dina, Christian, Dmitrzak-Weglarz, Monika, Docampo, Elisa, Duncan, Laramie E., Egberts, Karin, Ehrlich, Stefan, Escaramís, Geòrgia, Esko, Tõnu, Estivill, Xavier, Farmer, Anne, Favaro, Angela, Fernández-Aranda, Fernando, Fichter, Manfred M., Fischer, Krista, Föcker, Manuel, Foretova, Lenka, Forstner, Andreas J., Forzan, Monica, Franklin, Christopher S., Gallinger, Steven, Giegling, Ina, Giuranna, Johanna, Gonidakis, Fragiskos, Gorwood, Philip, Mayora, Monica Gratacos, Guillaume, Sébastien, Guo, Yiran, Hakonarson, Hakon, Hatzikotoulas, Konstantinos, Hauser, Joanna, Hebebrand, Johannes, Helder, Sietske G., Herms, Stefan, Herpertz-Dahlmann, Beate, Herzog, Wolfgang, Huckins, Laura M., Hudson, James I., Imgart, Hartmut, Inoko, Hidetoshi, Janout, Vladimir, Jiménez-Murcia, Susana, Julià, Antonio, Kalsi, Gursharan, Kaminská, Deborah, Kaprio, Jaakko, Karhunen, Leila, Karwautz, Andreas, Kas, Martien J. H., Kennedy, James L., Keski-Rahkonen, Anna, Kiezebrink, Kirsty, Kim, Youl-Ri, Klareskog, Lars, Klump, Kelly L., Knudsen, Gun Peggy S., La Via, Maria C., Le Hellard, Stephanie, Levitan, Robert D., Li, Dong, Lilenfeld, Lisa, Lin, Bochao Danae, Lissowska, Jolanta, Luykx, Jurjen, Magistretti, Pierre J., Maj, Mario, Mannik, Katrin, Marsal, Sara, Marshall, Christian R., Mattingsdal, Morten, McDevitt, Sara, McGuffin, Peter, Metspalu, Andres, Meulenbelt, Ingrid, Micali, Nadia, Mitchell, Karen, Monteleone, Alessio Maria, Monteleone, Palmiero, Munn-Chernoff, Melissa A., Nacmias, Benedetta, Navratilova, Marie, Ntalla, Ioanna, O’Toole, Julie K., Ophoff, Roel A., Padyukov, Leonid, Palotie, Aarno, Pantel, Jacques, Papezova, Hana, Pinto, Dalila, Rabionet, Raquel, Raevuori, Anu, Ramoz, Nicolas, Reichborn-Kjennerud, Ted, Ricca, Valdo, Ripatti, Samuli, Ritschel, Franziska, Roberts, Marion, Rotondo, Alessandro, Rujescu, Dan, Rybakowski, Filip, Santonastaso, Paolo, Scherag, André, Scherer, Stephen W., Schmidt, Ulrike, Schork, Nicholas J., Schosser, Alexandra, Seitz, Jochen, Slachtova, Lenka, Slagboom, P. Eline, Slof-Op ‘t Landt, Margarita C. T., Slopien, Agnieszka, Sorbi, Sandro, Świątkowska, Beata, Szatkiewicz, Jin P., Tachmazidou, Ioanna, Tenconi, Elena, Tortorella, Alfonso, Tozzi, Federica, Treasure, Janet, Tsitsika, Artemis, Tyszkiewicz-Nwafor, Marta, Tziouvas, Konstantinos, van Elburg, Annemarie A., van Furth, Eric F., Wagner, Gudrun, Walton, Esther, Widen, Elisabeth, Zeggini, Eleftheria, Zerwas, Stephanie, Zipfel, Stephan, Bergen, Andrew W., Boden, Joseph M., Brandt, Harry, Crawford, Steven, Halmi, Katherine A., Horwood, L. John, Johnson, Craig, Kaplan, Allan S., Kaye, Walter H., Mitchell, James E., Olsen, Catherine M., Pearson, John F., Pedersen, Nancy L., Strober, Michael, Werge, Thomas, Whiteman, David C., Woodside, D. Blake, Stuber, Garret D., Gordon, Scott, Grove, Jakob, Henders, Anjali K., Juréus, Anders, Kirk, Katherine M., Larsen, Janne T., Parker, Richard, Petersen, Liselotte, Jordan, Jennifer, Kennedy, Martin, Montgomery, Grant W., Wade, Tracey D., Birgegård, Andreas, Lichtenstein, Paul, Norring, Claes, Landén, Mikael, Martin, Nicholas G., Mortensen, Preben Bo, Sullivan, Patrick F., Breen, Gerome, and Bulik, Cynthia M.

Published
2019
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18. Inhibition of ventral tegmental area projections to the nucleus accumbens shell increases premature responding in the five-choice serial reaction time task in rats

Author

Flores-Dourojeanni, Jacques P, van den Munkhof, Marleen H, Luijendijk, Mieneke C M, Vanderschuren, Louk J M J, Adan, Roger A H, Flores-Dourojeanni, Jacques P, van den Munkhof, Marleen H, Luijendijk, Mieneke C M, Vanderschuren, Louk J M J, and Adan, Roger A H

Abstract

Exaggerated impulsivity and attentional impairments are hallmarks of certain disorders of behavioural control such as attention-deficit/hyperactivity disorder (ADHD), schizophrenia and addiction. Pharmacological studies have implicated elevated dopamine (DA) levels in the nucleus accumbens shell (NAcbS) in impulsive actions. The NAcbS receives its DA input from the ventral tegmental area (VTA), and we have previously shown that optogenetic activation of VTA-NAcbS projections impaired impulse control and attention in the five-choice serial reaction time task (5-CSRTT) in rats. To better understand the role of VTA-NAcbS projections in impulsivity and attention, the present study sought to inhibit this projection using optogenetics. We demonstrate that inhibiting VTA-NAcbS efferents during the last seconds of the inter-trial interval (i.e. immediately before presentation of the instructive cue) induces exaggerated impulsive action, in the absence of changes in attentional or motivational parameters in the 5-CSRTT. Together with our earlier observations, this suggests that impulse control in the 5-CSRTT is tightly controlled by VTA-NAcbS activity, with deviations in both directions resulting in increased impulsivity.

