17 results on '"Adaş, Gökhan"'
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2. The effect of mesenchymal stem cells administration on DNA repair gene expressions in critically ill COVID-19 patients: prospective controlled study.
- Author
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Işıksaçan, Nilgün, Adaş, Gökhan, Kasapoğlu, Pınar, Çukurova, Zafer, Yılmaz, Rabia, Kurt Yaşar, Kadriye, Irmak Koyuncu, Duygu, Tuncel, Fatima Ceren, Şahingöz Erdal, Gülçin, Gedikbaşı, Asuman, Pehlivan, Sacide, and Karaoz, Erdal
- Abstract
AbstractWhen the studies are evaluated, immunomodulatory effect of MSCs, administration in critically ill patients, obstacle situations in use and side effects, pulmonary fibrosis prevention, which stem cells and their products, regeneration effect, administration route, and dosage are listed under the main heading like. The effect of MSC administration on DNA repair genes in COVID-19 infection is unknown. Our aim is to determine the effect of mesenchymal stem cells (MSCs) therapy applied in critically ill patients with coronavirus infection on DNA repair pathways and genes associated with those pathways. Patients (
n = 30) divided into two equal groups. Group-1: Patients in a critically ill condition, Group-2: Patients in critically ill condition and transplanted MSCs. The mechanism was investigated in eleven genes of five different pathways; Base excision repair: PARP1, Nucleotide excision repair (NER): RAD23B and ERCC1, Homologous recombinational repair (HR): ATM, RAD51, RAD52 and WRN, Mismatch repair (MMR): MLH1, MSH2, and MSH6, Direct reversal repair pathway: MGMT. It was found that MSCs application had a significant effect on 6 genes located in 3 different DNA damage response pathways. These are NER pathway genes; RAD23 and ERCC1, HR pathway genes; ATM and RAD51, MMR pathway genes; MSH2 and MSH6 (p < 0.05). Two main points were shown. First, as a result of cellular damage in critical patients with COVID-19, DNA damage occurs and then DNA repair pathways and genes are activated in reaction to this situation. Second, administration of MSC to patients with COVID-19 infection plays a positive role by increasing the expression of DNA repair genes located in DNA damage pathways. [ABSTRACT FROM AUTHOR]- Published
- 2024
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3. Should Calcitonin Be Measured in Every Thyroid Nodule?
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Adaş, Mine, primary and Adaş, Gökhan, additional
- Published
- 2018
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4. Incidental Thorax CT Findings in Patients with Suspected COVID-19 Pneumonia.
- Author
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Nalbant, Mustafa Orhan, Yıldız, Ömer, Hocaoğlu, Elif, Polat, Ercan İnci1,Özlem, and Adaş, Gökhan Tolga
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COVID-19 ,COMPUTED tomography ,PULMONARY nodules ,OLDER patients ,PNEUMONIA ,LIVER histology - Abstract
Objective: In this study, we aimed to emphasize the importance and frequency of incidental findings detected in chest computed tomography (CT) imaging with suspected coronavirus disease-2019 (COVID-19) pneumonia. Methods: We evaluated lung nodules, emphysema, pleural and pericardial effusion, mediastinal and axillary lymphadenopathy (LAP), gallstones, kidney stones, hepatosteatosis, ascites, lung, breast, liver, adrenal gland, pancreas, and spleen masses whether or not the patients were positive for COVID-19 pneumonia and correlated with their gender and age. Polymerase chain reaction results of the patients were considered whose CT images were suspicious for COVID-19 pneumonia with chest CT. A total of 2,400 patients were included in the study. Patients who had major thoracic or abdominal operations, aged 18 and above 80 years, and images with artifacts were excluded from our study. Results: In older patients, the COVID-19 positivity rate was higher in our study. We also found that the risk of positive COVID-19 results was higher in the presence of incidental findings regardless of their number. Furthermore, incidental findings such as mediastinal LAP (p=0.001), air cyst (p=0.021), and size above 5 mm parenchymal lung nodule (p=0.001) were higher in patients whose COVID-19 results were positive. Conclusion: We demonstrated that clinicians and radiologists should be careful in terms of incidental findings when evaluating whether there is COVID-19 involvement in our study. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Does the subtotal cholecystectomy rate for acute cholecystitis change with previous endoscopic retrograde cholangiopancreatography?
