Based on the European commission, climate change has become a serious threat for all aspects of our lives, urgent action needs to be taken. All the industries need to monitor their contributions, among them the building industry has the highest emission (European Commission) This study aims to compare energy efficiency and global warming potential (GWP fossil) emission in two ventilation systems including Variable air volume (VAV) and active chilled beams (ACB) in their entire life cycles. The system boundary of this study covers Construction (A), use (B) and end of life (C) stages, however for use stage, maintenance (B2), replacement (B4) and operational energy use(B6) are calculated. The reference study lifetime of the project is 25 years. Although A stage of two systems was calculated through a reference project, in this study thanks to newly published EPD the A stage is updated, and an uncertainty of data is calculated to assess the validity of A1-A5 results compared to reference study. An energy simulation is done by IDA-ICE version 4.8 for B6 module calculation. This energy simulation only focuses on energy use of fan, cooling, and heating of building. Finally, three scenarios are assessed for B6 module’s results, including fossil-free energy target, and different geographical locations. Moreover, in order to assess the certainty of this module’s results, two types of databases for B6 were compared including, average values provided by Boverket and location specific values provider by district heating network and electricity grid providers. For maintenance (B2), cleaning of HVAC systems is taken into account and for B4, the replacement of those products that have a lower service life span than 25 years are calculated. Results indicate that ACB is more energy efficient than VAV, while the ACB system consumes more energy for cooling, it ultimately proves to be more energy efficient. Regarding GWP fossil emissions, ACB in an entire life cycle perspective has a lo, Based on the European Commission, climate change poses a serious threat to all aspects of our lives, it needs urgent actions. The construction industry, with a high emission, plays a critical role in this effort. This study compares the energy efficiency and global warming potential (GWP) of two ventilation systems, Variable Air Volume (VAV) and Active Chilled Beams (ACB), across their entire life cycles. The Variable Air Volume (VAV) system provides conditioned air through an air handling unit (AHU) via fans and ducts. The airflow rate changes during operation, based on the number of occupants and temperature in the rooms, this changing airflow is controlled by device name VAV box in each zone, to adjust airflow based on cooling demand. Active Chilled Beams (ACB) are air-water convection units integrated with a constant air volume (CAV) air handing unit. They provide cooling through chilled water pipes and maintain air quality with fresh air. Since a part of cooling demand of rooms provides by chilled water, therefore, the need for airflow rate is minimum, and accordingly the air volume is less than air volume in VAV system. So, by having a lower airflow the size of duct and air handling units can be smaller compared to VAV system. Each product has different life cycle stages from when it is produced till it will be deconstructed. These life cycle stages include construction (A), use (B), and end-of-life (C) stages. You might don’t know what these stages include, so let see what are they? A stage includes the steps from producing, transporting it to the user site and finally installing it for usage proposes. In B stage, there are stages about using a product, and all the aspects that will occur during usage time, like replacement, maintenance, any energy use, etc. In C stage, the lifespan of the product is over, and it needed to be removed and throw away or even reuse or recycled. So, in all these stages, some harmful impacts might be occurred to our environment. T