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1. Inadequate Reporting of Cointerventions, Other Methodological Factors, and Treatment Estimates in Cardiovascular Trials: A Meta-Epidemiological Study

Author

Bührer, Jonas, Del Giovane, Cinzia, Gencer, Baris, Adam, Luise, Lyko, Christina, Feller, Martin, Da Costa, Bruno R, Aujesky, Drahomir, Bauer, Douglas C, Rodondi, Nicolas, and Moutzouri, Elisavet

Subjects
Clinical Trials and Supportive Activities, Clinical Research, Good Health and Well Being
Abstract

ObjectiveTo assess how inadequate reporting of cointerventions influences estimated treatment effects in recent cardiovascular trials.MethodsMedline/Embase were systematically searched from January 1, 2011 to July 1, 2021 for trials evaluating pharmacologic interventions on clinical cardiovascular outcomes published in 5 high-impact journals. Information on adequate vs inadequate reporting of cointerventions, blinding, risk of bias due to deviations of intended interventions (low vs high/some concerns), funding (nonindustry vs industry), design (superiority vs noninferiority), and results were assessed by 2 reviewers. The association with effect sizes was assessed using meta-regression random-effect analysis, expressed as ratios of odds ratios (ROR). RORs of >1.0 indicated that trials with the methodological factor pointing to lower quality report larger treatment estimates.ResultsIn total, 164 trials were included. Of the 164 trials, 124 (74%) did not adequately report cointerventions; 89 of the 164 trials (54%) provided no information regarding cointerventions, and 70 of the 164 (43%) were at risk of bias due to inadequate blinding. Moreover, 86 of the 164 (53%) were at risk of bias due to deviation of intended interventions. Of the 164 trials, 144 (88%) were funded by the industries. Trials with inadequate reporting of cointerventions had larger treatment estimates for the primary end point (ROR, 1.08; 95% CI, 1.01-1.15; I2=0%). No significant association with results for blinding (ROR, 0.97; 95% CI, 0.91-1.03; I2=66%), deviation of intended interventions (ROR, 0.98; 95% CI, 0.92-1.04; I2=0%), or funding (ROR, 1.01; 95% CI, 0.93-1.09; I2=0%) was found.ConclusionWe conclude that trials with inadequate reporting of cointerventions showed larger treatment effect estimates, potentially indicating overestimation of therapeutic benefit.Trial registrationProspero Identifier: CRD42017072522.

Published
2023

2. Heart rate variability and stroke or systemic embolism in patients with atrial fibrillation

Author

Aeschbacher, Stefanie, Bhend, Katalin, Blum, Steffen, Bonati, Leo H., Carmine, Désirée, Conen, David, Eken, Ceylan, Fischer, Urs, Girroy, Corinne, Hennings, Elisa, Krisai, Philipp, Kühne, Michael, Mäder, Nina, Meyer-Zürn, Christine, Meyre, Pascal B., Monsch, Andreas U., Mosher, Luke, Müller, Christian, Osswald, Stefan, Paladini, Rebecca E., Peter, Raffaele, Schweigler, Adrian, Sticherling, Christian, Szucs, Thomas, Völlmin, Gian, Aujesky, Drahomir, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Netzer, Seraina, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Loewe, Axel, Moutzouri, Elisavet, Schneider, Claudio, Flückiger, Tanja, Groen, Cindy, Ehrsam, Lukas, Hellrigl, Sven, Nuoffer, Alexandra, Rakovic, Damiana, Schwab, Nathalie, Wenger, Rylana, Zarrabi Saffari, Tu Hanh, Rodondi, Nicolas, Reichlin, Tobias, Beynon, Christopher, Dillier, Roger, Deubelbeiss, Michèle, Eberli, Franz, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Murugiah, Samira, Nadler, Jacqueline, Obst, Thayze, Roth, Jasmin, Schlomowitsch, Fiona, Schneider, Xiaoye, Studerus, Katrin, Tynan, Noreen, Weishaupt, Dominik, Müller, Andreas, Friedli, Corinne, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Grau, Alexandra, Villinger, Jonas, Laube, Eva, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Montrasio, Giulia, Leuenberger, Stefanie, Rutz, Franziska, Beer, Jürg-Hans, Auricchio, Angelo, Anesini, Adriana, Camporini, Cristina, Caputo, Maria Luce, Peronaci, Rebecca, Regoli, Francois, Ronchi, Martina, Conte, Giulio, Brenner, Roman, Altmann, David, Fink, Karin, Gemperle, Michaela, Ammann, Peter, Firmann, Mathieu, Foucras, Sandrine, Rime, Martine, Hayoz, Daniel, Berte, Benjamin, Bühler, Kathrin, Justi, Virgina, Kellner-Weldon, Frauke, Koch, Melanie, Mehmann, Brigitta, Meier, Sonja, Roth, Myriam, Ruckli-Kaeppeli, Andrea, Russi, Ian, Schmidt, Kai, Young, Mabelle, Kobza, Richard, Rigamonti, Elia, Cereda, Carlo, Cianfoni, Alessandro, De Perna, Maria Luisa, Frangi-Kultalahti, Jane, Mayer Melchiorre, Patrizia Assunta, Pin, Anica, Terrot, Tatiana, Vicari, Luisa, Moschovitis, Giorgio, Ehret, Georg, Gallet, Hervé, Guillermet, Elise, Lazeyras, Francois, Lovblad, Karl-Olof, Perret, Patrick, Tavel, Philippe, Teres, Cheryl, Shah, Dipen, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Schläpfer, Jürg, Porretta, Alessandra Pia, Grêt, Andrea, Novak, Jan, Vitelli, Sandra, Stephan, Frank-Peter, Gallino, Augusto, Di Valentino, Marcello, Aebersold, Helena, Foster, Fabienne, Schwenkglenks, Matthias, Düring, Marco, Sinnecker, Tim, Altermatt, Anna, Amann, Michael, Huber, Petra, Hürbin, Manuel, Ruberte, Esther, Thöni, Alain, Würfel, Jens, Zuber, Vanessa, Coslovsky (Head), Michael, Neuschwander, Pia, Simon, Patrick, Wunderlin, Olivia, Schmid, Ramun, Baumann, Christian, Hämmerle, Peter, Schlageter, Vincent, Coslovsky, Michael, Coduri, Federica, Blum, Manuel R., Stauber, Annina, Beer, Jürg, and Zuern, Christine S.

Published
2024
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3. Low Reporting of Cointerventions in Recent Cardiovascular Clinical Trials: A Systematic Review

Author

Moutzouri, Elisavet, Adam, Luise, Feller, Martin, Syrogiannouli, Lamprini, Da Costa, Bruno R, Del Giovane, Cinzia, Bauer, Douglas C, Aujesky, Drahomir, Chiolero, Arnaud, and Rodondi, Nicolas

Subjects
Clinical Research, Prevention, Clinical Trials and Supportive Activities, Cancer, Good Health and Well Being, Bias, Cardiovascular Diseases, Data Accuracy, Humans, Randomized Controlled Trials as Topic, Research Design, Treatment Outcome, blinding, cardiovascular trials, cointerventions, competing treatments, reporting, risk of bias, Cardiorespiratory Medicine and Haematology
Abstract

Background A cointervention in a randomized clinical trial (RCT) is medical care given in addition to the tested intervention. If cointerventions are unbalanced between trial arms, the results may be biased. We hypothesized that cointerventions would be more adequately reported in RCTs without full blinding or at risk of bias. Methods and Results To describe the reporting of cointerventions and to evaluate the factors associated with their reporting, we did a systematic search of all RCTs evaluating pharmacological interventions on cardiovascular outcomes published in 5 high-impact journals. The reporting of cointerventions, blinding, and risk of bias were extracted and evaluated independently by 2 reviewers (E.M., L.A.). Cointerventions were inadequately reported in 87 of 123 RCTs (70.7%), with 56 (45.5%) providing no information on cointerventions and 31 (25.2%) providing only partial information. Of the RCTs, 52 (42.3%) had inadequate blinding of participants and/or personnel and 63 (51.2%) of the RCTs were judged at risk of bias. In univariable analysis, the reporting of cointerventions was not associated with blinding of participants and/or personnel (odds ratio [OR], 1.04; 95% CI, 0.47-2.27 for adequately versus inadequately blinded trials) or with risk of bias (OR, 1.47; 95% CI, 0.67-3.21 for at low risk of bias versus trials at risk of bias). In multivariable analysis, only a follow-up of

Published
2020

5. Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation

Author

Aeschbacher, Stefanie, Auberson, Chloé, Blum, Steffen, Bonati, Leo, Ceylan, Selinda, Conen, David, Doerpfeld, Simone, Eken, Ceylan, Girod, Marc, Hämmerle, Peter, Krisai, Philipp, Kühne, Michael, Meyer-Zürn, Christine, Meyre, Pascal, Monsch, Andreas U., Müller, Christian, Osswald, Stefan, Springer, Anne, Sticherling, Christian, Szucs, Thomas, Voellmin, Gian, Zwimpfer, Leon, Aujesky, Drahomir, Fischer, Urs, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Loewe, Axel, Moutzouri, Elisavet, Schneider, Claudio, Flückiger, Tanja, Groen, Cindy, Ehrsam, Lukas, Hellrigl, Sven, Nuoffer, Alexandra, Rakovic, Damiana, Schwab, Nathalie, Wenger, Rylana, Rodondi, Nicolas, Beynon, Christopher, Dillier, Roger, Deubelbeiss, Michèle, Eberli, Franz, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Nadler, Jacqueline, Obst, Thayze, Roth, Jasmin, Schlomowitsch, Fiona, Schneider, Xiaoye, Studerus, Katrin, Tynan, Noreen, Weishaupt, Dominik, Müller, Andreas, Fontana, Simone, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Grau, Alexandra, Villinger, Jonas, Laube, Eva, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Montrasio, Giulia, Leuenberger, Stefanie, Rutz, Franziska, Beer, Jürg-Hans, Auricchio, Angelo, Anesini, Adriana, Camporini, Cristina, Conte, Giulio, Caputo, Maria Luce, Regoli, Francois, Moccetti, Tiziano, Brenner, Roman, Altmann, David, Gemperle, Michaela, Ammann, Peter, Firmann, Mathieu, Foucras, Sandrine, Rime, Martine, Hayoz, Daniel, Berte, Benjamin, Justi, Virgina, Kellner-Weldon, Frauke, Mehmann, Brigitta, Meier, Sonja, Roth, Myriam, Ruckli-Kaeppeli, Andrea, Russi, Ian, Schmidt, Kai, Young, Mabelle, Zbinden, Melanie, Kobza, Richard, Frangi-Kultalahti, Jane, Pin, Anica, Vicari, Luisa, Moschovitis, Giorgio, Ehret, Georg, Gallet, Hervé, Guillermet, Elise, Lazeyras, Francois, Lovblad, Karl-Olof, Perret, Patrick, Tavel, Philippe, Teres, Cheryl, Shah, Dipen, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Schläpfer, Jürg, Grêt, Andrea, Novak, Jan, Vitelli, Sandra, Stephan, Frank-Peter, Gallino, Augusto, Di Valentino, Marcello, Witassek, Fabienne, Schwenkglenks, Matthias, Würfel, Jens, Altermatt, Anna, Amann, Michael, Huber, Petra, Ruberte, Esther, Sinnecker, Tim, Zuber, Vanessa, Coslovsky, Michael, Benkert, Pascal, Dutilh, Gilles, Markovic, Milica, Simon, Patrick, Schmid, Ramun, Beer, Jürg H., Bonati, Leo H., Blum, Manuel R., Kastner, Peter, and Baguley, Fiona

