Search

Additional file 1: Figure S1. Features calculated to score precursor peptides; Table S1. Features and scoring for class I precursors; Table S2. Features and scoring for class II precursors; Table S3. Features and scoring for class III precursors; Table S4. Features and scoring for class IV precursors; Figure S2. Sequence motifs present in more than 100 lanthipeptide precursor peptides; Figure S3. Sequence similarity network of predicted precursor peptides with permissive similarity cutoff; Table S5. Location of top BLAST hits of known lanthipeptides from the MIBiG and BAGEL databases in the sequence similarity networks presented in Fig. 2; Figure S4. Sequence logos generated from alignments of class I precursor peptides in clusters with 20 or more members; Figure S5. Sequence logos generated from alignments of class II precursor peptides in clusters with 20 or more members; Figure S6. Sequence logos generated from alignments of class III precursor peptides in clusters with 20 or more members; Figure S7. Sequence logos generated from alignments of class IV precursor peptides in clusters with 20 or more members; Table S6. Twenty most abundant proteins in class I BGCs that belong to at least one Pfam; Table S7. Twenty most abundant proteins in class II BGCs that belong to at least one Pfam; Table S8. Twenty most abundant proteins in class III BGCs that belong to at least one Pfam; Table S9. Twenty most abundant proteins in class IV BGCs that belong to at least one Pfam; Table S10. Distribution of Pfams that are in the 20 most abundant protein families in one class among the other three classes; Figure S8. Example biosynthetic gene clusters encoding the enzymes in Table S10; Table S11. Distribution of select Pfam protein families from BGCs; Figure S9. Example biosynthetic gene clusters encoding the enzymes in Table S11; Figure S10. Phylogenetic distribution of genomes in the dataset; Figure S11. A approximately maximum likelihood midpoint rooted phylogenetic tree of LanC and LanC-like domains including human LanC-like proteins; Figure S12. GC content of clusters versus genomes; Figure S13. ESI MS/MS and bioactivity of birimositide α and β; Table S12. Expected and observed monoisotopic masses for Brtα and Brtβ using ESI MS.