Published
2023

19. Inhibition of ventral tegmental area projections to the nucleus accumbens shell increases premature responding in the five-choice serial reaction time task in rats

Author

AISS Behaviour Neuroscience, Flores-Dourojeanni, Jacques P, van den Munkhof, Marleen H, Luijendijk, Mieneke C M, Vanderschuren, Louk J M J, Adan, Roger A H, AISS Behaviour Neuroscience, Flores-Dourojeanni, Jacques P, van den Munkhof, Marleen H, Luijendijk, Mieneke C M, Vanderschuren, Louk J M J, and Adan, Roger A H

Published
2023

25. On the interrelation between alcohol addiction-like behaviors in rats

Author

Smeets, Johanna A S, Minnaard, A Maryse, Ramakers, Geert M J, Adan, Roger A H, Vanderschuren, Louk J M J, Lesscher, Heidi M B, dASS BW-1, and AISS Behaviour Neuroscience

Subjects
Alcohol use disorder, Pharmacology, Motivation, Aversion, Individual differences, Alcohol consumption, Habit, Loss of control, Rats
Abstract

RATIONALE: Alcohol use disorder (AUD) is a complex, heterogeneous disorder that only occurs in a minority of alcohol users. Various behavioral constructs, including excessive intake, habit formation, motivation for alcohol and resistance to punishment have been implicated in AUD, but their interrelatedness is unclear. OBJECTIVE: The aim of this study was therefore to explore the relation between these AUD-associated behavioral constructs in rats. We hypothesised that a subpopulation of animals could be identified that, based on these measures, display consistent AUD-like behavior. METHODS: Lister Hooded rats (n = 47) were characterised for alcohol consumption, habit formation, motivation for alcohol and quinine-adulterated alcohol consumption. The interrelation between these measures was evaluated through correlation and cluster analyses. In addition, addiction severity scores were computed using different combinations of the behavioral measures, to assess the consistency of the AUD-like subpopulation. RESULTS: We found that the data was uniformly distributed, as there was no significant tendency of the behavioral measures to cluster in the dataset. On the basis of multiple ranked addiction severity scores, five animals (~ 11%) were classified as displaying AUD-like behavior. The composition of the remaining subpopulation of animals with the highest addiction severity score (9 rats; ~ 19%) varied, depending on the combination of measures included. CONCLUSION: Consistent AUD-like behavior was detected in a small proportion of alcohol drinking rats. Alcohol consumption, habit formation, motivation for alcohol and punishment resistance contribute in varying degrees to the AUD-like phenotype across the population. These findings emphasise the importance of considering the heterogeneity of AUD-like behavior.

Published
2022

26. Increased elasticity of sucrose demand during hyperdopaminergic states in rats

Author

Minnaard, A Maryse, Luijendijk, Mieneke C M, Baars, Annemarie M, Drost, Lisa, Ramakers, Geert M J, Adan, Roger A H, Lesscher, Heidi M B, Vanderschuren, Louk J M J, Minnaard, A Maryse, Luijendijk, Mieneke C M, Baars, Annemarie M, Drost, Lisa, Ramakers, Geert M J, Adan, Roger A H, Lesscher, Heidi M B, and Vanderschuren, Louk J M J

Abstract

RATIONALE: Deficits in cost-benefit decision-making are a core feature of several psychiatric disorders, including substance addiction, eating disorders and bipolar disorder. Mesocorticolimbic dopamine signalling has been implicated in various processes related to cognition and reward, but its precise role in reward valuation and cost-benefit trade-off decisions remains incompletely understood.OBJECTIVES: We assessed the role of mesocorticolimbic dopamine signalling in the relationship between price and consumption of sucrose, to better understand its role in cost-benefit decisions.METHODS: Dopamine neurons in the ventral tegmental area (VTA) were chemogenetically activated in rats, and a behavioural economics approach was used to quantify the relationship between price and consumption of sucrose. Motivation for sucrose was also assessed under a progressive ratio (PR) schedule of reinforcement. To further gauge the role of dopamine in cost-benefit trade-offs for sucrose, the effects of treatment with D-amphetamine and the dopamine receptor antagonist alpha-flupentixol were assessed.RESULTS: Chemogenetic activation of VTA dopamine neurons increased demand elasticity, while responding for sucrose under a PR schedule of reinforcement was augmented upon stimulation of VTA dopamine neurons. Treatment with amphetamine partially replicated the effects of chemogenetic dopamine neuron activation, whereas treatment with alpha-flupentixol reduced free consumption of sucrose and had mixed effects on demand elasticity.CONCLUSIONS: Stimulation of mesocorticolimbic dopaminergic neurotransmission altered cost-benefit trade-offs in a complex manner. It reduced the essential value of palatable food, increased incentive motivation and left free consumption unaltered. Together, these findings imply that mesocorticolimbic dopamine signalling differentially influences distinct components of cost expenditure processes aimed at obtaining rewards.