Published
2021
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6. Novel bleeding risk score for patients with atrial fibrillation on oral anticoagulants, including direct oral anticoagulants

Author

Adam, Luise, Feller, Martin, Syrogiannouli, Lamprini, Del‐Giovane, Cinzia, Donzé, Jacques, Baumgartner, Christine, Segna, Daniel, Floriani, Carmen, Roten, Laurent, Fischer, Urs, Aeschbacher, Stefanie, Moschovitis, Giorgio, Schläpfer, Jürg, Shah, Dipen, Amman, Peter, Kobza, Richard, Schwenkglenks, Matthias, Kühne, Michael, Bonati, Leo H., Beer, Jürg, Osswald, Stefan, Conen, David, Aujesky, Drahomir, and Rodondi, Nicolas

Published
2021
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7. Relationships of Overt and Silent Brain Lesions With Cognitive Function in Patients With Atrial Fibrillation

Author

Berger, Sebastian, Bernasconi, Raffaele, Fröhlich, Lorin, Göldi, Tobias, Gugganig, Rebecca, Kofler, Thomas, Krisai, Philipp, Mongiat, Michel, Pudenz, Christiane, Repilado, Javier Ruperti, Schweizer, Aleksandra, Springer, Anne, Stempfel, Samuel, Szucs, Thomas, van der Stouwe, Jan, Voellmin, Gian, Zwimpfer, Leon, Aujesky, Drahomir, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Schneider, Claudio, Loewe, Axel, Flückiger, Tanja, Groen, Cindy, Schwab, Nathalie, Beynon, Christopher, Dillier, Roger, Eberli, Franz, Fontana, Simone, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Nadler, Jacqueline, Obst, Thayze, Schneider, Xiaoye, Studerus, Katrin, Weishaupt, Dominik, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Bello, Corina, Isberg, Henriette, Grau, Alexandra, Villinger, Jonas, Papaux, Mary-Monica, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Anesini, Adriana, Camporini, Cristina, Conte, Giulio, Caputo, Maria Luce, Regoli, Francois, Moccetti, Tiziano, Brenner, Roman, Altmann, David, Forrer, Manuela, Gemperle, Michaela, Firmann, Mathieu, Foucras, Sandrine, Berte, Benjamin, Kaeppeli, Andrea, Mehmann, Brigitta, Pfeiffer, Markus, Russi, Ian, Schmidt, Kai, Weberndoerfer, Vanessa, Young, Mabelle, Zbinden, Melanie, Vicari, Luisa, Frangi, Jane, Terrot, Tatiana, Gallet, Hervé, Guillermet, Elise, Lazeyras, Francois, Lovblad, Karl-Olof, Perret, Patrick, Teres, Cheryl, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Arenja, Nisha, Grêt, Andrea, Vitelli, Sandra, Gallino, Augusto, Schoenenberger-Berzins, Renate, Witassek, Fabienne, Radue, Ernst-Wilhelm, Benkert, Pascal, Fabbro, Thomas, Simon, Patrick, Schmid, Ramun, Conen, David, Rodondi, Nicolas, Müller, Andreas, Beer, Juerg H., Ammann, Peter, Moschovitis, Giorgio, Auricchio, Angelo, Hayoz, Daniel, Kobza, Richard, Shah, Dipen, Novak, Jan, Schläpfer, Jürg, Di Valentino, Marcello, Aeschbacher, Stefanie, Blum, Steffen, Meyre, Pascal, Sticherling, Christian, Bonati, Leo H., Ehret, Georg, Moutzouri, Elisavet, Fischer, Urs, Monsch, Andreas U., Stippich, Christoph, Wuerfel, Jens, Sinnecker, Tim, Coslovsky, Michael, Schwenkglenks, Matthias, Kühne, Michael, and Osswald, Stefan

Published
2019
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9. Intervention protocol: OPtimising thERapy to prevent avoidable hospital Admission in the Multi-morbid elderly (OPERAM): a structured medication review with support of a computerised decision support system

Author

Crowley, Erin K., Sallevelt, Bastiaan T. G. M., Huibers, Corlina J. A., Murphy, Kevin D., Spruit, Marco, Shen, Zhengru, Boland, Benoît, Spinewine, Anne, Dalleur, Olivia, Moutzouri, Elisavet, Löwe, Axel, Feller, Martin, Schwab, Nathalie, Adam, Luise, Wilting, Ingeborg, Knol, Wilma, Rodondi, Nicolas, Byrne, Stephen, and O’Mahony, Denis

Published
2020
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10. Association of statin use and lipid levels with cerebral microbleeds and intracranial hemorrhage in patients with atrial fibrillation: A prospective cohort study.

Author

Moutzouri, Elisavet, Glutz, Matthias, Abolhassani, Nazanin, Feller, Martin, Adam, Luise, Gencer, Baris, Del Giovane, Cinzia, Bétrisey, Sylvain, Paladini, Rebecca E, Hennings, Elisa, Aeschbacher, Stefanie, Beer, Jürg H, Moschovitis, Giorgio, Seiffge, David, De Marchis, Gian Marco, Coslovsky, Michael, Reichlin, Tobias, Conte, Giulio, Sinnecker, Tim, and Schwenkglenks, Matthias

Subjects
INTRACRANIAL hemorrhage, STATINS (Cardiovascular agents), ATRIAL fibrillation, TRANSIENT ischemic attack, CORONARY disease
Abstract

Background: An increased risk of intracranial hemorrhage (ICH) associated with statins has been reported, but data on the relationship between statin use and cerebral microbleeds (CMBs) in patients with atrial fibrillation (AF), a population at high bleeding and cardiovascular risk, are lacking. Aims: To explore the association between statin use and blood lipid levels with the prevalence and progression of CMBs in patients with AF with a particular focus on anticoagulated patients. Methods: Data of Swiss-AF, a prospective cohort of patients with established AF, were analyzed. Statin use was assessed during baseline and throughout follow-up. Lipid values were measured at baseline. CMBs were assessed using magnetic resonance imagining (MRI) at baseline and at 2 years follow-up. Imaging data were centrally assessed by blinded investigators. Associations of statin use and low-density lipoprotein (LDL) levels with CMB prevalence at baseline or CMB progression (at least one additional or new CMB on follow-up MRI at 2 years compared with baseline) were assessed using logistic regression models; the association with ICH was assessed using flexible parametric survival models. Models were adjusted for hypertension, smoking, body mass index, diabetes, stroke/transient ischemic attack, coronary heart disease, antiplatelet use, anticoagulant use, and education. Results: Of the 1693 patients with CMB data at baseline MRI (mean ± SD age 72.5 ± 8.4 years, 27.6% women, 90.1% on oral anticoagulants), 802 patients (47.4%) were statin users. The multivariable adjusted odds ratio (adjOR) for CMBs prevalence at baseline for statin users was 1.10 (95% CI = 0.83–1.45). AdjOR for 1 unit increase in LDL levels was 0.95 (95% CI = 0.82–1.10). At 2 years, 1188 patients had follow-up MRI. CMBs progression was observed in 44 (8.0%) statin users and 47 (7.4%) non-statin users. Of these patients, 64 (70.3%) developed a single new CMB, 14 (15.4%) developed 2 CMBs, and 13 developed more than 3 CMBs. The multivariable adjOR for statin users was 1.09 (95% CI = 0.66–1.80). There was no association between LDL levels and CMB progression (adjOR 1.02, 95% CI = 0.79–1.32). At follow-up 14 (1.2%) statin users had ICH versus 16 (1.3%) non-users. The age and sex adjusted hazard ratio (adjHR) was 0.75 (95% CI = 0.36–1.55). The results remained robust in sensitivity analyses excluding participants without anticoagulants. Conclusions: In this prospective cohort of patients with AF, a population at increased hemorrhagic risk due to anticoagulation, the use of statins was not associated with an increased risk of CMBs. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Association of statin use and lipid levels with cerebral microbleeds and intracranial hemorrhage in patients with atrial fibrillation: A prospective cohort study

Author

Moutzouri, Elisavet; https://orcid.org/0000-0002-7713-7553, Glutz, Matthias, Abolhassani, Nazanin, Feller, Martin; https://orcid.org/0000-0003-2519-836X, Adam, Luise, Gencer, Baris; https://orcid.org/0000-0002-8954-9694, Del Giovane, Cinzia, Bétrisey, Sylvain, Paladini, Rebecca E; https://orcid.org/0000-0002-4502-1978, Hennings, Elisa; https://orcid.org/0000-0003-2616-5535, Aeschbacher, Stefanie; https://orcid.org/0000-0001-8134-2421, Beer, Jürg H; https://orcid.org/0000-0002-7199-0406, Moschovitis, Giorgio; https://orcid.org/0000-0002-4043-8061, Seiffge, David, De Marchis, Gian Marco; https://orcid.org/0000-0002-0342-9780, Coslovsky, Michael; https://orcid.org/0000-0001-7678-7354, Reichlin, Tobias; https://orcid.org/0000-0002-7197-8415, Conte, Giulio, Sinnecker, Tim, Schwenkglenks, Matthias; https://orcid.org/0000-0001-7217-1173, Bonati, Leo H; https://orcid.org/0000-0003-1163-8133, Kastner, Peter, Aujesky, Drahomir; https://orcid.org/0000-0002-3970-2670, Kühne, Michael; https://orcid.org/0000-0002-2937-3711, Osswald, Stefan; https://orcid.org/0000-0002-9240-6731, Fischer, Urs; https://orcid.org/0000-0003-0521-4051, Conen, David; https://orcid.org/0000-0002-2459-5251, Rodondi, Nicolas; https://orcid.org/0000-0001-9083-6896, Moutzouri, Elisavet; https://orcid.org/0000-0002-7713-7553, Glutz, Matthias, Abolhassani, Nazanin, Feller, Martin; https://orcid.org/0000-0003-2519-836X, Adam, Luise, Gencer, Baris; https://orcid.org/0000-0002-8954-9694, Del Giovane, Cinzia, Bétrisey, Sylvain, Paladini, Rebecca E; https://orcid.org/0000-0002-4502-1978, Hennings, Elisa; https://orcid.org/0000-0003-2616-5535, Aeschbacher, Stefanie; https://orcid.org/0000-0001-8134-2421, Beer, Jürg H; https://orcid.org/0000-0002-7199-0406, Moschovitis, Giorgio; https://orcid.org/0000-0002-4043-8061, Seiffge, David, De Marchis, Gian Marco; https://orcid.org/0000-0002-0342-9780, Coslovsky, Michael; https://orcid.org/0000-0001-7678-7354, Reichlin, Tobias; https://orcid.org/0000-0002-7197-8415, Conte, Giulio, Sinnecker, Tim, Schwenkglenks, Matthias; https://orcid.org/0000-0001-7217-1173, Bonati, Leo H; https://orcid.org/0000-0003-1163-8133, Kastner, Peter, Aujesky, Drahomir; https://orcid.org/0000-0002-3970-2670, Kühne, Michael; https://orcid.org/0000-0002-2937-3711, Osswald, Stefan; https://orcid.org/0000-0002-9240-6731, Fischer, Urs; https://orcid.org/0000-0003-0521-4051, Conen, David; https://orcid.org/0000-0002-2459-5251, and Rodondi, Nicolas; https://orcid.org/0000-0001-9083-6896