- Author
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Kesgin, Yasir Musa, Gümüşoğlu, Alpen Yahya, Kabuli, Hamit Ahmet, Karabulut, Mehmet, Bulut, Sezer, Dönmez, Turgut, Kocataş, Ali, and Adaş, Gökhan Tolga
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LENGTH of stay in hospitals ,ENDOSCOPIC retrograde cholangiopancreatography ,CHOLECYSTITIS ,LAPAROSCOPIC surgery ,RETROSPECTIVE studies ,ACQUISITION of data ,SURGICAL complications ,TREATMENT duration ,CHOLECYSTECTOMY ,TREATMENT effectiveness ,MEDICAL records ,PATIENT safety ,EVALUATION - Abstract
Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
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6. Percutaneous Cholecystostomy as a Step or Final Treatment for Acute Cholecystitis
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Gümüşoğlu, Alpen Yahya, primary, Kabuli, Hamit Ahmet, additional, Erbahçeci Salık, Aysun, additional, Çakır, Çağlayan, additional, Abdullayev, Seymur, additional, Peker, Kıvanç Derya, additional, Karabulut, Mehmet, additional, and Adaş, Gökhan Tolga, additional
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- 2021
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7. Effectiveness of Zero-Angle Gastrojejunostomy Anastomosis Technique Applied to Pancreaticoduodenectomy on Delayed Gastric Emptying.
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Gümüşoğlu, Alpen Yahya, Kabuli, Hamit Ahmet, Akbulut, Sezer, Peker, Kıvanç Derya, Yılmaz, Serhan, Karabulut, Mehmet, and Adaş, Gökhan Tolga
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GASTRIC bypass ,PANCREATICODUODENECTOMY ,PREOPERATIVE risk factors ,BLOOD loss estimation ,PATIENT care - Abstract
Copyright of Medical Journal of Istanbul Kanuni Sultan Süleyman / İstanbul Kanuni Sultan Süleyman Tıp Dergisi is the property of Logos Medical Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
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8. Dispepsili Hastalarda H. pylori ve Histopatolojik Bulguların Değerlendirilmesi
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SOYLU, Aliye, PEKER, Kıvanç Derya, YIRGIN, Hakan, POLAT SARI, Silva, AKGÜL, Özer, SAPMAZ, Burcu, ADAŞ, Gökhan Tolga, ÖNER, Yaşar Ali, KAYACAN, Zeynep Çiğdem, and ÇALIŞKAN, Reyhan
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Medicine ,Sydney sınıflma sistemi,H. pylori,Dispepsi ,Tıp - Abstract
Amaç: Çalışmamızda, dispepsi tanısı almış hastaların biyopsi materyallerinde Sydney SınıflmaSistemine göre H. pylori ve histopatolojik değişikliklerin tespit edilmesi ve bu parametrelerin H.pylori ile birlikteliğinin değerlendirilmesi amaçlandı.Gereç ve yöntem: Dispeptik şikayetlerle başvuran ve endoskopi endikasyonu olan 88 hastadanantrum ve korpus biyopsi örnekleri alınarak gastrik mukozada meydana gelen değişikliklerSydney sınıflma sistemine göre (H. pylori, kronik enflmasyon, PNL aktivitesi, atrofi, intestinalmetaplazi) değerlendirildi.Bulgular: Çalışmaya alınan biyopsi örneklerinde H. pylori 88 hastanın 46’sında (%52,3) pozitifiken, 76’sında (%86.3) kronik enflmasyon, 54’ünde (%61.3) PNL aktivasyonu, 8’inde (%9.1)atrofi, 12’sinde (%13.6) intestinal metaplazi saptandı. Çalışmaya alınan H. pylori ile enfekteolan 46 hastadan 45’inde (%97.8) kronik enflmasyon, 42’sinde (%91.3), PNL aktivasyonu,6’sında (%13) atrofi ve 8’inde (%17.4) intestinal metaplazi görülürken, H. pylori ile enfekteolmayan 42 hastanın 31’inde (%73.8) kronik enflmasyon, 12’sinde (%28.6) PNL aktivasyonu,2’sinde (%4.8) atrofi ve 4’ünde (%9.5) intestinal metaplazi saptandı.Sonuçlar: H. pylori ve mide kanseri ilişkisinde hastalığın öncüsü olabilen bu lezyonların erkendönemde tanımlanmasının hastalığın takip ve tedavisi açısından önemli olduğu bilinmektedir.Bu nedenle, ülkemizde yaygın olarak bulunan H. pylori enfeksiyonunun Sydney sınıflmasıile saptanan pre-kanseröz değişikliklerle birlikte değerlendirilmesinin önemli olabileceğidüşünülmüştür.
