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2. Current Situation of the Monitoring of Graduates and Labor Insertion in the Electrical Mechanical Engineering Career

Author

Acero, Julio Fredy Chura, Velasquez, Omar Chayña, Apaza, Fredy Bernardo Coyla, Callata, Leonidas Vilca, Lloclla, Henry Shuta, Howlett, Robert J., Series Editor, Jain, Lakhmi C., Series Editor, Iano, Yuzo, editor, Saotome, Osamu, editor, Kemper Vásquez, Guillermo Leopoldo, editor, Cotrim Pezzuto, Claudia, editor, Arthur, Rangel, editor, and Gomes de Oliveira, Gabriel, editor

Published
2023
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4. Harmonics of the Microinverters for the Operation of the Grid-Connected Photovoltaic Energy System Considering the Uncertainty of Irradiance

Author

Acero, Julio Fredy Chura, Castañon, Norman Jesus Beltran, Yucra, Reynaldo Condori, Viveros, Henry Pizarro, Coaquira, Alex Mario Lerma, Howlett, Robert J., Series Editor, Jain, Lakhmi C., Series Editor, Iano, Yuzo, editor, Saotome, Osamu, editor, Kemper Vásquez, Guillermo Leopoldo, editor, Cotrim Pezzuto, Claudia, editor, Arthur, Rangel, editor, and Gomes de Oliveira, Gabriel, editor

Published
2022
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11. Influence of Genetic Polymorphisms on the Response to Tramadol, Ibuprofen, and the Combination in Patients With Moderate to Severe Pain After Dental Surgery

Author

Saiz-Rodríguez, Miriam, Valdez-Acosta, Sarahí, Borobia, Alberto M., Burgueño, Miguel, Gálvez-Múgica, María Ángeles, Acero, Julio, Cabaleiro, Teresa, Muñoz-Guerra, Mario Fernando, Puerro, Miguel, Llanos, Lucia, Martínez-Pérez, Dolores, Ochoa, Dolores, Carcas, Antonio J., and Abad-Santos, Francisco

Published
2021
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14. Artificial Intelligence Used for Diagnosis in Facial Deformities: A Systematic Review.

Author

Ravelo, Victor, Acero, Julio, Fuentes-Zambrano, Jorge, García Guevara, Henry, and Olate, Sergio

Subjects
*ARTIFICIAL intelligence, *ORTHOGNATHIC surgery, *HUMAN abnormalities, *DIAGNOSIS, *THREE-dimensional imaging
Abstract

AI is included in a lot of different systems. In facial surgery, there are some AI-based software programs oriented to diagnosis in facial surgery. This study aims to evaluate the capacity and training of models for diagnosis of dentofacial deformities in class II and class III patients using artificial intelligence and the potential use for indicating orthognathic surgery. The search strategy is from 1943 to April 2024 in PubMed, Embase, Scopus, Lilacs, and Web of Science. Studies that used imaging to assess anatomical structures, airway volume, and craniofacial positions using the AI algorithm in the human population were included. The methodological quality of the studies was assessed using the Effective Public Health Practice Project instrument. The systematic search identified 697 articles. Eight studies were obtained for descriptive analysis after exclusion according to our inclusion and exclusion criteria. All studies were retrospective in design. A total of 5552 subjects with an age range between 14.7 and 56 years were obtained; 2474 (44.56%) subjects were male, and 3078 (55.43%) were female. Six studies were analyzed using 2D imaging and obtained highly accurate results in diagnosing skeletal features and determining the need for orthognathic surgery, and two studies used 3D imaging for measurement and diagnosis. Limitations of the studies such as age, diagnosis in facial deformity, and the included variables were observed. Concerning the overall analysis bias, six studies were at moderate risk due to weak study designs, while two were at high risk of bias. We can conclude that, with the few articles included, using AI-based software allows for some craniometric recognition and measurements to determine the diagnosis of facial deformities using mainly 2D analysis. However, it is necessary to perform studies based on three-dimensional images, increase the sample size, and train models in different populations to ensure accuracy of AI applications in this field. After that, the models can be trained for dentofacial diagnosis [ABSTRACT FROM AUTHOR]