Abstract

BACKGROUND An increased risk of intracranial hemorrhage (ICH) associated with statins has been reported, but data on the relationship between statin use and cerebral microbleeds (CMBs) in patients with atrial fibrillation (AF), a population at high bleeding and cardiovascular risk, are lacking. AIMS To explore the association between statin use and blood lipid levels with the prevalence and progression of CMBs in patients with AF with a particular focus on anticoagulated patients. METHODS Data of Swiss-AF, a prospective cohort of patients with established AF, were analyzed. Statin use was assessed during baseline and throughout follow-up. Lipid values were measured at baseline. CMBs were assessed using magnetic resonance imagining (MRI) at baseline and at 2 years follow-up. Imaging data were centrally assessed by blinded investigators. Associations of statin use and low-density lipoprotein (LDL) levels with CMB prevalence at baseline or CMB progression (at least one additional or new CMB on follow-up MRI at 2 years compared with baseline) were assessed using logistic regression models; the association with ICH was assessed using flexible parametric survival models. Models were adjusted for hypertension, smoking, body mass index, diabetes, stroke/transient ischemic attack, coronary heart disease, antiplatelet use, anticoagulant use, and education. RESULTS Of the 1693 patients with CMB data at baseline MRI (mean ± SD age 72.5 ± 8.4 years, 27.6% women, 90.1% on oral anticoagulants), 802 patients (47.4%) were statin users. The multivariable adjusted odds ratio (adjOR) for CMBs prevalence at baseline for statin users was 1.10 (95% CI = 0.83-1.45). AdjOR for 1 unit increase in LDL levels was 0.95 (95% CI = 0.82-1.10). At 2 years, 1188 patients had follow-up MRI. CMBs progression was observed in 44 (8.0%) statin users and 47 (7.4%) non-statin users. Of these patients, 64 (70.3%) developed a single new CMB, 14 (15.4%) developed 2 CMBs, and 13 developed more than 3 CMBs. The

Published
2023

14. sj-docx-1-wso-10.1177_17474930231181010 – Supplemental material for Association of statin use and lipid levels with cerebral microbleeds and intracranial hemorrhage in patients with atrial fibrillation: A prospective cohort study

Author

Moutzouri, Elisavet, Glutz, Matthias, Abolhassani, Nazanin, Feller, Martin, Adam, Luise, Gencer, Baris, Del Giovane, Cinzia, Bétrisey, Sylvain, Paladini, Rebecca E, Hennings, Elisa, Aeschbacher, Stefanie, Beer, Jürg H, Moschovitis, Giorgio, Seiffge, David, De Marchis, Gian Marco, Coslovsky, Michael, Reichlin, Tobias, Conte, Giulio, Sinnecker, Tim, Schwenkglenks, Matthias, Bonati, Leo H, Kastner, Peter, Aujesky, Drahomir, Kühne, Michael, Osswald, Stefan, Fischer, Urs, Conen, David, and Rodondi, Nicolas

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-wso-10.1177_17474930231181010 for Association of statin use and lipid levels with cerebral microbleeds and intracranial hemorrhage in patients with atrial fibrillation: A prospective cohort study by Elisavet Moutzouri, Matthias Glutz, Nazanin Abolhassani, Martin Feller, Luise Adam, Baris Gencer, Cinzia Del Giovane, Sylvain Bétrisey, Rebecca E Paladini, Elisa Hennings, Stefanie Aeschbacher, Jürg H Beer, Giorgio Moschovitis, David Seiffge, Gian Marco De Marchis, Michael Coslovsky, Tobias Reichlin, Giulio Conte, Tim Sinnecker, Matthias Schwenkglenks, Leo H Bonati, Peter Kastner, Drahomir Aujesky, Michael Kühne, Stefan Osswald, Urs Fischer, David Conen and Nicolas Rodondi in International Journal of Stroke

Published
2023
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15. False versus True Statin Intolerance in Patients with Peripheral Artery Disease

Author

Dopheide, Jörn F, Gillmann, Patrick, Spirk, David, Khorrami Borozadi, Meisam, Adam, Luise, and Drexel, Heinz

Subjects
360 Social problems & social services, 360 Soziale Probleme, Sozialdienste, 610 Medicine & health, General Medicine, lipid-lowering therapy, low-density lipoprotein cholesterol, mortality, peripheral artery disease, statin intolerance, 610 Medizin und Gesundheit
Abstract

Background: Statin intolerance (SI) is often documented in patients’ charts but rarely confirmed by objective methods. Objective: We aimed to identify the rate of true SI in a large population with peripheral artery disease (PAD) as well as the subsequent use of such drugs and the impact on cardiovascular outcomes. Methods: Patients with PAD and reported SI were retrospectively classified in those with “probable/possible” (pp) and “unlikely” (u) SI, after the application of the “Statin Myalgia Clinical Index Score” (SAMS-CI). Both groups were compared after 62 months (date of observation period?). Results: Among the 4,505 included patients, 139 (3%) had been reported as having SI. Of those, 33 (24%) had ppSI, and 106 (76%) had uSI. During the observation period, statin use decreased in patients with both ppSI (from 97% to 21%; p < 0.0001) and uSI (from 87% to 53%; p < 0.0001). At the end of the observation period, patients with ppSI more often received PCSK9 inhibitors (55% vs. 7%; p < 0.0001), had a stronger decrease in LDL-C from baseline to follow-up (1.82 ± 1.69 mmol/L vs. 0.85 ± 1.41 mmol/L; p < 0.01), and a lower rate of mortality (3% vs. 21%; p = 0.04) than those with uSI. Conclusions: SI is low in PAD patients (3.1%), with only one quarter fulfilling the criteria of ppSI. The overdiagnosis of SI is related to an underuse of statins and an increased mortality in a short time period.

Published
2022
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16. Experience of hospital-initiated medication changes in older people with multimorbidity: a multicentre mixed-methods study embedded in the OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM) trial.

Author

UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - (MGD) Département de pharmacie, UCL - (SLuc) Département de pharmacie, Thevelin, Stefanie, Pétein, Catherine, Metry, Beatrice, Adam, Luise, van Herksen, Anniek, Murphy, Kevin, Knol, Wilma, O'Mahony, Denis, Rodondi, Nicolas, Spinewine, Anne, Dalleur, Olivia, UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - (MGD) Département de pharmacie, UCL - (SLuc) Département de pharmacie, Thevelin, Stefanie, Pétein, Catherine, Metry, Beatrice, Adam, Luise, van Herksen, Anniek, Murphy, Kevin, Knol, Wilma, O'Mahony, Denis, Rodondi, Nicolas, Spinewine, Anne, and Dalleur, Olivia

Abstract

A patient-centred approach to medicines optimisation is considered essential. The OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM) trial evaluated the effectiveness of medication review with shared decision-making (SDM) in older people with multimorbidity. Beyond evaluating the clinical effectiveness, exploring the patient experience facilitates a better understanding of contextual factors and mechanisms affecting medication review effectiveness. To explore experiences of hospital-initiated medication changes in older people with multimorbidity. We conducted a multicentre mixed-methods study, embedded in the OPERAM trial, combining semi-structured interviews and the Beliefs about Medicines Questionnaire (BMQ) with a purposive sample of 48 patients (70-94 years) from four European countries. Interviews were analysed using the Framework approach. Trial implementation data on SDM were collected and the 9-item SDM questionnaire was conducted with 17 clinicians. Patients generally displayed positive attitudes towards medication review, yet emphasised the importance of long-term, trusting relationships such as with their general practitioners for medication review. Many patients reported a lack of information and communication about medication changes and predominantly experienced paternalistic decision-making. Patients' beliefs that 'doctors know best', 'blind trust', having limited opportunities for questions, use of jargon terms by clinicians, 'feeling too ill', dismissive clinicians, etc highlight the powerlessness some patients felt during hospitalisation, all representing barriers to SDM. Conversely, involvement of companions, health literacy, empathetic and trusting patient-doctor relationships, facilitated SDM. Paradoxical to patients' experiential accounts, clinicians reported high levels of SDM. The BMQ showed that most patients had high necessity and low concern beliefs about medicines. Beliefs about medicines, ex

Published
2022

17. Experience of hospital-initiated medication changes in older people with multimorbidity: a multicentre mixed-methods study embedded in the OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM) trial

Author

MS Geriatrie, Circulatory Health, Thevelin, Stefanie, Pétein, Catherine, Metry, Beatrice, Adam, Luise, van Herksen, Anniek, Murphy, Kevin, Knol, Wilma, O'Mahony, Denis, Rodondi, Nicolas, Spinewine, Anne, Dalleur, Olivia, MS Geriatrie, Circulatory Health, Thevelin, Stefanie, Pétein, Catherine, Metry, Beatrice, Adam, Luise, van Herksen, Anniek, Murphy, Kevin, Knol, Wilma, O'Mahony, Denis, Rodondi, Nicolas, Spinewine, Anne, and Dalleur, Olivia

Published
2022

18. Experience of hospital-initiated medication changes in older people with multimorbidity: a multicentre mixed-methods study embedded in the OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM) trial

Author

Thevelin, Stefanie, primary, Pétein, Catherine, additional, Metry, Beatrice, additional, Adam, Luise, additional, van Herksen, Anniek, additional, Murphy, Kevin, additional, Knol, Wilma, additional, O'Mahony, Denis, additional, Rodondi, Nicolas, additional, Spinewine, Anne, additional, and Dalleur, Olivia, additional

Published
2022
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19. Subclinical thyroid function and cardiovascular events in patients with atrial fibrillation

