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2. Immunocompromised-Associated Pediatric Acute Respiratory Distress Syndrome: Experience From the 2016/2017 Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Prospective Cohort Study*

Author

Gertz, Shira J., Bhalla, Anoopindar, Chima, Ranjit S., Emeriaud, Guillaume, Fitzgerald, Julie C., Hsing, Deyin D., Jeyapalan, Asumthia S., Pike, Francis, Sallee, Colin J., Thomas, Neal J., Yehya, Nadir, Rowan, Courtney M., Sforza, Jesica, Poterala, Rossana, Fernandez, Analia, Avila Vera, Antonio, Orqueda, Daniel, Agueda Vidal, Nilda, Rosemary, Deheza, Turon, Gonzalo, Monjes, Cecilia, Fernando Espanol, Segundo, Siaba Serrate, Alejandro, Iolster, Thomas, Torres, Silvio, Cinquegrani, Karina, Jose Montes, Maria, Capocasa, Patricia, Ferreyra, Marcela, Castellani, Pablo, Giampieri, Martin, Pedraza, Claudia, Martin Landry, Luis, Althabe, Maria, Vanesa Fortini, Yanina, Botta, Priscila, Paziencia, Fernando, Erickson, Simon, Barr, Samantha, Shea, Sara, Butt, Warwick, Delzoppo, Carmel, Pintimalla, Alyssa, Martinez Leon, Alejandro Fabio, Guzman Rivera, Gustavo Alfredo, Jouvet, Philippe, Emeriaud, Guillaume, Dumitrascu, Mariana, Ellen French, Mary, Caro, Daniel, Castillo, I, Andres, E., Cruces Romero, Pablo, Medina, Tania, Pavez Madrid, Paula, Cortez, Ambar, Alvear, Jimena, Acuna, Carlos, Diaz, Franco, Jose Nunez, Maria, Wegner Araya, Adriana, Godoy Mundaca, Loreto, Chen, Yang, Perez Lozano, German, Pardo Carrero, Rosalba, Lopez Alarcon, Yurika Paola, Mazzillo Vega, Liliana, Maria Izquierdo, Ledys, Piñeres Olave, Byron Enrique, Zuluaga Orrego, Cesar, Quinonez Lopez, Deyanira, Vasquez Hoyos, Pablo, Vavrina, Martin, Zurek, Jiri, Campos-Miño, Santiago, Yerovi, Rocio, Bridier, Armelle, Payen, Valerie, Milesi, Christophe, Bourgoin, Pierre, Travert, Brendan, Genuini, Mathieu, Starck, Julie, Maria, Matthieu, Guichoux, Julie, Baudin, Florent, Briassoulis, George, Ilia, Stavroula, Di Nardo, Matteo, Camporesi, Anna, Chiusolo, Fabrizio, Shime, Nobuaki, Ohshimo, Shinichiro, Kida, Yoshiko, Kyo, Michihito, Tabata, Yuichi, Fong Tang, Swee, Wern Tai, Chian, See Lum, Lucy Chai, Elghuwael, Ismail, Jimenez Rivera, Nestor Javier, Jarillo Quijada, Alberto E, Kneyber, Martin, Dijkstra, Sandra, Beca, John, Sherring, Claire, Miriam, Rea, Vargas G, Sonia I, Vasquez Miranda, Daniel, Ramirez Cortez, Grimaldo, Tantalean, Jose, Pagowska-Klimek, Izabela, Gil Escobar, Carlos, Sousa Moniz, Marta, Camilo, Cristina, Hazwani, Tarek, Aldairi, Nedaa, Al Amoudi, Ahmed, Alahmadti, Ahmad, Taylor, Ryan, Mendizabal, Mikel, Goni Orayen, Concepcion, Lopez Fernandez, Yolanda, Ramon Valle, Juan, Martinez, Lidia, Pilar Orive, Javier, Brezmes, Marta, Lopez-Herce, Jesus, Parrilla, Julio, Gaboli, Mirella, Gonzalez Gomez, Jose Manuel, Morales Martinez, Antonio, Alapont, Vicent Modesto I, Sanchez Diaz, Juan Ignacio, Llorente de la Fuente, Ana M., Palanca Arias, Daniel, Madurga Revilla, Paula, Martinez de Azagra, Amelia, Garcia Gonzalez, Maria, Arjona Villanueva, David, Garcia Casas, Paula, Brio Sanagustin, Sonia, Pons Odena, Marti, Medina, Alberto, Onate Vergara, Eider, Rodriguez Campoy, Patricia, Reyes Dominguez, Susana, Dursun, Oguz, Atike Ongun, Ebru, Kamit Can, Fulya, Berna Anil, Ayse, Baines, Paul, Walsh, Laura, Jones, Dawn, Sadasivam, Kalaimaran, Mildner, Reinout, Plunkett, Adrian, Lillie, Jon, Tibby, Shane, Wellman, Paul, Belfield, Holly, Brierley, Joe, Dominguez, Troy E., Abaleke, Eugenia, Feinstein, Yael, Deep, Akash, Sundararajan, Santosh, Oruganti, Siva, Silvestre, Catarina, Weitz, James, Sheward, Victoria, Macrae, Duncan, Aramburo, Angela, Fortune, Peter-Marc, Subramanian, Gayathri, Jennings, Claire, Dwarakanathan, Buvana, Inwald, David, Feather, Calandra, Agbeko, Rachel, Lawton-Woodhall, Angela, McIntyre, Karen, Sykes, Kim, Pappachan, Jon, Gale, Helen, Mellish, Christie, McCorkell, Jenni, Torero, Luis, Nofziger, Ryan, Latifi, Samir, Anthony, Heather, Sanders, Ron, Hefley, Glenda, Virk, Manpreet, Jaimon, Nancy, Maddux, Aline B., Mourani, Peter M., Ralston, Kimberly, Sierra, Yamila, Khemani, Robinder, Newth, Christopher, Bhalla, Anoopindar, Kwok, Jeni, Morzov, Rica, Mahapatra, Sidharth, Truemper, Edward, Kustka, Lucinda, Nett, Sholeen T., Singleton, Marcy, Dean Jarvis, J., Yehya, Nadir, Napolitano, Natalie, Murphy, Marie, Ronan, Laurie, Morgan, Ryan, Kubis, Sherri, Broden, Elizabeth, Willson, Douglas, Henderson, Grace, Gedeit, Rainer, Murkowski, Kathy, Woods, Katherine, Kasch, Mary, Han, Yong Y, Affolter, Jeremy T, Tieves, Kelly S, Hughes-Schalk, Amber, Chima, Ranjit S., Krallman, Kelli, Stoneman, Erin, Benken, Laura, Yunger, Toni, Schneider, James, Sweberg, Todd, Kessel, Aaron, Carroll, Christopher L., Santanelli, James, Ackerman, Kate G, Cullimore, Melissa, Rowan, Courtney, Bales, Melissa, Keith Dockery, W., Jafari-Namin, Shirin, Barry, Dana, Jane’t, Keary, Alibrahim, Omar, Patankar, Nikhil, Qiao, Haiping, Gertz, Shira, Su, Felice, Haileselassie, Bereketeab, Song, Hanqiu, Bysani, Kris, Monjure, Tracey, Beltramo, Fernando, Totapally, Balagangadhar, Govantes, Beatriz, Coates, Bria, Wellisch, Lawren, Allen, Kiona, Shukla, Avani, Thomas, Neal J., Spear, Debbie, Shein, Steven L., Gertz, Shira, Parker, Margaret M., Sloniewsky, Daniel, Allen, Christine, Harrell, Amy, Pinto, Neethi, Kniola, Allison, Rodgers, Chiara, Cvijanovich, Natalie, Typpo, Katri, Kelley, Connor, King, Caroline, Sapru, Anil, Ratiu, Anna, Ashtari, Neda, Sikora, Lindsay, Jeyapalan, Asumthia S., Coronado-Munoz, Alvaro, Flori, Heidi, Dahmer, Mary K., Jayachandran, Chaandini, Hume, Janet, Nerheim, Dan, Smith, Rebecca, Spaeder, Michael, Adu-Darko, Michelle, Smith, Lincoln, Hartmann, Silvia, Sullivan, Erin, Merritt, Courtney, Al-Subu, Awni, Blom, Andrea, Lin, John C., Spinella, Philip, Hsing, Deyin D., Pon, Steve, Brian Estil, Jim, Gautam, Richa, Giuliano, John S., Jr, and Tala, Joana

Published
2024
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3. Perspectives from the Society for Pediatric Research: advice on sustaining science and mentoring during COVID-19.