Published
2022

27. Increased elasticity of sucrose demand during hyperdopaminergic states in rats

Author

dASS BW-1, AISS Behaviour Neuroscience, Anatomie en fysiologie, Minnaard, A Maryse, Luijendijk, Mieneke C M, Baars, Annemarie M, Drost, Lisa, Ramakers, Geert M J, Adan, Roger A H, Lesscher, Heidi M B, Vanderschuren, Louk J M J, dASS BW-1, AISS Behaviour Neuroscience, Anatomie en fysiologie, Minnaard, A Maryse, Luijendijk, Mieneke C M, Baars, Annemarie M, Drost, Lisa, Ramakers, Geert M J, Adan, Roger A H, Lesscher, Heidi M B, and Vanderschuren, Louk J M J

Published
2022

28. On the interrelation between alcohol addiction-like behaviors in rats

Author

dASS BW-1, AISS Behaviour Neuroscience, Smeets, Johanna A S, Minnaard, A Maryse, Ramakers, Geert M J, Adan, Roger A H, Vanderschuren, Louk J M J, Lesscher, Heidi M B, dASS BW-1, AISS Behaviour Neuroscience, Smeets, Johanna A S, Minnaard, A Maryse, Ramakers, Geert M J, Adan, Roger A H, Vanderschuren, Louk J M J, and Lesscher, Heidi M B

Published
2022

29. Studying Synaptic Connectivity and Strength with Optogenetics and Patch-Clamp Electrophysiology

Author

TN groep Meye, Brain, The Neural Circuits Underlying Stress Eating, TN groep Adan, Linders, Louisa E, Supiot, Laura F, Du, Wenjie, D'Angelo, Roberto, Adan, Roger A H, Riga, Danai, Meye, Frank J, TN groep Meye, Brain, The Neural Circuits Underlying Stress Eating, TN groep Adan, Linders, Louisa E, Supiot, Laura F, Du, Wenjie, D'Angelo, Roberto, Adan, Roger A H, Riga, Danai, and Meye, Frank J

Published
2022

30. Characterizing and TRAPing a Social Stress-Activated Neuronal Ensemble in the Ventral Tegmental Area

Author

TN groep Meye, Brain, The Neural Circuits Underlying Stress Eating, TN groep Adan, Koutlas, Ioannis, Linders, Louisa E, van der Starre, Stef E, Wolterink-Donselaar, Inge G, Adan, Roger A H, Meye, Frank J, TN groep Meye, Brain, The Neural Circuits Underlying Stress Eating, TN groep Adan, Koutlas, Ioannis, Linders, Louisa E, van der Starre, Stef E, Wolterink-Donselaar, Inge G, Adan, Roger A H, and Meye, Frank J

Published
2022

31. Characterization of orexin input to dopamine neurons of the ventral tegmental area projecting to the medial prefrontal cortex and shell of nucleus accumbens

Author

Brain, TN groep Meye, TN groep Adan, The Neural Circuits Underlying Stress Eating, Kalló, Imre, Omrani, Azar, Meye, Frank J, de Jong, Han, Liposits, Zsolt, Adan, Roger A H, Brain, TN groep Meye, TN groep Adan, The Neural Circuits Underlying Stress Eating, Kalló, Imre, Omrani, Azar, Meye, Frank J, de Jong, Han, Liposits, Zsolt, and Adan, Roger A H

Published
2022

33. Temporally specific roles of ventral tegmental area projections to the nucleus accumbens and prefrontal cortex in attention and impulse control

Author

Flores-Dourojeanni, Jacques P, van Rijt, Coby, Vanden Munkhof, Marleen H, Boekhoudt, Linde, Luijendijk, Mieneke C M, Vanderschuren, Louk J M J, Adan, Roger A H, AISS Behaviour Neuroscience, dASS BW-1, AISS Behaviour Neuroscience, and dASS BW-1

Subjects
Male, 0301 basic medicine, Dopamine, Nucleus Accumbens, 0302 clinical medicine, Neural Pathways, Taverne, Premovement neuronal activity, Attention, Prefrontal cortex, Research Articles, Accumbens, musculoskeletal, neural, and ocular physiology, General Neuroscience, Ventral tegmental area, medicine.anatomical_structure, Female, Cues, medicine.symptom, Psychology, psychological phenomena and processes, VTA, medicine.drug, Impulsivity, Neuroscience(all), Prefrontal Cortex, Serial Learning, Nucleus accumbens, Optogenetics, 03 medical and health sciences, mental disorders, Reaction Time, medicine, Animals, Attention deficit hyperactivity disorder, Rats, Long-Evans, Dopaminergic Neurons, Ventral Tegmental Area, medicine.disease, Electric Stimulation, Rats, 030104 developmental biology, nervous system, Attention Deficit Disorder with Hyperactivity, Impulsive Behavior, 5-CSRTT, Neuroscience, 030217 neurology & neurosurgery
Abstract

Deficits in impulse control and attention are prominent in the symptomatology of mental disorders such as attention deficit hyperactivity disorder (ADHD), substance addiction, schizophrenia, and bipolar disorder, yet the underlying mechanisms are incompletely understood. Frontostriatal structures, such as the nucleus accumbens (NAcb), the medial prefrontal cortex (mPFC), and their dopaminergic innervation from the ventral tegmental area (VTA) have been implicated in impulse control and attention. What remains unclear is how the temporal pattern of activity of these VTA projections contributes to these processes. Here, we optogenetically stimulated VTA dopamine (DA) cells, as well as VTA projections to the NAcb core (NAcbC), NAcb shell (NAcbS), and the mPFC in male rats performing the 5-choice serial reaction time task (5-CSRTT). Our data show that stimulation of VTA DA neurons, and VTA projections to the NAcbC and the mPFC immediately before presentation of the stimulus cue, impaired attention but spared impulse control. Importantly, in addition to reducing attention, activation of VTA-NAcbS also increased impulsivity when tested under a longer intertrial interval (ITI), to provoke impulsive behavior. Optogenetic stimulation at the beginning of the ITI only partially replicated these effects. In sum, our data show how attention and impulsivity are modulated by neuronal activity in distinct ascending output pathways from the VTA in a temporally specific manner. These findings increase our understanding of the intricate mechanisms by which mesocorticolimbic circuits contribute to cognition.SIGNIFICANCE STATEMENTDeficits in impulse control and attention are prominent in the symptomatology of several mental disorders, yet the brain mechanisms involved are incompletely understood. Since frontostriatal circuits have been implicated in impulse control and attention, we here examined the role of ascending projections from the midbrain ventral tegmental area (VTA) to the nucleus accumbens (NAcb) and prefrontal cortex (PFC). Using optogenetics to individually stimulate these projections with time-locked precision, we distinguished the role that each of these projections plays, in both impulse control and attention. As such, our study enhances our understanding of the neuronal circuitry that drives impulsive and attentive behavior.