Author

Moutzouri, Elisavet, primary, Lyko, Christina, additional, Feller, Martin, additional, Blum, Manuel Raphael, additional, Adam, Luise, additional, Blum, Steffen, additional, Aeschbacher, Stefanie, additional, Fischer, Urs, additional, Roten, Laurent, additional, Del Giovane, Cinzia, additional, Meyer-Zuern, Christine S, additional, Conte, Giulio, additional, Bonati, Leo H, additional, Moschovitis, Giorgio, additional, Kühne, Michael, additional, Beer, Juerg, additional, Aujesky, Drahomir, additional, Osswald, Stefan, additional, Conen, David, additional, and Rodondi, Nicolas, additional

Published
2021
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20. Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial

Author

Blum, Manuel R, primary, Sallevelt, Bastiaan T G M, additional, Spinewine, Anne, additional, O’Mahony, Denis, additional, Moutzouri, Elisavet, additional, Feller, Martin, additional, Baumgartner, Christine, additional, Roumet, Marie, additional, Jungo, Katharina Tabea, additional, Schwab, Nathalie, additional, Bretagne, Lisa, additional, Beglinger, Shanthi, additional, Aubert, Carole E, additional, Wilting, Ingeborg, additional, Thevelin, Stefanie, additional, Murphy, Kevin, additional, Huibers, Corlina J A, additional, Drenth-van Maanen, A Clara, additional, Boland, Benoit, additional, Crowley, Erin, additional, Eichenberger, Anne, additional, Meulendijk, Michiel, additional, Jennings, Emma, additional, Adam, Luise, additional, Roos, Marvin J, additional, Gleeson, Laura, additional, Shen, Zhengru, additional, Marien, Sophie, additional, Meinders, Arend-Jan, additional, Baretella, Oliver, additional, Netzer, Seraina, additional, de Montmollin, Maria, additional, Fournier, Anne, additional, Mouzon, Ariane, additional, O’Mahony, Cian, additional, Aujesky, Drahomir, additional, Mavridis, Dimitris, additional, Byrne, Stephen, additional, Jansen, Paul A F, additional, Schwenkglenks, Matthias, additional, Spruit, Marco, additional, Dalleur, Olivia, additional, Knol, Wilma, additional, Trelle, Sven, additional, and Rodondi, Nicolas, additional

Published
2021
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21. Safety and efficacy of currently utilized treatment modalities in the management of patients with PIK3CA-related overgrowth syndrome - a systematic review

Author

Bernhard, Sarah M., Adam, Luise, Atef, Hady, Häberli, Dario, Bramer, Wichor M, Minder, Beatrice, Döring, Yvonne, Laine, Jessica E., Muka, Taulant, Rössler, Jochen, and Baumgartner, Iris

Subjects
020 Library & information sciences, education, 610 Medicine & health, humanities, 360 Social problems & social services
Abstract

BACKGROUND PIK3CA-related overgrowth syndromes (PROS) include a variety of clinical presentations that are associated with hypertrophy of different parts of the body. AIM Perform a systematic literature review to assess the current treatment options and their efficacy and safety in PROS. METHODS A literature search was performed in EMBASE, MEDLINE (Ovid), Web of Science Core Collection, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov and Google Scholar to retrieve publications on the treatment for hypertrophy in PROS and randomized controlled trials, cohort studies or case series including ≥10 patients reporting were included in the review. Titles, abstracts and full texts were assessed by two reviewers independently. The Risk of Bias (RoB) was assessed using the Newcastle Ottawa Scale. RESULTS 16 articles for the treatment of hypertrophy in PROS patients were included, 13 (81.3%) from clinical retrospective studies and 3 (13.7%) from prospective cohort studies. The ROB grade was low for 2, medium for 12 and high for 2 studies. 13 articles reported surgical treatment, while 3 reported pharmacological treatment using PIK3/mTOR pathway inhibitors in PROS patients. In 3 studies, PROS was defined by a mutation in the PIK3CA gene, while the other studies relied on a clinical definition of PROS. Surgical therapy was beneficial for a specific subgroup of PROS (macrodactyly), but little was reported concerning surgery and potential benefits in other PROS entities. Reported side effects in surgical therapy were mostly prolonged wound healing or scarring. PIK3/mTOR pathway inhibition was beneficial in patients with PROS reducing hypertrophy as well as systemic symptoms. Adverse effects reported included infection, changes in blood count, liver enzymes and metabolic measures. CONCLUSION Surgery is a locally limited treatment option in specific types of PROS. A promising treatment option in PROS is the pharmacological PIK3CA inhibition. However, the level of evidence on treatment of overgrowth in PROS patients is limited.

Published
2021
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22. Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial

Author

UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - (MGD) Département de pharmacie, UCL - (SLuc) Département de pharmacie, UCL - SSS/IRSS - Institut de recherche santé et société, Blum, Manuel R, Sallevelt, Bastiaan T G M, Spinewine, Anne, O’Mahony, Denis, Moutzouri, Elisavet, Feller, Martin, Baumgartner, Christine, Roumet, Marie, Jungo, Katharina Tabea, Schwab, Nathalie, Bretagne, Lisa, Beglinger, Shanthi, Aubert, Carole E, Wilting, Ingeborg, Thevelin, Stefanie, Murphy, Kevin, Huibers, Corlina J A, Drenth-van Maanen, A Clara, Boland, Benoit, Crowley, Erin, Eichenberger, Anne, Meulendijk, Michiel, Jennings, Emma, Adam, Luise, Roos, Marvin J, Gleeson, Laura, Shen, Zhengru, Marien, Sophie, Meinders, Arend-Jan, Baretella, Oliver, Netzer, Seraina, de Montmollin, Maria, Fournier, Anne, Mouzon, Ariane, O’Mahony, Cian, Aujesky, Drahomir, Mavridis, Dimitris, Byrne, Stephen, Jansen, Paul A F, Schwenkglenks, Matthias, Spruit, Marco, Dalleur, Olivia, Knol, Wilma, Trelle, Sven, Rodondi, Nicolas, UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - (MGD) Département de pharmacie, UCL - (SLuc) Département de pharmacie, UCL - SSS/IRSS - Institut de recherche santé et société, Blum, Manuel R, Sallevelt, Bastiaan T G M, Spinewine, Anne, O’Mahony, Denis, Moutzouri, Elisavet, Feller, Martin, Baumgartner, Christine, Roumet, Marie, Jungo, Katharina Tabea, Schwab, Nathalie, Bretagne, Lisa, Beglinger, Shanthi, Aubert, Carole E, Wilting, Ingeborg, Thevelin, Stefanie, Murphy, Kevin, Huibers, Corlina J A, Drenth-van Maanen, A Clara, Boland, Benoit, Crowley, Erin, Eichenberger, Anne, Meulendijk, Michiel, Jennings, Emma, Adam, Luise, Roos, Marvin J, Gleeson, Laura, Shen, Zhengru, Marien, Sophie, Meinders, Arend-Jan, Baretella, Oliver, Netzer, Seraina, de Montmollin, Maria, Fournier, Anne, Mouzon, Ariane, O’Mahony, Cian, Aujesky, Drahomir, Mavridis, Dimitris, Byrne, Stephen, Jansen, Paul A F, Schwenkglenks, Matthias, Spruit, Marco, Dalleur, Olivia, Knol, Wilma, Trelle, Sven, and Rodondi, Nicolas

Abstract

Objective: To examine the effect of optimising drug treatment on drug related hospital admissions in older adults with multimorbidity and polypharmacy admitted to hospital. Design: Cluster randomised controlled trial. Setting: 110 clusters of inpatient wards within university based hospitals in four European countries (Switzerland, Netherlands, Belgium, and Republic of Ireland) defined by attending hospital doctors. Participants: 2008 older adults (≥70 years) with multimorbidity (≥3 chronic conditions) and polypharmacy (≥5 drugs used long term). Intervention: Clinical staff clusters were randomised to usual care or a structured pharmacotherapy optimisation intervention performed at the individual level jointly by a doctor and a pharmacist, with the support of a clinical decision software system deploying the screening tool of older person’s prescriptions and screening tool to alert to the right treatment (STOPP/START) criteria to identify potentially inappropriate prescribing. Main outcome measure: Primary outcome was first drug related hospital admission within 12 months. Results: 2008 older adults (median nine drugs) were randomised and enrolled in 54 intervention clusters (963 participants) and 56 control clusters (1045 participants) receiving usual care. In the intervention arm, 86.1% of participants (n=789) had inappropriate prescribing, with a mean of 2.75 (SD 2.24) STOPP/START recommendations for each participant. 62.2% (n=491) had ≥1 recommendation successfully implemented at two months, predominantly discontinuation of potentially inappropriate drugs. In the intervention group, 211 participants (21.9%) experienced a first drug related hospital admission compared with 234 (22.4%) in the control group. In the intention-to-treat analysis censored for death as competing event (n=375, 18.7%), the hazard ratio for first drug related hospital admission was 0.95 (95% confidence interval 0.77 to 1.17). In the per protocol analysis, the hazard ratio for a drug relate

Published
2021

23. Impact of Thyroid Hormone Therapy on Atherosclerosis in the Elderly With Subclinical Hypothyroidism: A Randomized Trial

Author

Blum, Manuel R., Gencer, Baris, Adam, Luise, Feller, Martin, Collet, Tinh-Hai, da Costa, Bruno R., Moutzouri, Elisavet, Dopheide, Jörn, Depairon, Michèle, Sykiotis, Gerasimos P., Kearney, Patricia, Gussekloo, Jacobijn, Westendorp, Rudi, Stott, David J., Bauer, Douglas C., Rodondi, Nicolas, Blum, Manuel R., Gencer, Baris, Adam, Luise, Feller, Martin, Collet, Tinh-Hai, da Costa, Bruno R., Moutzouri, Elisavet, Dopheide, Jörn, Depairon, Michèle, Sykiotis, Gerasimos P., Kearney, Patricia, Gussekloo, Jacobijn, Westendorp, Rudi, Stott, David J., Bauer, Douglas C., and Rodondi, Nicolas

Abstract

Context Subclinical hypothyroidism (SHypo) has been associated with atherosclerosis, but no conclusive clinical trials assessing the levothyroxine impact on carotid atherosclerosis exist. Objective To assess the impact of treatment of SHypo with levothyroxine on carotid atherosclerosis. Design and Setting Randomized, double-blind, placebo-controlled trial nested within the Thyroid Hormone Replacement for Subclinical Hypothyroidism trial. Participants Participants aged ≥65 years with SHypo [thyroid-stimulating hormone (TSH), 4.60 to 19.99 mIU/L; free thyroxine level within reference range]. Intervention Levothyroxine dose-titrated to achieve TSH normalization or placebo, including mock titrations. Main Outcome Measures Carotid intima media thickness (CIMT), maximum plaque thickness measured with ultrasound. Results One hundred eighty-five participants (mean age 74.1 years, 47% women, 96 randomized to levothyroxine) underwent carotid ultrasound. Overall mean TSH ± SD was 6.35 ± 1.95 mIU/L at baseline and decreased to 3.55 ± 2.14 mIU/L with levothyroxine compared with 5.29 ± 2.21 mIU/L with placebo (P < 0.001). After a median treatment of 18.4 months (interquartile range 12.2 to 30.0 months), mean CIMT was 0.85 ± 0.14 mm under levothyroxine and 0.82 ± 0.13 mm under placebo [between-group difference = 0.02 mm; 95% CI, −0.01 to 0.06; P = 0.30]. The proportion of carotid plaque was similar (n = 135; 70.8% under levothyroxine and 75.3% under placebo; P = 0.46). Maximum carotid plaque thickness was 2.38 ± 0.92 mm under levothyroxine and 2.37 ± 0.91 mm under placebo (between-group difference −0.03; 95% CI, −0.34 to 0.29; P = 0.86). There were no significant interactions between levothyroxine treatment and mean CIMT, according to sex, baseline TSH (categories 4.6 to 6.9, 7.0 to 9.9, and ≥10 mIU/L), or established cardiovascular disease (all P for interaction ≥ 0.14). Conclusion Normalization of TSH with levothyroxine was associated with no difference in CIMT and caro