Author

Forster, Catherine S, Nguyen, Suong T, Powell, Weston T, Moore, Daniel J, Ho, Jacqueline, Heyman, Melvin B, Wenger, Tara L, Gonzalez, Fernando, Hostetter, Margaret, Nowalk, Andrew, Rassbach, Caroline E, Boyer, Debra, Weiss, Pnina, Blankenburg, Rebecca L, Orange, Jordan S, Ackerman, Kate G, Burns, Audrea M, and National Pediatric Physician-Scientist Collaborative Workgroup

Subjects
National Pediatric Physician-Scientist Collaborative Workgroup, Humans, Interpersonal Relations, Mental Health, Efficiency, Pediatrics, Biomedical Research, Career Mobility, Education, Medical, Graduate, Mentors, Societies, Medical, Pediatricians, COVID-19, Good Health and Well Being, Paediatrics and Reproductive Medicine, Public Health and Health Services
Abstract

The COVID-19 pandemic will leave an indelible mark on the careers of current medical trainees. Given the disruptions to medical education, economic impact on institutions, and the uncertainties around future job prospects, trainees are facing unprecedented challenges. This situation is especially concerning for futures of pediatric physician-scientist trainees, where concerns regarding maintaining the pipeline were well documented prior to the emergence of COVID-19. In this Perspectives article, we leverage the unique expertise of our workgroup to address concerns of physician-scientist trainees and to provide suggestions on how to navigate career trajectories in the post-COVID-19 era. We identified and addressed four major areas of concern: lack of in-person conferences and the associated decrease access to mentors and networking activities, decreased academic productivity, diminished job prospects, and mental health challenges. We also suggest actions for trainees, mentors and educational leaders, and institutions to help support trainees during the pandemic, with a goal of maintaining the pediatric physician-scientist pipeline.

Published
2021

4. Mechanisms to expedite pediatric clinical trial site activation: The DOSE trial experience

Author

Boutzoukas, Angelique E., Olson, Rachel, Sellers, Mary Ann, Fischer, Gwenyth, Hornik, Chi D., Alibrahim, Omar, Iheagwara, Kelechi, Abulebda, Kamal, Bass, Andora L., Irby, Katherine, Subbaswamy, Anjali, Zivick, Elizabeth E., Sweney, Jill, Stormorken, Anne G., Barker, Erin E., Lutfi, Riad, McCrory, Michael C., Costello, John M., Ackerman, Kate G., Munoz Pareja, Jennifer C., Dean, J. Michael, Abdelsamad, Nael, Hanley, Daniel F., Jr, Mould, W. Andrew, Lane, Karen, Stroud, Mary, Feger, Bryan J., Greenberg, Rachel G., Smith, P. Brian, Benjamin, Daniel K., Jr, Hornik, Christoph P., Zimmerman, Kanecia O., and Becker, Mara L.

Published
2023
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5. Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study

Author

Khemani, Robinder G, Smith, Lincoln, Lopez-Fernandez, Yolanda M, Kwok, Jeni, Morzov, Rica, Klein, Margaret J, Yehya, Nadir, Willson, Douglas, Kneyber, Martin CJ, Lillie, Jon, Fernandez, Analia, Newth, Christopher JL, Jouvet, Philippe, Thomas, Neal J, Investigators, Pediatric Acute Respiratory Distress syndrome Incidence and Epidemiology, Abaleke, Eugenia, Ackerman, Kate G, Acuña, Carlos, Adu-Darko, Michelle, Affolter, Jeremy T, Agbeko, Rachel, Amoudi, Ahmed Al, Alahmadti, Ahmad, Aldairi, Nedaa, Alibrahim, Omar, Allen, Kiona, Allen, Christine, Al-Subu, Awni, Althabe, María, Alvear, Jimena, Anil, Ayse Berna, Anthony, Heather, Aramburo, Angela, Villanueva, David Arjona, Ashtari, Neda, Vera, Antonio Ávila, Baines, Paul, Bales, Melissa, Barr, Samantha, Barry, Dana, Baudin, Florent, Beca, John, Belfield, Holly, Beltramo, Fernando, Benken, Laura, Bhalla, Anoopindar, Blom, Andrea, Botta, Priscila, Bourgoin, Pierre, Brezmes, Marta, Briassoulis, George, Bridier, Armelle, Brierley, Joe, Sanagustin, Sonia Brio, Broden, Elizabeth, Butt, Warwick, Bysani, Kris, Camilo, Cristina, Camporesi, Anna, Campos-Miño, Santiago, Can, Fulya Kamit, Capocasa, Patricia, Caro, Daniel, Carroll, Christopher, Castellani, Pablo, Castillo, Andres E, Chen, Yang, Chima, Ranjit S, Chiusolo, Fabrizio, Cinquegrani, Karina, Coates, Bria, Coronado-Munoz, Alvaro, Cortéz, Ambar, Romero, Pablo Cruces, Cullimore, Melissa, Cvijanovich, Natalie, Dahmer, Mary K, Deep, Akash, Delzoppo, Carmel, Di Nardo, Matteo, Díaz, Franco, Dijkstra, Sandra, Dockery, W Keith, Dominguez, Troy E, Dumitrascu, Mariana, Dursun, Oguz, Dwarakanathan, Buvana, Elghuwael, Ismail, Emeriaud, Guillaume, Erickson, Simon, Español, Segundo Fernando, Estil, Jim Brian, Feather, Calandra, Feinstein, Yael, Fernández, Analía, Ferreyra, Marcela, Flori, Heidi, Fortini, Yanina Vanesa, Fortune, Peter-Marc, and French, Mary Ellen