Published
2024
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15. Emerging histological and serological biomarkers in oral squamous cell carcinoma: Applications in diagnosis, prognosis evaluation and personalized therapeutics (Review)

Author

Pekarek, Leonel, primary, Garrido‑Gil, Maria, additional, Sánchez‑Cendra, Alicia, additional, Cassinello, Javier, additional, Pekarek, Tatiana, additional, Fraile‑Martinez, Oscar, additional, García‑Montero, Cielo, additional, Lopez‑Gonzalez, Laura, additional, Rios‑Parra, Antonio, additional, Álvarez‑Mon, Melchor, additional, Acero, Julio, additional, Diaz‑Pedrero, Raul, additional, and Ortega, Miguel, additional

Published
2023
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19. A worldwide comparison of the management of T1 and T2 anterior floor of the mouth and tongue squamous cell carcinoma – Extent of surgical resection and reconstructive measures

Author

Kansy, Katinka, Mueller, Andreas Albert, Mücke, Thomas, Koersgen, Friederike, Wolff, Klaus Dietrich, Zeilhofer, Hans-Florian, Hölzle, Frank, Pradel, Winnie, Schneider, Matthias, Kolk, Andreas, Smeets, Ralf, Acero, Julio, Haers, Piet, Ghali, G.E., and Hoffmann, Jürgen

Published
2017
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20. Osteomyelitis of the Jaw Due to Mucormycosis after Coronavirus Disease 2019 Infection - A Prospective Study.

Author

Datarkar, Abhay, Bhawalkar, Amit, Shah, Vartik, Manekar, Varsha, Gadve, Vandana, Daware, Surendra, Walkey, Damyanti, Gioia, Francesca, and Acero, Julio

Abstract

Introduction: The objective of the study was to describe the incidence, clinical characteristics, treatment and outcome of patients with rhinocerebral coronavirus disease 2019-associated mucormycosis (CAM). Materials and Methods: We performed an unicentric observational study. A total of 113 cases of CAM were evaluated from January 2021 to June 2021. We described the overall incidence of CAM in Nagpur district up to June 2021, the clinical presentation of CAM, the subtype of CAM, the laboratory diagnosis, the type of surgical management in CAM, the pre-operative and 3-month post-operative C-reactive protein marker values, the post-operative healing and complications and the mortality rate. Results: The mean age of the patients was 38.8 years. Rhinomaxillary subtype was the most common. All patients underwent medical as well as surgical intervention as the treatment modality. There was mortality in two patients. Discussion: Study highlights the need for physicians to closely monitor coronavirus disease 2019 (COVID-19) patients, especially severe cases with pre-existing diabetes/receiving corticosteroid therapy and the need for patient education as early diagnosis and prompt treatment leads to better prognosis. [ABSTRACT FROM AUTHOR]

Published
2024
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31. SARS-CoV-2 Virus in Cancer Patients: A New Unknown in an Unsolved Equation

Author

Martín, Margarita, primary, Vallejo, Carmen, additional, López-Campos, Fernando, additional, Quereda, Carmen, additional, Muñoz, Teresa, additional, Sánchez-Conde, Matilde, additional, Dominguez, Jose Antonio, additional, Soriano, Cruz, additional, Martín, Mercedes, additional, Suárez-Carantoña, Cecilia, additional, Muriel, Alfonso, additional, Garrido, Pilar, additional, Acero, Julio, additional, Alvarez-Diaz, Ana, additional, de la Pinta, Carolina, additional, Martínez-García, Laura, additional, Hernánz, Raúl, additional, Fernández, Eva, additional, Alarza, Marina, additional, Hervás, Asunción, additional, and Sancho, Sonsoles, additional

Published
2022
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35. SARS-CoV-2 Virus in Cancer Patients: A New Unknown in an Unsolved Equation.