Published
2021

24. Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): Cluster randomised controlled trial

Author

Apotheek Opleiding, Apotheek, Apotheek Klinische Farmacie, MS Geriatrie, Circulatory Health, Blum, Manuel R., Sallevelt, Bastiaan T.G.M., Spinewine, Anne, O'Mahony, Denis, Moutzouri, Elisavet, Feller, Martin, Baumgartner, Christine, Roumet, Marie, Jungo, Katharina Tabea, Schwab, Nathalie, Bretagne, Lisa, Beglinger, Shanthi, Aubert, Carole E., Wilting, Ingeborg, Thevelin, Stefanie, Murphy, Kevin, Huibers, Corlina J.A., Clara Drenth-Van Maanen, A., Boland, Benoit, Crowley, Erin, Eichenberger, Anne, Meulendijk, Michiel, Jennings, Emma, Adam, Luise, Roos, Marvin J., Gleeson, Laura, Shen, Zhengru, Marien, Sophie, Meinders, Arend Jan, Baretella, Oliver, Netzer, Seraina, De Montmollin, Maria, Fournier, Anne, Mouzon, Ariane, O'Mahony, Cian, Aujesky, Drahomir, Mavridis, Dimitris, Byrne, Stephen, Jansen, Paul A.F., Schwenkglenks, Matthias, Spruit, Marco, Dalleur, Olivia, Knol, Wilma, Trelle, Sven, Rodondi, Nicolas, Apotheek Opleiding, Apotheek, Apotheek Klinische Farmacie, MS Geriatrie, Circulatory Health, Blum, Manuel R., Sallevelt, Bastiaan T.G.M., Spinewine, Anne, O'Mahony, Denis, Moutzouri, Elisavet, Feller, Martin, Baumgartner, Christine, Roumet, Marie, Jungo, Katharina Tabea, Schwab, Nathalie, Bretagne, Lisa, Beglinger, Shanthi, Aubert, Carole E., Wilting, Ingeborg, Thevelin, Stefanie, Murphy, Kevin, Huibers, Corlina J.A., Clara Drenth-Van Maanen, A., Boland, Benoit, Crowley, Erin, Eichenberger, Anne, Meulendijk, Michiel, Jennings, Emma, Adam, Luise, Roos, Marvin J., Gleeson, Laura, Shen, Zhengru, Marien, Sophie, Meinders, Arend Jan, Baretella, Oliver, Netzer, Seraina, De Montmollin, Maria, Fournier, Anne, Mouzon, Ariane, O'Mahony, Cian, Aujesky, Drahomir, Mavridis, Dimitris, Byrne, Stephen, Jansen, Paul A.F., Schwenkglenks, Matthias, Spruit, Marco, Dalleur, Olivia, Knol, Wilma, Trelle, Sven, and Rodondi, Nicolas

Published
2021

25. Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation

Author

Blum, Steffen, primary, Aeschbacher, Stefanie, additional, Meyre, Pascal, additional, Kühne, Michael, additional, Rodondi, Nicolas, additional, Beer, Jürg H., additional, Ammann, Peter, additional, Moschovitis, Giorgio, additional, Bonati, Leo H., additional, Blum, Manuel R., additional, Kastner, Peter, additional, Baguley, Fiona, additional, Sticherling, Christian, additional, Osswald, Stefan, additional, Conen, David, additional, Auberson, Chloé, additional, Blum, Steffen, additional, Bonati, Leo, additional, Ceylan, Selinda, additional, Doerpfeld, Simone, additional, Eken, Ceylan, additional, Girod, Marc, additional, Hämmerle, Peter, additional, Krisai, Philipp, additional, Meyer-Zürn, Christine, additional, Monsch, Andreas U., additional, Müller, Christian, additional, Springer, Anne, additional, Szucs, Thomas, additional, Voellmin, Gian, additional, Zwimpfer, Leon, additional, Aujesky, Drahomir, additional, Fischer, Urs, additional, Fuhrer, Juerg, additional, Roten, Laurent, additional, Jung, Simon, additional, Mattle, Heinrich, additional, Adam, Luise, additional, Aubert, Carole Elodie, additional, Feller, Martin, additional, Loewe, Axel, additional, Moutzouri, Elisavet, additional, Schneider, Claudio, additional, Flückiger, Tanja, additional, Groen, Cindy, additional, Ehrsam, Lukas, additional, Hellrigl, Sven, additional, Nuoffer, Alexandra, additional, Rakovic, Damiana, additional, Schwab, Nathalie, additional, Wenger, Rylana, additional, Beynon, Christopher, additional, Dillier, Roger, additional, Deubelbeiss, Michèle, additional, Eberli, Franz, additional, Franzini, Christine, additional, Juchli, Isabel, additional, Liedtke, Claudia, additional, Nadler, Jacqueline, additional, Obst, Thayze, additional, Roth, Jasmin, additional, Schlomowitsch, Fiona, additional, Schneider, Xiaoye, additional, Studerus, Katrin, additional, Tynan, Noreen, additional, Weishaupt, Dominik, additional, Müller, Andreas, additional, Fontana, Simone, additional, Kuest, Silke, additional, Scheuch, Karin, additional, Hischier, Denise, additional, Bonetti, Nicole, additional, Grau, Alexandra, additional, Villinger, Jonas, additional, Laube, Eva, additional, Baumgartner, Philipp, additional, Filipovic, Mark, additional, Frick, Marcel, additional, Montrasio, Giulia, additional, Leuenberger, Stefanie, additional, Rutz, Franziska, additional, Beer, Jürg-Hans, additional, Auricchio, Angelo, additional, Anesini, Adriana, additional, Camporini, Cristina, additional, Conte, Giulio, additional, Caputo, Maria Luce, additional, Regoli, Francois, additional, Moccetti, Tiziano, additional, Brenner, Roman, additional, Altmann, David, additional, Gemperle, Michaela, additional, Firmann, Mathieu, additional, Foucras, Sandrine, additional, Rime, Martine, additional, Hayoz, Daniel, additional, Berte, Benjamin, additional, Justi, Virgina, additional, Kellner-Weldon, Frauke, additional, Mehmann, Brigitta, additional, Meier, Sonja, additional, Roth, Myriam, additional, Ruckli-Kaeppeli, Andrea, additional, Russi, Ian, additional, Schmidt, Kai, additional, Young, Mabelle, additional, Zbinden, Melanie, additional, Kobza, Richard, additional, Frangi-Kultalahti, Jane, additional, Pin, Anica, additional, Vicari, Luisa, additional, Ehret, Georg, additional, Gallet, Hervé, additional, Guillermet, Elise, additional, Lazeyras, Francois, additional, Lovblad, Karl-Olof, additional, Perret, Patrick, additional, Tavel, Philippe, additional, Teres, Cheryl, additional, Shah, Dipen, additional, Lauriers, Nathalie, additional, Méan, Marie, additional, Salzmann, Sandrine, additional, Schläpfer, Jürg, additional, Grêt, Andrea, additional, Novak, Jan, additional, Vitelli, Sandra, additional, Stephan, Frank-Peter, additional, Gallino, Augusto, additional, Di Valentino, Marcello, additional, Witassek, Fabienne, additional, Schwenkglenks, Matthias, additional, Würfel, Jens, additional, Altermatt, Anna, additional, Amann, Michael, additional, Huber, Petra, additional, Ruberte, Esther, additional, Sinnecker, Tim, additional, Zuber, Vanessa, additional, Coslovsky, Michael, additional, Benkert, Pascal, additional, Dutilh, Gilles, additional, Markovic, Milica, additional, Simon, Patrick, additional, and Schmid, Ramun, additional

Published
2021
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27. Supplemental Material, Suppl._Fig_S9_A-D - Development of a 3-Dimensional Prognostic Score for Patients With Symptomatic Peripheral Artery Disease: PAD3D Score

Author

Dopheide, Jörn F., Ramadani, Hana, Adam, Luise, Gahl, Brigitta, Papac, Lucija, Veit, Jonas, Kaspar, Mathias, Schindewolf, Marc, Baumgartner, Iris, and Drexel, Heinz

Subjects
Cardiology
Abstract

Supplemental Material, Suppl._Fig_S9_A-D for Development of a 3-Dimensional Prognostic Score for Patients With Symptomatic Peripheral Artery Disease: PAD3D Score by Jörn F. Dopheide, Hana Ramadani, Luise Adam, Brigitta Gahl, Lucija Papac, Jonas Veit, Mathias Kaspar, Marc Schindewolf, Iris Baumgartner and Heinz Drexel in Angiology

Published
2020
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28. Supplemental Material, Suppl._Fig_S1-3 - Development of a 3-Dimensional Prognostic Score for Patients With Symptomatic Peripheral Artery Disease: PAD3D Score

Author

Dopheide, Jörn F., Ramadani, Hana, Adam, Luise, Gahl, Brigitta, Papac, Lucija, Veit, Jonas, Kaspar, Mathias, Schindewolf, Marc, Baumgartner, Iris, and Drexel, Heinz

Subjects
Cardiology
Abstract

Supplemental Material, Suppl._Fig_S1-3 for Development of a 3-Dimensional Prognostic Score for Patients With Symptomatic Peripheral Artery Disease: PAD3D Score by Jörn F. Dopheide, Hana Ramadani, Luise Adam, Brigitta Gahl, Lucija Papac, Jonas Veit, Mathias Kaspar, Marc Schindewolf, Iris Baumgartner and Heinz Drexel in Angiology

Published
2020
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29. Supplemental Material, Supplement_table - Development of a 3-Dimensional Prognostic Score for Patients With Symptomatic Peripheral Artery Disease: PAD3D Score

Author

Dopheide, Jörn F., Ramadani, Hana, Adam, Luise, Gahl, Brigitta, Papac, Lucija, Veit, Jonas, Kaspar, Mathias, Schindewolf, Marc, Baumgartner, Iris, and Drexel, Heinz