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Pediatric, Lung, Clinical Research, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Respiratory, Good Health and Well Being, Acute Lung Injury, Age Factors, Area Under Curve, Cause of Death, Child, Child, Preschool, Combined Modality Therapy, Cross-Sectional Studies, Female, Hospital Mortality, Humans, Intensive Care Units, Pediatric, Internationality, Kaplan-Meier Estimate, Male, Prognosis, Prospective Studies, Respiratory Distress Syndrome, Severity of Illness Index, Sex Factors, Survival Analysis, United States, Pediatric Acute Respiratory Distress syndrome Incidence and Epidemiology (PARDIE) Investigators, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Public Health and Health Services, Other Medical and Health Sciences, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundPaediatric acute respiratory distress syndrome (PARDS) is associated with high mortality in children, but until recently no paediatric-specific diagnostic criteria existed. The Pediatric Acute Lung Injury Consensus Conference (PALICC) definition was developed to overcome limitations of the Berlin definition, which was designed and validated for adults. We aimed to determine the incidence and outcomes of children who meet the PALICC definition of PARDS.MethodsIn this international, prospective, cross-sectional, observational study, 145 paediatric intensive care units (PICUs) from 27 countries were recruited, and over a continuous 5 day period across 10 weeks all patients were screened for enrolment. Patients were included if they had a new diagnosis of PARDS that met PALICC criteria during the study week. Exclusion criteria included meeting PARDS criteria more than 24 h before screening, cyanotic heart disease, active perinatal lung disease, and preparation or recovery from a cardiac intervention. Data were collected on the PICU characteristics, patient demographics, and elements of PARDS (ie, PARDS risk factors, hypoxaemia severity metrics, type of ventilation), comorbidities, chest imaging, arterial blood gas measurements, and pulse oximetry. The primary outcome was PICU mortality. Secondary outcomes included 90 day mortality, duration of invasive mechanical and non-invasive ventilation, and cause of death.FindingsBetween May 9, 2016, and June 16, 2017, during the 10 study weeks, 23 280 patients were admitted to participating PICUs, of whom 744 (3·2%) were identified as having PARDS. 95% (708 of 744) of patients had complete data for analysis, with 17% (121 of 708; 95% CI 14-20) mortality, whereas only 32% (230 of 708) of patients met Berlin criteria with 27% (61 of 230) mortality. Based on hypoxaemia severity at PARDS diagnosis, mortality was similar among those who were non-invasively ventilated and with mild or moderate PARDS (10-15%), but higher for those with severe PARDS (33% [54 of 165; 95% CI 26-41]). 50% (80 of 160) of non-invasively ventilated patients with PARDS were subsequently intubated, with 25% (20 of 80; 95% CI 16-36) mortality. By use of PALICC PARDS definition, severity of PARDS at 6 h after initial diagnosis (area under the curve [AUC] 0·69, 95% CI 0·62-0·76) discriminates PICU mortality better than severity at PARDS diagnosis (AUC 0·64, 0·58-0·71), and outperforms Berlin severity groups at 6 h (0·64, 0·58-0·70; p=0·01).InterpretationThe PALICC definition identified more children as having PARDS than the Berlin definition, and PALICC PARDS severity groupings improved the stratification of mortality risk, particularly when applied 6 h after PARDS diagnosis. The PALICC PARDS framework should be considered for use in future epidemiological and therapeutic research among children with PARDS.FundingUniversity of Southern California Clinical Translational Science Institute, Sainte Justine Children's Hospital, University of Montreal, Canada, Réseau en Santé Respiratoire du Fonds de Recherche Quebec-Santé, and Children's Hospital Los Angeles, Department of Anesthesiology and Critical Care Medicine.

Published
2019

6. Noninvasive Ventilation for Pediatric Acute Respiratory Distress Syndrome: Experience From the 2016/2017 Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Prospective Cohort Study*

Author