- Published
- 2019
9. Wharton’s Jelly-Derived Mesenchymal Stem Cell Transplantation in a Patient with Hypoxic-Ischemic Encephalopathy
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Kabataş, Serdar, Civelek, Erdinç, İnci, Çiğdem, Yalçınkaya, Ebru Yılmaz, Günel, Gülşen, Kır, Gülay, Albayrak, Esra, Öztürk, Erek, Adaş, Gökhan, and Karaöz, Erdal
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Male ,Adolescent ,lcsh:R ,Brain ,lcsh:Medicine ,post-cardiopulmonary resuscitation ,Mesenchymal Stem Cells ,Pilot Projects ,Original Articles ,Mesenchymal Stem Cell Transplantation ,stem cell therapy ,wharton’s jelly ,Hypoxia-Ischemia, Brain ,Humans ,hypoxic-ischemic encephalopathy ,Wharton Jelly - Abstract
Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) have been introduced as a possible therapy in hypoxic-ischemic encephalopathy (HIE). We report a 16-year-old boy who was treated with WJ-MSCs in the course of HIE due to post-cardiopulmonary resuscitation. He received a long period of mechanical ventilation and tracheostomy with spastic quadriparesis. He underwent the intrathecal (1×10 6 /kg in 3 mL), intramuscular (1×10 6 /kg in 20 mL) and intravenous (1×10 6 /kg in 30 mL) administrations of WJ-MSCs for each application route (twice a month for 2 months). After stem cell infusions, progressive improvements were shown in his neurological examination, neuroradiological, and neurophysiological findings. To our best knowledge, this is a pioneer project to clinically study the neural repair effect of WJ-MSCs in a patient with HIE.
- Published
- 2018
10. İntraoperatif hipertansiyon krizi ile tanı konan retroperitoneal paraganglioma: olgu sunumu
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Şahin, Gürol, Adaş, Gökhan Tolga, Nilhan Kansu Alemdar, Bahaeddin Tapkan, Er, Ahmet Muzaffer, and Kımıloğlu, Elife
- Published
- 2016
- Full Text
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11. Role of mesenchymal stem cells transfected with vascular endothelial growth factor in maintaining renal structure and function in rats with unilateral ureteral obstruction
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Özbek, Emin, Adaş, Gökhan, Ötünçtemur, Alper, Duruksu, Gökhan, Koç, Bora, Polat, Emre Can, Sarvan, Ahu Kemik, Okçu, Alparslan, Kamalı, Gülçin, Subaşı, Cansu, and Karaöz, Erdal
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Epithelial-Mesenchymal Transition ,Renal Injury ,Ureter Obstruction ,urologic and male genital diseases ,Obstructive Nephropathy - Abstract
WOS: 000356908200009 PubMed ID: 25542189 Objectives: Mesenchymal stem cells hold promise for renal disease treatment. Vascular endothelial growth factor may heal tubule-interstitial fibrosis in unilateral ureteral obstruction by inhibiting epithelial-mesenchymal transition. We investigated the protective effect of vascular endothelial growth factor in transfected mesenchymal stem cells in unilateral ureteral obstruction-induced renal injury in rats. Materials and Methods: Male Wistar Albino rats (32 rats; weight, 250-300 g) were divided into 4 equal groups: group 1, control; group 2, unilateral ureteral obstruction; group 3, unilateral ureteral obstruction and mesenchymal stem cells; and group 4, unilateral ureteral obstruction and vascular endothelial growth factor-transfected mesenchymal stem cells. Vascular endothelial growth factor-transfected mesenchymal stem cells were administered intravenously before onset of unilateral ureteral obstruction. On day 14, the rats were killed and kidneys were retrieved. Tubular necrosis, mono-nuclear cell infiltration, and interstitial fibrosis were evaluated in paraffin blocks. We evaluated green fluorescent protein-positive and vascular endothelial growth factor-positive cells; anti-inflammatory (Prostaglandin E2 Receptor) and interleukin 1 receptor antagonist), proinflammatory/anti-inflammatory (interleukin 6), and proinflammatory (MPO) cytokine expression levels; and levels of nitric oxide; transforming growth factor beta 1, E-cadherin, and hydroxyproline. Results: Green fluorescent protein-positive cells were negative in the renal parenchyma in groups 1 and 2 and positive in groups 3 and 4. Vascular endothelial growth factor levels were significantly higher in group 4. Transforming growth factor 131, nitric oxide, and E-cadherin levels were significantly higher in the unilateral ureteral obstruction than control group; however, in the study groups, these values were not significantly different from the unilateral ureteral obstruction group. In stem cell-transplanted tissue samples, EP3, interleukin 1 receptor antagonist, and interleukin 6 levels were elevated, but MPO expression levels were low. Although there were significant differences for tubular necrosis and fibrosis in group 2, there were significant reductions in tubular injury and fibrosis in groups 3 and 4. Conclusions: Systemic stem cells transplanted into the kidney protected against unilateral ureteral obstruction-induced renal epithelial-mesenchymal transition and renal fibrosis.