Subjects
Cardiology
Abstract

Supplemental Material, Supplement_table for Development of a 3-Dimensional Prognostic Score for Patients With Symptomatic Peripheral Artery Disease: PAD3D Score by Jörn F. Dopheide, Hana Ramadani, Luise Adam, Brigitta Gahl, Lucija Papac, Jonas Veit, Mathias Kaspar, Marc Schindewolf, Iris Baumgartner and Heinz Drexel in Angiology

Published
2020
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30. Development of a 3-Dimensional Prognostic Score for Patients With Symptomatic Peripheral Artery Disease: PAD3D Score

Author

Dopheide, Jörn, Ramadani, Hana, Adam, Luise, Gahl, Brigitta, Papac, Lucija, Veit, Jonas, Kaspar, Mathias, Schindewolf, Marc, Baumgartner, Iris, and Drexel, Heinz

Subjects
610 Medicine & health
Abstract

Peripheral artery disease (PAD) is a high-risk condition for cardiovascular (CV) events, but no specific prognosis assessment tool exists. We developed an individual risk score (PAD3D) based on the combined predictive value for mortality, including (1) age, (2) severity of PAD, and (3) extent of atherosclerosis. Patients (n = 1310) with symptomatic PAD were followed up for a mean of 50 ± 26 months. The cohort was randomly subdivided into a test and validation cohort. All-cause and CV mortality were prospectively analyzed for PAD3D score and in combination with classical risk factors. For the test and validation cohort (n = 655 each), all-cause and CV mortality were predicted (P < .001) by the PAD3D score. Additional inclusion of classical risk factors did not increase discrimination compared with PAD3D as "area under receiver-operating characteristic" curves were similar for both scores at any time point. Thus, the addition of the classical risk factors to PAD3D did not further improve the prognostic value. The PAD3D score provides a risk gradient of a 4.5-fold increase in all-cause and CV mortality. We developed a score for precise prediction of all-cause and CV mortality. The PAD3D score promises to allow for personalized goals in risk intervention.

Published
2020
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31. Supplemental Material, Suppl._Fig_S7-8 - Development of a 3-Dimensional Prognostic Score for Patients With Symptomatic Peripheral Artery Disease: PAD3D Score

Author

Dopheide, Jörn F., Ramadani, Hana, Adam, Luise, Gahl, Brigitta, Papac, Lucija, Veit, Jonas, Kaspar, Mathias, Schindewolf, Marc, Baumgartner, Iris, and Drexel, Heinz

Subjects
Cardiology
Abstract

Supplemental Material, Suppl._Fig_S7-8 for Development of a 3-Dimensional Prognostic Score for Patients With Symptomatic Peripheral Artery Disease: PAD3D Score by Jörn F. Dopheide, Hana Ramadani, Luise Adam, Brigitta Gahl, Lucija Papac, Jonas Veit, Mathias Kaspar, Marc Schindewolf, Iris Baumgartner and Heinz Drexel in Angiology

Published
2020
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32. Supplemental Material, Suppl._Fig_S10_A-G - Development of a 3-Dimensional Prognostic Score for Patients With Symptomatic Peripheral Artery Disease: PAD3D Score

Author

Dopheide, Jörn F., Ramadani, Hana, Adam, Luise, Gahl, Brigitta, Papac, Lucija, Veit, Jonas, Kaspar, Mathias, Schindewolf, Marc, Baumgartner, Iris, and Drexel, Heinz

Subjects
Cardiology
Abstract

Supplemental Material, Suppl._Fig_S10_A-G for Development of a 3-Dimensional Prognostic Score for Patients With Symptomatic Peripheral Artery Disease: PAD3D Score by Jörn F. Dopheide, Hana Ramadani, Luise Adam, Brigitta Gahl, Lucija Papac, Jonas Veit, Mathias Kaspar, Marc Schindewolf, Iris Baumgartner and Heinz Drexel in Angiology

Published
2020
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33. Supplemental Material, Suppl._Fig_S4-6 - Development of a 3-Dimensional Prognostic Score for Patients With Symptomatic Peripheral Artery Disease: PAD3D Score

Author

Dopheide, Jörn F., Ramadani, Hana, Adam, Luise, Gahl, Brigitta, Papac, Lucija, Veit, Jonas, Kaspar, Mathias, Schindewolf, Marc, Baumgartner, Iris, and Drexel, Heinz

Subjects
Cardiology
Abstract

Supplemental Material, Suppl._Fig_S4-6 for Development of a 3-Dimensional Prognostic Score for Patients With Symptomatic Peripheral Artery Disease: PAD3D Score by Jörn F. Dopheide, Hana Ramadani, Luise Adam, Brigitta Gahl, Lucija Papac, Jonas Veit, Mathias Kaspar, Marc Schindewolf, Iris Baumgartner and Heinz Drexel in Angiology

Published
2020
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34. Intervention protocol: OPtimising thERapy to prevent avoidable hospital Admission in the Multi-morbid elderly (OPERAM): A structured medication review with support of a computerised decision support system

Author

Apotheek Opleiding, MS Geriatrie, Apotheek Klinische Farmacie, Circulatory Health, Crowley, Erin K., Sallevelt, Bastiaan T.G.M., Huibers, Corlina J.A., Murphy, Kevin D., Spruit, Marco, Shen, Zhengru, Boland, Benoît, Spinewine, Anne, Dalleur, Olivia, Moutzouri, Elisavet, Löwe, Axel, Feller, Martin, Schwab, Nathalie, Adam, Luise, Wilting, Ingeborg, Knol, Wilma, Rodondi, Nicolas, Byrne, Stephen, O'Mahony, Denis, Apotheek Opleiding, MS Geriatrie, Apotheek Klinische Farmacie, Circulatory Health, Crowley, Erin K., Sallevelt, Bastiaan T.G.M., Huibers, Corlina J.A., Murphy, Kevin D., Spruit, Marco, Shen, Zhengru, Boland, Benoît, Spinewine, Anne, Dalleur, Olivia, Moutzouri, Elisavet, Löwe, Axel, Feller, Martin, Schwab, Nathalie, Adam, Luise, Wilting, Ingeborg, Knol, Wilma, Rodondi, Nicolas, Byrne, Stephen, and O'Mahony, Denis

Published
2020

35. Health-related quality of life in patients with atrial fibrillation: The role of symptoms, comorbidities, and the type of atrial fibrillation

Author

Witassek, Fabienne, Springer, Anne, Adam, Luise, Aeschbacher, Stefanie, Beer, Jürg H., Blum, Steffen, Bonati, Leo H., Conen, David, Kobza, Richard, Kühne, Michael, Moschovitis, Giorgio, Osswald, Stefan, Rodondi, Nicolas, Sticherling, Christian, Szucs, Thomas, and Schwenkglenks, Matthias

Subjects
Male, Sleep Apnea, Pulmonology, Patients, Apnea, Cardiology, 610 Medicine & health, Pathology and Laboratory Medicine, Vascular Medicine, Signs and Symptoms, Diagnostic Medicine, 360 Social problems & social services, Thromboembolism, Atrial Fibrillation, Medicine and Health Sciences, Humans, Prospective Studies, Fatigue, Aged, Heart Failure, Aged, 80 and over, Biology and Life Sciences, Heart, Venous Thromboembolism, Arteries, humanities, Deep Vein Thrombosis, Health Care, Neurology, Cardiovascular Anatomy, Quality of Life, Blood Vessels, Female, Anatomy, Sleep Disorders, Arrhythmia, Switzerland, Research Article
Abstract

AIMS This study aimed to analyse health related quality of life (HRQoL) for patients with different atrial fibrillation (AF) types and to identify patient characteristics, symptoms and comorbidities that influence HRQoL. METHODS We used baseline data from the Swiss Atrial Fibrillation (Swiss-AF) study, a prospective multicentre observational cohort study conducted in 13 clinical centres in Switzerland. Between April 2014 and August 2017, 2415 AF patients were recruited. Patients were included in this analysis if they had baseline HRQoL data as assessed with EQ-5D-based utilities and visual analogue scale (VAS) scores. Patient characteristics and HRQoL were described stratified by AF type. The impact of symptoms, comorbidities and socio-economic factors on HRQoL was analysed using multivariable regression analysis. RESULTS Based on 2412 patients with available baseline HRQoL data, the lowest unadjusted mean HRQoL was found in patients with permanent AF regardless of whether measured with utilities (paroxysmal: 0.83, persistent: 0.84, permanent: 0.80, p

Published
2019

36. Blood Pressure and Brain Lesions in Patients With Atrial Fibrillation

Author

Aeschbacher, Stefanie, primary, Blum, Steffen, additional, Meyre, Pascal B., additional, Coslovsky, Michael, additional, Vischer, Annina S., additional, Sinnecker, Tim, additional, Rodondi, Nicolas, additional, Beer, Jürg H., additional, Moschovitis, Giorgio, additional, Moutzouri, Elisavet, additional, Hunkeler, Christof, additional, Burkard, Thilo, additional, Eken, Ceylan, additional, Roten, Laurent, additional, Zuern, Christine S., additional, Sticherling, Christian, additional, Wuerfel, Jens, additional, Bonati, Leo H., additional, Conen, David, additional, Osswald, Stefan, additional, Kühne, Michael, additional, Auberson, Chloé, additional, Ceylan, Selinda, additional, Doerpfeld, Simone, additional, Girod, Marc, additional, Hennings, Elisa, additional, Krisai, Philipp, additional, Monsch, Andreas U., additional, Müller, Christian, additional, Springer, Anne, additional, Voellmin, Gian, additional, Aujesky, Drahomir, additional, Fischer, Urs, additional, Fuhrer, Juerg, additional, Jung, Simon, additional, Mattle, Heinrich, additional, Adam, Luise, additional, Elodie Aubert, Carole, additional, Feller, Martin, additional, Loewe, Axel, additional, Schneider, Claudio, additional, Flückiger, Tanja, additional, Groen, Cindy, additional, Ehrsam, Lukas, additional, Hellrigl, Sven, additional, Nuoffer, Alexandra, additional, Rakovic, Damiana, additional, Schwab, Nathalie, additional, Wenger, Rylana, additional, Müller, Andreas, additional, Beynon, Christopher, additional, Dillier, Roger, additional, Deubelbeiss, Michèle, additional, Eberli, Franz, additional, Franzini, Christine, additional, Juchli, Isabel, additional, Liedtke, Claudia, additional, Nadler, Jacqueline, additional, Obst, Thayze, additional, Roth, Jasmin, additional, Schlomowitsch, Fiona, additional, Schneider, Xiaoye, additional, Studerus, Katrin, additional, Tynan, Noreen, additional, Weishaupt, Dominik, additional, Fontana, Simone, additional, Kuest, Silke, additional, Scheuch, Karin, additional, Hischier, Denise, additional, Bonetti, Nicole, additional, Grau, Alexandra, additional, Villinger, Jonas, additional, Laube, Eva, additional, Baumgartner, Philipp, additional, Filipovic, Mark, additional, Frick, Marcel, additional, Montrasio, Giulia, additional, Leuenberger, Stefanie, additional, Rutz, Franziska, additional, Moccetti, Tiziano, additional, Auricchio, Angelo, additional, Anesini, Adriana, additional, Camporini, Cristina, additional, Conte, Giulio, additional, Luce Caputo, Maria, additional, Regoli, Francois, additional, Ammann, Peter, additional, Brenner, Roman, additional, Altmann, David, additional, Gemperle, Michaela, additional, Hayoz, Daniel, additional, Firmann, Mathieu, additional, Foucras, Sandrine, additional, Rime, Martine, additional, Kobza, Richard, additional, Berte, Benjamin, additional, Justi, Virgina, additional, Kellner-Weldon, Frauke, additional, Mehmann, Brigitta, additional, Meier, Sonja, additional, Roth, Myriam, additional, Ruckli-Kaeppeli, Andrea, additional, Russi, Ian, additional, Schmidt, Kai, additional, Young, Mabelle, additional, Zbinden, Melanie, additional, Frangi-Kultalahti, Jane, additional, Pin, Anica, additional, Shah, Dipen, additional, Ehret, Georg, additional, Gallet, Hervé, additional, Guillermet, Elise, additional, Lazeyras, Francois, additional, Lovblad, Karl-Olof, additional, Perret, Patrick, additional, Tavel, Philippe, additional, Teres, Cheryl, additional, Schläpfer, Jürg, additional, Lauriers, Nathalie, additional, Méan, Marie, additional, Salzmann, Sandrine, additional, Stephan, Frank-Peter, additional, Grêt, Andrea, additional, Novak, Jan, additional, Vitelli, Sandra, additional, Di Valentino, Marcello, additional, Gallino, Augusto, additional, Witassek, Fabienne, additional, Schwenkglenks, Matthias, additional, Altermatt, Anna, additional, Amann, Michael, additional, Huber, Petra, additional, Ruberte, Esther, additional, Zuber, Vanessa, additional, Benkert, Pascal, additional, Dutilh, Gilles, additional, Markovic, Milica, additional, Neuschwander, Pia, additional, Simon, Patrick, additional, and Schmid, Ramun, additional

