1. Invasive Fungal Infections in Children with Leukemia: Clinical Features and Prognosis
- Author
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Melike Sezgin Evim, Özlem Tüfekçi, Birol Baytan, Hale Ören, Solmaz Celebi, Beyza Ener, Kevser Üstün Elmas, Şebnem Yılmaz, Melek Erdem, Mustafa Kemal Hacımustafaoğlu, and Adalet Meral Güneş
- Subjects
fungal infections ,pediatric leukemia ,acute lymphoblastic leukemia ,acute myeloid leukemia ,febrile neutropenia ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Objective: The incidence of invasive fungal infections (IFIs) has increased due to intensive chemotherapy in childhood leukemia. The aim of this study was to evaluate the incidence, risk factors, causative pathogens, and impact on survival of IFIs among pediatric leukemia patients. Materials and Methods: The hospital records of 307 children with acute lymphoblastic leukemia (ALL, n=238), acute myeloid leukemia (AML, n=51), and relapsed leukemia (n=18) between January 2010 and December 2015 were retrospectively evaluated. Results: A total of 1213 febrile neutropenia episodes were recorded and 127 (10.4%) of them were related to an IFI. Of 307 children, 121 (39.4%) developed IFIs. The mean age was significantly older in the IFI group compared to children without IFIs (p
- Published
- 2022
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