Published
2021

36. Additional file 1 of The temporal relationship between parental concern of overeating and childhood obesity considering genetic susceptibility: longitudinal results from the IDEFICS/I.Family study

Author

Masip, Guiomar, Foraita, Ronja, Silventoinen, Karri, Adan, Roger A. H., Ahrens, Wolfgang, De Henauw, Stefaan, Hebestreit, Antje, Keski-Rahkonen, Anna, Lissner, Lauren, Mehlig, Kirsten, Molnar, D��n��s, Moreno, Luis A., Pigeot, Iris, Russo, Paola, Veidebaum, Toomas, Bogl, Leonie H., and Kaprio, Jaakko

Abstract

Additional file 1: Table S1. Eating behavior patterns and factor loadings in varimax-rotated principal components. Table S2. Baseline characteristics of the study sample of the three study waves (n = 1848). Figure S1. Sensitivity plots from causal mediation analyses.

Published
2021
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39. Impact of Free‐Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety‐Like Behavior in Rats

Author

Peris‐Sampedro, Fiona, Mounib, Myriam, Schéle, Erik, Edvardsson, Christian E., Stoltenborg, Iris, Adan, Roger A. H., and Dickson, Suzanne L.

Subjects
Male, Rats, Sprague-Dawley, Dietary Sucrose, Animals, Original Article, Obesity Biology and Integrated Physiology, Original Articles, Obesity, Anxiety, Diet, High-Fat, Rats
Abstract

Objective Rats were exposed to free‐choice diets (fat plus one of two different sugar solutions, glucose or sucrose), and the metabolic consequences and impact on locomotor activity and anxiety‐like behavior were explored. Methods For 3 weeks, 7‐week‐old male rats were offered either chow only or free‐choice high‐fat diets differing in their added sugar: no sugar, sucrose, or glucose. In a second experiment, after 2 weeks on the diets, rats were switched from high sucrose to high glucose for two additional weeks. Metabolic end points included body weight, food intake, food choice, glycemic control, metabolic hormones, fat pad weight, brown adipose tissue weight, and gene expression. Behavioral analysis included locomotor and anxiety‐like activity in the open field and elevated plus maze. Results Both sugar diets enhanced adiposity and induced hyperphagia, favoring unhealthier dietary selection above that of the control diets (chow or free‐choice high‐fat with no sugar). Despite isocaloric intake in the sugar‐containing diets, offering glucose instead of sucrose was associated with improved insulin sensitivity. The sugar‐containing diets reduced activity (but with movements of increased velocity) and induced an anxiety‐like phenotype. Conclusions Although free‐choice diets negatively impacted on metabolism and anxiety‐like behavior, replacing sucrose with glucose improved insulin sensitivity and may therefore be better for health.

Published
2019

40. The continued need for animals to advance brain research

Author

Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, Genzel, Lisa, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, and Genzel, Lisa

Abstract

Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available and the value of these alternatives has been proven, the use of animals should not be compromised.

Published
2021

41. The continued need for animals to advance brain research

Author

Afd Pharmacology, AISS Behaviour Neuroscience, dASS BW-1, Sub Cell Biology, Pharmacology, Celbiologie, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, Genzel, Lisa, Afd Pharmacology, AISS Behaviour Neuroscience, dASS BW-1, Sub Cell Biology, Pharmacology, Celbiologie, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, and Genzel, Lisa

Published
2021

42. Temporally specific roles of ventral tegmental area projections to the nucleus accumbens and prefrontal cortex in attention and impulse control

Author

AISS Behaviour Neuroscience, dASS BW-1, Flores-Dourojeanni, Jacques P, van Rijt, Coby, Vanden Munkhof, Marleen H, Boekhoudt, Linde, Luijendijk, Mieneke C M, Vanderschuren, Louk J M J, Adan, Roger A H, AISS Behaviour Neuroscience, dASS BW-1, Flores-Dourojeanni, Jacques P, van Rijt, Coby, Vanden Munkhof, Marleen H, Boekhoudt, Linde, Luijendijk, Mieneke C M, Vanderschuren, Louk J M J, and Adan, Roger A H