Published
2021
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40. Search for heavy charged long-lived particles in the ATLAS detector in 36.1 fb-1 of proton-proton collision data at root s=13 Te V

Author

Aaboud, M., Aad, G., Abbott, B., Abbott, DC, Abdinov, O., Abeloos, B, Abhayasinghe, DK, Abidi, S.H., AbouZeid, Ossama Sherif Alexander, Abraham, NL, Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B.S., Adachi, Sosuke, Adam, Luise, Adamczyk, L., Adamek, L., Adelman, J., Adersberger, M., Adiguzel, A., Adye, T., Affolder, A. A., Afik, Y., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmadov, F., Aielli, G., Bajic, Milena, Hansen, Jørgen Beck, Hansen, Peter Henrik, de Almeida Dias, Flavia, Galster, Gorm Aske Gram Krohn, Besjes, Geert-Jan, Dam, Mogens, Wiglesworth, Graig, Stark, Simon Holm, Petersen, Troels Christian, Hansen, Jørn Dines, Monk, James William, hqz214, hqz214, Alonso Diaz, Alejandro, and Xella, Stefania

Published
2019

41. Search for the Production of a Long-Lived Neutral Particle Decaying within the ATLAS Hadronic Calorimeter in Association with a Z Boson from pp Collisions at root s=13 TeV

Author

Aaboud, M., Aad, G., Abbott, B., Abdinov, O., Abeloos, B, Abhayasinghe, DK, Abidi, S.H., Abouzeid, Ossama Sherif Alexander, Abraham, NL, Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B.S., Adachi, Sosuke, Adam, Luise, Adamczyk, L., Adelman, J., Adersberger, M., Adiguzel, A., Adye, T., Affolder, A. A., Afik, Y., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmadov, F., Dam, Mogens, Stark, Simon Holm, de Almeida Dias, Flavia, Alonso Diaz, Alejandro, Galster, Gorm Aske Gram Krohn, Besjes, Geert-Jan, Hansen, Jørgen Beck, Bajic, Milena, hqz214, hqz214, Hansen, Jørn Dines, Hansen, Peter Henrik, Petersen, Troels Christian, Wiglesworth, Graig, Monk, James William, and Xella, Stefania

Published
2019

43. Rationale and design of OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM): a cluster randomised controlled trial

Author

Adam, Luise, Moutzouri, Elisavet, Baumgartner, Christine, Loewe, Axel Lennart, Feller, Martin, M'Rabet-Bensalah, Khadija, Schwab, Nathalie, Hossmann, Stefanie, Schneider, Claudio, Jegerlehner, Sabrina, Floriani, Carmen, Limacher, Andreas, Jungo, Katharina Tabea, Huibers, Corlina Johanna Alida, Streit, Sven, Schwenkglenks, Matthias, Spruit, Marco, Van Dorland, Anette, Donzé, Jacques, Kearney, Patricia M, Jüni, Peter, Aujesky, Drahomir, Jansen, Paul, Boland, Benoit, Dalleur, Olivia, Byrne, Stephen, Knol, Wilma, Spinewine, Anne, O'Mahony, Denis, Trelle, Sven, Rodondi, Nicolas, University of Zurich, Rodondi, Nicolas, UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - SSS/IRSS - Institut de recherche santé et société, UCL - (SLuc) Service de gériatrie, UCL - (SLuc) Département de pharmacie, and UCL - (MGD) Département de pharmacie

Subjects
Male, Drug-Related Side Effects and Adverse Reactions, Optimising therapy, Inappropriate Prescribing, 610 Medicine & health, 2700 General Medicine, general medicine (see internal medicine), Protocol, Journal Article, Cluster Analysis, Humans, Potentially Inappropriate Medication List, Hospital admissions, Aged, Aged, 80 and over, Medicine(all), geriatric medicine, Multimorbidity, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), Decision Support Systems, Clinical, OPERAM, Europe, Hospitalization, internal medicine, Geriatrics, Chronic Disease, Polypharmacy, Quality of Life, Female, clinical pharmacology
Abstract

INTRODUCTION: Multimorbidity and polypharmacy are important risk factors for drug-related hospital admissions (DRAs). DRAs are often linked to prescribing problems (overprescribing and underprescribing), as well as non-adherence with drug regimens for different reasons. In this trial, we aim to assess whether a structured medication review compared with standard care can reduce DRAs in multimorbid older patients with polypharmacy. METHODS AND ANALYSIS: OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people is a European multicentre, cluster randomised, controlled trial. Hospitalised patients ≥70 years with ≥3 chronic medical conditions and concurrent use of ≥5 chronic medications are included in the four participating study centres of Bern (Switzerland), Utrecht (The Netherlands), Brussels (Belgium) and Cork (Ireland). Patients treated by the same prescribing physician constitute a cluster, and clusters are randomised 1:1 to either standard care or Systematic Tool to Reduce Inappropriate Prescribing (STRIP) intervention with the help of a clinical decision support system, the STRIP Assistant. STRIP is a structured method performing customised medication reviews, based on Screening Tool of Older People's Prescriptions/Screening Tool to Alert to Right Treatment criteria to detect potentially inappropriate prescribing. The primary endpoint is any DRA where the main reason or a contributory reason for the patient's admission is caused by overtreatment or undertreatment, and/or inappropriate treatment. Secondary endpoints include number of any hospitalisations, all-cause mortality, number of falls, quality of life, degree of polypharmacy, activities of daily living, patient's drug compliance, the number of significant drug-drug interactions, drug overuse and underuse and potentially inappropriate medication. ETHICS AND DISSEMINATION: The local Ethics Committees in Switzerland, Ireland, The Netherlands and Belgium approved this trial protocol. We will publish the results of this trial in a peer-reviewed journal. MAIN FUNDING: European Union's Horizon 2020 programme. TRIAL REGISTRATION NUMBER: NCT02986425 , SNCTP000002183 , NTR6012, U1111-1181-9400.

Published
2019
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44. Search for Higgs boson pair production in the b(b)over-barWW* decay mode at root s=13 TeV with the ATLAS detector

Author

Aaboud, M., Aad, G., Abbott, B., Abdinov, O., Abeloos, B, Abhayasinghe, DK, Abidi, S.H., AbouZeid, Ossama Sherif Alexander, Abraham, NL, Abramowicz, H., Abreu, H., Acharya, B.S., Adachi, J, Adam, Luise, Adamczyk, L., Adelman, J., Adersberger, M., Adiguzel, A., Adye, T., Affolder, A. A., Afik, Y., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmadov, F., Aielli, G., Alonso Diaz, Alejandro, de Almeida Dias, Flavia, Bajic, Milena, hqz214, hqz214, Dam, Mogens, Besjes, Geert-Jan, Hansen, Jørgen Beck, Galster, Gorm Aske Gram Krohn, Hansen, Peter Henrik, Hansen, Jørn Dines, Monk, James William, Petersen, Troels Christian, Stark, Simon Holm, Wiglesworth, Graig, Xella, Stefania, Aaboud, M., Aad, G., Abbott, B., Abdinov, O., Abeloos, B, Abhayasinghe, DK, Abidi, S.H., AbouZeid, Ossama Sherif Alexander, Abraham, NL, Abramowicz, H., Abreu, H., Acharya, B.S., Adachi, J, Adam, Luise, Adamczyk, L., Adelman, J., Adersberger, M., Adiguzel, A., Adye, T., Affolder, A. A., Afik, Y., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmadov, F., Aielli, G., Alonso Diaz, Alejandro, de Almeida Dias, Flavia, Bajic, Milena, hqz214, hqz214, Dam, Mogens, Besjes, Geert-Jan, Hansen, Jørgen Beck, Galster, Gorm Aske Gram Krohn, Hansen, Peter Henrik, Hansen, Jørn Dines, Monk, James William, Petersen, Troels Christian, Stark, Simon Holm, Wiglesworth, Graig, and Xella, Stefania

Published
2019

45. Rationale and design of OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM): a cluster randomised controlled trial.