Author

Martín, Margarita, Vallejo, Carmen, López-Campos, Fernando, Quereda, Carmen, Muñoz, Teresa, Sánchez-Conde, Matilde, Dominguez, Jose Antonio, Soriano, Cruz, Martín, Mercedes, Suárez-Carantoña, Cecilia, Muriel, Alfonso, Garrido, Pilar, Acero, Julio, Alvarez-Diaz, Ana, de la Pinta, Carolina, Martínez-García, Laura, Hernánz, Raúl, Fernández, Eva, Alarza, Marina, and Hervás, Asunción

Subjects
COVID-19, CONFIDENCE intervals, INFLAMMATION, MULTIVARIATE analysis, RETROSPECTIVE studies, LUNG tumors, CANCER patients, COMPARATIVE studies, TUMORS, SOCIODEMOGRAPHIC factors, ODDS ratio, POLYMERASE chain reaction, COMORBIDITY
Abstract

Introduction: Cancer patients are more susceptible to infections, and infection can be more severe than in patients without cancer diagnosis. We conducted this retrospective study in patients admitted for SARS-CoV-2 infection in order to find differences in inflammatory markers and mortality in cancer patients compared to others. Methods: We reviewed the electronic records of patients admitted for SARS-CoV-2 infection confirmed by PCR from March to September 2020. Data on socio-demographics, comorbidities, inflammatory makers, and cancer-related features were analyzed. Results: 2,772 patients were admitted for SARS-CoV-2, to the Hospital Universitario Ramón y Cajal in Madrid during this period. Of these, 2,527 (91%) had no history of neoplastic disease, 164 (5.9%) patients had a prior history of cancer but were not undergoing oncological treatment at the time of infection, and 81 (2.9%) were in active treatment. Mortality in patients without a history of cancer was 19.5%, 28.6% for patients with a prior history of cancer, and 34% in patients with active cancer treatment. Patients in active oncology treatment with the highest mortality rate were those diagnosed with lung cancer (OR 5.6 95% CI: 2.2–14.1). In the multivariate study, active oncological treatment (OR 2.259 95% CI: 1.35–3.77) and chemotherapy treatment (OR 3.624 95% CI: 1.17–11.17), were statistically significant factors for the risk of death for the whole group and for the group with active oncological treatment, respectively. Conclusion: Cancer patients on active systemic treatment have an increased risk of mortality after SARS-CoV-2 infection, especially with lung cancer or chemotherapy treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Contributors

Author

Acero, Julio, Akin, Jennifer N., Alcon, Andre, Alkureishi, Lee WT, Aminzada, Amir, Arias, Eduardo, Arnold, Sydney H., Carlson, Anna R., Cronin, Brendan J., Davidson, Edward, de Leyva, Patricia, Dorafshar, Amir H., Egbert, Mark, Flores, Roberto L., Forrest, Christopher R., Gideon, Mickey, Grayson, Warren, Haglund, Thomas, Hammoudeh, Jeffrey A., Harmon, Kelly A., Hirsch, David, Hopper, Richard A., Hsieh, Tsung-yen, Jacobson, Adam S., Jeelani, Noor ul Owase, Jimenez, Christian, Kalmar, Chris, Kapadia, Hitesh, Kokosis, George, Kondra, Katelyn, Kravchenko, Dmitriy, Kumar, Anand Raj, Lee, Justine C., Levine, Jamie P., Liang, Fan, Lopez, Christopher D., Lopez, Joseph, Maduekwe, Uma, Manson, Paul N., Matros, Evan, Mittermiller, Paul A., Musavi, Leila, Patel, Harsh, Piccinini, Pedro Salomao, Podolsky, Dale, Prescher, Hannes, Purnell, Chad A., Rana, Majeed, Regmi, Nikesh, Reid, Russell R., Reisberg, David J., Roohani, Idean, Roy, Tulsi, Seu, Michelle, Shahzad, Farooq, Shakoori, Pasha, Shetye, Pradip R., Silbertstein, Eldad, Silva, Amanda, Singh, Srujan, Srivastava, Akanksha, Staffenberg, David A., Stanton, Eloise, Steinbacher, Derek M., Steinberg, Jordan P., Strong, Edward Bradley, Susarla, Srinivas M., Taylor, Jesse A., Timberlake, Andrew, Tragos, Christina, Urata, Mark M., Wang, Howard, Wilkat, Max, Wolfe, Erin M., Wolfe, S. Anthony, Wolfswinkel, Erik M., Xun, Helen, Yang, Robin, Yesantharao, Pooja, Yoon, Joshua, and Zhou, Yuxiao