Published
2021

43. Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Author

Munn-Chernoff, Melissa A, Johnson, Emma C, Chou, Yi-Ling, Coleman, Jonathan R I, Thornton, Laura M, Walters, Raymond K, Yilmaz, Zeynep, Baker, Jessica H, Hübel, Christopher, Gordon, Scott, Medland, Sarah E, Watson, Hunna J, Gaspar, Héléna A, Bryois, Julien, Hinney, Anke, Leppä, Virpi M, Mattheisen, Manuel, Ripke, Stephan, Yao, Shuyang, Giusti-Rodríguez, Paola, Hanscombe, Ken B, Adan, Roger A H, Alfredsson, Lars, Ando, Tetsuya, Andreassen, Ole A, Berrettini, Wade H, Boehm, Ilka, Boni, Claudette, Boraska Perica, Vesna, Buehren, Katharina, Burghardt, Roland, Cassina, Matteo, Cichon, Sven, Clementi, Maurizio, Cone, Roger D, Courtet, Philippe, Crow, Scott, Crowley, James J, Danner, Unna N, Davis, Oliver S P, de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, DeSocio, Janiece E, Dick, Danielle M, Dikeos, Dimitris, Dina, Christian, Dmitrzak-Weglarz, Monika, Docampo, Elisa, Duncan, Laramie E, Egberts, Karin, Ehrlich, Stefan, Escaramís, Geòrgia, Esko, Tõnu, Estivill, Xavier, Farmer, Anne, Favaro, Angela, Fernández-Aranda, Fernando, Fichter, Manfred M, Fischer, Krista, Föcker, Manuel, Foretova, Lenka, Forstner, Andreas J, Forzan, Monica, Franklin, Christopher S, Gallinger, Steven, Giegling, Ina, Giuranna, Johanna, Gonidakis, Fragiskos, Gorwood, Philip, Gratacos Mayora, Monica, Guillaume, Sébastien, Guo, Yiran, Hakonarson, Hakon, Hatzikotoulas, Konstantinos, Hauser, Joanna, Hebebrand, Johannes, Helder, Sietske G, Herms, Stefan, Herpertz-Dahlmann, Beate, Herzog, Wolfgang, Huckins, Laura M, Hudson, James I, Imgart, Hartmut, Inoko, Hidetoshi, Janout, Vladimir, Jiménez-Murcia, Susana, Julià, Antonio, Kalsi, Gursharan, Kaminská, Deborah, Karhunen, Leila, Karwautz, Andreas, Kas, Martien J H, Kennedy, James L, Keski-Rahkonen, Anna, Kiezebrink, Kirsty, Kim, Youl-Ri, Klump, Kelly L, Knudsen, Gun Peggy S, La Via, Maria C, Le Hellard, Stephanie, Levitan, Robert D, Li, Dong, Lilenfeld, Lisa, Lin, Bochao Danae, Lissowska, Jolanta, Luykx, Jurjen, Magistretti, Pierre J, Maj, Mario, Mannik, Katrin, Marsal, Sara, Marshall, Christian R, Mattingsdal, Morten, McDevitt, Sara, McGuffin, Peter, Metspalu, Andres, Meulenbelt, Ingrid, Micali, Nadia, Mitchell, Karen, Monteleone, Alessio Maria, Monteleone, Palmiero, Nacmias, Benedetta, Navratilova, Marie, Ntalla, Ioanna, O'Toole, Julie K, Ophoff, Roel A, Padyukov, Leonid, Palotie, Aarno, Pantel, Jacques, Papezova, Hana, Pinto, Dalila, Rabionet, Raquel, Raevuori, Anu, Ramoz, Nicolas, Reichborn-Kjennerud, Ted, Ricca, Valdo, Ripatti, Samuli, Ritschel, Franziska, Roberts, Marion, Rotondo, Alessandro, Rujescu, Dan, Rybakowski, Filip, Santonastaso, Paolo, Scherag, André, Scherer, Stephen W, Schmidt, Ulrike, Schork, Nicholas J, Schosser, Alexandra, Seitz, Jochen, Slachtova, Lenka, Slagboom, P Eline, Slof-Op't Landt, Margarita C T, Slopien, Agnieszka, Sorbi, Sandro, Świątkowska, Beata, Szatkiewicz, Jin P, Tachmazidou, Ioanna, Tenconi, Elena, Tortorella, Alfonso, Tozzi, Federica, Treasure, Janet, Tsitsika, Artemis, Tyszkiewicz-Nwafor, Marta, Tziouvas, Konstantinos, van Elburg, Annemarie A, van Furth, Eric F, Wagner, Gudrun, Walton, Esther, Widen, Elisabeth, Zeggini, Eleftheria, Zerwas, Stephanie, Zipfel, Stephan, Bergen, Andrew W, Boden, Joseph M, Brandt, Harry, Crawford, Steven, Halmi, Katherine A, Horwood, L John, Johnson, Craig, Kaplan, Allan S, Kaye, Walter H, Mitchell, James, Olsen, Catherine M, Pearson, John F, Pedersen, Nancy L, Strober, Michael, Werge, Thomas, Whiteman, David C, Woodside, D Blake, Grove, Jakob, Henders, Anjali K, Larsen, Janne T, Parker, Richard, Petersen, Liselotte V, Jordan, Jennifer, Kennedy, Martin A, Birgegård, Andreas, Lichtenstein, Paul, Norring, Claes, Landén, Mikael, Mortensen, Preben Bo, Polimanti, Renato, McClintick, Jeanette N, Adkins, Amy E, Aliev, Fazil, Bacanu, Silviu-Alin, Batzler, Anthony, Bertelsen, Sarah, Biernacka, Joanna M, Bigdeli, Tim B, Chen, Li-Shiun, Clarke, Toni-Kim, Degenhardt, Franziska, Docherty, Anna R, Edwards, Alexis C, Foo, Jerome C, Fox, Louis, Frank, Josef, Hack, Laura M, Hartmann, Annette M, Hartz, Sarah M, Heilmann-Heimbach, Stefanie, Hodgkinson, Colin, Hoffmann, Per, Hottenga, Jouke-Jan, Konte, Bettina, Lahti, Jari, Lahti-Pulkkinen, Marius, Lai, Dongbing, Ligthart, Lannie, Loukola, Anu, Maher, Brion