Emeriaud, Guillaume, Pons-Òdena, Marti, Bhalla, Anoopindar K., Shein, Steven L., Killien, Elizabeth Y., Modesto i Alapont, Vicent, Rowan, Courtney, Baudin, Florent, Lin, John C., Grégoire, Gabrielle, Napolitano, Natalie, Mayordomo-Colunga, Juan, Diaz, Franco, Cruces, Pablo, Medina, Alberto, Smith, Lincoln, Khemani, Robinder G., Sforza, Jesica, Poterala, Rossana, Fernandez, Analia, Avila Vera, Antonio, Orqueda, Daniel, Agueda Vidal, Nilda, Rosemary, Deheza, Turon, Gonzalo, Monjes, Cecilia, Espanol, Segundo Fernando, Serrate, Alejandro Siaba, Iolster, Thomas, Torres, Silvio, Cinquegrani, Karina, Jose Montes, Maria, Capocasa, Patricia, Ferreyra, Marcela, Castellani, Pablo, Giampieri, Martin, Pedraza, Claudia, Landry, Luis Martin, Althabe, Maria, Fortini, Yanina Vanesa, Botta, Priscila, Paziencia, Fernando, Erickson, Simon, Barr, Samantha, Shea, Sara, Butt, Warwick, Delzoppo, Carmel, Pintimalla, Alyssa, Leon, Alejandro Fabio Martinez, Rivera, Gustavo Alfredo Guzman, Jouvet, Philippe, Emeriaud, Guillaume, Dumitrascu, Mariana, Ellen French, Mary, Caro I, Daniel, Castillo, Andres E., Romero, Pablo Cruces, Medina, Tania, Madrid, Paula Pavez, Cortez, Ambar, Alvear, Jimena, Acuna, Carlos, Diaz, Franco, Nunez, Maria Jose, Araya, Adriana Wegner, Mundaca, Loreto Godoy, Chen, Yang, Lozano, German Perez, Carrero, Rosalba Pardo, Alarcon, Yurika Paola Lopez, Vega, Liliana Mazzillo, Izquierdo, Ledys Maria, Olave, Byron Enrique Piñeres, Orrego, Cesar Zuluaga, Lopez, Deyanira Quinonez, Hoyos, Pablo Vasquez, Vavrina, Martin, Zurek, Jiri, Campos-Miño, Santiago, Yerovi, Rocio, Bridier, Armelle, Payen, Valerie, Milesi, Christophe, Bourgoin, Pierre, Travert, Brendan, Genuini, Mathieu, Starck, Julie, Maria, Matthieu, Guichoux, Julie, Baudin, Florent, Briassoulis, George, Ilia, Stavroula, Di Nardo, Matteo, Camporesi, Anna, Chiusolo, Fabrizio, Shime, Nobuaki, Ohshimo, Shinichiro, Kida, Yoshiko, Kyo, Michihito, Tabata, Yuichi, Tang, Swee Fong, Tai, Chian Wern, Lum, Lucy Chai See, Elghuwael, Ismail, Rivera, Nestor Javier Jimenez, Jarillo Quijada, Alberto E, Kneyber, Martin, Dijkstra, Sandra, Beca, John, Sherring, Claire, Rea, Miriam, Vargas G, Sonia I, Miranda, Daniel Vasquez, Cortez, Grimaldo Ramirez, Tantalean, Jose, Pagowska-Klimek, Izabela, Escobar, Carlos Gil, Moniz, Marta Sousa, Camilo, Cristina, Hazwani, Tarek, Aldairi, Nedaa, Al Amoudi, Ahmed, Alahmadti, Ahmad, Taylor, Ryan, Mendizabal, Mikel, Orayen, Concepcion Goni, Fernandez, Yolanda Lopez, Valle, Juan Ramon, Martinez, Lidia, Orive, Javier Pilar, Brezmes, Marta, Lopez-Herce, Jesus, Parrilla, Julio, Gaboli, Mirella, Gomez, Jose Manuel Gonzalez, Morales Martinez, Antonio, Alapont, Vicent Modesto I, Diaz, Juan Ignacio Sanchez, Llorente de la Fuente, Ana M., Palanca Arias, Daniel, Madurga Revilla, Paula, Martinez de Azagra, Amelia, Garcia Gonzalez, Maria, Arjona Villanueva, David, Garcia Casas, Paula, Brio Sanagustin, Sonia, Pons Odena, Marti, Medina, Alberto, Onate Vergara, Eider, Rodriguez Campoy, Patricia, Reyes Dominguez, Susana, Dursun, Oguz, Atike Ongun, Ebru, Kamit Can, Fulya, Berna Anil, Ayse, Baines, Paul, Walsh, Laura, Jones, Dawn, Sadasivam, Kalaimaran, Mildner, Reinout, Plunkett, Adrian, Lillie, Jon, Tibby, Shane, Wellman, Paul, Belfield, Holly, Brierley, Joe, Dominguez, Troy E., Abaleke, Eugenia, Feinstein, Yael, Deep, Akash, Sundararajan, Santosh, Oruganti, Siva, Silvestre, Catarina, Weitz, James, Sheward, Victoria, Macrae, Duncan, Aramburo, Angela, Fortune, Peter-Marc, Subramanian, Gayathri, Jennings, Claire, Dwarakanathan, Buvana, Inwald, David, Feather, Calandra, Agbeko, Rachel, Lawton-Woodhall, Angela, McIntyre, Karen, Sykes, Kim, Pappachan, Jon, Gale, Helen, Mellish, Christie, McCorkell, Jenni, Torero, Luis, Nofziger, Ryan, Latifi, Samir, Anthony, Heather, Sanders, Ron, Hefley, Glenda, Virk, Manpreet, Jaimon, Nancy, Maddux, Aline B., Mourani, Peter M., Ralston, Kimberly, Sierra, Yamila, Khemani, Robinder, Newth, Christopher, Bhalla, Anoopindar, Kwok, Jeni, Morzov, Rica, Mahapatra, Sidharth, Truemper, Edward, Kustka, Lucinda, Nett, Sholeen T., Singleton, Marcy, Dean Jarvis, J., Yehya, Nadir, Napolitano, Natalie, Murphy, Marie, Ronan, Laurie, Morgan, Ryan, Kubis, Sherri, Broden, Elizabeth, Willson, Douglas, Henderson, Grace, Gedeit, Rainer, Murkowski, Kathy, Woods, Katherine, Kasch, Mary, Han, Yong Y, Affolter, Jeremy T, Tieves, Kelly S, Hughes-Schalk, Amber, Chima, Ranjit S., Krallman, Kelli, Stoneman, Erin, Benken, Laura, Yunger, Toni, Schneider, James, Sweberg, Todd, Kessel, Aaron, Carroll, Christopher L., Santanelli, James, Ackerman, Kate G, Cullimore, Melissa, Rowan, Courtney, Bales, Melissa, Keith Dockery, W., Jafari-Namin, Shirin, Barry, Dana, Jane’t, Keary, Alibrahim, Omar, Patankar, Nikhil, Qiao, Haiping, Gertz, Shira, Su, Felice, Haileselassie, Bereketeab, Song, Hanqiu, Bysani, Kris, Monjure, Tracey, Beltramo, Fernando, Totapally, Balagangadhar, Govantes, Beatriz, Coates, Bria, Wellisch, Lawren, Allen, Kiona, Shukla, Avani, Thomas, Neal J., Spear, Debbie, Shein, Steven L., Gertz, Shira, Parker, Margaret M., Sloniewsky, Daniel, Allen, Christine, Harrell, Amy, Pinto, Neethi, Kniola, Allison, Rodgers, Chiara, Cvijanovich, Natalie, Typpo, Katri, Kelley, Connor, King, Caroline, Sapru, Anil, Ratiu, Anna, Ashtari, Neda, Sikora, Lindsay, Jeyapalan, Asumthia S., Coronado-Munoz, Alvaro, Flori, Heidi, Dahmer, Mary K., Jayachandran, Chaandini, Hume, Janet, Nerheim, Dan, Smith, Rebecca, Spaeder, Michael, Adu-Darko, Michelle, Smith, Lincoln, Hartmann, Silvia, Sullivan, Erin, Merritt, Courtney, Al-Subu, Awni, Blom, Andrea, Lin, John C., Spinella, Philip, Hsing, Deyin D., Pon, Steve, Brian Estil, Jim, Gautam, Richa, Giuliano, John S., Jr, and Tala, Joana