Published
2024
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37. Contributors

Author

Abubaker, A. Omar, Acero, Julio, Agarwal, Ravi, Aghaloo, Tara, Akbari, Maryam, Allen, Kyle P., Allon, Dror M., Almeida, Fernando, Alpert, Brian, Altay, Mehmet Ali, Amarista, Felix Jose, Amer, Hatem, Appugounder, Suganya, Aravindaksha, Shyam Prasad, Aronovich, Sharon, Assael, Leon, Awadallah, Michael, Aziz, Shahid R., Bagheri, Shahrokh C., Bailey, Jonathan, Baker, Andrew M., Bakri, Karim, Barnes, Suzanne, Bast, Brian, Batal, Hussam, Baur, Dale A., Bedrossian, Edmond, Bedrossian, Edmond Armand, Bell, R. Bryan, Bitonti, David A., Bohluli, Behnam, Bonin, Genevieve C., Bouloux, Gary F., Bradley, Meaghan, Breik, Omar, Brockhoff, Hans C., II, Buchbinder, Daniel, Bui, Tuan G., Byrne, Patrick, Caccamese, John Francis, Jr, Caloss, Ron, Caplin, Courtney, Carlson, Eric R., Casap, Nardy, Hill, Carrie E. Cera, Chakrabarti, Swagnik, Chandran, Ravi, Chaney, Blake, Cheng, Allen C., Chigurupati, Radhika, Cho, Nam, Chou, Joli, Christensen, Louis J., Cillo, Joseph E., Jr, Claiborne, Scott T., Collette, David, Contasti-Bocco, Gisela, Costello, Bernard J., Cotofana, Sebastian, Couey, Marcus A., Cunningham, Larry, Jr, Curtis, William J., L. Cuzalina, Angelo, Dang, Rushil R., Daniel, Renie, Dattilo, David J., Dean, Jeffrey S., Desai, Shaun C., Dillon, Jasjit K., Doucet, Jean-Charles, Drew, Stephanie Joy, Dyalram, Donita, Edwards, Sean P., Emam, Hany, Emmerling, Max R., Engelstad, Mark, Erickson, Helaman, Evasovich, Maria, Fagin, Adam P., Fanelli, Christopher A., Fantuzzo, Joseph J., Fattahi, Tirbod, Fernandes, Rui P., Finn, Richard Allen, Franco, Peter B., Gailey, David, Gangwani, Pooja, Ghali, Ghali E., Gibreel, Waleed, Girod, Sabine C., Golden, Brent, Gonzalez, Jorge, Gonzalez, Marianela, Granquist, Eric J., Grant, Jaime, Gray, Mingyang Liu, Guerrero, Cesar A., Hadaya, Danny, Hamlar, David, Hammer, Daniel A., Hanba, Curtis, Heggie, Andrew Alistair, Henriquez, Mariana, Henry, Andrew, Herford, Alan S., Herman, Brandyn, Hinkl, David, Holmes, Anthony David, Holton, James B., Hossaini-Zadeh, Mehran, Hossameldin, Reem H., Hsieh, Tsung-yen, Huang, Allen, Hughes, Pamela J., Hutchinson, Tanisha, Idle, Matthew R., Sunder Indrakanti, Shyam, Jaskolka, Michael, Jelmini, Jonathan James, Jensen, Ole T., Jethwa, Ashok R., Jones, Baxter, Kademani, Deepak, Kang, David R., Kao, Herman, Karlis, Vasiliki, Kim, Beomjune, Kim, D. David, Kim, Roderick Y., Kloostra, Paul, Kolokythas, Antonia, Koppel, David A., Krishnan, Deepak G., Kuriakose, Moni A., Lai, Li Han, Laster, Zvi, Laviv, Amir, Lee, Andrew