S, Mbarek, Hamdi, McIntosh, Andrew M, McQueen, Matthew B, Meyers, Jacquelyn L, Milaneschi, Yuri, Palviainen, Teemu, Peterson, Roseann E, Ryu, Euijung, Saccone, Nancy L, Salvatore, Jessica E, Sanchez-Roige, Sandra, Schwandt, Melanie, Sherva, Richard, Streit, Fabian, Strohmaier, Jana, Thomas, Nathaniel, Wang, Jen-Chyong, Webb, Bradley T, Wedow, Robbee, Wetherill, Leah, Wills, Amanda G, Zhou, Hang, Boardman, Jason D, Chen, Danfeng, Choi, Doo-Sup, Copeland, William E, Culverhouse, Robert C, Dahmen, Norbert, Degenhardt, Louisa, Domingue, Benjamin W, Frye, Mark A, Gäbel, Wolfgang, Hayward, Caroline, Ising, Marcus, Keyes, Margaret, Kiefer, Falk, Koller, Gabriele, Kramer, John, Kuperman, Samuel, Lucae, Susanne, Lynskey, Michael T, Maier, Wolfgang, Mann, Karl, Männistö, Satu, Müller-Myhsok, Bertram, Murray, Alison D, Nurnberger, John I, Preuss, Ulrich, Räikkönen, Katri, Reynolds, Maureen D, Ridinger, Monika, Scherbaum, Norbert, Schuckit, Marc A, Soyka, Michael, Treutlein, Jens, Witt, Stephanie H, Wodarz, Norbert, Zill, Peter, Adkins, Daniel E, Boomsma, Dorret I, Bierut, Laura J, Brown, Sandra A, Bucholz, Kathleen K, Costello, E Jane, de Wit, Harriet, Diazgranados, Nancy, Eriksson, Johan G, Farrer, Lindsay A, Foroud, Tatiana M, Gillespie, Nathan A, Goate, Alison M, Goldman, David, Grucza, Richard A, Hancock, Dana B, Harris, Kathleen Mullan, Hesselbrock, Victor, Hewitt, John K, Hopfer, Christian J, Iacono, William G, Johnson, Eric O, Karpyak, Victor M, Kendler, Kenneth S, Kranzler, Henry R, Krauter, Kenneth, Lind, Penelope A, McGue, Matt, MacKillop, James, Madden, Pamela A F, Maes, Hermine H, Magnusson, Patrik K E, Nelson, Elliot C, Nöthen, Markus M, Palmer, Abraham A, Penninx, Brenda W J H, Porjesz, Bernice, Rice, John P, Rietschel, Marcella, Riley, Brien P, Rose, Richard J, Shen, Pei-Hong, Silberg, Judy, Stallings, Michael C, Tarter, Ralph E, Vanyukov, Michael M, Vrieze, Scott, Wall, Tamara L, Whitfield, John B, Zhao, Hongyu, Neale, Benjamin M, Wade, Tracey D, Heath, Andrew C, Montgomery, Grant W, Martin, Nicholas G, Sullivan, Patrick F, Kaprio, Jaakko, Breen, Gerome, Gelernter, Joel, Edenberg, Howard J, Bulik, Cynthia M, Agrawal, Arpana, Munn-Chernoff, Melissa A, Johnson, Emma C, Chou, Yi-Ling, Coleman, Jonathan R I, Thornton, Laura M, Walters, Raymond K, Yilmaz, Zeynep, Baker, Jessica H, Hübel, Christopher, Gordon, Scott, Medland, Sarah E, Watson, Hunna J, Gaspar, Héléna A, Bryois, Julien, Hinney, Anke, Leppä, Virpi M, Mattheisen, Manuel, Ripke, Stephan, Yao, Shuyang, Giusti-Rodríguez, Paola, Hanscombe, Ken B, Adan, Roger A H, Alfredsson, Lars, Ando, Tetsuya, Andreassen, Ole A, Berrettini, Wade H, Boehm, Ilka, Boni, Claudette, Boraska Perica, Vesna, Buehren, Katharina, Burghardt, Roland, Cassina, Matteo, Cichon, Sven, Clementi, Maurizio, Cone, Roger D, Courtet, Philippe, Crow, Scott, Crowley, James J, Danner, Unna N, Davis, Oliver S P, de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, DeSocio, Janiece E, Dick, Danielle M, Dikeos, Dimitris, Dina, Christian, Dmitrzak-Weglarz, Monika, Docampo, Elisa, Duncan, Laramie E, Egberts, Karin, Ehrlich, Stefan, Escaramís, Geòrgia, Esko, Tõnu, Estivill, Xavier, Farmer, Anne, Favaro, Angela, Fernández-Aranda, Fernando, Fichter, Manfred M, Fischer, Krista, Föcker, Manuel, Foretova, Lenka, Forstner, Andreas J, Forzan, Monica, Franklin, Christopher S, Gallinger, Steven, Giegling, Ina, Giuranna, Johanna, Gonidakis, Fragiskos, Gorwood, Philip, Gratacos Mayora, Monica, Guillaume, Sébastien, Guo, Yiran, Hakonarson, Hakon, Hatzikotoulas, Konstantinos, Hauser, Joanna, Hebebrand, Johannes, Helder, Sietske G, Herms, Stefan, Herpertz-Dahlmann, Beate, Herzog, Wolfgang, Huckins, Laura M, Hudson, James I, Imgart, Hartmut, Inoko, Hidetoshi, Janout, Vladimir, Jiménez-Murcia, Susana, Julià, Antonio, Kalsi, Gursharan, Kaminská, Deborah, Karhunen, Leila, Karwautz, Andreas, Kas, Martien J H, Kennedy, James L, Keski-Rahkonen, Anna, Kiezebrink, Kirsty, Kim, Youl-Ri, Klump, Kelly L, Knudsen, Gun Peggy S, La Via, Maria C, Le Hellard, Stephanie, Levitan, Robert D, Li, Dong, Lilenfeld, Lisa, Lin, Bochao Danae, Lissowska, Jolanta, Luykx, Jurjen, Magistretti, Pierre J, Maj, Mario, Mannik, Katrin, Marsal, Sara, Marshall, Christian