- Published
- 2015
12. Safra Yolu Obstrüksiyonunda Manyetik Rezonans Kolanjiopankreatografi'nin Tanıya Katkısı: Ek Bulgular ve Yanılgılar.
- Author
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Yıldız, Hülya Kurtul, Şahin, Gürol, Ekin, Elif Evrim, Erok, Berrin, and Adaş, Gökhan Tolga
- Abstract
Copyright of Journal of Academic Research in Medicine is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
13. Eğitimde Farklı Bir Makro Organizasyon Modeli Olarak Sağlık Bilimleri Üniversitesi.
- Author
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Bektemür, Güven, Taşcı, Ali İhsan, and Adaş, Gökhan
- Abstract
Copyright of Journal of Academic Research in Medicine is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2016
- Full Text
- View/download PDF
14. İleus: Günlük Pratikte Radyolojik Yaklaşım.
- Author
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Yıldız, Hülya Kurtul, Ekin, Elif Evrim, Bayrak, Aylin Hasanefendioğlu, Duman, İsmail Sinan, Sayar, Samed, and Adaş, Gökhan Tolga
- Abstract
Copyright of Journal of Academic Research in Medicine is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2016
- Full Text
- View/download PDF
15. Does the subtotal cholecystectomy rate for acute cholecystitis change with previous endoscopic retrograde cholangiopancreatography?
- Author
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Kesgin YM, Gümüşoğlu AY, Kabuli HA, Karabulut M, Bulut S, Dönmez T, Kocataş A, and Adaş GT
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- Humans, Cholangiopancreatography, Endoscopic Retrograde, Retrospective Studies, Length of Stay, Cholecystitis, Acute surgery, Cholecystectomy, Laparoscopic methods
- Abstract
Background: Acute cholecystitis is one of the most common emergent surgeries. As a safe alternative in challenging operations, laparoscopic subtotal cholecystectomy (LSC) is widely used. We questioned whether the results in acute cholecystitis cases changed with a history of endoscopic retrograde cholangiopancreatography (ERCP). When we searched the literature, we could not find a study focusing on the subtotal cholestectomy results in acute cholecystitis. In our study, we aimed to investigate whether the history of ERCP affects the rates of subtotal cholecystectomy (SC) in acute cholecystitis., Methods: The results of patients (n=470) who underwent surgery for acute cholecystitis at our clinic between 2016 and 2019 were retrospectively evaluated. The patients were divided into two groups according to their history of ERCP. The primary outcome was the SC rate. The secondary outcomes were conversion to open, postoperative complications, serious complications, operative duration, and length of hospital stay., Results: The standard group included 437 patients, whereas the ERCP group included 33 patients. A total of 16 patients underwent SC, with 15 in the standard group and 1 in the ERCP group. There was no significant difference in terms of SC rates between groups (P=0.902). While four cases of operation were completed with conversion to open in the non-ERCP group, no conversion was seen in the ERCP group (P=0.581). No significant differences were detected between the groups in terms of complications, serious compli-cations, operation duration, length of hospital stay, and mortality., Conclusion: The results of this study showed that ERCP is not related to an increased rate of SC and conversion in patients with acute cholecystitis. Laparoscopic cholecystectomy for acute cholecystitis can be safely performed in patients with a history of ERCP. LSC is a safe procedure in challenging patients, and fenestrating SC can be preferred to avoid hazardous consequences in such cases.
- Published
- 2023
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16. Gastrointestinal stromal tumor presenting as dyspareunia.
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Kamali S, Akan A, Aydin T, Karatepe O, Kamali G, and Adaş G
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- Adult, Biopsy, Female, Gastrointestinal Stromal Tumors surgery, Humans, Immunohistochemistry, Magnetic Resonance Imaging, Dyspareunia diagnosis, Gastrointestinal Stromal Tumors diagnosis
- Published
- 2011
- Full Text
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17. [Retrospective analysis of the patients with penetrating cardiac trauma].
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Arikan S, Yücel AF, Kocakuşak A, Dadük Y, Adaş G, and Onal MA
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- Adolescent, Adult, Female, Heart Injuries pathology, Humans, Injury Severity Score, Male, Medical Records, Retrospective Studies, Turkey epidemiology, Wounds, Stab pathology, Heart Injuries mortality, Wounds, Stab mortality
- Abstract
Background: Penetrating cardiac stab wounds are among rarely seen traumas, associated with high mortality. We aimed to present and investigate our experience in such cases., Methods: Eighteen cases with penetrating cardiac stab wounds, between 1993-2001, were investigated retrospectively. Gender, age, conditions at application, injured areas, extent of cardiac damage, accompanying organ damages and outcomes of these patients were studied., Results: All patients were male with a mean age of 25.38 years (between 16-42 years). Heart was the only affected organ in nine 9 patients, whereas there were additional organ injuries in the remaining patients. The injuries were at left ventricle in 11, right ventricle in 4 and right atrium in three patients. Only two patients survived among 14 patients who developed cardiac arrest. There was additional organ damage in three of the six survivors., Conclusion: The overall mortality was 66%. Suspect of cardiac injury should be considered in patients who are injured close around cardiac area and one should intervene quickly both in diagnosis and treatment.
- Published
- 2003
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