Published
2023
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8. Fixing the leaky pipeline: identifying solutions for improving pediatrician-scientist training during pediatric residency

Author

Burns, Audrea M., Ackerman, Kate G., Thammasitboon, Satid, Rassbach, Caroline E., Ward, Mark A., Blankenburg, Rebecca L., Forster, Catherine S., McPhillips, Heather A., Wenger, Tara L., Powell, Weston T., Heyman, Melvin B., Hogarty, Michael D., Boyer, Debra, Hostetter, Margaret, Weiss, Pnina, Nguyen, Suong T., Parsons, Donald Williams, Moore, Daniel J., Byrne, Bobbi J., French, Anthony R., and Orange, Jordan S.

Published
2020
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9. Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study

Author

Abaleke, Eugenia, Ackerman, Kate G, Acuña, Carlos, Adu-Darko, Michelle, Affolter, Jeremy T, Agbeko, Rachel, Al Amoudi, Ahmed, Alahmadti, Ahmad, Aldairi, Nedaa, Alibrahim, Omar, Allen, Kiona, Allen, Christine, Al-Subu, Awni, Althabe, María, Alvear, Jimena, Anil, Ayse Berna, Anthony, Heather, Aramburo, Angela, Arjona Villanueva, David, Ashtari, Neda, Ávila Vera, Antonio, Baines, Paul, Bales, Melissa, Barr, Samantha, Barry, Dana, Baudin, Florent, Beca, John, Belfield, Holly, Beltramo, Fernando, Benken, Laura, Bhalla, Anoopindar, Blom, Andrea, Botta, Priscila, Bourgoin, Pierre, Brezmes, Marta, Briassoulis, George, Bridier, Armelle, Brierley, Joe, Brio Sanagustin, Sonia, Broden, Elizabeth, Butt, Warwick, Bysani, Kris, Camilo, Cristina, Camporesi, Anna, Campos-Miño, Santiago, Can, Fulya Kamit, Capocasa, Patricia, Caro I, Daniel, Carroll, Christopher, Castellani, Pablo, Castillo, Andres E., Chen, Yang, Chima, Ranjit S., Chiusolo, Fabrizio, Cinquegrani, Karina, Coates, Bria, Coronado-Munoz, Alvaro, Cortéz, Ambar, Cruces Romero, Pablo, Cullimore, Melissa, Cvijanovich, Natalie, Dahmer, Mary K., Deep, Akash, Delzoppo, Carmel, Di Nardo, Matteo, Díaz, Franco, Dijkstra, Sandra, Dockery, W. Keith, Dominguez, Troy E., Dumitrascu, Mariana, Dursun, Oguz, Dwarakanathan, Buvana, Elghuwael, Ismail, Emeriaud, Guillaume, Erickson, Simon, Español, Segundo Fernando, Estil, Jim Brian, Feather, Calandra, Feinstein, Yael, Fernández, Analía, Ferreyra, Marcela, Flori, Heidi, Fortini, Yanina Vanesa, Fortune, Peter-Marc, French, Mary Ellen, Gaboli, Mirella, Gale, Helen, García Casas, Paula, García González, Maria, Gautam, Richa, Gedeit, Rainer, Genuini, Mathieu, Gertz, Shira, Giampieri, Martin, Gil Escobar, Carlos, Giuliano Jr, John S., Godoy Mundaca, Loreto, Goni Orayen, Concepción, Gonzalez Gomez, Jose Manuel, Govantes, Beatriz, Guichoux, Julie, Guzman Rivera, Gustavo Alfredo, Haileselassie, Bereketeab, Han, Yong Y, Harrell, Amy, Hartmann, Silvia, Hazwani, Tarek, Hefley, Glenda, Henderson, Grace, Hsing, Deyin D., Hughes-Schalk, Amber, Hume, Janet, Ilia, Stavroula, Inwald, David, Iolster, Thomas, Izquierdo, Ledys María, Jafari-Namin, Shirin, Jaimon, Nancy, Jarillo Quijada, Alberto E, Jarvis, J. Dean, Jayachandran, Chaandini, Jennings, Claire, Jeyapalan, Asumthia S., Jimenez Rivera, Nestor Javier, Jones, Dawn, Jouvet, Philippe, Kasch, Mary, Keary, Jane't, Kelley, Connor, Kessel, Aaron, Khemani, Robinder, Kida, Yoshiko, King, Caroline, Kneyber, Martin, Kniola, Allison, Krallman, Kelli, Kubis, Sherri, Kustka, Lucinda, Kwok, Jeni, Kyo, Michihito, Landry, Luis Martín, Latifi, Samir, Lawton-Woodhall, Angela, Lillie, Jon, Lin, John C., Llorente de la Fuente, Ana M., Lopez Alarcón, Yurika Paola, López Fernández, Yolanda, Lopez-Herce, Jesús, Lum, Lucy Chai See, Macrae, Duncan, Maddux, Aline B., Madurga Revilla, Paula, Mahapatra, Sidharth, Maria, Matthieu, Martínez, Lidia, Martinez de Azagra, Amelia, Martínez León, Alejandro Fabio, Mazzillo Vega, Liliana, McCorkell, Jenni, McIntyre, Karen, Medina, Tania, Medina, Alberto, Mellish, Christie, Mendizabal, Mikel, Merritt, Courtney, Mildner, Reinout, Milesi, Christophe, Modesto I Alapont, Vicent, Monjes, Cecilia, Monjure, Tracey, Montes, María José, Morales Martinez, Antonio, Morgan, Ryan, Morzov, Rica, Mourani, Peter M., Murkowski, Kathy, Murphy, Marie, Napolitano, Natalie, Nerheim, Dan, Nett, Sholeen T., Newth, Christopher, Nofziger, Ryan, Nunez, Maria Jose, Ohshimo, Shinichiro, Onate Vergara, Eider, Ongun, Ebru A, Orqueda, Daniel, Oruganti, Siva, Pagowska-Klimek, Izabela, Palanca Arias, Daniel, Pappachan, Jon, Pardo Carrero, Rosalba, Parker, Margaret M., Parrilla, Julio, Patankar, Nikhil, Pávez Madrid, Paula, Payen, Valerie, Paziencia, Fernando, Pedraza, Claudia, Perez Lozano, Germán, Pilar Orive, Javier, Piñeres Olave, Byron Enrique, Pintimalla, Alyssa, Pinto, Neethi, Plunkett, Adrian, Pon, Steve, Pons Odena, Marti, Poterala, Rossana, Qiao, Haiping, Quiñonez Lopez, Deyanira, Ralston, Kimberly, Ramirez Cortez, Grimaldo, Ratiu, Anna, Rea, Miriam, Reyes Dominguez, Susana, Rodgers, Chiara, Rodriguez Campoy, Patricia, Ronan, Laurie, Rosemary, Deheza, Rowan, Courtney, Sadasivam, Kalaimaran, Sanchez Diaz, Juan Ignacio, Sanders, Ron, Santanelli, James, Sapru, Anil, Schneider, James, Sforza, Jesica, Shea, Sara, Shein, Steven L., Sherring, Claire, Sheward, Victoria, Shime, Nobuaki, Shukla, Avani, Siaba Serrate, Alejandro, Sierra, Yamila, Sikora, Lindsay, Silvestre, Catarina, Singleton, Marcy, Sloniewsky, Daniel, Smith, Rebecca, Smith, Lincoln, Song, Hanqiu, Sousa Moniz, Marta, Spaeder, Michael, Spear, Debbie, Spinella, Philip, Starck, Julie, Stoneman, Erin, Su, Felice, Subramanian, Gayathri, Sullivan, Erin, Sundararajan, Santosh, Sweberg, Todd, Sykes, Kim, Tabata, Yuichi, Tai, Chian Wern, Tala, Joana, Tang, Swee Fong, Tantalean, José, Taylor, Ryan, Thomas, Neal, Tibby, Shane, Tieves, Kelly S, Torero, Luis, Torres, Silvio Fabia, Totapally, Balagangadhar, Travert, Brendan, Truemper, Edward, Turón, Gonzalo, Typpo, Katri, Valle, Juan Ramón, Vargas G, Sonia I, Vasquez Hoyos, Pablo, Vasquez Miranda, Daniel, Vavrina, Martin, Vidal, Nilda Águeda, Virk, Manpreet, Walsh, Laura, Wegner Araya, Adriana, Weitz, James, Wellisch, Lawren, Wellman, Paul, Willson, Douglas, Woods, Katherine, Yehya, Nadir, Yerovi, Rocio, Yunger, Toni, Zuluaga Orrego, Cesar, Zurek, Jiri, Khemani, Robinder G, Lopez-Fernandez, Yolanda M, Klein, Margaret J, Kneyber, Martin C J, Fernandez, Analia, Newth, Christopher J L, and Thomas, Neal J

Published
2019
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10. Transcriptomic profiles of multiple organ dysfunction syndrome phenotypes in pediatric critical influenza

Author

Novak, Tanya, primary, Crawford, Jeremy Chase, additional, Hahn, Georg, additional, Hall, Mark W., additional, Thair, Simone A., additional, Newhams, Margaret M., additional, Chou, Janet, additional, Mourani, Peter M., additional, Tarquinio, Keiko M., additional, Markovitz, Barry, additional, Loftis, Laura L., additional, Weiss, Scott L., additional, Higgerson, Renee, additional, Schwarz, Adam J., additional, Pinto, Neethi P., additional, Thomas, Neal J., additional, Gedeit, Rainer G., additional, Sanders, Ronald C., additional, Mahapatra, Sidharth, additional, Coates, Bria M., additional, Cvijanovich, Natalie Z., additional, Ackerman, Kate G., additional, Tellez, David W., additional, McQuillen, Patrick, additional, Kurachek, Stephen C., additional, Shein, Steven L., additional, Lange, Christoph, additional, Thomas, Paul G., additional, and Randolph, Adrienne G., additional

Published
2023
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11. Dexmedetomidine Opioid Sparing Effect in Mechanically Ventilated Children (DOSE): Trial of Fentanyl versus Fentanyl + Dexmedetomidine for Maintenance of Sedation

Author

Becker, Mara L., additional, Fischer, Gwenyth, additional, Hornik, Chi D., additional, Alibrahim, Omar, additional, Iheagwara, Kelechi, additional, Abulebda, Kamal, additional, Bass, Andora L., additional, Irby, Katherine, additional, Subbaswamy, Anjali, additional, Zivick, Elizabeth E., additional, Sweney, Jill, additional, Stormorken, Anne G., additional, Barker, Erin E., additional, Mahadaveiah, Shruthi, additional, Lutfi, Riad, additional, McCrory, Michael C., additional, Costello, John M., additional, Ackerman, Kate G., additional, Munoz-Pareja, Jennifer C., additional, Feger, Bryan J., additional, Dean, J. Michael, additional, Hanley, Daniel F., additional, Greenberg, Rachel G., additional, Avadhani, Radhika, additional, Thompson, Richard E., additional, Benjamin, Daniel K., additional, Hornik, Christoph P., additional, and Zimmerman, Kanecia O., additional

Published
2023
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17. Physician-Scientist Training and Programming in Pediatric Residency Programs: A National Survey