R, Mattingsdal, Morten, McDevitt, Sara, McGuffin, Peter, Metspalu, Andres, Meulenbelt, Ingrid, Micali, Nadia, Mitchell, Karen, Monteleone, Alessio Maria, Monteleone, Palmiero, Nacmias, Benedetta, Navratilova, Marie, Ntalla, Ioanna, O'Toole, Julie K, Ophoff, Roel A, Padyukov, Leonid, Palotie, Aarno, Pantel, Jacques, Papezova, Hana, Pinto, Dalila, Rabionet, Raquel, Raevuori, Anu, Ramoz, Nicolas, Reichborn-Kjennerud, Ted, Ricca, Valdo, Ripatti, Samuli, Ritschel, Franziska, Roberts, Marion, Rotondo, Alessandro, Rujescu, Dan, Rybakowski, Filip, Santonastaso, Paolo, Scherag, André, Scherer, Stephen W, Schmidt, Ulrike, Schork, Nicholas J, Schosser, Alexandra, Seitz, Jochen, Slachtova, Lenka, Slagboom, P Eline, Slof-Op't Landt, Margarita C T, Slopien, Agnieszka, Sorbi, Sandro, Świątkowska, Beata, Szatkiewicz, Jin P, Tachmazidou, Ioanna, Tenconi, Elena, Tortorella, Alfonso, Tozzi, Federica, Treasure, Janet, Tsitsika, Artemis, Tyszkiewicz-Nwafor, Marta, Tziouvas, Konstantinos, van Elburg, Annemarie A, van Furth, Eric F, Wagner, Gudrun, Walton, Esther, Widen, Elisabeth, Zeggini, Eleftheria, Zerwas, Stephanie, Zipfel, Stephan, Bergen, Andrew W, Boden, Joseph M, Brandt, Harry, Crawford, Steven, Halmi, Katherine A, Horwood, L John, Johnson, Craig, Kaplan, Allan S, Kaye, Walter H, Mitchell, James, Olsen, Catherine M, Pearson, John F, Pedersen, Nancy L, Strober, Michael, Werge, Thomas, Whiteman, David C, Woodside, D Blake, Grove, Jakob, Henders, Anjali K, Larsen, Janne T, Parker, Richard, Petersen, Liselotte V, Jordan, Jennifer, Kennedy, Martin A, Birgegård, Andreas, Lichtenstein, Paul, Norring, Claes, Landén, Mikael, Mortensen, Preben Bo, Polimanti, Renato, McClintick, Jeanette N, Adkins, Amy E, Aliev, Fazil, Bacanu, Silviu-Alin, Batzler, Anthony, Bertelsen, Sarah, Biernacka, Joanna M, Bigdeli, Tim B, Chen, Li-Shiun, Clarke, Toni-Kim, Degenhardt, Franziska, Docherty, Anna R, Edwards, Alexis C, Foo, Jerome C, Fox, Louis, Frank, Josef, Hack, Laura M, Hartmann, Annette M, Hartz, Sarah M, Heilmann-Heimbach, Stefanie, Hodgkinson, Colin, Hoffmann, Per, Hottenga, Jouke-Jan, Konte, Bettina, Lahti, Jari, Lahti-Pulkkinen, Marius, Lai, Dongbing, Ligthart, Lannie, Loukola, Anu, Maher, Brion S, Mbarek, Hamdi, McIntosh, Andrew M, McQueen, Matthew B, Meyers, Jacquelyn L, Milaneschi, Yuri, Palviainen, Teemu, Peterson, Roseann E, Ryu, Euijung, Saccone, Nancy L, Salvatore, Jessica E, Sanchez-Roige, Sandra, Schwandt, Melanie, Sherva, Richard, Streit, Fabian, Strohmaier, Jana, Thomas, Nathaniel, Wang, Jen-Chyong, Webb, Bradley T, Wedow, Robbee, Wetherill, Leah, Wills, Amanda G, Zhou, Hang, Boardman, Jason D, Chen, Danfeng, Choi, Doo-Sup, Copeland, William E, Culverhouse, Robert C, Dahmen, Norbert, Degenhardt, Louisa, Domingue, Benjamin W, Frye, Mark A, Gäbel, Wolfgang, Hayward, Caroline, Ising, Marcus, Keyes, Margaret, Kiefer, Falk, Koller, Gabriele, Kramer, John, Kuperman, Samuel, Lucae, Susanne, Lynskey, Michael T, Maier, Wolfgang, Mann, Karl, Männistö, Satu, Müller-Myhsok, Bertram, Murray, Alison D, Nurnberger, John I, Preuss, Ulrich, Räikkönen, Katri, Reynolds, Maureen D, Ridinger, Monika, Scherbaum, Norbert, Schuckit, Marc A, Soyka, Michael, Treutlein, Jens, Witt, Stephanie H, Wodarz, Norbert, Zill, Peter, Adkins, Daniel E, Boomsma, Dorret I, Bierut, Laura J, Brown, Sandra A, Bucholz, Kathleen K, Costello, E Jane, de Wit, Harriet, Diazgranados, Nancy, Eriksson, Johan G, Farrer, Lindsay A, Foroud, Tatiana M, Gillespie, Nathan A, Goate, Alison M, Goldman, David, Grucza, Richard A, Hancock, Dana B, Harris, Kathleen Mullan, Hesselbrock, Victor, Hewitt, John K, Hopfer, Christian J, Iacono, William G, Johnson, Eric O, Karpyak, Victor M, Kendler, Kenneth S, Kranzler, Henry R, Krauter, Kenneth, Lind, Penelope A, McGue, Matt, MacKillop, James, Madden, Pamela A F, Maes, Hermine H, Magnusson, Patrik K E, Nelson, Elliot C, Nöthen, Markus M, Palmer, Abraham A, Penninx, Brenda W J H, Porjesz, Bernice, Rice, John P, Rietschel, Marcella, Riley, Brien P, Rose, Richard J, Shen, Pei-Hong, Silberg, Judy, Stallings, Michael C, Tarter, Ralph E, Vanyukov, Michael M, Vrieze, Scott, Wall, Tamara L, Whitfield, John B, Zhao, Hongyu, Neale, Benjamin M, Wade, Tracey D, Heath, Andrew C, Montgomery, Grant W, Martin, Nicholas G, Sullivan, Patrick F, Kaprio, Jaakko, Breen, Gerome, Gelernter, Joel, Edenberg, Howard J, Bulik, Cynthia M, and Agrawal, Arpana