Author

UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - SSS/IRSS - Institut de recherche santé et société, UCL - (SLuc) Service de gériatrie, UCL - (SLuc) Département de pharmacie, UCL - (MGD) Département de pharmacie, Adam, Luise, Moutzouri, Elisavet, Baumgartner, Christine, Loewe, Axel Lennart, Feller, Martin, M'Rabet-Bensalah, Khadija, Schwab, Nathalie, Hossmann, Stefanie, Schneider, Claudio, Jegerlehner, Sabrina, Floriani, Carmen, Limacher, Andreas, Jungo, Katharina Tabea, Huibers, Corlina Johanna Alida, Streit, Sven, Schwenkglenks, Matthias, Spruit, Marco, Van Dorland, Anette, Donzé, Jacques, Kearney, Patricia M, Jüni, Peter, Aujesky, Drahomir, Jansen, Paul, Boland, Benoit, Dalleur, Olivia, Byrne, Stephen, Knol, Wilma, Spinewine, Anne, O'Mahony, Denis, Trelle, Sven, Rodondi, Nicolas, UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - SSS/IRSS - Institut de recherche santé et société, UCL - (SLuc) Service de gériatrie, UCL - (SLuc) Département de pharmacie, UCL - (MGD) Département de pharmacie, Adam, Luise, Moutzouri, Elisavet, Baumgartner, Christine, Loewe, Axel Lennart, Feller, Martin, M'Rabet-Bensalah, Khadija, Schwab, Nathalie, Hossmann, Stefanie, Schneider, Claudio, Jegerlehner, Sabrina, Floriani, Carmen, Limacher, Andreas, Jungo, Katharina Tabea, Huibers, Corlina Johanna Alida, Streit, Sven, Schwenkglenks, Matthias, Spruit, Marco, Van Dorland, Anette, Donzé, Jacques, Kearney, Patricia M, Jüni, Peter, Aujesky, Drahomir, Jansen, Paul, Boland, Benoit, Dalleur, Olivia, Byrne, Stephen, Knol, Wilma, Spinewine, Anne, O'Mahony, Denis, Trelle, Sven, and Rodondi, Nicolas

Abstract

INTRODUCTION: Multimorbidity and polypharmacy are important risk factors for drug-related hospital admissions (DRAs). DRAs are often linked to prescribing problems (overprescribing and underprescribing), as well as non-adherence with drug regimens for different reasons. In this trial, we aim to assess whether a structured medication review compared with standard care can reduce DRAs in multimorbid older patients with polypharmacy. METHODS AND ANALYSIS: OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people is a European multicentre, cluster randomised, controlled trial. Hospitalised patients ≥70 years with ≥3 chronic medical conditions and concurrent use of ≥5 chronic medications are included in the four participating study centres of Bern (Switzerland), Utrecht (The Netherlands), Brussels (Belgium) and Cork (Ireland). Patients treated by the same prescribing physician constitute a cluster, and clusters are randomised 1:1 to either standard care or Systematic Tool to Reduce Inappropriate Prescribing (STRIP) intervention with the help of a clinical decision support system, the STRIP Assistant. STRIP is a structured method performing customised medication reviews, based on Screening Tool of Older People's Prescriptions/Screening Tool to Alert to Right Treatment criteria to detect potentially inappropriate prescribing. The primary endpoint is any DRA where the main reason or a contributory reason for the patient's admission is caused by overtreatment or undertreatment, and/or inappropriate treatment. Secondary endpoints include number of any hospitalisations, all-cause mortality, number of falls, quality of life, degree of polypharmacy, activities of daily living, patient's drug compliance, the number of significant drug-drug interactions, drug overuse and underuse and potentially inappropriate medication. ETHICS AND DISSEMINATION: The local Ethics Committees in Switzerland, Ireland, The Netherlands and Belgium approved this trial proto

Published
2019

46. Rationale and design of OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM): a cluster randomised controlled trial

Author

Unit Opleiding Geriatrie, MS Geriatrie, Circulatory Health, Adam, Luise, Moutzouri, Elisavet, Baumgartner, Christine, Loewe, Axel Lennart, Feller, Martin, M'Rabet-Bensalah, Khadija, Schwab, Nathalie, Hossmann, Stefanie, Schneider, Claudio, Jegerlehner, Sabrina, Floriani, Carmen, Limacher, Andreas, Jungo, Katharina Tabea, Huibers, Corlina Johanna Alida, Streit, Sven, Schwenkglenks, Matthias, Spruit, Marco, Van Dorland, Anette, Donzé, Jacques, Kearney, Patricia M, Jüni, Peter, Aujesky, Drahomir, Jansen, Paul, Boland, Benoit, Dalleur, Olivia, Byrne, Stephen, Knol, Wilma, Spinewine, Anne, O'Mahony, Denis, Trelle, Sven, Rodondi, Nicolas, Unit Opleiding Geriatrie, MS Geriatrie, Circulatory Health, Adam, Luise, Moutzouri, Elisavet, Baumgartner, Christine, Loewe, Axel Lennart, Feller, Martin, M'Rabet-Bensalah, Khadija, Schwab, Nathalie, Hossmann, Stefanie, Schneider, Claudio, Jegerlehner, Sabrina, Floriani, Carmen, Limacher, Andreas, Jungo, Katharina Tabea, Huibers, Corlina Johanna Alida, Streit, Sven, Schwenkglenks, Matthias, Spruit, Marco, Van Dorland, Anette, Donzé, Jacques, Kearney, Patricia M, Jüni, Peter, Aujesky, Drahomir, Jansen, Paul, Boland, Benoit, Dalleur, Olivia, Byrne, Stephen, Knol, Wilma, Spinewine, Anne, O'Mahony, Denis, Trelle, Sven, and Rodondi, Nicolas

Published
2019

47. Measurements of inclusive and differential fiducial cross-sections of t(t)over-bar production with additional heavy-flavour jets in proton-proton collisions at root s=13 TeV with the ATLAS detector

Author

Aaboud, M., Aad, G., Abbott, B., Abdinov, O., Abeloos, B, Abhayasinghe, DK, Abidi, S.H., AbouZeid, Ossama Sherif Alexander, Abraham, NL, Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B.S., Adachi, Sosuke, Adam, Luise, Adamczyk, L., Adelman, J., Adersberger, M., Adiguzel, A., Adye, T., Affolder, A. A., Afik, Y., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmadov, F., Aielli, G., Alonso Diaz, Alejandro, de Almeida Dias, Flavia, Bajic, Milena, Besjes, Geert-Jan, Dam, Mogens, Galster, Gorm Aske Gram Krohn, Hansen, Jørgen Beck, Hansen, Jørn Dines, Hansen, Peter Henrik, Monk, James William, hqz214, hqz214, Petersen, Troels Christian, Stark, Simon Holm, Wiglesworth, Graig, Xella, Stefania, Aaboud, M., Aad, G., Abbott, B., Abdinov, O., Abeloos, B, Abhayasinghe, DK, Abidi, S.H., AbouZeid, Ossama Sherif Alexander, Abraham, NL, Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B.S., Adachi, Sosuke, Adam, Luise, Adamczyk, L., Adelman, J., Adersberger, M., Adiguzel, A., Adye, T., Affolder, A. A., Afik, Y., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmadov, F., Aielli, G., Alonso Diaz, Alejandro, de Almeida Dias, Flavia, Bajic, Milena, Besjes, Geert-Jan, Dam, Mogens, Galster, Gorm Aske Gram Krohn, Hansen, Jørgen Beck, Hansen, Jørn Dines, Hansen, Peter Henrik, Monk, James William, hqz214, hqz214, Petersen, Troels Christian, Stark, Simon Holm, Wiglesworth, Graig, and Xella, Stefania

Published
2019

48. Measurement of the four-lepton invariant mass spectrum in 13 TeV proton-proton collisions with the ATLAS detector

Author

Aaboud, M., Aad, G., Abbott, B., Abdinov, O., Abeloos, B, Abhayasinghe, DK, Abidi, S.H., AbouZeid, Ossama Sherif Alexander, Abraham, NL, Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B.S., Adachi, J, Adam, Luise, Adamczyk, L., Adelman, J., Adersberger, M., Adiguzel, A., Adye, T., Affolder, A. A., Afik, Y., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmadov, F., Aielli, G., Alonso Diaz, Alejandro, de Almeida Dias, Flavia, Bajic, Milena, Besjes, Geert-Jan, Dam, Mogens, Hansen, Jørgen Beck, Hansen, Jørn Dines, Galster, Gorm Aske Gram Krohn, Hansen, Peter Henrik, Monk, James William, hqz214, hqz214, Stark, Simon Holm, Petersen, Troels Christian, Wiglesworth, Graig, Xella, Stefania, Aaboud, M., Aad, G., Abbott, B., Abdinov, O., Abeloos, B, Abhayasinghe, DK, Abidi, S.H., AbouZeid, Ossama Sherif Alexander, Abraham, NL, Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B.S., Adachi, J, Adam, Luise, Adamczyk, L., Adelman, J., Adersberger, M., Adiguzel, A., Adye, T., Affolder, A. A., Afik, Y., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmadov, F., Aielli, G., Alonso Diaz, Alejandro, de Almeida Dias, Flavia, Bajic, Milena, Besjes, Geert-Jan, Dam, Mogens, Hansen, Jørgen Beck, Hansen, Jørn Dines, Galster, Gorm Aske Gram Krohn, Hansen, Peter Henrik, Monk, James William, hqz214, hqz214, Stark, Simon Holm, Petersen, Troels Christian, Wiglesworth, Graig, and Xella, Stefania

Published
2019

49. Combination of the Searches for Pair-Produced Vectorlike Partners of the Third-Generation Quarks at root s=13 TeV with the ATLAS Detector

Author

Aaboud, M., Aad, G., Abbott, B., Abdinov, O., Abeloos, B, Abhayasinghe, DK, Abidi, S.H., Abouzeid, Ossama Sherif Alexander, Abraham, NL, Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B.S., Adachi, Sosuke, Adam, Luise, Adamczyk, L., Adelman, J., Adersberger, M., Adiguzel, A., Adye, T., Affolder, A. A., Afik, Y., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmadov, F., Alonso Diaz, Alejandro, Besjes, Geert-Jan, Bajic, Milena, Dam, Mogens, Galster, Gorm Aske Gram Krohn, de Almeida Dias, Flavia, Hansen, Jørgen Beck, Hansen, Peter Henrik, Hansen, Jørn Dines, Monk, James William, Petersen, Troels Christian, Stark, Simon Holm, Thiele, Fabian Alexander Jürgen, Wiglesworth, Graig, and Xella, Stefania

Published
2018

50. Observation of H -> b(b)over-bar decays and V H production with the ATLAS detector

Author

Aaboud, M., Aad, G., Abbott, B., Abdinov, O., Abeloos, B, Abhayasinghe, DK, Abidi, S.H., Abouzeid, Ossama Sherif Alexander, Abraham, NL, Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B.S., Adachi, Sosuke, Adam, Luise, Adamczyk, L., Adelman, J., Adersberger, M., Adiguzel, A., Adye, T., Affolder, A. A., Afik, Y., Agheorghiesei, C., Aguilar-Saavedra, J. A., Alonso Diaz, Alejandro, Besjes, Geert-Jan, Bajic, Milena, Dam, Mogens, de Almeida Dias, Flavia, Galster, Gorm Aske Gram Krohn, Hansen, Peter Henrik, Hansen, Jørn Dines, Hansen, Jørgen Beck, Monk, James William, Petersen, Troels Christian, Thiele, Fabian A.J., Stark, Simon Holm, Wiglesworth, Graig, and Xella, Stefania

Published
2018

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