Author

Burns, Audrea M., primary, Moore, Daniel J., additional, Forster, Catherine S., additional, Powell, Weston, additional, Thammasitboon, Satid, additional, Hostetter, Margaret K., additional, Weiss, Pnina, additional, Boyer, Debra, additional, Ward, Mark A., additional, Blankenburg, Rebecca, additional, Heyman, Melvin B., additional, Rassbach, Caroline E., additional, McPhillips, Heather, additional, French, Anthony, additional, Nguyen, Suong, additional, Byrne, Bobbi J., additional, Parsons, Donald Williams, additional, Gonzalez, Fernando, additional, Nowalk, Andrew J., additional, Ho, Jacqueline, additional, Kumar, Shelley, additional, Orange, Jordan S., additional, and Ackerman, Kate G., additional

Published
2022
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18. Contributors

Author

Ackerman, Kate G., primary, Alexander, Peter G., additional, Bai, Xiaoying, additional, Baker, Jennifer L., additional, Beier, David R., additional, Belmont, John W., additional, Billmire, David A., additional, Blitz, Ira L., additional, Brugmann, Samantha A., additional, Butler, Matthew G., additional, Chang, Ching-Fang, additional, Chitnis, Ajay B., additional, Chiu, William T.Y., additional, Cho, Ken W.Y., additional, Courey, Albert J., additional, Dalle Nogare, Damian, additional, Davies, Jamie, additional, Ding, Sheng, additional, Dolezal, Darin, additional, Douglas, Nataki C., additional, Du, Hongling, additional, Feldman, Benjamin, additional, Fernandez, Alejandra, additional, Gannon, Maureen, additional, Grinstein, Mor, additional, Guo, Yanli, additional, Hoch, Renée V., additional, Itoh, Keiji, additional, Karpinski, Beverly A., additional, Kelley, Matthew W., additional, Kenyon, Kristy L., additional, Krieg, Paul A., additional, LaMantia, Anthony-Samuel, additional, Langhans, Mark T., additional, Li, Ke, additional, Livesey, Frederick J., additional, Luong, Mui, additional, Luttrell, Shawn M., additional, Malik, Nasir, additional, Mann, Zoë F., additional, Martin, Nathan, additional, Maynard, Thomas M., additional, Mayor, Roberto, additional, Meechan, Daniel, additional, Meilhac, Sigolène M., additional, Method, Anna M., additional, Moody, Sally A., additional, Moore, Steven, additional, Mulligan, Timothy S., additional, Naiche, L.A., additional, Papaioannou, Virginia E., additional, Perea-Gomez, Aitana, additional, Pignoni, Francesca, additional, Rao, Mahendra S., additional, Ratnaparkhi, Girish S., additional, Riley, Kimberly G., additional, Saint-Jeannet, Jean-Pierre, additional, Sause, Eric T., additional, Schock, Elizabeth N., additional, Schultheiss, Thomas M., additional, Shin, Soojung, additional, Sokol, Sergei Y., additional, Soriano, Philippe, additional, Stratman, Amber N., additional, Swalla, Billie J., additional, Taylor, Hugh S., additional, Thesleff, Irma, additional, Theveneau, Eric, additional, Tuan, Rocky S., additional, Viczian, Andrea S., additional, Warkman, Andrew S., additional, Washkowitz, Andrew J., additional, Weinstein, Brant M., additional, Wells, James M., additional, Wlizla, Marcin, additional, Xie, Min, additional, Yang, Yingzi, additional, Yu, Jianxin A., additional, Zhang, Mingliang, additional, Zohn, Irene E., additional, Zon, Leonard I., additional, Zorn, Aaron M., additional, and Zuber, Michael E., additional

Published
2015
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20. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart

Author

Zhou, Bin, Ma, Qing, Kong, Sek Won, Hu, Yongwu, Campbell, Patrick H., McGowan, Francis X., Ackerman, Kate G., Wu, Bingruo, Tevosian, Sergei G., and Pu, William T.

Subjects
DNA binding proteins -- Physiological aspects, DNA binding proteins -- Research, Cardiovascular diseases -- Risk factors, Cardiovascular diseases -- Genetic aspects, Cardiovascular diseases -- Research, Genetic transcription -- Research
Abstract

Aberrant transcriptional regulation contributes to the pathogenesis of both congenital and adult forms of heart disease. While the transcriptional regulator friend of Gata 2 (FOG2) is known to be essential for heart morphogenesis and coronary development, its tissue-specific function has not been previously investigated. Additionally, little is known about the role of FOG2 in the adult heart. Here we used spatiotemporally regulated inactivation of Fog2 to delineate its function in both the embryonic and adult mouse heart. Early cardiomyocyte-restricted loss of Fog2 recapitulated the cardiac and coronary defects of the Fog2 germline murine knockouts. Later cardiomyocyte-restricted loss of Fog2 ([Fog2.sup.MC]) did not result in defects in cardiac structure or coronary vessel formation. However, [Fog2.sup.MC] adult mice had severely depressed ventricular function and died at 8-14 weeks. [Fog2.sup.MC] adult hearts displayed a paucity of coronary vessels, associated with myocardial hypoxia, increased cardiomyocyte apoptosis, and cardiac fibrosis. Induced inactivation of Fog2 in the adult mouse heart resulted in similar phenotypes, as did ablation of the FOG2 interaction with the transcription factor GATA4. Loss of the FOG2 or FOG2-GATA4 interaction altered the expression of a panel of angiogenesis-related genes. Collectively, our data indicate that FOG2 regulates adult heart function and coronary angiogenesis., Introduction Heart disease is a leading cause of morbidity and mortality in both infancy and adulthood. Congenital and adult heart disease have both been linked to altered regulation of cardiac [...]

Published
2009

21. Timing of delivery and survival rates for infants with prenatal diagnoses of congenital diaphragmatic hernia

Author

Stevens, Timothy P., van Wijngaarden, Edwin, Ackerman, Kate G., and Lally, Pamela A.

Subjects
Prenatal diagnosis -- Research, Childbirth -- Research, Blood oxygenation, Extracorporeal -- Patient outcomes, Blood oxygenation, Extracorporeal -- Research, Gestational age -- Research, Diaphragm -- Hernia, Diaphragm -- Care and treatment, Diaphragm -- Patient outcomes, Diaphragm -- Research
Published
2009

30. Vancomycin Monotherapy May Be Insufficient to Treat Methicillin-resistant Staphylococcus aureus Coinfection in Children With Influenza-related Critical Illness.

Author

Randolph, Adrienne G, Xu, Ruifei, Novak, Tanya, Newhams, Margaret M, Wardenburg, Juliane Bubeck, Weiss, Scott L, Sanders, Ronald C, Thomas, Neal J, Hall, Mark W, Tarquinio, Keiko M, Cvijanovich, Natalie, Gedeit, Rainer G, Truemper, Edward J, Markovitz, Barry, Hartman, Mary E, Ackerman, Kate G, Giuliano, John S, Shein, Steven L, Moffitt, Kristin L, and Network, Pediatric Intensive Care Influenza Investigators from the Pediatric Acute Lung Injury and Sepsis Investigator's

Subjects
PNEUMONIA-related mortality, CONFIDENCE intervals, DRUG resistance in microorganisms, INFLUENZA, INTENSIVE care units, ORTHOMYXOVIRUSES, PEDIATRICS, PNEUMONIA, RESPIRATORY insufficiency, VANCOMYCIN, RELATIVE medical risk, TREATMENT effectiveness, METHICILLIN-resistant staphylococcus aureus, MIXED infections, PHARMACODYNAMICS, SYMPTOMS, PROGNOSIS
Abstract