Abstract

Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg ], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-sp

Published
2021
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44. The continued need for animals to advance brain research

Author

Homberg, Judith R., Adan, Roger A. H., Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P., Blokland, Arjan, Burger, Marilise E., van Dijk, Gertjan, Eisel, Ulrich L. M., Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P., van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J. A. G., Herden, Christiane, Hut, Roelof A., Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J., Kasri, Nael Nadif, Kiliaan, Amanda J., Kolk, Sharon M., Korosi, Aniko, Korte, S. Mechiel, Kozicz, Tamas, Kushner, Steven A., Leech, Kirk, Leech, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J., Luthi, Anita, Ma, Liya, Mallien, Anne S., Meerlo, Peter, Mejias, Jorge F., Meye, Frank J., Mitchell, Anna S., Mul, Joram D., Olcese, Umberto, Gonzalez, Azahara Oliva, Oliver, Jocelien D. A., Pasqualetti, Massimo, Pennartz, CyrielM. A., Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M., Ribeiro, Sidarta, Roozendaal, Benn, Rossato, Janine I., Salari, Ali-Akbar, Schoemaker, Regien G., Smit, August B., Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P., V. Vyazovskiy, Vladyslav, Wiesmann, Maximilian, Wierenga, Corette J., Williams, Bella, Willuhn, Ingo, Woehr, Markus, Wolvekamp, Monique, van der Zee, Eddy A., Genzel, Lisa, Vanderschuren, Louk J. M. J., Homberg, Judith R., Adan, Roger A. H., Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P., Blokland, Arjan, Burger, Marilise E., van Dijk, Gertjan, Eisel, Ulrich L. M., Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P., van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J. A. G., Herden, Christiane, Hut, Roelof A., Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J., Kasri, Nael Nadif, Kiliaan, Amanda J., Kolk, Sharon M., Korosi, Aniko, Korte, S. Mechiel, Kozicz, Tamas, Kushner, Steven A., Leech, Kirk, Leech, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J., Luthi, Anita, Ma, Liya, Mallien, Anne S., Meerlo, Peter, Mejias, Jorge F., Meye, Frank J., Mitchell, Anna S., Mul, Joram D., Olcese, Umberto, Gonzalez, Azahara Oliva, Oliver, Jocelien D. A., Pasqualetti, Massimo, Pennartz, CyrielM. A., Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M., Ribeiro, Sidarta, Roozendaal, Benn, Rossato, Janine I., Salari, Ali-Akbar, Schoemaker, Regien G., Smit, August B., Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P., V. Vyazovskiy, Vladyslav, Wiesmann, Maximilian, Wierenga, Corette J., Williams, Bella, Willuhn, Ingo, Woehr, Markus, Wolvekamp, Monique, van der Zee, Eddy A., Genzel, Lisa, and Vanderschuren, Louk J. M. J.

Abstract

C Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available and the value of these alternatives has been proven, the use of animals should not be compromised.

Published
2021

45. The continued need for animals to advance brain research

Author

TN groep Adan, Brain, TN groep Meye, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, Genzel, Lisa, TN groep Adan, Brain, TN groep Meye, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, and Genzel, Lisa

Published
2021

46. Identification of Novel Neurocircuitry Through Which Leptin Targets Multiple Inputs to the Dopamine System to Reduce Food Reward Seeking

Author

Brain, TN groep Adan, TN groep Meye, Omrani, Azar, de Vrind, Veronne A J, Lodder, Bart, Stoltenborg, Iris, Kooij, Karlijn, Wolterink-Donselaar, Inge G, Luijendijk-Berg, Mieneke C M, Garner, Keith M, Van't Sant, Lisanne J, Rozeboom, Annemieke, Dickson, Suzanne L, Meye, Frank J, Adan, Roger A H, Brain, TN groep Adan, TN groep Meye, Omrani, Azar, de Vrind, Veronne A J, Lodder, Bart, Stoltenborg, Iris, Kooij, Karlijn, Wolterink-Donselaar, Inge G, Luijendijk-Berg, Mieneke C M, Garner, Keith M, Van't Sant, Lisanne J, Rozeboom, Annemieke, Dickson, Suzanne L, Meye, Frank J, and Adan, Roger A H

Published
2021

47. Good taste or gut feeling?: A new method in rats shows oro-sensory stimulation and gastric distention generate distinct and overlapping brain activation patterns

Author

In Vivo NMR ISI, TN groep Adan, Brain, Circulatory Health, Beeldverwerking ISI, Roelofs, Theresia J M, Luijendijk, Mieneke C M, van der Toorn, Annette, Camps, Guido, Smeets, Paul A M, Dijkhuizen, Rick M, Adan, Roger A H, In Vivo NMR ISI, TN groep Adan, Brain, Circulatory Health, Beeldverwerking ISI, Roelofs, Theresia J M, Luijendijk, Mieneke C M, van der Toorn, Annette, Camps, Guido, Smeets, Paul A M, Dijkhuizen, Rick M, and Adan, Roger A H

Published
2021

48. The role of genetic variation of human metabolism for BMI, mental traits and mental disorders

Author

Hebebrand, Johannes, Peters, Triinu, Schijven, Dick, Hebebrand, Moritz, Grasemann, Corinna, Winkler, Thomas W, Heid, Iris M, Antel, Jochen, Föcker, Manuel, Tegeler, Lisa, Brauner, Lena, Adan, Roger A H, Luykx, Jurjen J, Correll, Christoph U, König, Inke R, Hinney, Anke, and Libuda, Lars

Subjects
lcsh:Internal medicine, Medizinische Fakultät » Universitätsklinikum Essen » Zentrum für Kinder- und Jugendmedizin » Klinik für Kinderheilkunde II, Mental Disorders, Intelligence, Medizin, Educational attainment, Polymorphism, Single Nucleotide, Body Mass Index, Metabolites Obesity, Metabolites, Schizophrenia, Metabolome, ddc:61, Humans, Original Article, ddc:610, Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, Obesity, lcsh:RC31-1245, Cross-trait analysis
Abstract

Objective The aim was to assess whether loci associated with metabolic traits also have a significant role in BMI and mental traits/disorders Methods We first assessed the number of single nucleotide polymorphisms (SNPs) with genome-wide significance for human metabolism (NHGRI-EBI Catalog). These 516 SNPs (216 independent loci) were looked-up in genome-wide association studies for association with body mass index (BMI) and the mental traits/disorders educational attainment, neuroticism, schizophrenia, well-being, anxiety, depressive symptoms, major depressive disorder, autism-spectrum disorder, attention-deficit/hyperactivity disorder, Alzheimer's disease, bipolar disorder, aggressive behavior, and internalizing problems. A strict significance threshold of p, Highlights • 5–10% of genomic regions that regulate blood/urine metabolite levels were associated with BMI and mental phenotypes. • Metabolite loci were particularly associated with BMI, Alzheimer's disease, schizophrenia, and educational attainment. • Confirmation was achieved for BMI and educational attainment.

Published
2018

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