W.C., Lewallen, James B., Yung-Chuan Liu, Stanley, Loetscher, Christian A., Louis, Patrick J., Lubek, Joshua E., Lugo, Ricardo, Lyford-Pike, Sofia, Kushner, George M., MacIver, Colin, MacLeod, Stephen P.R., Magraw, Caitlin B.L., Makhoul, Nicholas M., Manlove, Ashley E., Mardini, Samir, Markiewicz, Michael R., Marschall, Jeffrey S., Matthews, Nigel Shaun, McCain, Joseph P., McCoy, J. Michael, McKenna, Samuel J., Meara, Daniel J., Medeiros, Paulo Jose, Mehra, Pushkar, Mercuri, Louis G., Miles, Brett A., Miller, Meagan, Moe, Justine, Moon, Hwi Sean, Silva, Marina Morante, Morris, Christopher, Morton, Dean, Movahed, Reza, Mujica, Elena, Nadeau, Robert, Nathan, John M., Ness, Gregory M., Norbutt, Craig, Nuveen, Erik Jon, Obeid, George, Okay, Devin Joseph, Olivieri, Petra, Ord, Robert, Oreadi, Daniel, Panchal, Neeraj, Parmar, Sat, Patel, Ashish A., Peacock, Zachary S., Pennau, Karl, Perciaccante, Vincent J., Perenack, Jon D., Petukhova, Yuliya, Pfeiffer, Laurence D., Pham, Matthew H., Phelan, John N., Pi-Anfruns, Joan, Pierce, Brendan H.G., Pinkston, Daniel Joseph, Polido, Waldemar D., Posnick, Jeffrey C., Powers, David B., Prange-Kiel, Janine, Praveen, Prav, Precious, David S., Quereshy, Faisal A., Quinn, Peter D., Radant, Matthew, Ray, Christopher K., Read-Fuller, Andrew, Reddy, Likith, Renapurkar, Shravan, Reyneke, Johan P., Ritto, Fabio G., Robertson, Carrie E., Rogers, Jason, Ruggiero, Brian Louis, Ruiz, Ramon L., Sabino, Mary Ann C., Sabooree, Sepideh, Salama, Andrew, Salinas, Thomas J., Samman, Nabil, Sauerbier, Sebastian, Schlieve, Thomas, Schlissel, Edward R., Schmelzeisen, Rainer, Shand, Jocelyn M., Sharma, Kaushik H., Shirley, Brett, Shivers, Paul, Shupak, Raymond P., Van Sickels, Joseph E., Sinn, Douglas P., Smith, Kevin, Smith, Miller H., Soletic, Luke C., Stanek, Joel, Stanton, David, Steed, Martin B., Stevens, Mark, Suchyta, Marissa, Sullivan, Steven M., Sulyman, Omotara, Susarla, Srinivas M., Sylvester, David Knight, II, Talmant, Jean-Claude, Tandon, Rahul, Thakker, Jayini, Thayer, Stone, Tiwana, Paul S., Tolomeo, Pasquale G., Tran, Dan Q., Treasure, Trevor E., Trent, David C., Triplett, R. Gilbert, Tull, Greg, Turner, Michael D., Turvey, Timothy A., Uppgaard, Rachel, Vigliante, Craig E., Viozzi, Christopher F., Vorrasi, John, Waite, Peter D., Wan, Kenneth, Ward, Brent B., Wentland, Todd R., Williams, Fayette C., Woerner, Jennifer E., Wolford, Larry M., Wong, Patrick, Woo, Brian M., Wrzosek, Mariusz K., Yamashita, Duke, Yates, David M., Yeoh, Melvyn, Ying, Yedeh, Zakhary, George, and Zuniga, John R.