Background Coinfection with influenza virus and methicillin-resistant Staphylococcus aureus (MRSA) causes life-threatening necrotizing pneumonia in children. Sporadic incidence precludes evaluation of antimicrobial efficacy. We assessed the clinical characteristics and outcomes of critically ill children with influenza–MRSA pneumonia and evaluated antibiotic use. Methods We enrolled children (<18 years) with influenza infection and respiratory failure across 34 pediatric intensive care units 11/2008–5/2016. We compared baseline characteristics, clinical courses, and therapies in children with MRSA coinfection, non-MRSA bacterial coinfection, and no bacterial coinfection. Results We enrolled 170 children (127 influenza A, 43 influenza B). Children with influenza–MRSA pneumonia (N = 30, 87% previously healthy) were older than those with non-MRSA (N = 61) or no (N = 79) bacterial coinfections. Influenza–MRSA was associated with increased leukopenia, acute lung injury, vasopressor use, extracorporeal life support, and mortality than either group (P ≤.0001). Influenza-related mortality was 40% with MRSA compared to 4.3% without (relative risk [RR], 9.3; 95% confidence interval [CI], 3.8–22.9). Of 29/30 children with MRSA who received vancomycin within the first 24 hours of hospitalization, mortality was 12.5% (N = 2/16) if treatment also included a second anti-MRSA antibiotic compared to 69.2% (N = 9/13) with vancomycin monotherapy (RR, 5.5; 95% CI, 1.4, 21.3; P =.003). Vancomycin dosing did not influence initial trough levels; 78% were <10 µg/mL. Conclusions Influenza–MRSA coinfection is associated with high fatality in critically ill children. These data support early addition of a second anti-MRSA antibiotic to vancomycin in suspected severe cases. [ABSTRACT FROM AUTHOR]

Published
2019
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31. Staphylococcusaureusα-Toxin Response Distinguishes Respiratory Virus–Methicillin-ResistantS. aureusCoinfection in Children

Author

Yu, Karl O. A., primary, Randolph, Adrienne G., additional, Agan, Anna A., additional, Yip, Wai-Ki, additional, Truemper, Edward J., additional, Weiss, Scott L., additional, Ackerman, Kate G., additional, Schwarz, Adam J., additional, Giuliano, John S., additional, Hall, Mark W., additional, and Bubeck Wardenburg, Juliane, additional

Published
2016
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35. Staphylococcus aureus α-Toxin Response Distinguishes Respiratory Virus-Methicillin-Resistant S. aureus Coinfection in Children.

Author

Yu, Karl O. A., Randolph, Adrienne G., Agan, Anna A., Wai-Ki Yip, Truemper, Edward J., Weiss, Scott L., Ackerman, Kate G., Schwarz, Adam J., Giuliano Jr, John S., Hall, Mark W., Wardenburg, Juliane Bubeck, Yip, Wai-Ki, Giuliano, John S Jr, Bubeck Wardenburg, Juliane, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) PICFlu Study Group, and PALISI PICFlu Study Group

Subjects
STAPHYLOCOCCUS aureus, RESPIRATORY insufficiency, PEDIATRIC respiratory diseases, INFLUENZA, PNEUMONIA, INTENSIVE care units, INFLUENZA complications, ANIMAL experimentation, BACTERIAL toxins, METHICILLIN resistance, MICE, PROTEINS, RESEARCH funding, STAPHYLOCOCCAL diseases, SURVIVAL analysis (Biometry), BACTERIAL antibodies, NEUTRALIZATION tests, MIXED infections, DISEASE complications
Abstract

Background:  Development of methicillin-resistant Staphylococcus aureus (MRSA) pneumonia after a respiratory viral infection is frequently fatal in children. In mice, S. aureus α-toxin directly injures pneumocytes and increases mortality, whereas α-toxin blockade mitigates disease. The role of α-toxin in pediatric staphylococcal-viral coinfection is unclear.Methods:  We enrolled children across 34 North American pediatric intensive care units with acute respiratory failure and suspected influenza virus infection. Serial serum anti-α-toxin antibody titers and functional α-toxin neutralization capacity were compared across children coinfected with MRSA or methicillin-susceptible S. aureus (MSSA) and control children infected with influenza virus only. MRSA isolates were tested for α-toxin production and lethality in a murine pneumonia model.Results:  Influenza virus was identified in 22 of 25 children with MRSA coinfection (9 died) and 22 patients with MSSA coinfection (all survived). Initial α-toxin-specific antibody titers were similar, compared with those in the 13 controls. In patients with serial samples, only MRSA-coinfected patients showed time-dependent increases in anti-α-toxin titer and functional neutralization capacity. MRSA α-toxin production from patient isolates correlated with initial serologic titers and with mortality in murine pneumonia.Conclusions:  These data implicate α-toxin as a relevant antigen in severe pediatric MRSA pneumonia associated with respiratory viral infection, supporting a potential role for toxin-neutralizing therapy. [ABSTRACT FROM AUTHOR]

Published
2016
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37. Disruption of Striated Preferentially Expressed Gene Locus Leads to Dilated Cardiomyopathy in Mice

Author

Liu, Xiaoli, primary, Ramjiganesh, Tripurasundari, additional, Chen, Yen-Hsu, additional, Chung, Su Wol, additional, Hall, Sean R., additional, Schissel, Scott L., additional, Padera, Robert F., additional, Liao, Ronglih, additional, Ackerman, Kate G., additional, Kajstura, Jan, additional, Leri, Annarosa, additional, Anversa, Piero, additional, Yet, Shaw-Fang, additional, Layne, Matthew D., additional, and Perrella, Mark A., additional

Published
2009
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40. Fog2 Is Required for Normal Diaphragm and Lung Development in Mice and Humans

Author

Ackerman, Kate G, primary, Herron, Bruce J, additional, Vargas, Sara O, additional, Huang, Hailu, additional, Tevosian, Sergei G, additional, Kochilas, Lazaros, additional, Rao, Cherie, additional, Pober, Barbara R, additional, Babiuk, Randal P, additional, Epstein, Jonathan A, additional, Greer, John J, additional, and Beier, David R, additional

Published
2005
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41. Interacting genetic loci cause airway hyperresponsiveness

Author

Ackerman, Kate G., primary, Huang, Hailu, additional, Grasemann, Hartmut, additional, Puma, Chris, additional, Singer, Jonathan B., additional, Hill, Annie E., additional, Lander, Eric, additional, Nadeau, Joseph H., additional, Churchill, Gary A., additional, Drazen, Jeffrey M., additional, and Beier, David R., additional

Published
2005
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47. Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2

Author

Payne, Amanda B., Gilani, Zunera, Godfred-Cato, Shana, Belay, Ermias D., Feldstein, Leora R., Patel, Manish M., Randolph, Adrienne G., Newhams, Margaret, Thomas, Deepam, Magleby, Reed, Hsu, Katherine, Burns, Meagan, Dufort, Elizabeth, Maxted, Angie, Pietrowski, Michael, Longenberger, Allison, Bidol, Sally, Henderson, Justin, Sosa, Lynn, Edmundson, Alexandra, Tobin-D’Angelo, Melissa, Edison, Laura, Heidemann, Sabrina, Singh, Aalok R., Giuliano, John S., Kleinman, Lawrence C., Tarquinio, Keiko M., Walsh, Rowan F., Fitzgerald, Julie C., Clouser, Katharine N., Gertz, Shira J., Carroll, Ryan W., Carroll, Christopher L., Hoots, Brooke E., Reed, Carrie, Dahlgren, F. Scott, Oster, Matthew E., Pierce, Timmy J., Curns, Aaron T., Langley, Gayle E., Campbell, Angela P., Balachandran, Neha, Murray, Thomas S., Burkholder, Cole, Brancard, Troy, Lifshitz, Jenna, Leach, Dylan, Charpie, Ian, Tice, Cory, Coffin, Susan E., Perella, Dana, Jones, Kaitlin, Marohn, Kimberly L., Yager, Phoebe H., Fernandes, Neil D., Flori, Heidi R., Koncicki, Monica L., Walker, Karen S., Di Pentima, Maria Cecilia, Li, Simon, Horwitz, Steven M., Gaur, Sunanda, Coffey, Dennis C., Harwayne-Gidansky, Ilana, Hymes, Saul R., Thomas, Neal J., Ackerman, Kate G., and Cholette, Jill M.