Published
2024
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38. Applications of Polymeric Composites in Bone Tissue Engineering and Jawbone Regeneration

Author

Fraile-Martínez, Oscar, primary, García-Montero, Cielo, additional, Coca, Alejandro, additional, Álvarez-Mon, Miguel Angel, additional, Monserrat, Jorge, additional, Gómez-Lahoz, Ana M., additional, Coca, Santiago, additional, Álvarez-Mon, Melchor, additional, Acero, Julio, additional, Bujan, Julia, additional, García-Honduvilla, Natalio, additional, Asúnsolo, Ángel, additional, and Ortega, Miguel A., additional

Published
2021
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39. Orthognathic surgery and aligners. A comparative assessment of periodontal health and quality of life in postsurgical orthodontic treatment with aligners versus traditional fixed appliances: a randomized controlled trial.

Author

de Leyva, Patricia, Miguel Eslava, Jose, Hernández-Alfaro, Federico, and Acero, Julio

Subjects
ORTHODONTIC appliances, ORTHOGNATHIC surgery, CORRECTIVE orthodontics, RANDOMIZED controlled trials, GINGIVAL hemorrhage, TOOTH root planing, PERIODONTAL probe, ORAL hygiene
Abstract

Background: Removable clear aligners have become very popular in the last few decades, but they are still little used in the field of orthognathic surgery (OS). The objective of this study was to compare periodontal health and quality of life (QoL) associated to postsurgical orthodontic treatment. Material and Methods: Patients with dentofacial deformities undergoing OS were randomly allocated to receive postsurgical orthodontic treatment with either fixed orthodontic appliances or Invisalign. The main outcomes were periodontal health and QoL. Plaque index, probing depth and bleeding on probing were assessed as periodontal health indicators. QoL was assessed through the Orthognathic Quality of Life Questionnaire (OQLQ-22) and the Oral Health Impact Profile (OHIP-14). Data were analyzed before surgery and end of treatment. Total duration of treatment was also recorded. Results: Twenty-eight patients were randomized, (16 women, 12 men). Periodontal assessment showed better outcomes for the Invisalign group: bleeding on probing (p=0.013), plaque index (p=0.001) and probing depth (p<0.001). The QoL questionnaires showed significant differences in favor of the Invisalign group: OHIP-14 (p=0.004) and OQLQ-22 (p=0.002). Total duration of treatment was similar in both groups (p=0.575). Conclusions: Compared to traditional orthodontics with fixed appliances, patients managed with clear aligners after OS (surgery-first approach) had better periodontal health and QoL outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Lost in Translation: Evaluation of Subcutaneous Interferon-β Treatment for SARS-CoV-2 Infection in Real Life.

Author

Casado, José L., Vizcarra, Pilar, Del Rey, José M., Soriano, María Cruz, Rodriguez-Dominguez, Mario, Manzano, Luis, Acero, Julio, Palomar-Fernandez, Carmen, and Vallejo, Alejandro

Subjects
COVID-19, SARS-CoV-2, PROPENSITY score matching, INTENSIVE care units, NEUTROPHIL lymphocyte ratio
Abstract

Despite in vitro activity of interferon-β (IFN-β) against SARS-CoV-2 infection, its clinical efficacy remains controversial. We evaluated the impact of IFN-β treatment in a cohort of 3590 patients hospitalized with COVID-19 during March–April 2020. The primary endpoint was a composed variable of admission to intensive care unit (ICU)/death. Overall, 153 patients (4%) received IFN-β. They were significantly more severely ill, with a worse clinical and analytical situation, explaining a higher ICU admission (30% vs. 17%; p < 0.01), and a shorter time to the composed variable. In a Cox regression analysis, older age, lymphopenia, renal failure, or increased neutrophil-to-lymphocyte ratio were associated with a greater hazard ratio (HR) of admission at ICU/death. Notably, the HR of IFN-β for the outcome variable was no longer significant after adjustment (HR, 1.03; 95% CI, 0.82–1.30), and different sensitivity analysis (early IFN use, ICU admission) showed no changes in the estimates. A propensity score matching analysis showed no association of IFN-β therapy and outcome. In conclusion, in this large cohort of hospitalized COVID-19 patients, IFN-β was used mainly in patients with advanced disease, reflecting an important bias of selection. After adjusting by severity, IFN-β was not associated with a higher rate of ICU admission or mortality. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Towards an updated view on the clinical management of pancreatic adenocarcinoma: Current and future perspectives (Review)

Author

Pekarek, Leonel, primary, Fraile‑Μartinez, Oscar, additional, Garcia‑Montero, Cielo, additional, Alvarez‑Mon, Miguel, additional, Acero, Julio, additional, Ruiz‑Llorente, Lidia, additional, García‑Honduvilla, Natalio, additional, Albillos, Agustin, additional, Buján, Julia, additional, Alvarez‑Mon, Melchor, additional, Guijarro, Luis, additional, and Ortega, Miguel, additional