Abstract

IMPORTANCE: Multisystem inflammatory syndrome in children (MIS-C) is associated with recent or current SARS-CoV-2 infection. Information on MIS-C incidence is limited. OBJECTIVE: To estimate population-based MIS-C incidence per 1?000?000 person-months and to estimate MIS-C incidence per 1?000?000 SARS-CoV-2 infections in persons younger than 21 years. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used enhanced surveillance data to identify persons with MIS-C during April to June 2020, in 7 jurisdictions reporting to both the Centers for Disease Control and Prevention national surveillance and to Overcoming COVID-19, a multicenter MIS-C study. Denominators for population-based estimates were derived from census estimates; denominators for incidence per 1?000?000 SARS-CoV-2 infections were estimated by applying published age- and month-specific multipliers accounting for underdetection of reported COVID-19 case counts. Jurisdictions included Connecticut, Georgia, Massachusetts, Michigan, New Jersey, New York (excluding New York City), and Pennsylvania. Data analyses were conducted from August to December 2020. EXPOSURES: Race/ethnicity, sex, and age group (ie, =5, 6-10, 11-15, and 16-20 years). MAIN OUTCOMES AND MEASURES: Overall and stratum-specific adjusted estimated MIS-C incidence per 1?000?000 person-months and per 1?000?000 SARS-CoV-2 infections. RESULTS: In the 7 jurisdictions examined, 248 persons with MIS-C were reported (median [interquartile range] age, 8 [4-13] years; 133 [53.6%] male; 96 persons [38.7%] were Hispanic or Latino; 75 persons [30.2%] were Black). The incidence of MIS-C per 1?000?000 person-months was 5.1 (95% CI, 4.5-5.8) persons. Compared with White persons, incidence per 1?000?000 person-months was higher among Black persons (adjusted incidence rate ratio [aIRR], 9.26 [95% CI, 6.15-13.93]), Hispanic or Latino persons (aIRR, 8.92 [95% CI, 6.00-13.26]), and Asian or Pacific Islander (aIRR, 2.94 [95% CI, 1.49-5.82]) persons. MIS-C incidence per 1?000?000 SARS-CoV-2 infections was 316 (95% CI, 278-357) persons and was higher among Black (aIRR, 5.62 [95% CI, 3.68-8.60]), Hispanic or Latino (aIRR, 4.26 [95% CI, 2.85-6.38]), and Asian or Pacific Islander persons (aIRR, 2.88 [95% CI, 1.42-5.83]) compared with White persons. For both analyses, incidence was highest among children aged 5 years or younger (4.9 [95% CI, 3.7-6.6] children per 1?000?000 person-months) and children aged 6 to 10 years (6.3 [95% CI, 4.8-8.3] children per 1?000?000 person-months). CONCLUSIONS AND RELEVANCE: In this cohort study, MIS-C was a rare complication associated with SARS-CoV-2 infection. Estimates for population-based incidence and incidence among persons with infection were higher among Black, Hispanic or Latino, and Asian or Pacific Islander persons. Further study is needed to understand variability by race/ethnicity and age group.

Published
2021
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48. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart.

Author

Bin Zhou, Qing Ma, Sek Won Kong, Yongwu Hu, Campbell, Patrick H., McGowan, Francis X., Ackerman, Kate G., Bingruo Wu, Tevosian, Sergei G., Pu, William T., Zhou, Bin, Ma, Qing, Kong, Sek Won, Hu, Yongwu, and Wu, Bingruo

Subjects
*MORPHOGENESIS, *HEART cells, *HEART diseases, *LABORATORY mice, *CORONARY arteries, *APOPTOSIS, *HEART fibrosis
Abstract

Aberrant transcriptional regulation contributes to the pathogenesis of both congenital and adult forms of heart disease. While the transcriptional regulator friend of Gata 2 (FOG2) is known to be essential for heart morphogenesis and coronary development, its tissue-specific function has not been previously investigated. Additionally, little is known about the role of FOG2 in the adult heart. Here we used spatiotemporally regulated inactivation of Fog2 to delineate its function in both the embryonic and adult mouse heart. Early cardiomyocyte- restricted loss of Fog2 recapitulated the cardiac and coronary defects of the Fog2 germline murine knockouts. Later cardiomyocyte-restricted loss of Fog2 (Fog2MC) did not result in defects in cardiac structure or coronary vessel formation. However, Fog2MC adult mice had severely depressed ventricular function and died at 8-14 weeks. Fog2MC adult hearts displayed a paucity of coronary vessels, associated with myocardial hypoxia, increased cardiomyocyte apoptosis, and cardiac fibrosis. Induced inactivation of Fog2 in the adult mouse heart resulted in similar phenotypes, as did ablation of the FOG2 interaction with the transcription factor GATA4. Loss of the FOG2 or FOG2-GATA4 interaction altered the expression of a panel of angiogenesis-related genes. Collectively, our data indicate that FOG2 regulates adult heart function and coronary angiogenesis. [ABSTRACT FROM AUTHOR]

Published
2009
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49. Siblings with lethal primary pulmonary hypoplasia and compound heterozygous variants in the AARS2 gene: further delineation of the phenotypic spectrum.

Author

Kiraly-Borri C, Jevon G, Ji W, Jeffries L, Ricciardi JL, Konstantino M, Ackerman KG, and Lakhani SA

Subjects
Abnormalities, Multiple diagnostic imaging, Abnormalities, Multiple pathology, Amino Acid Substitution, Fatal Outcome, Frameshift Mutation, Genes, Recessive, Heterozygote, Humans, Infant, Newborn, Leukoencephalopathies diagnosis, Leukoencephalopathies pathology, Lung diagnostic imaging, Lung pathology, Lung Diseases diagnostic imaging, Lung Diseases pathology, Mitochondria genetics, Mitochondria pathology, Pedigree, Phenotype, Siblings, Exome Sequencing, Abnormalities, Multiple genetics, Alanine-tRNA Ligase genetics, Leukoencephalopathies genetics, Lung abnormalities, Lung Diseases genetics
Abstract

Variants in the mitochondrial alanyl-tRNA synthetase 2 gene AARS2 (OMIM 612035) are associated with infantile mitochondrial cardiomyopathy or later-onset leukoencephalopathy with premature ovarian insufficiency. Here, we report two newborn siblings who died soon after birth with primary pulmonary hypoplasia without evidence of cardiomyopathy. Whole-exome sequencing detected the same compound heterozygous AARS2 variants in both siblings (c.1774C>T, p.Arg592Trp and c.647dup, p.Cys218Leufs*6) that have previously been associated with infantile mitochondrial cardiomyopathy. Segregation analysis in the family confirmed carrier status of the parents and an unaffected sibling. To our knowledge, this is the first report of primary pulmonary hypoplasia in the absence of cardiomyopathy associated with recessive AARS2 variants and further defines the phenotypic spectrum associated with this gene., (© 2019 Kiraly-Borri et al.; Published by Cold Spring Harbor Laboratory Press.)

Published
2019
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