Published
2021
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43. Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall

Author

Ortega, Miguel A, primary, Fraile-Martínez, Oscar, additional, García-Montero, Cielo, additional, Ruiz-Grande, Fernando, additional, Barrena, Silve, additional, Montoya, Hector, additional, Pekarek, Leonel, additional, Zoullas, Sofia, additional, Alvarez-Mon, Miguel A, additional, Sainz, Felipe, additional, Asúnsolo, Angel, additional, Acero, Julio, additional, Álvarez-Mon, Melchor, additional, Buján, Julia, additional, García-Honduvilla, Natalio, additional, and Guijarro, Luis G, additional

Published
2021
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48. The Impact of Healthcare-Associated Infections in Patients Undergoing Oncological Microvascular Head and Neck Reconstruction: A Prospective Multicentre Study

Author

Ramos Zayas, Ana, López Medrano, Francisco, Urquiza Fornovi, Irene, Zubillaga Rodríguez, Ignacio, Gutiérrez, Ramón, Sánchez Aniceto, Gregorio, Acero, Julio, Almeida, Fernando, Galdona, Ana, Morán, María José, Pampin, Marta, Cebrián, José Luis, Ramos Zayas, Ana, López Medrano, Francisco, Urquiza Fornovi, Irene, Zubillaga Rodríguez, Ignacio, Gutiérrez, Ramón, Sánchez Aniceto, Gregorio, Acero, Julio, Almeida, Fernando, Galdona, Ana, Morán, María José, Pampin, Marta, and Cebrián, José Luis

Abstract

(1) Background: Healthcare-associated infections (HAIs) after head and neck free-flap reconstruction are a common postoperative complication. Risk factors for HAIs in this context and their consequences have not been adequately described. (2) Methods: Ongoing prospective multicentre study between 02/2019 and 12/2020. Demographic characteristics and outcomes were analysed, focusing on infections. (3) Results: Forty out of 65 patients (61.54%) suffered HAIs (surgical site infection: 52.18%, nosocomial pneumonia: 23.20%, bloodstream infection: 13% and urinary tract infection: 5.80%). Methicillin-resistant Staphylococcus aureus (MRSA) and resistant Pseudomonas aeruginosa, Klebsiella pneumoniae and Enterobacter cloacae were the most frequently implicated. The significant risk factors for infection were: previous radiotherapy (Odds ratio (OR): 5.42; 95% confidence interval (CI), 1.39–21.10), anaemia (OR: 8.00; 95% CI, 0.96–66.95), salvage surgery (eight out of eight patients), tracheostomy (OR: 2.86; 95% CI, 1.01–8.14), surgery duration (OR: 1.01; 95% CI, 1.00–1.02), microvascular reoperation <72 h (eight/eight) and flap loss (eight/eight). The major surgical complications were: a need to reoperate (OR: 6.89; 95% CI, 1.42–33.51), prolonged hospital admission (OR: 1.16; 95% CI, 1.06–1.27) and delay in the initiation of postoperative radiotherapy (OR: 9.07; 95% CI, 1.72–47.67). The sixth month mortality rate in patients with HAIs was 7.69% vs. 0% in patients without HAIs (p = 0.50). (4) Conclusions: HAIs were common after this type of surgery, many of them caused by resistant microorganisms. Some modifiable risk factors were identified. Infections played a role in cancer prognosis by delaying adjuvant therapy., Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2021

49. The Impact of Healthcare-Associated Infections in Patients Undergoing Oncological Microvascular Head and Neck Reconstruction: A Prospective Multicentre Study

Author

Ramos-Zayas, Ana, primary, López-Medrano, Francisco, additional, Urquiza-Fornovi, Irene, additional, Zubillaga, Ignacio, additional, Gutiérrez, Ramón, additional, Sánchez-Aniceto, Gregorio, additional, Acero, Julio, additional, Almeida, Fernando, additional, Galdona, Ana, additional, Morán, María José, additional, Pampin, Marta, additional, and Cebrián, José Luis, additional

Published
2021
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